Search results for: CD8
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Peripheral blood T-cell subset and its clinical significance in lupus nephritis patients.
Lupus nephritis (LN) is a common and severe manifestation of SLE. Memory T (TM) cells have been implicated in the pathogenesis of SLE. This study aimed to investigate the clinical significance of T-cell subsets in a cohort of patients with LN.Huijing Wang, Lan Lan, Jianghua Chen, Liang Xiao, Fei Han
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3x 500 ml10 ug
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#35973736 2022/08/16
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A novel dibenzofuran from endophytic fungus Mycosphaerella nawae preferentially inhibits CD4 T cell activation and proliferation.
To obtain promising immunosuppressants from endophytic fungus.Li-Wei Wang, Jie Li, Le-Xin Gao, Feng-Yang Chen
1398 related Products with: A novel dibenzofuran from endophytic fungus Mycosphaerella nawae preferentially inhibits CD4 T cell activation and proliferation.
2500 Tests24 tests200 100 ug25 mg0.5 mg25 Tests96T500 assays
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#35973731 2022/08/16
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Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function.
In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators of early kidney allograft inflammation are unclear, making it challenging to design therapeutic interventions.Anil Dangi, Irma Husain, Collin Z Jordan, Shuangjin Yu, Naveen Natesh, Xiling Shen, Jean Kwun, Xunrong Luo
1307 related Products with: Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function.
100.00 ug50.00 ug200.00 ug50 ug50 ug50 ug50 ug50 ug15 ml50 ug50 ug50 ug
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#35973636 2022/08/13
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Impairment of cytokine production following immunological synapse formation in patients with Wiskott-Aldrich syndrome and leukocyte adhesion deficiency type 1.
T cells following immunological synapse (IS) formation with antigen-presenting cells produce multiple cytokines through T cell receptor, integrin, and costimulatory signaling. Here, we investigated the cytokine profiles following IS formation in response to staphylococcal superantigen exposure in three adolescent patients with classical Wiskott-Aldrich syndrome (WAS) and in one patient with leukocyte adhesion deficiency (LAD) type 1. All WAS patients showed lower Th1 and Th2-skewed cytokine production; similar results were observed in the flow cytometric analysis of IFNγ- and IL-4-producing T cells. The patient with LAD type 1 with somatic mosaicism in 2% of CD8+ T cells showed lower Th1 and Th2 cytokine production than healthy controls. The patients with WAS were susceptible to infections and atopic manifestations, and the patients with LAD type 1 showed cold abscess on their skin, our findings using patient samples provide clinical insights into the mechanisms underlying immunodeficiency related to the symptoms of each disease.Yoji Sasahara, Taizo Wada, Tomohiro Morio