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Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients.

Deregulated circulating microRNAs (miRNAs) are potential biomarkers for the early detection and prognosis prediction of non-small-cell lung cancer (NSCLC). The aim of the present study was to investigate the expression pattern of serum exosomal miR-378 in NSCLC and its correlation with clinical variables.

2570 related Products with: Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients.

Non-small cell lung cance Lung non small cell cance Small cell lung carcinoma Middle advanced stage lun Non small cell lung carci Non small cell lung carci Multiple lung carcinoma ( High density non small ce Lung small cell carcinoma Lung cancer tissue array Lung cancer tissue array, Human Small Intestine Mic

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Recent findings in the genetics and epigenetics of asthma and allergy.

In asthma and allergy genetics, a trend towards a few main topics developed over the last 2 years. First, a number of studies have been published recently which focus on overlapping and/or very specific phenotypes: within the allergy spectrum but also reaching beyond, looking for common genetic traits shared between different diseases or disease entities. Secondly, an urgently needed focus has been put on asthma and allergy genetics in populations genetically different from European ancestry. This acknowledges that the majority of new asthma patients today are not white and asthma is a truly worldwide disease. In epigenetics, recent years have seen several large-scale epigenome-wide association studies (EWAS) being published and a further focus was on the interaction between the environment and epigenetic signatures. And finally, the major trends in current asthma and allergy genetics and epigenetics comes from the field of pharmacogenetics, where it is necessary to understand the susceptibility for and mechanisms of current asthma and allergy therapies while at the same time, we need to have scientific answers to the recent availability of novel drugs that hold the promise for a more individualized therapy.

2427 related Products with: Recent findings in the genetics and epigenetics of asthma and allergy.

FDA Standard Frozen Tissu Androgen Receptor , Mouse (5α,16β)-N-Acetyl-16-[2 (5α)-Androst-2-en-17-one Andarine C19H18F3N3O6� 1,4 Androstadiene 3,17 di Goat Anti-Human Androgen ELISA 5α-Androstane-3α, ∆1-Androstene-3α,17β- Androgen Receptor (Ab-650 FDA Standard Frozen Tissu Anti Androgen Receptor pr

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Dynamics of the localization of the plastid terminal oxidase PTOX inside the chloroplast.

The plastid terminal oxidase (PTOX) is a plastohydroquinone:oxygen oxidoreductase that shares structural similarities with alternative oxidases (AOX). Multiple roles have been attributed to PTOX, such as involvement in carotene desaturation, a safety valve function, participation in the processes of chlororespiration and setting the redox poise for cyclic electron transport. PTOX activity has been previously shown to depend on its localization at the thylakoid membrane. Here we investigated the dynamics of PTOX localization in dependence on the proton motive force. Infiltrating illuminated leaves with uncouplers led to a partial dissociation of PTOX from the thylakoid membrane. In vitro reconstitution experiments showed that the attachment of purified recombinant MBP-OsPTOX to liposomes and isolated thylakoid membranes was strongest at slightly alkaline pH values in the presence of lower millimolar concentrations of KCl or MgCl2. In A. thaliana overexpressing GFP-PTOX, confocal microscopy images showed that PTOX formed distinct spots in chloroplasts of dark-adapted or uncoupler-treated leaves while the protein was more equally distributed in a network-like structure in the light. We propose a dynamic PTOX association with the thylakoid membrane depending on the presence of a proton motive force.

2619 related Products with: Dynamics of the localization of the plastid terminal oxidase PTOX inside the chloroplast.

TCP-1 theta antibody Sour Rabbit anti PKC theta (pS Sheep Anti-Theophylline 3 FDA Standard Frozen Tissu MyGenie 32 Thermal Block Recombinant Thermostable Thermostable TDG Kit (DIS Rabbit anti PKC theta (Ab Tissue array of ovarian g FDA Standard Frozen Tissu Multiple organ cancer tis CSL Gradient Thermal Cycl

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Inhibition of store-operated calcium channels by N-arachidonoyl glycine (NAGly): no evidence for the involvement of lipid-sensing G protein coupled receptors.

N-arachidonoyl glycine (NAGly) is an endogenous lipid deriving from the endocannabinoid anandamide (AEA). Identified as a ligand of several G-protein coupled receptors (GPCRs), it can however exert biological responses independently of GPCRs. NAGly was recently shown to depress store-operated Ca entry (SOCE) but its mechanism of action remains elusive. The major aim of this study was to gain a better knowledge on the NAGly-dependent impairment of SOCE in neurons of the central nervous system (CNS) from mice. First, we examined the expression of genes encoding for putative lipid sensing GPCRs using transcriptomic data publicly available. This analysis showed that the most abundant GPCRs transcripts present in the cerebral cortices of embryonic brains were coding for lysophosphatidic acid (LPA) and sphingosine-1 phosphate (S1P) receptors. Next, the presence of functional receptors was assessed with live-cell calcium imaging experiments. In primary cortical cells S1P and LPA mobilize Ca from internal stores via a mechanism sensitive to the S1P and LPA receptor antagonists Ex26, H2L5186303, or Ki16425. However, none of these compounds prevented or attenuated the NAGly-dependent impairment of SOCE. We found no evidence for the requirement of lipid sensing GPCRs in this inhibitory process, indicating that NAGly is an endogenous modulator interfering with the core machinery of SOCE. Moreover, these data also raise the intriguing possibility that the depression of SOCE could play a role in the central effects of NAGly.

2646 related Products with: Inhibition of store-operated calcium channels by N-arachidonoyl glycine (NAGly): no evidence for the involvement of lipid-sensing G protein coupled receptors.

G Protein Coupled Recepto G Protein Coupled Recepto G Protein Coupled Recepto G Protein Coupled Recepto G Protein Coupled Recepto G Protein Coupled Recepto G Protein Coupled Recepto G Protein Coupled Recepto G protein-coupled recepto G Protein Coupled Recepto G Protein Coupled Recepto G Protein Coupled Recepto

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Embryonic photosynthesis affects post-germination plant growth.

Photosynthesis is the fundamental process fuelling plant vegetative growth and development. The progeny of plants rely on maternal photosynthesis, via food reserves in the seed, to supply the necessary energy for seed germination and early seedling establishment. Intriguingly, prior to seed maturation, Arabidopsis thaliana embryos are also photosynthetically active, the biological significance of which remains poorly understood. Investigating this system is genetically challenging since mutations perturbing photosynthesis are expected to affect both embryonic and vegetative tissues. Here, we isolated a temperature-sensitive mutation affecting CPN60α2, which encodes a subunit of the chloroplast chaperonin complex CPN60. When exposed to cold temperatures, cpn60α2 mutants accumulate less chlorophyll in newly produced tissues, thus allowing the specific disturbance of embryonic photosynthesis. Analyses of cpn60α2 mutants were combined with independent genetic and pharmacological approaches to show that embryonic photosynthetic activity is necessary for normal skoto- and photomorphogenesis in juvenile seedlings as well as long-term adult plant development. Our results reveal the importance of embryonic photosynthetic activity for normal adult plant growth, development, and health.

2153 related Products with: Embryonic photosynthesis affects post-germination plant growth.

Human Connective Tissue G Mouse Anti-Growth Hormone Plant DNA Preparation Kit Mouse Fibroblast Growth F Goat Anti-Human Fibroblas Rabbit Polyclonal Antibod Rat transforming growth f Mouse Insulin-like Growth Rabbit Polyclonal Antibod Borellia grade BSA powde Rat Vascular Endothelial pCAMBIA0105.1R Vector, (G

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Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs.

The aggregation of the protein α-synuclein (α-Syn) leads to different synucleinopathies. We recently showed that structurally distinct fibrillar α-Syn polymorphs trigger either Parkinson's disease or multiple system atrophy hallmarks in vivo. Here, we establish a structural-molecular basis for these observations. We show that distinct fibrillar α-Syn polymorphs bind to and cluster differentially at the plasma membrane in both primary neuronal cultures and organotypic hippocampal slice cultures from wild-type mice. We demonstrate a polymorph-dependent and concentration-dependent seeding. We show a polymorph-dependent differential synaptic redistribution of α3-Na/K-ATPase, GluA2 subunit containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, and GluN2B-subunit containing N-methyl-D-aspartate receptors, but not GluA1 subunit containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and metabotropic glutamate receptor 5 receptors. We also demonstrate polymorph-dependent alteration in neuronal network activity upon seeded aggregation of α-Syn. Our findings bring new, to our knowledge, insight into how distinct α-Syn polymorphs differentially bind to and seed monomeric α-Syn aggregation within neurons, thus affecting neuronal homeostasis through the redistribution of synaptic proteins.

1415 related Products with: Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs.

Rabbit Anti-Rat Androgen anti-Diazepam Binding Inh Anti-Androgen Receptor pr IpPore track etched membr 1X Annexin V Binding Buff DNA Binding Protein-7 (DB Rabbit Anti-alpha-Synucle D Luciferin, ethyl ester, Anti basement membrane ma IpPore track etched membr Mouse Anti-Human Retinol AZD-3514 Mechanisms: Andr

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