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#35961596   2022/08/09 To Up

Angiotensin II can trigger HSC-LX2 pyroptosis through both classical and non-classical pathways.

Current evidence suggests that liver fibrosis is reversible even at late stages. Pyroptosis is reportedly regulated by classical and non-classical pathways and is also involved in the activation of the human hepatic stellate cell line LX2. This study sought to identify regulatory pathways that pyroptosis of HSC during AngII-ROS-induced HSC activation and provides novel insights for anti-fibrosis therapy by targeting HSC.
Ze-Yu Xie, Yi-Xiao Xu, Li Yao

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