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Search results for: Calcitonin

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#35041064   2022/01/18 To Up

[CGRP antibodies in migraine prophylaxis : The new standard in migraine treatment?]

Migraine is associated with a high individual level of suffering. Therefore, an effective preventive treatment is highly important. The spectrum of classical prophylactic drugs has now been expanded to include monoclonal antibodies against calcitonin gene-related peptide (CGRP) and its receptor. These antibodies have shown reliable efficacy compared to placebo and a rapid onset of action with a low rate of side effects and negligible interactions in pivotal studies. Recently, the efficacy of the antibody was shown in many studies even on drug-refractory migraine and migraine associated with medication overuse. Comprehensive head to head comparisons with previously established drugs and among the antibodies are not yet available; however, initial studies suggest better tolerability and efficacy compared to conventional drugs and other antibodies. The role of antibodies in established treatment cascades still needs to be clarified.
Till Hamann, Florian Rimmele, Tim Patrick Jürgens

1847 related Products with: [CGRP antibodies in migraine prophylaxis : The new standard in migraine treatment?]

100 μg100100 μg100 μg100 μg

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#35038983   2022/01/17 To Up

Monthly migraine days, tablet utilization, and quality of life associated with Rimegepant - post hoc results from an open label safety study (BHV3000-201).

The objective of this study was to describe patterns in monthly migraine days (MMD) and tablet utilization, and to estimate health-related quality of life (HRQoL) measures in patients treated as needed (PRN) with rimegepant 75 mg over 52-weeks.
Karissa Johnston, Linda Harris, Lauren Powell, Evan Popoff, Vladimir Coric, Gilbert L'Italien, Curtis P Schreiber

1972 related Products with: Monthly migraine days, tablet utilization, and quality of life associated with Rimegepant - post hoc results from an open label safety study (BHV3000-201).

10mg100 Tests25 100 25 1mg96T100 25 1.0mg100 Tests25 Tests

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#35036874   2021/12/24 To Up

The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis.

Pharmacological application of teleost calcitonin (CT) has been shown to exert chondroprotective and anti-resorptive effects in patients with rheumatoid arthritis (RA). However, the role of endogenous CT that signals through the calcitonin receptor (CTR) remains elusive. Collagen II antibody-induced arthritis (CAIA) was stimulated in wild type (WT) and CTR-deficient (Calcr) mice. Animals were monitored over 10 or 48 days. Joint inflammation, cartilage degradation, and bone erosions were assessed by clinical arthritis score, histology, histomorphometry, gene expression analysis, and μ-computed tomography. CAIA was accompanied by elevated systemic CT levels and CTR expression in the articular cartilage. Inflammation, cartilage degradation, and systemic bone loss were more pronounced in Calcr CAIA mice. Expression of various pro-inflammatory, bone resorption, and catabolic cartilage markers were exclusively increased in Calcr CAIA mice. Endogenous CT signaling through the mammalian CTR has the potential to protect against joint inflammation, cartilage degradation, and excessive bone remodeling in experimental RA.
Tazio Maleitzke, Alexander Hildebrandt, Tamara Dietrich, Jessika Appelt, Denise Jahn, Ellen Otto, Dario Zocholl, Anke Baranowsky, Georg N Duda, Serafeim Tsitsilonis, Johannes Keller

2225 related Products with: The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis.

100ug50 ul100ug100ug8 Sample Kit100ug16 Arrays/Slide50 ug 100ug100ug Lyophilized8 Sample Kit

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#35033025   2022/01/15 To Up

Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system.

Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanilloid 1 (TRPV1) receptor-dependent meningeal nociceptor functions in rats.
Judit Rosta, Máté Tóth, Nadine Friedrich, Péter Sántha, Gábor Jancsó, Mária Dux

2209 related Products with: Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system.

25 mg100.00 ug100ug Lyophilized100ug100ug Lyophilized100ug2 Pieces/Box10ug100ug Lyophilized96 wells (1 kit)100ug100ug

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#35032503   2022/01/12 To Up

Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling-Mediated Sensory Neuron-Dendritic Cell Communication.

Psoriasis is a chronic immune-mediated skin disorder with the nervous system contributing to its pathology. The neurogenic mediators of psoriasis are elusive and whether the intervention of cutaneous nervous system can treat psoriasis remains to be determined. Here we conducted a pilot study using epidural injection of lidocaine to treat patients with psoriasis. Lidocaine treatment markedly reduced patients' clinical scores, and improved an imiquimod (IMQ)-induced rat model of psoriasis as competent as systemic delivery of a TNF-α antibody. IMQ application elicited aberrant cutaneous nerve outgrowth and excessive generation of neuropeptide calcitonin gene-related peptide (CGRP) from dorsal root ganglion (DRG) neurons, both of which were inhibited by epidural lidocaine treatment. Single-cell RNA sequencing unveiled the overrepresentation of CGRP receptors in dermal dendritic cell (DC) populations of patients with psoriasis. Through disturbing CGRP signaling, lidocaine inhibited IL-23 production by DCs co-cultured with DRG neurons. Thus, epidural nerve block with lidocaine demonstrates an effective therapy for psoriasis, which suppresses both inordinate sensory nerve growth in the inflamed skin and CGRP-mediated IL-23 production from psoriatic DCs.
Qianqian Yin, Libo Sun, Xiaojie Cai, Fangzhou Lou, Yang Sun, Bin Wang, Bowen Jiang, Lan Bao, Xia Li, Ningjing Song, Sibei Tang, Jing Bai, Zhikai Wang, Yue Wu, Hong Zhou, Hong Wang, Buwei Yu, Qifang Li, Honglin Wang

1936 related Products with: Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling-Mediated Sensory Neuron-Dendritic Cell Communication.

25 1.00 mg200 25 1.00 mg2 Pieces/Box1.5x10(6) cells2 ml1200 4 100ul

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#35031579   2022/01/14 To Up

Regulation of Cutaneous Immunity In Vivo by Calcitonin Gene-Related Peptide Signaling through Endothelial Cells.

Calcitonin gene-related peptide (CGRP) can bias the outcome of Ag presentation to responsive T cells in vitro away from Th1-type immunity and toward the Th2 and Th17 poles through actions on endothelial cells (ECs). To test the in vivo significance of this observation, we engineered a mouse lacking functional CGRP receptors on ECs (EC receptor activity modifying protein 1 [RAMP1] knockout mice). On percutaneous immunization to 1-fluoro-2,4-dinitrobenzene, stimulated CD4 T cells from draining lymph nodes showed significantly reduced IL-17A expression with significantly increased IFN-γ, IL-4, and IL-22 expression at the protein and mRNA levels compared with control mice. Retinoic acid receptor-related orphan receptor γ t mRNA was significantly reduced, while mRNAs for T-box expressed in T cells and GATA binding protein 3 were significantly increased. In addition, EC RAMP1 knockout mice had significantly reduced contact hypersensitivity responses, and systemic administration of a CGRP receptor antagonist similarly inhibited contact hypersensitivity in wild-type mice. These observations provide compelling evidence that CGRP is a key regulator of cutaneous immunity through effects on ECs and suggest a novel pathway for potential therapeutic manipulation.
Wanhong Ding, Lori L Stohl, Jad Saab, Shayan Azizi, Xi K Zhou, Devina Mehta, Richard D Granstein

1934 related Products with: Regulation of Cutaneous Immunity In Vivo by Calcitonin Gene-Related Peptide Signaling through Endothelial Cells.

1.00 flask96 assays1.00 flask96 tests1.00 flask96 tests2 Pieces/Box300 units1.00 flask96 wells50 ug

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#35030439   2021/12/21 To Up

Calcitonin gene-related peptide upregulates IL-17A and IL-22 in γδ-T cells through the paracrine effect of langerhans cells on LC/γδ-T co-culture model.

Intense mental stimulation and stress often directly induce or exacerbate psoriasis. On the contrary, patients with nerve injury and nervous system dysfunction have psoriasis remission. The nervous system plays an important role in the inflammatory process of psoriasis, and neuropeptides are considered as local mediators of disease maintenance. To examine the molecular mechanism involved in this, first we analyzed calcitonin gene-related peptide (CGRP)-treated langerhans Cells and γδ-T cells separately. CGRP induced IL-23 mRNA and protein expression via PDK1-Rsk signaling pathway. However, CGRP had no effect on secretion of IL-17A and IL-22 in γδ-T cells. Then we treated LCs/γδ-T cells Co-culture Model with CGRP. CGRP upregulated IL-17A and IL-22 expression in co-culture model through the paracrine effect of LCs. IL-17A and IL-22 are key cytokines of psoriasis. These findings provide a potential mechanism by which nerve factors affect the development of psoriasis.
Fen Peng, Siqi Zhao, Xuan Zhang, Siyu Long, Yanling He

2456 related Products with: Calcitonin gene-related peptide upregulates IL-17A and IL-22 in γδ-T cells through the paracrine effect of langerhans cells on LC/γδ-T co-culture model.

96 tests50 ug96 tests100 extractions100 extractions50 ug1

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#35028080   2021/08/05 To Up

Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study.

Genetics plays a role in the susceptibility to periodontitis and tooth loss. Several studies examined the involvement of polymorphisms in candidate genes. We hypothesize that bone metabolism-related polymorphisms could be associated with the number of remaining teeth.
Estella Musacchio, Pierluigi Binotto, Fatima Silva-Netto, Egle Perissinotto, Leonardo Sartori

2047 related Products with: Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study.

500 MG100ul25 mg2 Pieces/Box10 mg100ug50 mg2.5 mg

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#35026523   2021/12/25 To Up

Wuzhuyu Decoction relieves hyperalgesia by regulating central and peripheral 5-HT in chronic migraine model rats.

Chronic migraine (CM) is a highly disabling and burdensome disease. Wuzhuyu decoction (WZYD), a clinical used formula to treat and prevent episodic migraine and CM, has been reported to relieve the hyperalgesia of CM and increase brainstem and blood serotonin (5-hydroxytryptamine, 5-HT) in migraine model rats in previous studies; yet the mechanism is unclear.
Nan Nan, Mu-Xin Gong, Qi Wang, Mei-Jing Li, Rui Xu, Zhe Ma, Si-Hui Wang, Hui Zhao, Yong-Song Xu

1915 related Products with: Wuzhuyu Decoction relieves hyperalgesia by regulating central and peripheral 5-HT in chronic migraine model rats.

100 μg2 Pieces/Box100 μg100 μg 100 UG

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#35018361   2021/12/08 To Up

Administration of High-Dose Methylprednisolone Worsens Bone Loss after Acute Spinal Cord Injury in Rats.

The administration of high-dose methylprednisolone (MP) for 24-48 h after traumatic spinal cord injury (SCI) has been shown to improve functional recovery. The known adverse effects of MP on skeletal muscle and the immune system, though, have raised clinically relevant safety concerns. However, the effect of MP administration on SCI-induced bone loss has not been evaluated to date. This study examined the adverse effects of high-dose MP administration on skeletal bone after acute SCI in rodents. Male rats underwent spinal cord transection at T3-T4, which was followed by an intravenous injection of MP and subsequent infusion of MP for 24 h. At 2 days, animals were euthanized and hindlimb bone samples were collected. MP significantly reduced bone mineral density (-6.7%) and induced deterioration of bone microstructure (trabecular bone volume/tissue volume, -18.4%; trabecular number, -19.4%) in the distal femur of SCI rats. MP significantly increased expression in the hindlimb bones of osteoclastic genes receptor activator of nuclear factor-κB ligand (RANKL; +402%), triiodothyronine receptor auxiliary protein (+32%), calcitonin receptor (+41%), and reduced osteoprotegerin/RANKL ratio (-72%) compared to those of SCI-vehicle animals. Collectively, 1 day of high-dose MP at a dose comparable to the dosing regimen prescribed to patients who qualify to receive this treatment approach with acute SCI increased loss of bone mass and integrity below the level of lesion than that of animals that had SCI alone, and was associated with further elevation in the expression of genes involved in pathways associated with osteoclastic bone resorption than that observed in SCI animals.
Yuanzhen Peng, Wei Zhao, Yizhong Hu, X Edward Guo, Jun Wang, Ke Hao, Zhiming He, Carlos Toro, William A Bauman, Weiping Qin

2278 related Products with: Administration of High-Dose Methylprednisolone Worsens Bone Loss after Acute Spinal Cord Injury in Rats.

96 wells (1 kit)

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