Only in Titles

Search results for: Cancer

paperclip

#33098753   // To Up

Are children with SARS-CoV-2 infection at high risk for thrombosis? Viscoelastic testing and coagulation profiles in a case series of pediatric patients.

The coagulopathy of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well documented in adults, with increases in D-dimer and prothrombin time found to be strong predictors of mortality, and anticoagulation shown to decrease this mortality. Viscoelastic parameters such as elevations in maximum clot firmness (MCF) on rotational thromboelastometry (ROTEM) have correlated with a hypercoagulable state in adults with SARS-CoV-2. We report our experience in children infected with SARS-CoV-2, with noted elevations in D-dimer and MCF on ROTEM (indicating hypercoagulability). Exploration of viscoelastic testing to provide additional laboratory-based evidence for pediatric-specific risk assessment for thromboprophylaxis in SARS-CoV-2 is warranted.
Maha Al-Ghafry, Banu Aygun, Abena Appiah-Kubi, Adrianna Vlachos, Gholamabbas Ostovar, Christine Capone, Tod Sweberg, Nancy Palumbo, Pratichi Goenka, Lawrence W Wolfe, Jeffrey M Lipton, Suchitra S Acharya

1545 related Products with: Are children with SARS-CoV-2 infection at high risk for thrombosis? Viscoelastic testing and coagulation profiles in a case series of pediatric patients.

case4 Membranes/Box

Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

#33098744   2020/10/24 To Up

Clinical utilization of blinatumomab and inotuzumab immunotherapy in children with relapsed or refractory B-acute lymphoblastic leukemia.

The treatment paradigm for patients with relapsed/refractory B-cell acute lymphoblastic leukemia (rrALL) has been revolutionized given recent clinical trials demonstrating remarkable success of immunotherapies and leading to drug approvals by United States and European agencies. We report experience with commercial blinatumomab and inotuzumab use at two North American pediatric oncology centers in children and adolescents/young adults with B-ALL.
Cristina F Contreras, Christine S Higham, Astrid Behnert, Kailyn Kim, Elliot Stieglitz, Sarah K Tasian

1645 related Products with: Clinical utilization of blinatumomab and inotuzumab immunotherapy in children with relapsed or refractory B-acute lymphoblastic leukemia.



Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

#33098737   2020/10/24 To Up

Alterations in Plasma Kynurenine Pathway Metabolites in Children and Adolescents with Bipolar Disorder and Unaffected Offspring of Bipolar Parents: A preliminary study.

There has been growing scientific evidence in recent years that bipolar disorder (BD) is associated with alterations in the kynurenine (KYN) pathway. However, many of these studies have been limited by their focus on adults. Thus, this preliminary study investigated differences in the peripheral levels of KYN metabolites in children and adolescents with BD, unaffected offspring of parents with BD, and healthy controls (HCs).
Deborah Benevenuto, Kirti Saxena, Gabriel R Fries, Samira S Valvassori, Ramandeep Kahlon, Johanna Saxena, Sherin Kurian, Cristian P Zeni, Iram Kazimi, Giselli Scaini, Jair C Soares, João Quevedo

1840 related Products with: Alterations in Plasma Kynurenine Pathway Metabolites in Children and Adolescents with Bipolar Disorder and Unaffected Offspring of Bipolar Parents: A preliminary study.

100 μg2 Pieces/Box2 Pieces/Box96T2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box

Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

Error loading info... Pleas try again later.
paperclip

#33098714   2020/10/24 To Up

Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.

Ningetinib is a tyrosine kinase inhibitor for the treatment of non-small cell lung cancer (NSCLC). The present study aims to investigate the drug interaction of ningetinib and gefitinib and the mechanism of high plasma exposure of N-demethylated ningetinib (M1) in NSCLC patients.
Lu Liu, Qian Wang, Cen Xie, Ning Xi, Zitao Guo, Ming Li, Xiangyu Hou, Ningjie Xie, Mingming Sun, Jing Li, Xiaoyan Chen

1933 related Products with: Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.



Related Pathways

paperclip

#33098704   2020/10/24 To Up

The role of local radiotherapy following rituximab-containing chemotherapy in patients with transformed indolent B-cell lymphoma.

This study aimed to evaluate the outcomes of local radiotherapy (LRT) in patients with histologic transformation (HT) following rituximab-containing chemotherapy.
Kenji Nozaki, Dai Maruyama, Akiko Miyagi Maeshima, Kinuko Tajima, Jun Itami, Takafumi Shichijo, Sayako Yuda, Tomotaka Suzuki, Kosuke Toyoda, Nobuhiko Yamauchi, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Yukio Kobayashi, Hirokazu Taniguchi, Koji Izutsu, Kensei Tobinai

2144 related Products with: The role of local radiotherapy following rituximab-containing chemotherapy in patients with transformed indolent B-cell lymphoma.

100ug Lyophilized1 mL24 tests1x10e7 cells1 mg96 samples

Related Pathways

    No related Items
paperclip

#33098702   2020/10/24 To Up

Recurrence patterns in patients with Stage II melanoma: The evolving role of routine imaging for surveillance.

The relatively recent availability of effective systemic therapies for metastatic melanoma necessitates reconsideration of current surveillance patterns. Evidence supporting surveillance guidelines for resected Stage II melanoma is lacking. Prior reports note routine imaging detects only 21% of recurrent disease. This study aims to define recurrence patterns for Stage II melanoma to inform future surveillance guidelines.
Josh Bleicher, Douglas S Swords, Meghan E Mali, Lauren McGuire, Maranda K Pahlkotter, Elliot A Asare, Tawnya L Bowles, John R Hyngstrom

1291 related Products with: Recurrence patterns in patients with Stage II melanoma: The evolving role of routine imaging for surveillance.



Related Pathways