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Search results for: Cardiac

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#33098750   2020/10/24 To Up

Brachyury engineers cardiac repair competent stem cells.

To optimize the regenerative proficiency of stem cells, a cardiopoietic protein-based cocktail consisting of multiple growth factors has been developed and advanced into clinical trials for treatment of ischemic heart failure. Streamlining the inductors of cardiopoiesis would address the resource intensive nature of the current stem cell enhancement protocol. To this end, the microencapsulated-modified-mRNA (M RNA) technique was here applied to introduce early cardiogenic genes into human adipose-derived mesenchymal stem cells (AMSCs). A single mesodermal transcription factor, Brachyury, was sufficient to trigger high expression of cardiopoietic markers, Nkx2.5 and Mef2c. Engineered cardiopoietic stem cells (eCP) featured a transcriptome profile distinct from pre-engineered AMSCs. In vitro, eCP demonstrated protective antioxidant capacity with enhanced superoxide dismutase expression and activity; a vasculogenic secretome driving angiogenic tube formation; and macrophage polarizing immunomodulatory properties. In vivo, in a murine model of myocardial infarction, intramyocardial delivery of eCP (600 000 cells per heart) improved cardiac performance and protected against decompensated heart failure. Thus, heart repair competent stem cells, armed with antioxidant, vasculogenic, and immunomodulatory traits, are here engineered through a protein-independent single gene manipulation, expanding the available regenerative toolkit.
Mark Li, Satsuki Yamada, Ao Shi, Raman Deep Singh, Tyler J Rolland, Ryounghoon Jeon, Natalia Lopez, Lukas Shelerud, Andre Terzic, Atta Behfar

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#33098726   2020/10/24 To Up

Dyskalemia: a management problem for students.

Although dyskalemia is common, its management can be problematic for students and general practitioners, especially when it occurs in patients with heart and renal failure. The basic academic knowledge of general medicine students, who have often not yet encountered clinical situations of dyskalemia, remains unclear in this regard.
Lisa Senninger, Laure Abensur Vuillaume, Luc Frimat, Nicolas Girerd, Zohra Lamiral, Patrick Rossignol, Jean-Marc Boivin

2336 related Products with: Dyskalemia: a management problem for students.

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#33098700   2020/10/24 To Up

Ivabradine Improves Survival and Attenuates Cardiac Remodelling in Isoproterenol-Induced Myocardial Injury.

This study investigated whether ivabradine, a selective I -current inhibitor reducing heart rate (HR), is able to improve survival and prevent left ventricular (LV) remodelling in isoproterenol-induced heart damage. Wistar rats were treated for six weeks: controls (n=10), ivabradine (10 mg/kg/day orally; n=10), isoproterenol (5 mg/kg/day intraperitoneally; n=40), and isoproterenol plus ivabradine (n=40). Isoproterenol increased mortality, induced hypertrophy of both ventricles and LV fibrotic rebuilding, and reduced systolic blood pressure (SBP). Ivabradine significantly increased survival rate (by 120%) and prolonged average survival time (by 20%). Furthermore, ivabradine reduced LV weight and hydroxyproline content in soluble and insoluble collagen fraction, reduced HR and attenuated SBP decline. We conclude that ivabradine improved survival in isoproterenol-damaged hearts.
Fedor Simko, Tomas Baka, Kristina Repova, Silvia Aziriova, Kristina Krajcirovicova, Ludovit Paulis, Michaela Adamcova

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#33098645   2020/10/24 To Up

QTc interval prolongation and life-threatening arrhythmias during hospitalization in patients with COVID-19. Results from a multi-center prospective registry.

Prolonged QTc interval and life-threatening arrhythmias (LTA) are potential drug induced complications previously reported with antimalarial, antivirals and antibiotics.
Francesco Santoro, Francesco Monitillo, Pasquale Raimondo, Agostino Lopizzo, Gaetano Brindicci, Michele Gilio, Francesco Musaico, Michele Mazzola, Domenico Vestito, Rossella Di Benedetto, Mohammad Abumayyaleh, Ibrahim El-Battrawy, Carmen Rita Santoro, Luigi Flavio Massimiliano Di Martino, Ibrahim Akin, Giulio De Stefano, Rosario Fiorilli, Michele Cannone, Annalisa Saracino, Salvatore Angarano, Sergio Carbonara, Salvatore Grasso, Luigi Di Biase, Natale Daniele Brunetti

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#33098631   2020/10/12 To Up

Calcium and s100a1 protein balance in the brain-heart axis in diabetic male Wistar rats.

Objectives Calcium deregulation in diabetes mellitus (DM) is central to the brain-heart axis pathology. This has led to the use of medical plants in complementary medicine such as Amaranthus hypochondriacus (GA). The objective of the study was to establish the effects of grain amaranth feed supplementation on calcium, s100al protein and antioxidant levels on the brain-heart axis in diabetic male Wistar rats. Methods The study involved six groups (n=5) with DM being induced in 20 rats. To the diabetic rats, Group I received mixtard®, Group II was positive control, Groups III and IV received GA feed supplementation at 25 and 50%. In the nondiabetic rats (n=10), Group V received 50% grain amaranth while Group VI was the negative control. The brain and heart tissues were harvested after five weeks and processed using standard methods. Results Grain amaranth feed supplementation led to improved calcium levels in DM as compared to the positive control. This also led to increased s100a1, antioxidant levels in the brain-heart axis during DM. This then protected the tissues against oxidative damage, thus preserving tissue function and structure. Conclusions Grain amaranth's actions on calcium signaling subsequently affected s100a1 protein levels, leading to improved tissue function in diabetes.
Keneth Iceland Kasozi, Dorothy Nakimbugwe, Herbert Izo Ninsiima, Josephine Kasolo, Kevin Matama, Abass Alao Safiriyu, Elna Owembabazi, Fred Ssempijja, Alfred Omachonu Okpanachi, Miriela Betancourt Valladares

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#33098559   2020/10/24 To Up

Wild black rats (Rattus rattus Linnaeus, 1758) as zoomonitor of genotoxicity and systemic toxicity induced by hazardous emissions from Abule Egba unsanitary landfill, Lagos, Nigeria.

Wild black rats (Rattus rattus) inhabiting Abule Egba landfill (AEL) were used as zoomonitor to assess health risk associated with exposure to hazardous chemicals from landfills. Twenty five R. rattus (16♂ and 9♀) captured within AEL and 15 (9♂ and 6♀) (control) caught from Iyano Ipaja (10 km away from AEL) were examined for bone marrow micronucleated polychromatic erythrocytes (MNPCE) and polychromatic erythrocytes/normochromatic erythrocytes (PCE/NCE) ratio, abnormal sperm morphology, alterations in hematological indices and erythrocyte morphology, and histopathology of the viscera using standard protocols. There was significant (p < 0.05) increase in MNPCE but decrease PCE/NCE ratio in bone marrow cells of exposed rats than the reference site. MNPCE was insignificantly higher in male than females. Cauda epididymal sperms from exposed rats showed significant high frequency of teratozoospermia. Erythrocyte count, hemoglobin concentrations, percentage hematocrits, mean corpuscular hemoglobin concentrations, leucocyte count, and lymphocytes decreased while mean corpuscular volume, neutrophils, and mean corpuscular hemoglobin increased in the exposed rats compared to the control. Also, abnormal erythrocyte morphology: acanthocytes, codocytes (target cells), schizocytes, and tear drops significantly increased in the exposed rats. Marginal sexual dimorphism was observed between males and females in the incidence of hematological indices. Histopathological lesions including interstitial edema, hemorrhage, lymphoid depletion, cellular infiltrations, proliferation of the alveolar pneumocytes, necrosis, tissue degeneration, and reduced germinal epithelium were observed in the testes, liver, lungs, heart, kidney, and spleen from the exposed rats compared to the control. Some physicochemicals and metals analyzed in leachates from the landfill are capable of inducing genome instability and systemic toxicity in the exposed rats. Rattus rattus exposed to hazardous chemicals from AEL harbored somatic and germ cell mutations, and tissue damage compared to the control rats. We suggest that R. rattus are useful sentinel for genotoxicity and system toxicity assessment of landfill-polluted sites.Graphical abstract.
Chibuisi G Alimba, Olusoji O Adewumi, Olufisayo M Binuyo, Peter G C Odeigah

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#33098553   2020/10/24 To Up

Covariables of Myocardial Function in Women and Men with Increased Body Mass Index.

Sex-difference in types of cardiac organ damage has been reported in subjects with increased body mass index (BMI). However less is known about sex-differences in left ventricular (LV) myocardial function assessed by global longitudinal strain (GLS) in these subjects.
Nadia Pristaj, Sahrai Saeed, Helga Midtbø, Hilde Halland, Knut Matre, Eva Gerdts

2523 related Products with: Covariables of Myocardial Function in Women and Men with Increased Body Mass Index.

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#33098529   2020/10/24 To Up

Non-heart transplant surgical approaches with mitral valve operation and surgical ventricular reconstruction for non-ischaemic dilated cardiomyopathy: a Japanese multicenter study.

There is uncertainty over the efficacy of additional surgical ventricular reconstruction (SVR) associated with mitral valve operation for non-ischaemic dilated cardiomyopathy (DCM). This study aims to assess mid-term outcomes of these non-heart transplant surgical approaches for DCM.
Yasunori Cho, Satoru Wakasa, Akihiko Usui, Kenji Minatoya, Hirokuni Arai, Hitoshi Yaku, Atsushi Yamaguchi, Tatsuhiko Komiya, Goro Matsumiya, Kimikazu Hamano, Yoshikatsu Saiki, Yoshiro Matsui

2739 related Products with: Non-heart transplant surgical approaches with mitral valve operation and surgical ventricular reconstruction for non-ischaemic dilated cardiomyopathy: a Japanese multicenter study.

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#33098525   2020/10/24 To Up

Venoarterial Extracorporeal Membrane Oxygenation as a Bridge to Recovery or Bridge to Heart Replacement Therapy in Refractory Cardiogenic Shock.

The purpose of this review is to describe the outcomes following refractory cardiogenic shock (CS) requiring mechanical circulatory support and factors associated with successful and unsuccessful weaning from VA-ECMO. Based on the presented data, we will propose a weaning and bridging algorithm with the aim of facilitating this complex process.
F Sertic, C Bermudez, J E Rame

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