Only in Titles

Search results for: Cell

paperclip

#   // To Up


2409 related Products with:



Related Pathways

    No related Items
paperclip

#   // To Up


1246 related Products with:



Related Pathways

    No related Items
paperclip

#   // To Up


2517 related Products with:



Related Pathways

    No related Items
paperclip

#34130368   2021/05/31 To Up

No Detectable Alteration of Inorganic Allogeneic Bone Matrix Colonizing Mesenchymal Cells: A Step Towards Personalized Bone Grafts.

During major bone substance loss, secured allogeneic bone matrix (ABM) is normally utilized for bone repair. Here, we propose a method to colonize ABM using autologous mesenchymal cells (MCs) to improve their integration. Moreover, in this study, the consequences of in vitro colonization on MCs have been evaluated.
Roger Erivan, Nicolas Samper, Guillaume Villatte, Stéphane Boisgard, Stéphane Descamps, Marc Berger

2388 related Products with: No Detectable Alteration of Inorganic Allogeneic Bone Matrix Colonizing Mesenchymal Cells: A Step Towards Personalized Bone Grafts.



Related Pathways

paperclip

#34130353   2021/06/15 To Up

Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography.

Despite rapid advances and discoveries in medical imaging, monitoring therapeutic efficacy for malignant gliomas and monitoring tumor vasculature remains problematic. The purpose of this study is to utilize optical coherence angiography for vasculature characterization inside and surrounding brain tumors in a murine xenograft brain tumor model. Features included in our analysis include fractional blood volume, vessel tortuosity, diameter, orientation, and directionality.
Farah Andleeb, Nitesh Katta, Aleksandra Gruslova, Bharadwaj Muralidharan, Arnold Estrada, Austin B McElroy, Hafeez Ullah, Andrew J Brenner, Thomas E Milner

1539 related Products with: Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography.



Related Pathways

paperclip

#34130336   2021/06/15 To Up

Toward a Liver Cell Atlas: Understanding Liver Biology in Health and Disease at Single-Cell Resolution.

Single-cell technologies are revolutionizing our understanding of cellular heterogeneity and functional diversity in health and disease. Here, we review the current knowledge and advances in liver biology using single-cell approaches. We focus on the landscape of the composition and the function of cells in a healthy liver in the context of its spatial organization. We also highlight the alterations of the molecular landscape in chronic liver disease and liver cancer, which includes the identification of disease-related cell types, altered cellular functions, dynamic cell-cell interactions, the plasticity of malignant cells, the collective behavior of a cell community, and microenvironmental reprogramming. We anticipate that the uncovered liver cell atlas will help deciphering the molecular and cellular mechanisms driving a healthy liver into a disease state. It also offers insight into the detection of new therapeutic targets and paves the way for effective disease interventions.
Lichun Ma, Subreen Khatib, Amanda J Craig, Xin Wei Wang

2799 related Products with: Toward a Liver Cell Atlas: Understanding Liver Biology in Health and Disease at Single-Cell Resolution.

100ug Lyophilized900 tests100ug Lyophilized

Related Pathways

paperclip

#34130335   2021/06/15 To Up

Interleukin-17 in Liver Disease Pathogenesis.

Interleukin 17A (IL-17A)-producing T helper 17 (Th17) cells were identified as a subset of T helper cells that play a critical role in host defense against bacterial and fungal pathogens. Th17 cells differentiate from Th0 naïve T-cells in response to transforming growth factor β1 (TGF-β1) and IL-6, the cytokines which also drive development of liver fibrosis, require activation of transcription factor retinoic acid receptor-related orphan nuclear receptor gamma (RORγ). IL-17A signals through the ubiquitously expressed receptor IL-17RA. Expression of IL-17RA is upregulated in patients with hepatitis B virus/hepatitis C virus (HBV/HCV) infections, nonalcoholic steatohepatitis (NASH), alcohol-associated liver disease (AALD), hepatocellular carcinoma (HCC), and experimental models of chronic toxic liver injury. The role of IL-17 signaling in the pathogenesis of NASH- and AALD-induced metabolic liver injury and HCC will be the focus of this review. The role of IL-17A-IL-17RA axis in mediation of the cross-talk between metabolically injured hepatic macrophages, hepatocytes, and fibrogenic myofibroblasts will be discussed.
Na Li, Gen Yamamoto, Hiroaki Fuji, Tatiana Kisseleva

2737 related Products with: Interleukin-17 in Liver Disease Pathogenesis.

5ug96 wells (1 kit)5ug5ug2ug5ug96 tests96 wells (1 kit)

Related Pathways

paperclip

#34130311   // To Up

MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.

Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, nonpeptidergic C fibers also respond to mechanical input in the innocuous range, so the degree to which they contribute to nociception remains unclear. To address this gap, we investigated the function of nonpeptidergic afferents using the MrgprdCre allele. In real-time place aversion studies, we found that low-frequency optogenetic activation of MrgrpdCre lineage neurons was not aversive in naive mice but became aversive after spared nerve injury (SNI). To address the underlying mechanisms of this allodynia, we recorded responses from lamina I spinoparabrachial (SPB) neurons using the semi-intact ex vivo preparation. After SNI, innocuous brushing of the skin gave rise to abnormal activity in lamina I SPB neurons, consisting of an increase in the proportion of recorded neurons that responded with excitatory postsynaptic potentials or action potentials. This increase was likely due, at least in part, to an increase in the proportion of lamina I SPB neurons that received input on optogenetic activation of MrgprdCre lineage neurons. Intriguingly, in SPB neurons, there was a significant increase in the excitatory postsynaptic current latency from MrgprdCre lineage input after SNI, consistent with the possibility that the greater activation post-SNI could be due to the recruitment of a new polysynaptic circuit. Together, our findings suggest that MrgprdCre lineage neurons can provide mechanical input to the dorsal horn that is nonnoxious before injury but becomes noxious afterwards because of the engagement of a previously silent polysynaptic circuit in the dorsal horn.
Charles Warwick, Colleen Cassidy, Junichi Hachisuka, Margaret C Wright, Kyle M Baumbauer, Peter C Adelman, Kuan H Lee, Kelly M Smith, Tayler D Sheahan, Sarah E Ross, H Richard Koerber

1237 related Products with: MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.

100 0.1 mg50 50 ug 100 1 Set100ug100 μg100.00 ug100ug Lyophilized0.5 mg

Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

#34130299   2021/06/15 To Up

Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-α Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.

The objective of this study is to examine the role of the tumour necrosis factor-α converting enzyme-epidermal growth factor receptor (TACE-EGFR) pathway in human neutrophil elastase (HNE)-induced MUC5AC mucin expression in mice.
Junmei Zhao, Tian Yang, Wei Qiao, Yu Ye, Jian Zhang, Qing Luo

1536 related Products with: Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-α Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.

2 Pieces/Box100 μg4 Membranes/Box100 μg1 kit(96 Wells)5ug5 x 50 ug20ug5 x 50 ug1 kit(96 Wells)1 mg50 ug

Related Pathways