Search results for: Cell
#34130368 2021/05/31 To Up
No Detectable Alteration of Inorganic Allogeneic Bone Matrix Colonizing Mesenchymal Cells: A Step Towards Personalized Bone Grafts.During major bone substance loss, secured allogeneic bone matrix (ABM) is normally utilized for bone repair. Here, we propose a method to colonize ABM using autologous mesenchymal cells (MCs) to improve their integration. Moreover, in this study, the consequences of in vitro colonization on MCs have been evaluated.
Roger Erivan, Nicolas Samper, Guillaume Villatte, StÃ©phane Boisgard, StÃ©phane Descamps, Marc Berger
2388 related Products with: No Detectable Alteration of Inorganic Allogeneic Bone Matrix Colonizing Mesenchymal Cells: A Step Towards Personalized Bone Grafts.
#34130353 2021/06/15 To Up
Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography.Despite rapid advances and discoveries in medical imaging, monitoring therapeutic efficacy for malignant gliomas and monitoring tumor vasculature remains problematic. The purpose of this studyÂ is to utilize optical coherence angiography for vasculature characterization inside and surrounding brain tumors in a murine xenograft brain tumor model. Features included in our analysis include fractional blood volume, vessel tortuosity, diameter, orientation, and directionality.
Farah Andleeb, Nitesh Katta, Aleksandra Gruslova, Bharadwaj Muralidharan, Arnold Estrada, Austin B McElroy, Hafeez Ullah, Andrew J Brenner, Thomas E Milner
1539 related Products with: Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography.
#34130336 2021/06/15 To Up
Toward a Liver Cell Atlas: Understanding Liver Biology in Health and Disease at Single-Cell Resolution.Single-cell technologies are revolutionizing our understanding of cellular heterogeneity and functional diversity in health and disease. Here, we review the current knowledge and advances in liver biology using single-cell approaches. We focus on the landscape of the composition and the function of cells in a healthy liver in the context of its spatial organization. We also highlight the alterations of the molecular landscape in chronic liver disease and liver cancer, which includes the identification of disease-related cell types, altered cellular functions, dynamic cell-cell interactions, the plasticity of malignant cells, the collective behavior of a cell community, and microenvironmental reprogramming. We anticipate that the uncovered liver cell atlas will help deciphering the molecular and cellular mechanisms driving a healthy liver into a disease state. It also offers insight into the detection of new therapeutic targets and paves the way for effective disease interventions.
Lichun Ma, Subreen Khatib, Amanda J Craig, Xin Wei Wang
2799 related Products with: Toward a Liver Cell Atlas: Understanding Liver Biology in Health and Disease at Single-Cell Resolution.100ug Lyophilized900 tests100ug Lyophilized
#34130335 2021/06/15 To Up
Interleukin-17 in Liver Disease Pathogenesis.Interleukin 17A (IL-17A)-producing T helper 17 (Th17) cells were identified as a subset of T helper cells that play a critical role in host defense against bacterial and fungal pathogens. Th17 cells differentiate from Th0 naÃ¯ve T-cells in response to transforming growth factor Î²1 (TGF-Î²1) and IL-6, the cytokines which also drive development of liver fibrosis, require activation of transcription factor retinoic acid receptor-related orphan nuclear receptor gamma (RORÎ³). IL-17A signals through the ubiquitously expressed receptor IL-17RA. Expression of IL-17RA is upregulated in patients with hepatitis B virus/hepatitis C virus (HBV/HCV) infections, nonalcoholic steatohepatitis (NASH), alcohol-associated liver disease (AALD), hepatocellular carcinoma (HCC), and experimental models of chronic toxic liver injury. The role of IL-17 signaling in the pathogenesis of NASH- and AALD-induced metabolic liver injury and HCC will be the focus of this review. The role of IL-17A-IL-17RA axis in mediation of the cross-talk between metabolically injured hepatic macrophages, hepatocytes, and fibrogenic myofibroblasts will be discussed.
Na Li, Gen Yamamoto, Hiroaki Fuji, Tatiana Kisseleva5ug96 wells (1 kit)5ug5ug2ug5ug96 tests96 wells (1 kit)
#34130311 // To Up
MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, nonpeptidergic C fibers also respond to mechanical input in the innocuous range, so the degree to which they contribute to nociception remains unclear. To address this gap, we investigated the function of nonpeptidergic afferents using the MrgprdCre allele. In real-time place aversion studies, we found that low-frequency optogenetic activation of MrgrpdCre lineage neurons was not aversive in naive mice but became aversive after spared nerve injury (SNI). To address the underlying mechanisms of this allodynia, we recorded responses from lamina I spinoparabrachial (SPB) neurons using the semi-intact ex vivo preparation. After SNI, innocuous brushing of the skin gave rise to abnormal activity in lamina I SPB neurons, consisting of an increase in the proportion of recorded neurons that responded with excitatory postsynaptic potentials or action potentials. This increase was likely due, at least in part, to an increase in the proportion of lamina I SPB neurons that received input on optogenetic activation of MrgprdCre lineage neurons. Intriguingly, in SPB neurons, there was a significant increase in the excitatory postsynaptic current latency from MrgprdCre lineage input after SNI, consistent with the possibility that the greater activation post-SNI could be due to the recruitment of a new polysynaptic circuit. Together, our findings suggest that MrgprdCre lineage neurons can provide mechanical input to the dorsal horn that is nonnoxious before injury but becomes noxious afterwards because of the engagement of a previously silent polysynaptic circuit in the dorsal horn.
Charles Warwick, Colleen Cassidy, Junichi Hachisuka, Margaret C Wright, Kyle M Baumbauer, Peter C Adelman, Kuan H Lee, Kelly M Smith, Tayler D Sheahan, Sarah E Ross, H Richard Koerber
1237 related Products with: MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.100 0.1 mg50 50 ug 100 1 Set100ug100 μg100.00 ug100ug Lyophilized0.5 mg
Error loading info... Pleas try again later.
#34130299 2021/06/15 To Up
Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-Î± Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.The objective of this study is to examine the role of the tumour necrosis factor-Î± converting enzyme-epidermal growth factor receptor (TACE-EGFR) pathway in human neutrophil elastase (HNE)-induced MUC5AC mucin expression in mice.
Junmei Zhao, Tian Yang, Wei Qiao, Yu Ye, Jian Zhang, Qing Luo
1536 related Products with: Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-Î± Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.2 Pieces/Box100 μg4 Membranes/Box100 μg1 kit(96 Wells)5ug5 x 50 ug20ug5 x 50 ug1 kit(96 Wells)1 mg50 ug
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45 Fax 0032 16 50 90 45
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50 Fax 01 43 25 01 60
52062 Aachen Deutschland
Tel 0241 40 08 90 86 Fax 0241 55 91 05 36
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
Schweiz Züri +41435006251
Česká republika Praha +420246019719
Ireland Dublin +35316526556
Norge Oslo +4721031366
Finland Helsset +358942419041
Sverige Stockholm +46852503438
Ελλάς Αθήνα +302111768494
Magyarország Budapest +3619980547
GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
Tel 058 710 33 44
Fax 058 710 33 48
GENTAUR Nederland BV
5521 DG Eersel Nederland
Tel 0208-080893 Fax 0497-517897
Piazza Giacomo Matteotti, 6, 24122 Bergamo
Tel 02 36 00 65 93 Fax 02 36 00 65 94
53 Iskar Str. 1191 Kokalyane, Sofia