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Search results for: Colon

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#33096137   2020/10/20 To Up

Characteristics of contents of lower intestine in the 65-74 years of age range could impact the performance of safe and efficacious modified release products.

We characterized the contents of distal ileum and proximal colon of older people from a pharmaceutical product performance perspective, under two extreme situations, i.e. 5h after a glass of water to fasted volunteers (fasted state) and 5h after a high-calorie, high-fat meal to fasted volunteers (fed state). Five males and three females (65-70y) participated in a two-phase crossover study. Contents were collected via colonoscopy. In distal ileum, luminal pH was lower and buffer capacity was higher than in young adults; differences reached significance for pH in the fed state. In proximal colon, differences reached significance for pH/fasted state and for buffer capacity/both fasted and fed states. Aqueous fraction of contents contained more short chain fatty acids than previously observed in young adults. In distal ileum, osmolality was significantly higher than in young adults. In proximal colon, aqueous fraction in the fasted state was significantly lower and long chain fatty acids 5h after meal was significantly higher than in young adults. Characteristics of contents of lower intestine that are relevant to the performance of certain modified release products differ between individuals 65-74 years old and young adults, the typical age group employed in safety and efficacy studies of oral drug products.
Maria Vertzoni, Sarah Sulaiman, Konstantinos Goumas, Elisabeth Kersten, Johanna Anlahr, Uwe Muenster, Christos Reppas

1481 related Products with: Characteristics of contents of lower intestine in the 65-74 years of age range could impact the performance of safe and efficacious modified release products.

5 G 50 UG1 50 UG

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#33096119   2020/10/20 To Up

Preparation of liposomes containing IFN-gamma and their potentials in cancer immunotherapy: In vitro and in vivo studies in a colon cancer mouse model.

The purpose of this study was to prepare non-PEGylated (HSPC/DSPG/Chol, LIPF1) and PEGylated (HSPC/DSPG/Chol/mPEG2000-DSPE, LIPF2) liposomal formulations containing Interferon-gamma (IFN-γ) and evaluation their effects on macrophages and their antitumor properties. The results showed that the size of liposomal formulations LIP-F1 and LIP-F2 was 120 and 135 nm, respectively. The encapsulation efficiencies of LIP-F1 and LIP-F2 were 52.79% and 49.2%, respectively. Nitric Oxide Synthase (INOS) and arginase assays showed an increase in nitric oxide (NO) level and a reduction in arginase level after the treatment of M2 phenotype macrophage cell line with IFN-γ liposomes. The biodistribution study illustrated the amplitude of iodinated-IFN-γ liposomal formulations in the tumor site, the circulation time and tumor accumulation of LIP-F2 was significantly more than LIPF1. As a result, PEGylated liposomes containing IFN-γ induced significant antitumor responses due to the increased delivery of the cargo to the immune cells and induction of antitumor immune responses.
Maryam Kateh Shamshiri, Mahmoud Reza Jaafari, Ali Badiee

1191 related Products with: Preparation of liposomes containing IFN-gamma and their potentials in cancer immunotherapy: In vitro and in vivo studies in a colon cancer mouse model.



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#33096076   2020/10/20 To Up

Pharmacological activation of REV-ERBα improves nonalcoholic steatohepatitis by regulating intestinal permeability.

The gut-liver axis plays an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH), and increased intestinal permeability causes transfer of endotoxin to the liver, which activates the immune response, ultimately leading to hepatic inflammation. Nuclear receptor Rev-erbα is a critical regulator of circadian rhythm, cellular metabolism, and inflammatory responses. However, the role and mechanism of Rev-erbα in gut barrier function and NASH remain unclear. In the present study, we investigated the involvement of Rev-erbα in the regulation of intestinal permeability and the treatment of NASH.
Yinhua Ni, Yufeng Zhao, Lingyan Ma, Zhe Wang, Liyang Ni, Luting Hu, Zhengwei Fu

2973 related Products with: Pharmacological activation of REV-ERBα improves nonalcoholic steatohepatitis by regulating intestinal permeability.

100ug2 mg100ug200 96 wells100ug100μg100ug Lyophilized200 100ug100ug

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#33095374   2020/10/23 To Up

Astragaloside IV Exerts Anti-tumor Effect on Murine Colorectal Cancer by Re-educating Tumor-Associated Macrophage.

Astragaloside IV (AS-IV) has shown anti-tumorigenic properties in certain cancers for its effect of boosting the body's immune system, but its role in colorectal cancer (CRC) remains unclear. In this study, we investigated the therapeutic effect of AS-IV in CRC and explored its underlying mechanism. CT26 colon cancer cells and mouse model by injection of CT26 cells subcutaneously were used as in vitro and in vivo model. M1 and M2 macrophage-associated markers, mRNA and protein expression levels were analyzed after AS-IV treatment. Inflammatory factors and cytokines in the tumors from mouse model were detected. Repolarization effect of AS-IV in vitro on bone-marrow-derived macrophages was also detected. In vitro, AS-IV inhibited the proliferation of CT26 cells and induced cell apoptosis dose-dependently, and significantly reduced M2 macrophages and increased M1 macrophages. In mouse model, it suppressed tumor growth and decreased the production of anti-inflammatory factors such as TGF-β, IL-10 and VEGF-A, while increased the production of pro-inflammatory factors like IFN-γ, IL-12 and TNF-α in tumor. Combination of AS-IV and checkpoint inhibitor aPD-1 exhibited synergistic antitumor effect by inhibiting tumor growth and increasing T cell infiltration. AS-IV could induce M2 macrophages polarization to the M1 phenotype. Its combination with immune checkpoint inhibitors could be expected to become a potential new strategy for the treatment of CRC.
Feng Liu, Fang Ran, Hongqin He, Linyun Chen

1068 related Products with: Astragaloside IV Exerts Anti-tumor Effect on Murine Colorectal Cancer by Re-educating Tumor-Associated Macrophage.

100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized

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#33095121   2020/10/23 To Up

Cancer prevalence by phase of care: an indicator for assessing health service needs.

Cancer prevalence (people alive on a certain date in a population who previously had a cancer diagnosis) is expected to increase in the United States and Europe due to improvements in survival and population aging. Examination of prevalence by phase of care allows us to identify subgroups of patients according to their care trajectories, thus allowing us to improve health care planning, resource allocation, and calculation of costs.
Anna Gigli, Silvia Francisci, Stefano Guzzinati, Aaron Hall, Mark Hachey, Steve Scoppa, Angela Mariotto

2581 related Products with: Cancer prevalence by phase of care: an indicator for assessing health service needs.

500 6 ml Ready-to-use 100μg 100ul

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#33095019   2020/10/23 To Up

Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic ( L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis.

Garlic polysaccharides are great potential agents because of their anti-inflammation, antioxidation, and immunomodulation properties. However, few studies have reported their anti-inflammatory effects on improving the colon system and corresponding intestinal microbiota. Herein, a water-soluble garlic polysaccharide (WSGP) was extracted from Jinxiang garlic to evaluate its effects on ameliorating dextran sulfate sodium (DSS)-induced colitis in a mouse model. The results showed that (1) after administration of the WSGP (200 or 400 mg/kg/day), the feed intake, body weight, and colon length of colitic mice were increased, while the disease activity index and the histological score of colitic mice were decreased; (2) the WSGP reduced the colonic tissue damage and inhibited the expression of inflammatory factors (interleukin 6, interleukin 1 beta , and tumor necrosis factor alpha); and (3) the WSGP enhanced the production of short-chain fatty acids and improved the composition of intestinal microbiota. The key microorganisms, including Muribaculaceae, Lachnospiraceae, , , , , and , were identified to be associated with inflammatory bowel diseases. Taken together, this study proved that WSGP supplementation could alleviate DSS-induced colitis by improving mucosal barriers, blocking proinflammatory cytokines, and modulating gut microbiota.
Xin Shao, Chongzhen Sun, Xin Tang, Xiaosa Zhang, Duo Han, Shan Liang, Rong Qu, Xiaodan Hui, Yangwei Shan, Linhui Hu, Heng Fang, Huidan Zhang, Xiyang Wu, Chunbo Chen

1940 related Products with: Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic ( L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis.

100ug0.1 ml20 mg100ug Lyophilized100ul100ul1 ml200 100ug100ug Lyophilized20 25 mg

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#33094876   2020/10/23 To Up

Multicolor sparse viral labeling and 3D digital tracing of enteric plexus in mouse proximal colon using a novel adeno-associated virus capsid.

Intravenous administration of adeno-associated virus (AAV) can be used as a noninvasive approach to trace neuronal morphology and links. AAV-PHP.S is a variant of AAV9 that effectively transduces the peripheral nervous system. The objective was to label randomly and sparsely enteric plexus in the mouse colon using AAV-PHP.S with a tunable two-component multicolor vector system and digitally trace individual neurons and nerve fibers within microcircuits in three dimensions (3D).
Lixin Wang, Collin Challis, Songlin Li, Charless C Fowlkes, Sripriya Ravindra Kumar, Pu-Qing Yuan, Yvette F Taché

1276 related Products with: Multicolor sparse viral labeling and 3D digital tracing of enteric plexus in mouse proximal colon using a novel adeno-associated virus capsid.

1 mg50ug1 mg10.25 mg100 100 1 mg1 mg500 200 1 mg

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#33094859   2020/10/23 To Up

Identification of a stool long non-coding RNAs panel as a potential biomarker for early detection of colorectal cancer.

The feces of colorectal cancer (CRC) patients contain tumor colonocytes, which constantly shed into the lumen area. Therefore, stool evaluation can be considered as a rapid and low-risk way to directly determine the colon and rectum status. As long non-coding RNAs (lncRNAs) alterations are important in cancer cells fate regulation, we aimed to assess the level of a panel of cancer-related lncRNAs in fecal colonocytes.
Ehsan Gharib, Ehsan Nazemalhosseini-Mojarad, Kaveh Baghdar, Zahra Nayeri, Hossein Sadeghi, Sama Rezasoltani, Arezo Jamshidi-Fard, Pegah Larki, Amir Sadeghi, Mehrdad Hashemi, Hamid Asadzadeh Aghdaei

1981 related Products with: Identification of a stool long non-coding RNAs panel as a potential biomarker for early detection of colorectal cancer.

400 assays10 plates50 assays1,000 tests100tests100 assays1 kit100μg12

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#33094586   // To Up

Surveillance recommendations for patients with Lynch syndrome and FAP : a monocentric study.

The most important causes of hereditary colorectal cancer are Lynch syndrome (LS) and the adenomatous polyposis syndromes (familial adenomatous poly- posis syndrome or FAP, attenuated FAP or AFAP and MUTYH associated polyposis syndrome or MAP). The aim of this study was to investigate whether all patients with a hereditary syndrome within one center receive uniform advice regarding surveillance and treatment.
L Baert, K Claes, M De Man, D J Tate, K Geboes

1086 related Products with: Surveillance recommendations for patients with Lynch syndrome and FAP : a monocentric study.

100ug50 mg 1 G50 ug 25 mg100ug 100 G1000 TESTS/0.65ml96T

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