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Search results for: Colon

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#32650119   2020/07/07 To Up

Comparison of the sigmoid take-off with other definitions of the rectosigmoid junction: A retrospective comparative cohort analysis.

The diversity in definitions for the rectosigmoid junction is becoming a major obstacle in standardizing optimal treatment of rectal cancers. The study aimed to determine the average distance of the sigmoid take-off from the anal verge and its association with individual factors.
Fei Li, Bingyan Wang, Siyi Lu, Yuxia Wang, Tao Sun, Hao Wang, Xin Zhou, Wei Fu

2700 related Products with: Comparison of the sigmoid take-off with other definitions of the rectosigmoid junction: A retrospective comparative cohort analysis.

100.00 ul0.1 mg1100.00 ul

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#32650112   2020/07/07 To Up

Colon Specific Enzyme Responsive Oligoester Crosslinked Dextran Nanoparticles for Controlled Release of 5-Fluorouracil.

Targeting bioactives selectively to diseased sites is one of the most challenging aspects of cancer therapy. Herein, fabrication of colonic enzyme-responsive dextran based oligoester crosslinked nanoparticles is reported for the controlled release of 5-fluorouracil (5-FU) - an anticancer drug. The 5-FU drug loaded nanoparticles (DNPs, size ∼237±25 nm, ζ-potential -17.0±3 mV) were developed by in-situ crosslinking of dextran with bifunctional telechelic oligoester followed by physical drug encapsulation via nanoprecipitation. Drug encapsulation efficiency and drug loading capacity of DNPs were found to be ∼76% (±0.1) and ∼8% (±0.1), respectively. The DNPs were demonstrated to release the encapsulated drug selectively in the presence of dextranase enzyme. The in vitro release kinetics assay revealed that the DNPs released about 75% (±4) of the entrapped drug within 12 h of incubation with dextranase enzyme. No drug was released in a control experiment where DNPs were exposed to pH conditions encountered in stomach and small intestine. Moreover, the treatment of HCT116 colon cancer cell line with the developed DNPs highlighted its biocompatibility as well as dextranase triggered cytotoxicity. The developed system offers an avenue to reduce non-specific cytotoxicity of encapsulated 5-FU, and colon specific delivery of the encapsulated drug in response to the dextranase enzyme.
Mehwish Abid, Muhammad Naveed, Iqra Azeem, Amir Faisal, Muhammad Faizan Nazar, Basit Yameen

2861 related Products with: Colon Specific Enzyme Responsive Oligoester Crosslinked Dextran Nanoparticles for Controlled Release of 5-Fluorouracil.

1 LITRE100 ml25 µg1 ml0.1 ml0.25 mg25 µg0.1 mg100 TESTS0.2 mg250 ml0.1 mg

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#32650111   2020/07/07 To Up

Oxymatrine loaded nitric oxide-releasing liposomes for the treatment of ulcerative colitis.

Oxymatrine (OM) is the biologically active ingredient of Chinese medicinal herb Sophora flavescens, which is reported to be effective on alleviating ulcerative colitis (UC) due to its anti-inflammatory property. However, its highly effective dose is an obstacles to its application. Therefore, liposome was used to encapsulate OM, realize targeting delivery to colitis and thus reduce drug dosage. Meanwhile, considering the potential anti-inflammatory ability of nitric oxide (NO), a NO donor, d-α-tocopheryl polyethylene glycol succinate nitrate (TN), was introduced into the liposomal system and OM loaded NO-releasing liposomes ([email protected]) were prepared in order to co-deliver OM and NO to the inflammatory lesions of DSS-induced UC mice to achieve the combination therapy. [email protected] was multilamelar sphere with the encapsulation efficiency of ∼70%, the diameter of ∼200 nm and ζ-potential of about -13mV. Bio-distribution results revealed the liposomes could efficiently accumulate in the inflammatory colon by diffusion and maintain for more than 36 h. In UC mice model, [email protected] showed significant alleviation of inflammation and the treatment were highly related to down-regulation of pro-inflammatory cytokines TNF-α, IFN-γ, IL-1β and IL-6, decrease of macrophages infiltration, activity decrease of myeloperoxidase (MPO) and cyclooxygenase-2 (COX-2), and remodeling antioxidant/oxidation balance by reducing reactive oxygen species (ROS) and increasing Glutathione (GSH) in colon.
Qing Tang, Wei Zhang, Chong Zhang, Yang Guan, Jiahui Ding, Caiyan Yuan, Chen Tan, Xueqin Gao, Songwei Tan

1639 related Products with: Oxymatrine loaded nitric oxide-releasing liposomes for the treatment of ulcerative colitis.

100Tests100 2 x 96 assays1002 x 96 well plate196tests100 100 100200 assays5 mg

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#32649737   2020/07/10 To Up

GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells.

In cancer, resistance to chemotherapy is one of the main reasons for therapeutic failure. Cells that survive after treatment with anticancer drugs undergo various changes, including in cell metabolism. In this study, we investigated the effects of AKT-mediated miR-125b-5p alteration on metabolic changes and examined how these molecules enhance migration and induce drug resistance in colon cancer cells. AKT1 and AKT3 activation in drug-resistant colon cancer cells caused aberrant downregulation of miR-125b-5p, leading to GLUT5 expression. Targeted inhibition of AKT1 and AKT3 restored miR-125b-5p expression and prevented glycolysis- and lipogenesis-related enzyme activation. In addition, restoring the level of miR-125b-5p by transfection with the mimic sequence not only significantly blocked the production of lactate and intracellular fatty acids but also suppressed the migration and invasion of chemoresistant colon cancer cells. GLUT5 silencing with small interfering RNA (siRNA) attenuated mesenchymal marker expression and migratory activity in drug-resistant colon cancer cells. Additionally, treatment with 2,5-anhydro-D-mannitol (2,5-AM) resensitized chemoresistant cancer cells to oxaliplatin and 5-fluorouracil. In conclusion, our findings suggest that changes in miR-125b-5p and GLUT5 expression after chemotherapy can serve as a new marker to indicate metabolic change-induced migration and drug resistance development.
Ga Bin Park, Jee-Yeong Jeong, Daejin Kim

1721 related Products with: GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells.

96 wells0.1ml (1mg/ml)1 Set

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#32649468   2020/07/07 To Up

Colon Involvement in Necrotizing Pancreatitis: Incidence, Risk Factors, and Outcomes.

To investigate the incidence, risk factors, and outcomes of colon involvement in patients with necrotizing pancreatitis.
Thomas K Maatman, Megan E Nicolas, Alexandra M Roch, Kyle A Lewellen, Hayder H Al-Azzawi, Eugene P Ceppa, Michael G House, Attila Nakeeb, Christian M Schmidt, Nicholas J Zyromski

1752 related Products with: Colon Involvement in Necrotizing Pancreatitis: Incidence, Risk Factors, and Outcomes.

100 units

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#32649097   // To Up

Hypoglossal Nerve Palsy After Anterior Cervical Spine Surgery: A Case Report and Literature Review.

A 37-year-old man was found to have hypoglossal nerve palsy after undergoing anterior cervical spine surgery at C3-C5, an injury that would cause him severe disability and further complications.
Luis Felipe Colón, Jorge Isaza, Yoshihiro Katsuura, Daniel Nuss

2222 related Products with: Hypoglossal Nerve Palsy After Anterior Cervical Spine Surgery: A Case Report and Literature Review.



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#32648873   2020/07/10 To Up

Orally administered mesoporous silica capped with the cucurbit[8]uril complex to combat colitis and improve intestinal homeostasis by targeting the gut microbiota.

Inflammatory bowel diseases (IBDs) are still awaiting innovative treatments that can maximize the efficiency of site-specific drug release in the colon while enhancing intestinal homeostasis.
Shujie Cheng, Haowen Shen, Sibo Zhao, Yuanxin Zhang, Hui Xu, Lancheng Wang, Bin Di, Lili Xu, Chi Hu

2237 related Products with: Orally administered mesoporous silica capped with the cucurbit[8]uril complex to combat colitis and improve intestinal homeostasis by targeting the gut microbiota.

100.00 ulmin 2 cartons1200 units1 100 G500 Units

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#32648844   2020/07/09 To Up

Isothymusin, a potential inhibitor of cancer cell proliferation: An in silico and in vitro investigation.

Since centuries plant-based compounds are known for the treatment of cancer in both traditional and contemporary medicine. The problems like target non-specificity and toxicity are well-known regarding anticancer drugs. Therefore, target specific search of novel entities is constant. Isothymusin is a dimethoxy, trihydroxy flavone present in plants like Ocimum sanctum, Limnophilla geoffrayi. There are limited reports available on the anticancer potential of isothymusin.
Shilpi Singh, Priyanka Kumari, Yusuf Hussain, Suaib Luqman, Abha Meena, Deepika Kanaojia

2855 related Products with: Isothymusin, a potential inhibitor of cancer cell proliferation: An in silico and in vitro investigation.

96 tests100ug Lyophilized100.00 ug100ug Lyophilized

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#32648742   2020/07/10 To Up

Combinatory data independent acquisition and parallel reaction monitoring method for deep profiling of gangliosides.

Ganglioside is an important class of lipid species involving in intercellular signaling and various diseases, especially for neurodegenerative diseases. Systematic ganglioside profiling is challenging due to their naturally low abundance and highly diverse species. Herein, a new data independent acquisition and parallel reaction monitoring (DIA/PRM) method with superior sensitivity was developed. The untargeted DIA acquisition consecutively records all the precursor ion and fragment ions at the same time, while the targeted PRM analysis with versatile higher collisional dissociation generates full MS/MS spectra for structure elucidation and verification. As compared with traditional data dependent acquisition (DDA), the DIA/PRM method unbiasedly detected majority of abundant ganglioside species and as low as 50 pg ganglioside in the untargeted manner. Gangliosides in four kinds of biological samples including the mouse brain, mouse plasma, Hela cell and human colon cancer tissue were systematically identified, and low abundant ganglioside species were further extended based on linear chromatography retention rules of the most frequently detected ganglioside species. A total of 383 ganglioside features were defined with 329 of them derived from 32 ganglioside species. Taking advantage of the high-resolution MS analysis, rare ganglioside species were further elucidated according to their characteristic fragment ions and neutral losses. In total, 18 gangliosides with ceramide carbon number from 20 to 25 and modified gangliosides, including 18 acetylated, 8 di-acetylated, 1 phosphorylated, 36 N-glycolyneuraminic acid (NeuGc)-containing and 7 di-NeuGc-containing gangliosides, were newly identified. The developed DIA/PRM method therefore generated a rich ganglioside resource for further functional exploration and is an unique alternative of DDA analysis for global ganglioside profiling in various biological systems.
Hua Li, Ruilian Xu, Lijun Yang, Hemi Luan, Shili Chen, Lan Chen, Zongwei Cai, Ruijun Tian

2080 related Products with: Combinatory data independent acquisition and parallel reaction monitoring method for deep profiling of gangliosides.

100Tests1 kit500 Reactions10 mg24 reactions 500 ml 1 ml1 mg

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#32648302   2020/07/09 To Up

Physical activity and advanced cancer: evidence of exercise-sensitive genes regulating prostate cancer cell proliferation and apoptosis.

Physical activity is known to protect against cancer. We found that the resistance exercise method whole-body electromyostimulation (WB-EMS) has a significant anti-cancer effect. WB-EMS-conditioned serum from advanced prostate cancer patients decreased human prostate carcinoma cell growth and viability in vitro. Multiplex analysis revealed that genes associated with human prostate cancer cell proliferation and apoptosis are sensitive for exercise. Feasible exercise should be part of multimodal anti-cancer therapies, also for physically weakened patients.
Raphaela Schwappacher, Kristin Schink, Svetlana Sologub, Walburga Dieterich, Dejan Reljic, Oliver Friedrich, Hans J Herrmann, Markus F Neurath, Yurdagül Zopf

2998 related Products with: Physical activity and advanced cancer: evidence of exercise-sensitive genes regulating prostate cancer cell proliferation and apoptosis.

1 kit100 TestsEach

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