Search results for: Colorectal
#32770859 2020/08/08 To Up
Randomised clinical study: oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk.Aspirin is associated with decreased risk of colorectal cancer (CRC), potentially by modulating the gut microbiome.
Anna E Prizment, Christopher Staley, Guillaume C Onyeaghala, Sithara Vivek, Bharat Thyagarajan, Robert J Straka, Ryan T Demmer, Dan Knights, Katie A Meyer, Aasma Shaukat, Michael J Sadowsky, Timothy R Church
2752 related Products with: Randomised clinical study: oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk.
#32770742 2020/08/08 To Up
Rectal cancer lateral pelvic sidewall lymph nodes: a review of controversies and management.The management of lateral pelvic lymphadenopathy in low rectal cancer poses an oncological and technical challenge. Interpretation of the literature is confounded by different approaches to management in the East and West, and a lack of randomized data from which to draw accurate conclusions regarding the optimal approach. Recent collaboration between Eastern and Western centres has increased the standardization of care. Despite this, significant differences in international guidelines remain. The aim of this review was to appraise the available literature and propose a management algorithm.
J S Williamson, A J Quyn, P M Sagar
2825 related Products with: Rectal cancer lateral pelvic sidewall lymph nodes: a review of controversies and management.
#32770704 2020/08/08 To Up
Placement of a fine bore rectal balloon catheter in the anal canal does not affect anal sphincter pressures: improving understanding of physiological function with anal acoustic reflectometry (AAR).The recto-anal inhibitory reflex (RAIR) is currently measured using anorectal manometry catheters, which may distort the anal canal. Anal acoustic reflectometry (AAR) is considered a catheter free technique for evaluating physiological function of the anal canal, however, it has yet to be used to elicit RAIR. For RAIR to be measured with AAR, the effect of placing an additional rectal balloon catheter on measured AAR parameters needs to be investigated.
N A Heywood, A Sharma, E S Kiff, N Klarskov, K J Telford
1609 related Products with: Placement of a fine bore rectal balloon catheter in the anal canal does not affect anal sphincter pressures: improving understanding of physiological function with anal acoustic reflectometry (AAR).1 module1 module1 module2 modules2 modules 120 ml 11 module1 module1 module1 module1 module
#32770635 2020/08/07 To Up
Engineered Live Biotherapeutics: Progress and Challenges.The human microbiome plays an important role in human health, from metabolism to immunity. In the last few decades, advances in synthetic biology have enabled scientists to design and engineer live microorganisms for therapeutic purposes. In this review, we outline major strategies for manipulating the microbiome, which include three emerging areas with promising therapeutic applications: engineered commensal bacteria, synthetic microbial consortia and targeted modulation by phages. Furthermore, we highlight the applications of engineered live biotherapeutics in treating a variety of human diseases, including pathogenic infections, metabolic disorders, inflammatory bowel disease and colorectal cancer. Finally, we provide an overview of the challenges and opportunities in the future development of engineered live biotherapeutics. This article is protected by copyright. All rights reserved.
Yang Tan, Juntao Shen, Tong Si, Chun Loong Ho, Yinqing Li, Lei Dai1.00 flask100ug100 tests1,000 tests50 mg
#32770529 2020/08/08 To Up
Efficacy and Safety of Regorafenib in Combination with Chemotherapy as Second-Line Treatment in Patients with Metastatic Colorectal Cancer: A Network Meta-Analysis and Systematic Literature Review.Although various therapies are available for the treatment of metastatic colorectal cancer (mCRC), there is lack of head-to-head evidence. Recent studies have demonstrated the efficacy of chemotherapy in combination with different biological agents including regorafenib in second-line therapy in patients with mCRC. We conducted a network meta-analysis (NMA) to estimate the relative efficacy and safety of regorafenib in combination with chemotherapy compared to other biological agents with chemotherapy combinations.
Xiaoyu Xie, Jianwei Zhang, Huabin Hu, Yue Cai, Zehua Wu, Jiayu Ling, Weiwei Li, Yanhong Deng
1323 related Products with: Efficacy and Safety of Regorafenib in Combination with Chemotherapy as Second-Line Treatment in Patients with Metastatic Colorectal Cancer: A Network Meta-Analysis and Systematic Literature Review.
#32770466 2020/08/08 To Up
Deadlock of proctologic practice in Italy during COVID-19 pandemic: a national report from ProctoLock2020.Proctology is one of the surgical specialties that suffered the most during COVID-19 pandemic. Using data from a cross-sectional worldwide web survey, we aimed to snapshot the current status of proctologic practice in Italy with differences between three macro areas (North, Centre, South). Specialists affiliated to renowned scientific societies with an interest in coloproctology were invited to join a 27-item survey. Predictive power of respondents' and hospitals' demographics on the change of status of surgical activities was calculated. The study was registered at ClinicalTrials.gov (NCT04392245). Of 299 respondents from Italy, 94 (40%) practiced in the North, 60 (25%) in the Centrer and 82 (35%) in the South and Islands. The majority were men (79%), at consultant level (70%), with a mean age of 46.5 years, practicing in academic hospitals (39%), where a dedicated proctologist was readily available (68%). Southern respondents were more at risk of infection compared to those from the Center (OR, 3.30; 95%CI 1.46; 7.47, P = 0.004), as were males (OR, 2.64; 95%CI 1.09; 6.37, P = 0.031) and those who routinely tested patients prior to surgery (OR, 3.02; 95%CI 1.39; 6.53, P = 0.005). The likelihood of ongoing surgical practice was higher in the South (OR 1.36, 95%CI 0.75; 2.46, P = 0.304) and in centers that were not fully dedicated to COVID-19 care (OR 4.00, 95%CI 1.88; 8.50, P < 0.001). The results of this survey highlight important factors contributing to the deadlock of proctologic practice in Italy and may inform the development of future management strategies.
Gaetano Gallo, Alessandro Sturiale, Veronica De Simone, Stefano Mancini, Gian Luca Di Tanna, Giovanni Milito, Francesco Bianco, Roberto Perinotti, Iacopo Giani, Ugo Grossi, , Domenico Aiello, Francesco Bianco, Andrea Bondurri, Gaetano Gallo, Marco La Torre, Giovanni Milito, Roberto Perinotti, Renato Pietroletti, Alberto Serventi, Marina Fiorino, Veronica De Simone, Ugo Grossi, Michele Manigrasso, Alessandro Sturiale, Gloria Zaffaroni, Ferruccio Boffi, Vittoria Bellato, Francesco Cantarella, Simona Deidda, Fabio Marino, Jacopo Martellucci, Marco Milone, Arcangelo Picciariello, Ana Minaya Bravo, Vincenzo Vigorita, Miguel Fernandes Cunha, Sezai Leventoglu, Tatiana Garmanova, Petr Tsarkov, Alaa El-Hussuna, Alice Frontali, Argyrios Ioannidis, Gabriele Bislenghi, Mostafa Shalaby, Felipe Celedon Porzio, Jiong Wu, David Zimmerman, Claudio Elbetti, Julio Mayol, Gabriele Naldini, Mario Trompetto, Giuseppe Sammarco, Giulio Aniello Santoro
2177 related Products with: Deadlock of proctologic practice in Italy during COVID-19 pandemic: a national report from ProctoLock2020.5 mg2 Pieces/Box1 kit100 μg100 μg100 μg100ug100 μg
#32770454 2020/08/08 To Up
COX10-AS1 Facilitates Cell Proliferation and Inhibits Cell Apoptosis in Glioblastoma Cells at Post-Transcription Level.Glioblastoma (GBM) is an invasive cancer with poor prognosis in patients. Researching on molecular functions in GBM has attracted more and more attention. Actin gamma 1 (ACTG1) was reported as a pathogenic gene in skin cancer and colorectal cancer. Present study was designed to explore the biological role and underlying mechanism of ACTG1 in GBM cells. It was uncovered that ACTG1 presented high expression trends in GBM cells. Moreover, ACTG1 suppression hindered cell proliferation and boosted cell apoptosis in GBM. Then, according to the results of bioinformatics analysis and mechanism assays including RIP, RNA pull down and luciferase reporter assay, ACTG1 was verified to be targeted by miR-361-5p in GBM. Next, COX10-AS1 (COX10 antisense RNA 1) was identified as an endogenous sponge for miR-361-5p in GBM. Moreover, COX10-AS1 acted as a competing endogenous RNA (ceRNA) to positively regulate ACTG1 expression via sponging miR-361-5p. The following rescue assays demonstrated that COX10-AS1 promoted GBM cell proliferation and inhibited GBM cell apoptosis through ACTG1 up-regulation at a miR-361-5p dependent way. On the whole, present study uncovered a novel ceRNA pattern in which COX10-AS1 sponged miR-361-5p to elevate ACTG1 expression, therefore accelerating tumorigenesis in GBM. The findings suggested new promising targets for GBM treatment.
Chaoyang Zhou, Xingxing Jiang, Aijun Liang, Ronglan Zhu, Yu Yang, Liangchen Zhong, Dengfeng Wan
1082 related Products with: COX10-AS1 Facilitates Cell Proliferation and Inhibits Cell Apoptosis in Glioblastoma Cells at Post-Transcription Level.100 ml.1 mg1.00 flask1 mg2 ml1x10e7 cells96 tests10 rxns-25 ml.
#32770366 2020/08/08 To Up
Variation in abdominal wall closure techniques in lower transverse incisions: a nationwide survey across specialties.Lower transverse abdominal incisions are typically used by obstetricians/gynecologists and colorectal surgeons. The suture technique and choice of material when closing the abdomen is an essential factor to decrease the risk of incisional hernia. We conducted a nationwide survey among obstetricians/gynecologists and colorectal surgeons investigating the surgical handling of the fascia, rectus muscle, subcutis, peritoneum, and skin, in lower transverse incisions.
C B Paulsen, D Zetner, J Rosenberg
2795 related Products with: Variation in abdominal wall closure techniques in lower transverse incisions: a nationwide survey across specialties.
#32770356 2020/08/08 To Up
An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer.The aim of current systematic review was to update the body of evidence on associations between adherence to the Mediterranean diet (MedDiet) and risk of cancer mortality, site-specific cancer in the general population; all-cause, and cancer mortality as well as cancer reoccurrence among cancer survivors.
Jakub Morze, Anna Danielewicz, Katarzyna Przybyłowicz, Hongmei Zeng, Georg Hoffmann, Lukas Schwingshackl
1492 related Products with: An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer.10 mg1 module100ul1 module100 mg3 modules10 mg1000 TESTS/0.65ml1 module200 1 module1 module
#32770331 2020/08/08 To Up
Is a colorectal neoplasm diagnosis a trigger to change dietary and other lifestyle habits for persons with Lynch syndrome? A prospective cohort study.A cancer diagnosis is suggested to be associated with changes in dietary and lifestyle habits. Whether this applies to persons with familial cancer, such as Lynch syndrome (LS) is unknown. We investigated whether a colorectal neoplasm (CRN) diagnosis in persons with LS is associated with changes in dietary and lifestyle habits over time. We used data of confirmed LS mutation carriers from the GEOLynch study, a prospective cohort study. Information on dietary intake and lifestyle habits was collected with a validated semi-quantitative food frequency questionnaire and a general questionnaire administered at baseline (2006-2008) and follow-up (2012-2017). Participants' medical records were used to identify CRN diagnoses. Changes in dietary and lifestyle habits in the CRN and the no-CRN group were compared using multivariable linear regression models for continuous variables and cross-tables with percentage change at follow-up compared with baseline for categorical variables. Of the 324 included participants, 146 developed a CRN (CRN group) between baseline and follow-up, while 178 did not (no-CRN group). Smoking cessation was more often reported in the CRN than in the no-CRN group (41.4% vs. 35.0%). There were no differences in changes of energy intake, alcohol, red meat, processed meat, dairy, fruit, vegetables and dietary fiber consumption, BMI, physical activity and NSAID use. Apart from a potentially higher likelihood of smoking cessation, we found little evidence that a CRN diagnosis is associated with changes in lifestyle habits in persons with LS.
Jesca G M Brouwer, Merel Snellen, Tanya M Bisseling, Jan Jacob Koornstra, Hans F A Vasen, Ellen Kampman, Fränzel J B van Duijnhoven
1490 related Products with: Is a colorectal neoplasm diagnosis a trigger to change dietary and other lifestyle habits for persons with Lynch syndrome? A prospective cohort study.0.2 mg100 ug0.1 mg1 mL200 ug1 g25 µg1 mg200 ug0.25 mg200 ug1 ml
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