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#33080630   2020/10/20 To Up

Impact of the COVID-19 pandemic on gastrointestinal endoscopy in the Netherlands: analysis of a prospective endoscopy database.

 COVID-19 has dramatically affected gastrointestinal endoscopy practice. We aimed to investigate its impact on procedure types, indications, and findings.
Marten A Lantinga, Felix Theunissen, Pieter C J Ter Borg, Marco J Bruno, Rob J T Ouwendijk, Peter D Siersema,

1411 related Products with: Impact of the COVID-19 pandemic on gastrointestinal endoscopy in the Netherlands: analysis of a prospective endoscopy database.

11 ml0.1 mg

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#33080605   2020/10/20 To Up

Can Vascular Endothelial Growth Factors and CD34 Expression Implement NICE (Narrow-Band Imaging International Colorectal Endoscopic) Classification in Colorectal Polypoid Lesion Diagnosis?

Vascular endothelial growth factor (VEGF) is a subfamily of growth factors involved in angiogenesis; CD34+ cells are normally found in endothelial progenitor cells and endothelial cells of blood vessels. Colonic adenomatous polyps may not always be completely removable endoscopically, and a preoperative diagnosis might still be necessary. The aim of the study was to evaluate whether VEGF-A, VEGF-C and CD34 mRNA expression along colorectal carcinogenesis steps can implement NICE (Narrow-Band Imaging International Colorectal Endoscopic) classification in the diagnosis of malignancy in colorectal polypoid lesions.
Cesare Ruffolo, Francesco Ferrara, Elisabetta Trevellin, Ivana Cataldo, Caterina Fornasier, Anna Pozza, Marta Campo Dell'Orto, Imerio Angriman, Angelo Paolo Dei Tos, Romeo Bardini, Marco Massani, Andromachi Kotsafti, Marco Scarpa

2650 related Products with: Can Vascular Endothelial Growth Factors and CD34 Expression Implement NICE (Narrow-Band Imaging International Colorectal Endoscopic) Classification in Colorectal Polypoid Lesion Diagnosis?

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#33080566   2020/10/03 To Up

Effect of the isoflavone corylin from cullen corylifolium on colorectal cancer growth, by targeting the STAT3 signaling pathway.

Colorectal cancer (CRC) is one of the most common cancers worldwide. Corylin is an isoflavone extracted from Cullen corylifolium (L.) Medik., which is widely used anti-inflammatory and anticancer in Asian countries. Signal transducer and activator of transcription 3 (STAT3) plays an important role in the occurrence and development of CRC.
Lehe Yang, Yulei Yao, Ying Bai, Dandan Zheng, Feng Zhou, Luye Chen, Wanle Hu, Youqun Xiang, Haiyang Zhao, Zhiguo Liu, Liangxing Wang, Xiaoying Huang, Chengguang Zhao

2102 related Products with: Effect of the isoflavone corylin from cullen corylifolium on colorectal cancer growth, by targeting the STAT3 signaling pathway.

2 Pieces/Boxmin 2 cartons2 Pieces/Box100.00 ul200 units12 Pieces/Box1500 Units

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#33080474   2020/10/17 To Up

The impact of ARID1A mutation on molecular characteristics in colorectal cancer.

ARID1A is a key subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex which regulates dynamic repositioning of nucleosomes to repair DNA damage. Only small pilot studies have evaluated the role of ARID1A mutation in colorectal cancer (CRC). The aim of the present study was to explore the potential impact of ARID1A mutation on clinicopathological and molecular characteristics in CRC.
Ryuma Tokunaga, Joanne Xiu, Richard M Goldberg, Philip A Philip, Andreas Seeber, Francesca Battaglin, Hiroyuki Arai, Jae Ho Lo, Madiha Naseem, Alberto Puccini, Martin D Berger, Shivani Soni, Wu Zhang, Sting Chen, Jimmy J Hwang, Anthony F Shields, John L Marshall, Hideo Baba, W Michael Korn, Heinz-Josef Lenz

2312 related Products with: The impact of ARID1A mutation on molecular characteristics in colorectal cancer.



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#33080322   2020/10/17 To Up

The Nrf2 in the pathophysiology of the intestine: molecular mechanisms and therapeutic implications for inflammatory bowel diseases.

Nrf2 (nuclear factor erythroid 2-related factor 2) is a stress-responsive transcription factor, associated with cellular homeostasis. Under normal conditions Nrf2 is kept in the cytoplasm by Kelch-like ECH-associated protein 1 (Keap1) which facilitates its degradation. Meanwhile, oxidative or electrophilic stress trigger Keap1 dissociation from the Nrf2/Keap1 complex and Nrf2 translocation to the nucleus where it induces the expression of numerous anti-oxidative and anti-inflammatory genes. The Nrf2/Keap1 axis plays a crucial role in the development of gastrointestinal (GI) tract and the maintenance of its proper functionality. This axis also seems to be a promising candidate for prevention of inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), as well as their severe complications such as intestinal fibrosis and colorectal cancer. This review focuses on the role of Nrf2/Keap1 in 1) the development and proper functionality of GI tract, 2) the pathophysiology of GI diseases and their long-term complications, 3) the effectiveness of currently used drugs and non-conventional treatments which influence Nrf2/Keap1 and are potentially effective in IBD treatment, as well as 4) the effect of gut microbiota on Nrf2/Keap1 pathway in IBD.
Marta Piotrowska, Mikolaj Swierczynski, Jakub Fichna, Aleksandra Piechota-Polanczyk

1908 related Products with: The Nrf2 in the pathophysiology of the intestine: molecular mechanisms and therapeutic implications for inflammatory bowel diseases.



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#33079781   2020/10/16 To Up

The potential value of miRNA-223 as a diagnostic biomarker for Egyptian colorectal patients.

Colorectal cancer (CRC) is the third lethal malignancy worldwide. Dysregulation of microRNAs (miRNAs) mediates several growth factors signaling pathways and induces abnormal genes expression, which leads to colorectal carcinogenesis. We aimed to comprehensively assess the expression of miRNA-200c, miRNA-203a, miRNA-223 in Egyptian CRC tissue and their corresponding serum samples and to explore if they have any potential prognostic or diagnostic value for CRC patients.
Noha G Bader El Din, Sally Farouk, Lubna O Abdel-Salam, Ahmed Khairy

1429 related Products with: The potential value of miRNA-223 as a diagnostic biomarker for Egyptian colorectal patients.

100 plates1,000 tests100 assays1 kit10 plates961 kit50 assays

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#33079702   2020/10/20 To Up

Assuring the quality of examinations using faecal immunochemical tests for haemoglobin (FIT).


Callum G Fraser

2965 related Products with: Assuring the quality of examinations using faecal immunochemical tests for haemoglobin (FIT).

96 Tests100 TESTS100 tests1,000 tests100 TESTS100 tests10 Tests96 tests100 Tests25 Tests100 TESTS/0.5ml

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#33079606   // To Up

Patterns of Biomarker Use in Cancer Treatment Among Medical Oncologists in the Philippines.

Several factors affect how medical oncologists in the Philippines use biomarkers in real-world practice. This study describes patterns of biomarker testing for the management of breast, colorectal, and lung cancers among medical oncologists in the Philippines.
Lance Isidore Catedral, Harold Nathan Tan, Alfredo Chua, Danielle Benedict Sacdalan, Dennis L Sacdalan

1585 related Products with: Patterns of Biomarker Use in Cancer Treatment Among Medical Oncologists in the Philippines.



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#33079605   2020/10/20 To Up

The prevalence, characteristics and treatment of hemorrhoidal disease: results of an international web-based survey.

This international study assessed the characteristics and treatment of individuals with hemorrhoids. Online survey among nationally representative populations of adults from Brazil, Czech Republic, France, Hungary, Italy, Romania, Russia and Spain, that identified participants who self-reported having hemorrhoidal disease. Hemorrhoid prevalence was 11% (1725/16015); most respondents had low-severity disease (71%). Compared with the general population, participants with hemorrhoidal disease had more comorbidities (mean 3.1 vs 1.3) and included more women who had been pregnant (81 vs 68%). Common initial signs/symptoms were pain (60%), bleeding (47%) and discomfort (43%). Hemorrhoid respondents who consulted a physician were more likely to undergo interventions and take medications. The prevalence of hemorrhoidal disease in the adult population is 11%, mostly low-severity disease.
Parvez Sheikh, Catherine Régnier, Fabienne Goron, Ghislaine Salmat

2864 related Products with: The prevalence, characteristics and treatment of hemorrhoidal disease: results of an international web-based survey.

25 mg1000 tests0.1 mg200 200ul100 mg10 mg 50 UG100ul

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