Search results for: Complement
#39372635 
2024/06/24
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State-of-Art Therapeutics in IgA Nephropathy.
Immunoglobulin-A nephropathy (IgAN) is the most common primary glomerulonephritis in the world, with up to 40% of patients progressing to end-stage kidney disease (ESKD) within 30 years of diagnosis. IgAN is characterized by elevated serum levels of galactose-deficient IgA1 (Gd-IgA1), which leads to immune complex formation and deposition in the glomerular mesangium, causing kidney injury. A diverse disease course and the long-term follow-up required for clinically relevant endpoints (e.g., ESKD) have been barriers to the development of novel therapies in IgAN. Disease management has focused on supportive care with inhibitors of the renin-angiotensin system and, more recently, sodium-glucose transporter inhibitors to control proteinuria. The recent acceptance of proteinuria as a surrogate endpoint by regulatory bodies and a better understanding of disease pathology have helped to initiate the development of several novel treatments. Subsequently, a targeted-release formulation of budesonide and a dual endothelin/angiotensin inhibitor (sparsentan) have received accelerated approval for patients with IgAN. However, additional therapies are needed to target the different pathogenic mechanisms and individualize patient care. Several compounds currently under investigation target various effectors of pathology. There are promising clinical results from emerging compounds that target the generation of Gd-IgA1 by B cells, including inhibitors of A PRoliferation-Inducing Ligand (APRIL) and dual inhibitors of APRIL and B-cell activating factor (BAFF). Other investigational therapies target the complement cascade by inhibiting proteins of the lectin or alternative pathways. As the therapeutic landscape evolves, it will be important to revise treatment guidelines and develop updated standards of care.Mohit Mathur, Manisha Sahay, Brian J G Pereira, Dana V Rizk
2834 related Products with: State-of-Art Therapeutics in IgA Nephropathy.
1.00 flask1.00 flask60100 μg100 μg100ug Lyophilized3 mg100 μg100ug100ug Lyophilized25 mg
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#39372034 2024/09/18
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Impact of the Graphene Production Methods Sonication and Microfluidization on and Toxicity, Macrophage Response, and Complement Activation.
Graphene, a material composed of a two-dimensional lattice of carbon atoms, has due to its many unique properties a wide array of potential applications in the biomedical field. One of the most common production methods is exfoliation through sonication, which is simple but has low yields. Another approach, using microfluidization, has shown promise through its scalability for commercial production. Regardless of their production method, materials made for biomedical applications need to be tested for biocompatibility. Here, we investigated the differences in toxicity, macrophage response, and complement activation of similar-sized graphene flakes produced through sonication and microfluidization, using cell assays and assays on zebrafish larvae. toxicity testing showed that sonicated graphene had a high toxicity, with an EC of 100 μg mL for endothelial cells and 60 μg mL for carcinoma cells. In contrast, microfluidized graphene did not reach EC at any of the tested concentrations. The potency to activate the complement system in whole blood was 10-fold higher for sonicated than for microfluidized graphene. In zebrafish larvae, graphene of either production method was found to mainly agglomerate in the caudal hematopoietic tissue; however, no acute toxic effects were found. Sonicated graphene led to an increase in macrophage count and a macrophage migration to the ventral tail area, while microfluidized graphene led to a transient reduction in macrophage count and fewer cells in the ventral trail area. The observed reduction in macrophages and change in macrophage distribution following exposure to microfluidized graphene was less pronounced compared to sonicated graphene and contributed to masking of the fluorescent signal rather than cytotoxic effects. Summarized, we observed higher toxicity, macrophage response, and complement activation with graphene produced through sonication, which could be due to oxygen-containing functional groups introduced to the edge of the carbon lattice by this production method. These findings indicate that microfluidization produces graphene more suitable for biomedical applications.Jan-Lukas Førde, Abdelnour Alhourani, Tian Carey, Adrees Arbab, Kari Espolin Fladmark, Silje Skrede, Tom Eirik Mollnes, Lars Herfindal, Hanne Røland Hagland
1752 related Products with: Impact of the Graphene Production Methods Sonication and Microfluidization on and Toxicity, Macrophage Response, and Complement Activation.
200 10 mg100.00 ul500 mg25 mg100ug96T25 mg 5 G1000 tests100ug
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#39371664 2024/10/04
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Increasing Diversity in Orthopaedic Surgery Residency: A Case Report of One Program's Experience Using Pipeline Programs.
African American, Hispanic, Asian, and Pacific Islanders are groups who are underrepresented in medicine (URM groups). Similarly, although women comprise more than 50% of medical students in the United States, women comprise a smaller percentage of all orthopaedic surgery trainees. Therefore, underrepresented in orthopaedics (URiO) represents the URM groups and women. The purpose of this study is to examine the impact of specific steps to recruit a qualified, diverse trainee complement within a single academic orthopaedic surgery residency program between 2000 and 2023. We aim to explore changes in the representation of URiO during this period as well as explore the strategies and programs implemented by the department that may have impacted recruitment of a diverse complement of trainees.Hans K Owuor, Eric J Strauss, Toni McLaurin, Joseph D Zuckerman, Kenneth A Egol
1027 related Products with: Increasing Diversity in Orthopaedic Surgery Residency: A Case Report of One Program's Experience Using Pipeline Programs.
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#39371476 2024/10/01
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Strategies for Non-Covalent Attachment of Antibodies to PEGylated Nanoparticles for Targeted Drug Delivery.
Polyethylene glycol (PEG)-modified nanoparticles (NPs) often struggle with reduced effectiveness against metastasis and liquid tumors due to limited tumor cell uptake and therapeutic efficacy. To address this, actively targeted liposomes with enhanced tumor selectivity and internalization are being developed to improve uptake and treatment outcomes. Using bi-functional proteins to functionalize PEGylated NPs and enhance targeted drug delivery through non-covalent attachment methods has emerged as a promising approach. Among these, the one-step and two-step targeting strategies stand out for their simplicity, efficiency, and versatility. The one-step strategy integrates streptavidin-tagged antibodies or bispecific antibodies (bsAbs: PEG/DIG × marker) directly into PEGylated NPs. This method uses the natural interactions between antibodies and PEG for stable, specific binding, allowing the modification of biotin/Fc-binding molecules like protein A, G, or anti-Fc peptide. Simply mixing bsAbs with PEGylated NPs improves tumor targeting and internalization. The two-step strategy involves first accumulating bsAbs (PEG/biotin × tumor marker) on the tumor cell surface, triggering an initial attack via antibody-dependent and complement-dependent cytotoxicity. These bsAbs then capture PEGylated NPs, initiating a second wave of internalization and cytotoxicity. Both strategies aim to enhance the targeting capabilities of PEGylated NPs by enabling specific recognition and binding to disease-specific markers or receptors. This review provides potential pathways for accelerating clinical translation in the development of targeted nanomedicine.Kai-Wen Ho, Yen-Ling Liu, Tzu-Yi Liao, En-Shuo Liu, Tian-Lu Cheng
2133 related Products with: Strategies for Non-Covalent Attachment of Antibodies to PEGylated Nanoparticles for Targeted Drug Delivery.
2.5 mg100 ug1 g50 assays100μg10 mg100 ug 1000 ml 1 mg0.1 mg100 ug100
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#39371252 2024/08/21
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Classical Haematology: Dynamic Development at the Interface of Transfusion Medicine and Haematology.
Hubert Schrezenmeier
2364 related Products with: Classical Haematology: Dynamic Development at the Interface of Transfusion Medicine and Haematology.
1 ml100ul100ug Lyophilized300 units10 mg100 μg100ul3reactions200 assays1 Set100ul
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#39371251 2024/08/21
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Paroxysmal Nocturnal Hemoglobinuria, Pathophysiology, Diagnostics, and Treatment.
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by intravascular hemolysis (IVH) due to diminished or absent inhibition of the complement system because of deficient expression of cell-anchored complement regulating surface proteins. IVH leads to heterogeneous symptoms such as anemia, abdominal pain, dyspnea, fatigue and increased rates of thrombophilia. Inhibitors of the terminal Complement cascade can reverse IVH leading to a significant reduction of disease burden such as thrombembolic events and also mortality.Jens Peter Panse, Britta Höchsmann, Jörg Schubert
2260 related Products with: Paroxysmal Nocturnal Hemoglobinuria, Pathophysiology, Diagnostics, and Treatment.
25 mg2.5 mg10 mg100ug500 mg 5 G50 ug 5 G100ul25 mg96 wells (1 kit)each
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#39371250 2024/08/27
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Autoimmune Hemolytic Anemias: Challenges in Diagnosis and Therapy.
Autoimmune hemolytic anemia (AIHA) is a rare disease due to increased destruction of erythrocytes by autoantibodies, with or without complement activation.Wilma Barcellini, Bruno Fattizzo
2956 related Products with: Autoimmune Hemolytic Anemias: Challenges in Diagnosis and Therapy.
100 μg8 x 25 ul 100ul100 μg100ug Lyophilized1 mg100ugProtein1.00 mg100 ml1 Set
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#39371156 2024/09/19
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From the Ground Up: Stakeholder Perspectives on Housing Interventions to Reduce Environmentally Mediated Infections.
Housing conditions are intrinsically linked to human health, with inadequate housing potentially increasing exposure to environmentally mediated pathogens. Housing interventions that aim to improve housing and reduce environmentally mediated infections, such as finished floors and housing upgrades for vector-borne diseases, remain relatively under-explored as health interventions. This study explored facilitators of and barriers to funding, implementing, and scaling up housing improvements as health interventions to reduce environmentally mediated infectious diseases.Matthias Acklin, Jay P Graham, Jade Benjamin-Chung
2083 related Products with: From the Ground Up: Stakeholder Perspectives on Housing Interventions to Reduce Environmentally Mediated Infections.
1 mg1 module10 5 100ul1 kit(96 Wells)25 mg1 g
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#39370914 2024/10/07
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ChatGPT as a psychotherapist for anxiety disorders: An empirical study with anxiety patients.
this study aims to investigate the role of ChatGPT as a psychotherapist for anxiety disorders, examining its effectiveness, acceptability, and potential benefits among individuals with anxiety disorders. a quasi-experimental design was adopted, involving a 4-week intervention where participants used ChatGPT as a therapeutic tool. The study included outpatients aged above 18 years from public hospitals in Saudi Arabia. A total of 399 participants completed a survey questionnaire that focused on their experiences with AI-based psychotherapy (six items), perceptions of ChatGPT (four items), and its role in different therapy modalities for anxiety management (seven items). Measures were taken to ensure the validity and reliability of responses by using Cronbach's alpha reliability testing (> 0.7), including the use of a translated and verified questionnaire. majority received prior therapy (89.6%), reporting severe anxiety symptoms (36.1%). ChatGPT was widely used and perceived as accurate by 91.2% of users. Concerns included privacy (67.2%) and ethics (64.9%). Statistically significant differences ( < .05) in perceptions of ChatGPT for anxiety disorders were observed. While urban residents generally rated ChatGPT more positively, females consistently reported higher levels of trustworthiness, effectiveness, and coherence in guidance compared to males. ChatGPT has the potential to complement traditional psychotherapeutic approaches and enhance access to quality mental health care.Turki M Alanzi, Abdulaziz Alharthi, Sarah Alrumman, Sobhia Abanmi, Ammar Jumah, Hatun Alansari, Taif Alharthi, Abdulrahman Alibrahim, Abdullah Algethami, Mishaal Aburass, Abdullah Mohammed Alshahrani, Shahad Alzahrani, Batool Alotaibi, Talah Magadmi, Mohammed Saeed Almasodi
1707 related Products with: ChatGPT as a psychotherapist for anxiety disorders: An empirical study with anxiety patients.
50 assays96 Tests100ug Lyophilized100ug Lyophilized200 assays100ug100μl100 100ug Lyophilized100ug Lyophilized
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