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#35752253   2022/06/22 To Up

35 years of discussions with Prof. Maeda on the EPR effect and future directions.

In May 2021, 35 years after first announcing the enhanced permeability and retention (EPR) effect, Dr. Maeda passed away. As a theoretical pillar of high molecular weight drug delivery systems (DDS) with high biocompatibility, the EPR effect has been proven worldwide in experimental mouse models. However, in clinical solid tumors, awareness of the EPR effect is insufficient, and more importantly, DDS has not become the mainstream cancer treatment. Both Dr. Maeda and I were acutely aware of this, and for 35 years, we discussed what to do about it and strived to make up for the inadequacies of the EPR effect by employing different strategies. Dr. Maeda came up with ways to use tumor vascular permeability more effectively and to apply oxidative stress to tumor cells. I proposed cancer stromal targeting (CAST) therapy using the anti-insoluble fibrin antibody conjugated with an anticancer agent in order to overcome the insufficiency of the EPR effect in clinical solid cancers, which possess abundant stromal tissue. Clinical cancers are surrounded by an abundant stroma and survive even under hypoxia and malnutrition due to this stromal barrier. Cancer cells become resistant to any external attack, including with anticancer drugs and radiation. While it goes without saying that EPR effects are important in clinical solid cancer strategies, DDSs that offer both accumulation and even distribution in solid cancers are also required.
Yasuhiro Matsumura

1134 related Products with: 35 years of discussions with Prof. Maeda on the EPR effect and future directions.

5mg250 mg1 mg1 g100 U 2 ml Ready-to-use 3 Pcs Per Pack5 mg100.00 ul25 mg

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#35752088   2022/06/18 To Up

Selection and identification of a DNA aptamer for fluorescent detection of netilmicin.

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Hong Yu, Chaoqiang Pan, Jiangxiong Zhu, Guoqing Shen, Yun Deng, Xicheng Xie, Xueqing Geng, Lumei Wang

2553 related Products with: Selection and identification of a DNA aptamer for fluorescent detection of netilmicin.

100ug 100ul250 mg100 TESTS50 ug 100 assays

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#35752076   2022/06/13 To Up

Simiao Wan modulates the gut microbiota and bile acid metabolism during improving type 2 diabetes mellitus in mice.

Gut microbiota coupled with their metabolites (bile acids, BAs) get involved in diabetic pathogenesis. Simiao Wan is a famous traditional Chinese formula consisting on Phellodendron chinense C.K.Schneid. (Rutaceae), Atractylodes lancea (Thunb.) DC. (Asteraceae), Achyranthes bidentata Blume (Amaranthaceae) and Coix lacryma-jobi var. ma-yuen (Rom.Caill.) Stapf (Poaceae), and used to treat gouty arthritis and hyperuricemia for thousands of years. However, the mechanisms underlying its beneficial efficacy on diabetes still needs to be explored.
Yimeng Chen, Lijuan Zhu, Wenxin Hu, Yuping Wang, Xiaodong Wen, Jie Yang

2293 related Products with: Simiao Wan modulates the gut microbiota and bile acid metabolism during improving type 2 diabetes mellitus in mice.

1 G 500 G 1 G20mg200ul10 mg 25 G10 5mg100ug2000 Units

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#35751415   2022/06/24 To Up

Dual Function of β-hydroxy Dithiocinnamic Esters: RAFT Agent and Ligand for Metal Complexation.

The reversible addition-fragmentation chain-transfer (RAFT) process has become a versatile tool for the preparation of defined polymers tolerating a large variety of functional groups. Several dithioesters, trithiocarbonates, xanthates, or dithiocarbamates have been developed as effective chain transfer agents (CTA), but only few examples have been reported, where the resulting end groups are directly considered for a secondary use besides controlling the polymerization. We here demonstrate that β-hydroxy dithiocinnamic esters represent a hitherto overlooked class of materials, which were originally designed for the complexation of transition metals but might as well act as reversible CTA. Modified with a suitable leaving group (R-group), these vinyl conjugated dithioesters indeed provide reasonable control over the polymerization of acrylates, acrylamides, or styrene via the RAFT process. Kinetic studies revealed linear evolutions of molar mass with conversion, while different substituents on the aromatic unit had only a minor influence. Block extensions prove the livingness of the polymer chains, although extended polymerization times may lead to side reactions. The resulting dithiocinnamic ester end groups are still able to form complexes with platinum, which verifies that the structural integrity of the end group is maintained. These findings open a versatile new route to tailor-made polymer bound metal complexes. This article is protected by copyright. All rights reserved.
Micheal K Farh, Franka V Gruschwitz, Nicole Ziegenbalg, Hassan Abul-Futouh, Helmar Görls, Wolfgang Weigand, Johannes C Brendel

1765 related Products with: Dual Function of β-hydroxy Dithiocinnamic Esters: RAFT Agent and Ligand for Metal Complexation.

5 G100μg100μg 25 MG1 mg1 mg100μg1 mg1,000 tests1 kit(96 Wells) 1 G48 assays

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#35751212   2022/06/07 To Up

Freeze-synthesized bio-barcode immunoprobe based multiplex fluorescence immunosensor for simultaneous determination of four nitrofuran metabolites.

Here we have reported a simple and sensitive bio-barcode immunosensor for simultaneous detection of 3-amino-2-oxazolidinone (AOZ), 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), 1-aminohydantoin (AHD), and semicarbazide (SEM) in aquatic products. According to freeze-thaw strategy, four fluorophores (FAM, HEX, ROX, Cy5) labeled single-stranded DNA (ssDNA) were conjugated onto the surface of gold nanoparticles (AuNPs) with corresponding four nitrofuran metabolites monoclonal antibodies (mAbs) for forming four bio-barcode fluorescence immunoprobes. The fluorescence of immunoprobes was quenched by AuNPs. In test progress, the ssDNA with fluorophores were released by adding the dithiothreitol (DTT) and the fluorescence recovered. The immunosensor exhibited sensitive and specific detection of nitrofuran metabolites from 0.05 to 28 μg/L. The limit of detection (LOD) was 0.01, 0.02, 0.02, and 0.05 μg/L for AOZ, AMOZ, AHD, and SEM, respectively. The recoveries of four nitrofuran metabolites in spiked aquatic products have been confirmed by UPLC-MS/MS. The bio-barcode based multiplex immunosensor provides a promising strategy for simultaneous detection of multiple targets.
Wanli Zhang, Wei Sheng, Haoyu Zhang, Zixin Jin, Biao Zhang, Na Huang, Shuo Wang

1984 related Products with: Freeze-synthesized bio-barcode immunoprobe based multiplex fluorescence immunosensor for simultaneous determination of four nitrofuran metabolites.

100Tests1 kit100 Tests1 kit100tests1 g1 g10 mg1 kit25 Tests

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#35750278   2022/06/21 To Up

Reversing multi-drug resistance by polymeric metformin to enhance antitumor efficacy of chemotherapy.

Multi-drug resistance (MDR) in breast cancer poses a great threat to chemotherapy. The expression and function of the ATP binding cassette (ABC) transporter are the major cause of MDR. Herein, a linear polyethylene glycol (PEI) conjugated with dicyandiamide, which called polymeric metformin (PolyMet), was successfully synthesized as a simple and biocompatible polymer of metformin. PolyMet showed the potential to reverse MDR by inhibiting the efflux of the substrate of ATP-binding cassette (ABC) transporter from DOX resistant MCF-7 cells (MCF-7/DOX). To test its MDR reversing effect, PolyMet was combined with DOX to treat mice carrying MCF-7/DOX xenografts. In order to decrease the toxicities of DOX and delivery PolyMet and DOX to tumor at the same time, PolyMet was complexed with poly-γ-glutamic acid-doxorubicin (PGA-DOX) electrostatically at the optimal ratio of 2 : 3, which were further coated with lipid membrane to form lipid/PolyMet-(PGA-DOX) nanoparticles (LPPD). The particle size of LPPD was 165.8 nm, and the zeta potential was +36.5 mV. LPPD exhibited favorable cytotoxicity and cellular uptake in MCF-7/DOX. Meanwhile, the bioluminescence imaging and immunohistochemical analysis indicated that LPPD effectively conquered DOX-associated MDR by blocking ABC transporters (ABCB1 and ABCC1) via PolyMet. Remarkably, LPPD significantly inhibited the tumor growth and lowered the systemic toxicity in a murine MCF-7/DOX tumor model. This is the first time to reveal that PolyMet can enhance the anti-tumor efficacy of DOX by dampening ABC transporters and activating the AMPK/mTOR pathway, which is a promising strategy for drug-resistant breast cancer therapy.
Hongyan Zhang, Jiandong Yu, Lisha Ma, Yue Zhao, Shujun Xu, Jingbin Shi, Ke Qian, Mancang Gu, Hongsheng Tan, Li Xu, Yun Liu, Chaofeng Mu, Yang Xiong

2435 related Products with: Reversing multi-drug resistance by polymeric metformin to enhance antitumor efficacy of chemotherapy.

30 ml 96T0.5mg5 g1 kit100 1 module100 ug100 assays

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#35749956   2022/06/17 To Up

Study on model plant based functional beverage emulsion (non-dairy) using ultrasound - A physicochemical and functional characterization.

This study reports the development of non-dairy functional beverage emulsion employing ultrasound (US) of 20 kHz at 130 W and 195 W at processing times of 2 to 8 min using chickpea milk extract and bioactive, flaxseed oil (4%). The pre-emulsion was formed with high shear homogenizer followed by main sonication process. The sonicated emulsions were stored at 4 ± 2 °C till 14 days and characterized for physicochemical and functional properties. A comparative study was carried out using conventional high shear homogenizer (UT) at 10,000 RPM for 5 min. Upon optimization, 130 W - 8 min, 195 W - 6 min and 195 W - 8 min sono-emulsions showed creaming stability of 100%; with particle sizes as 1.12, 0.97 and 0.78 µm; and zetapotential values as - 40.4 mV, -37.52 and -36.91 mV, respectively. The improvement in protein solubility by 86% proved the emulsifying capability of chickpea proteins, which had partially denatured upon physical effects of acoustic cavitation producing stable and finer emulsion droplets. The reduced sedimentation values of sonicated chickpea extract in comparison to UT showed improvement in physical stability of plant-based milk. Oxidative stability is observed for 130 W - 8 min sonicated emulsions with no change in conjugated dienes, indicating the absence of process generated free radicals. The US process did not have any effect on reduction of stachyose content. But extracted chickpea milk had lower amount of stachyose in comparison to raw chickpeas, reducing the flatulence problem, mainly due to adaptation of high temperature pressure cooking process.
Aarcha Vallath, Akalya Shanmugam

2187 related Products with: Study on model plant based functional beverage emulsion (non-dairy) using ultrasound - A physicochemical and functional characterization.

1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)

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#35749853   2022/06/10 To Up

Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves.

Nine new cadinane-type sesquiterpenoids (1-9) and three new eucalyptane -type sesquiterpenes (10-12) were isolated from the ethyl acetate extract of Burdock leaves, which were commonly used for preventing or treating atherosclerosis in China. Their structures were confirmed by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis and ECD calculations. Compound 1 possessed the rare large conjugated skeleton. All the isolates were evaluated for anti-inflammatory and cholesterol-lowering activities by the LPS- and oxidized-low-density-lipoprotein-stimulated RAW 264.7 cells, respectively. As the results, all isolates could decrease the productions of NO, and down-regulate the accumulation of cholesterol. Among them, 4 showed the most potent cholesterol-lowering effect. For the high content of 4 in the herb, mechanistic study of 4 was performed and the results showed that 4 markedly reduced the release of pro-inflammatory mediators which was probably associated with inhibition of the PI3K/Akt and 5-LOX signaling pathways. The findings of this study demonstrated the anti-inflammatory/cholesterol-lowering effects of the new sesquiterpenes from burdock leaves, which provides chemical basis and scientific evidence for the herb used as anti-atherosclerosis agents for the further study. The sesquiterpene lactones of burdock leaves are expected to become new small molecule inhibitors for the treatment of AS.
Hanjing Liang, Qingmei Feng, Hui Guo, Jiangnan Lv, Lingxia Zhang, Qingxia Li, Jun Chi, Qiuyan Liu, Zhimin Wang, Liping Dai

1849 related Products with: Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves.

1000 0.1 ml0.1 mg1 ml100ul100.00 ul100ul200 1000 TESTS/0.65ml100ug Lyophilized100 100 μg

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#35749672   2022/06/24 To Up

Antibody-based therapy for acute myeloid leukemia: a review of phase 2 and 3 trials.

Despite recent advances in the treatment of adult acute myeloid leukemia (AML), the clinical outcome of patients continues to be unsatisfactory especially among older patients, those with a high-risk profile, and in the relapsed/refractory setting. For this reason, recent clinical trials have explored novel therapeutic agents either used alone or in combination with intensive chemotherapy or low-intensity treatments.
Xavier Thomas, Mohamed Elhamri, Alexandre Deloire, Maël Heiblig

2033 related Products with: Antibody-based therapy for acute myeloid leukemia: a review of phase 2 and 3 trials.

25ug200ug200ul200ul100ul100ug Lyophilized200ul100ug200ul100ug Lyophilized200ul200ul

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