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Search results for: Conjugated

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#35045148   2022/01/19 To Up

Heterostructure FeO [email protected] covalent organic framework for long cycling and high-rate lithium storage.

FeO as an anode for lithium-ion batteries has attracted intense attention because of its high theoretical capacity, natural abundance, and good safety. However, the inferior cycling stability, low-rate performance, and limited composite varieties hinder the application of FeO-based materials. In this work, an [email protected] ([email protected]) anode was prepared an imine-based covalent organic framework (COF-LZU1) covering on the exterior surface of FeO after rational optimization. With its unique heterostructure, the COF-LZU1 layer not only effectively alleviated the volume expansion during cycling but also improved the charge-transfer capability because of the π-conjugated system. Moreover, the organic functional group (CN, benzene ring) for COF-LZU1 provided more redox-active sites for Li storage. Under the contributions of both FeO nanorods and COF-LZU1, the [email protected] exhibited an ultrahigh initial capacity and long-term cycling performance with initial discharge capacities of 2143 and 2171 mA h g after 300 cycles under 0.1 A g, and rate performance of 1310 and 501 mA h g at 0.3 and 3 A g, respectively. In addition, a high retention capacity of 1185 mA h g was achieved at 1 A g after 500 cycles. Furthermore, a full-cell with the [email protected] anode and LiCoO cathode exhibited superior cycling and rate performance, which still maintained a reversible capacity of 260 mA h g after 200 cycles even at a current density of 1 A g. The proposed strategy offers a new perspective for exploring the high-rate capability and designability of FeO-based electrode materials.
Zhiwen Long, Chu Shi, Caiqin Wu, Luhan Yuan, Hui Qiao, Keliang Wang

1864 related Products with: Heterostructure FeO [email protected] covalent organic framework for long cycling and high-rate lithium storage.

25 μg100μg100μg100μg100ug100μg96 wells (1 kit)200 mg100ug

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#35044767   2022/01/19 To Up

Novel Two-Dimensional Metal-Based π-d Conjugated Nanosheets as Photocatalyst for Nitrogen Reduction Reaction: The First-Principle Investigation.

Photocatalytic nitrogen reduction reaction (NRR) is becoming a promising route for producing green and sustainable ammonia under ambient conditions. However, the development of highly efficient photocatalysts for NRR still remains a grand challenge as a result of the sluggish activation of inert N, the competitive hydrogen evolution reaction (HER), and inadequate photogenerated external potential, which usually cause extremely poor NRR performance and low light utilization efficiency. Herein, on the basis of density functional theory (DFT) computations, we rationally designed a series of two-dimensional (2D) π-d conjugated metal-BN (MBNS) semiconductors. Using the electron "σ acceptance-π* backdonation" process, MoBNS and NbBNS can efficiently activate and reduce N to ammonia with a rather low overpotential of 0.07 and 0.21 V, respectively. Importantly, a high photogenerated external potential enables spontaneous NRR on MoBNS and NbBNS under visible/infrared light irradiation, contributing to the extraordinary photoactivity of MoBNS and NbBNS as promising solar light-driven N fixation catalysts. Meanwhile, the competing HER is effectively restrained. For the first time, we rationally propose a series of MBNS semiconductors as promising metal-based photocatalysts for N reduction with extraordinary photoactivity and a high photogenerated external potential. This work paves a new path for the rational designing of 2D metal-based NRR photocatalysts with high activity, good selectivity, and high stability.
Lixue Xia, Zhaoyang Wang, Yan Zhao

1804 related Products with: Novel Two-Dimensional Metal-Based π-d Conjugated Nanosheets as Photocatalyst for Nitrogen Reduction Reaction: The First-Principle Investigation.

100tests100Tests1,000 tests100ug Lyophilized100ug Lyophilized100tests100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#35044590   2022/01/19 To Up

Development of a Physiologically-Based Pharmacokinetic Model for Whole-Body Disposition of MMAE Containing Antibody-Drug Conjugate in Mice.

To quantitate and mathematically characterize the whole-body pharmacokinetics (PK) of different ADC analytes following administration of an MMAE-conjugated ADC in tumor-bearing mice.
Hsuan-Ping Chang, Zhe Li, Dhaval K Shah

1559 related Products with: Development of a Physiologically-Based Pharmacokinetic Model for Whole-Body Disposition of MMAE Containing Antibody-Drug Conjugate in Mice.

100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized100ug100ug100ug100ug Lyophilized100ug100ug100ug Lyophilized100ug

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#35044379   2022/01/19 To Up

A self-amplified ROS-responsive chemodrug-inhibitor conjugate for multi-drug resistance tumor therapy.

P-glycoprotein (P-gp) induced multidrug resistance (MDR) is the main reason for the failure of cancer chemotherapy. The combined delivery of chemodrug and P-gp inhibitor is a promising pathway to reverse MDR. However, the intrinsic stimuli in the tumor microenvironment could not realize a complete drug release, which would induce poor cancer therapeutic efficacy. Herein, we conjugated tamoxifen (TAM) with D-α-tocopherol polyethylene glycol1000 succinate (TPGS) based on a reactive oxygen species (ROS)-responsive aryl boronic ester bond to construct a self-amplified ROS-responsive chemodrug-inhibitor (TPGS-TAM) co-delivery system. Due to its amphiphilic property, the TPGS-TAM conjugates could self-assemble into uniform spherical nanoparticles (NPs). After effective endocytosis by cancer cells, the intracellular ROS cleaved the aryl boronic ester bond and initiated the release of TAM and α-tocopherol succinate (α-TOS) from the NPs. Subsequently, the released α-TOS further generated ROS to facilitate the release of TAM. Moreover, α-TOS also consumed adenosine triphosphate (ATP) to impair ATP-dependent P-gp mediated drug efflux to reverse the tumor's drug resistance. As a result, the TPGS-TAM NPs enhanced the antitumor effect with a tumor inhibition rate (TIR) high up to 74.6 ± 6.1% in an MCF-7/ADR tumor model. Based on systematic and assessments, this self-amplified ROS-responsive carrier-free conjugate of chemodrug/P-gp inhibitor may shed light on the potential application for the MDR cancer therapy.
Tingting Sun, Jie Xu, Tianbao Chen, Chunlai Tu, Lijuan Zhu, Deyue Yan

1224 related Products with: A self-amplified ROS-responsive chemodrug-inhibitor conjugate for multi-drug resistance tumor therapy.

100ug Lyophilized100ug Lyophilized100 assays100μg100 assays100ug Lyophilized100ug Lyophilized100 assays100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#35044192   2022/01/19 To Up

Untargeted Identification of Alkyne-Containing Natural Products Using Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reactions Coupled to LC-MS/MS.

Alkyne-containing natural products have been identified from plants, insects, algae, fungi, and bacteria. This class of natural products has been characterized as having a variety of biological activities. Polyynes are a subclass of acetylenic natural products that contain conjugated alkynes and are underrepresented in natural product databases due to the fact that they decompose during purification. Here we report a workflow that utilizes alkyne azide cycloaddition (AAC) reactions followed by LC-MS/MS analysis to identify acetylenic natural products. In this report, we demonstrate that alkyne azide cycloaddition reactions with -bromobenzyl azide result in -bromobenzyl-substituted triazole products that fragment to a common brominated tropylium ion. We were able to identify a synthetic alkyne spiked into the extract of sp. PCC 7120 at a concentration of 10 μg/mL after optimization of MS/MS conditions. We then successfully identified the known natural product fischerellin A in the extract of PCC 9339. Lastly, we identified the recently identified natural products protegenins A and C from Pf-5 through a combination of genome mining and RuAAC reactions. This is the first report of RuAAC reactions to detect acetylenic natural products. We also compare CuAAC and RuAAC reactions and find that CuAAC reactions produce fewer byproducts compared to RuAAC but is limited to terminal-alkyne-containing compounds. In contrast, RuAAC is capable of identification of both terminal and internal acetylenic natural products, but byproducts need to be eliminated from analysis by creation of an exclusion list. We believe that both CuAAC and RuAAC reactions coupled to LC-MS/MS represent a method for the untargeted identification of acetylenic natural products, but each method has strengths and weaknesses.
Daniel Back, Brenda T Shaffer, Joyce E Loper, Benjamin Philmus

1208 related Products with: Untargeted Identification of Alkyne-Containing Natural Products Using Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reactions Coupled to LC-MS/MS.

1 mg500 reactions1 mg5 mg1 mg1 mg100 reactions1 mg1 mg1 mg1 mg1 mg

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#35044177   2022/01/19 To Up

Investigation of 2,2'-Bipyridine Biosynthesis Reveals a Common Two-Component System for Aldehydes Production by Carboxylate Reduction.

Here, we report a two-component enzymatic system that efficiently catalyzes the reduction of a carboxylate to an aldehyde in the biosynthesis of 2,2'-bipyridine antibiotics caerulomycins. The associated paradigm involves the activation of carboxylate by ATP-dependent adenylation protein CaeF, followed by its reduction catalyzed by CaeB2, a new class of NADPH-dependent aldehyde dehydrogenase (ALDH) that directly reduces AMP-conjugated carboxylate, which is distinct from the known aldehyde-producing enzymes that reduce ACP- or CoA-conjugated carboxylates.
Ming Chen, Bo Pang, Wenping Ding, Qunfei Zhao, Zhijun Tang, Wen Liu

2648 related Products with: Investigation of 2,2'-Bipyridine Biosynthesis Reveals a Common Two-Component System for Aldehydes Production by Carboxylate Reduction.

500 Slides 100 mg 70 Slides 1 Pcs Per Pack0.2 mg 50 UG 6 ml Ready-to-use 100.00 ug 100ul10ìg

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#35044106   2021/12/20 To Up

Peptide-Conjugated Silver Nanoparticles for the Colorimetric Detection of the Oncoprotein Mdm2 in Human Serum.

The development of efficient, reliable, and easy-to-use biosensors allowing early cancer diagnosis is of paramount importance for patients. Herein, we report a biosensor based on silver nanoparticles functionalized by peptide aptamers for the detection of a cancer biomarker, i. e. the Mdm2 protein. Silver nanoparticles (AgNPs) were produced and stabilized with a thin PEGylated-calix[4]arene layer that allows (i) the steric stabilization of the AgNPs and (ii) the covalent conjugation of the peptide aptamers via the formation of an amide bond. These peptide-conjugated AgNPs were then used to detect Mdm2 via a dual trapping strategy that was previously reported with gold nanoparticles (AuNPs). Our results showed that replacing AuNPs by AgNPs improves the detection limit by nearly one order of magnitude, down to 5 nM, while the high selectivity of the system and the stability of the particles provided by the calixarene coating allow the detection of Mdm2 in human serum.
Maurice Retout, Bryan Gosselin, Alice Mattiuzzi, Indiana Ternad, Ivan Jabin, Gilles Bruylants

2300 related Products with: Peptide-Conjugated Silver Nanoparticles for the Colorimetric Detection of the Oncoprotein Mdm2 in Human Serum.

100 μg10 96T1mg 100ul10100ug Lyophilized100μg100ug Lyophilized

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#35043820   2022/01/19 To Up

Verteporfin-loaded supramolecular micelles for enhanced cisplatin-based chemotherapy autophagy inhibition.

Cisplatin (CDDP) is one of the most successful chemotherapeutic agents for cancer therapy. However, CDDP can activate pro-survival autophagy, which inhibits the therapeutic efficacy of CDDP. Herein, autophagy inhibitor verteporfin (VTPF) is integrated into CDDP-conjugated micelles to address this issue. The CDDP-conjugated micelles are prepared by host-guest interaction of zwitterionic poly(2-(methacryloyloxy)ethyl phosphorylcholine)--poly(2-(methacryloyloxy)ethyl adamantane-1-carboxylate) (P(MPC--MAd)) and CDDP conjugated β-cyclodextrin (CD-CDDP). VTPF is then physically encapsulated into the supramolecular micelles by hydrophobic interaction. Due to the zwitterionic corona of the supramolecular micelles, the micelles are stable in different media. CDDP and VTPF could be released in a reductive environment. CDDP-activated autophagy could be inhibited by VTPF, which is fully characterized by western blot, fluorescence imaging, and transmission electron microscopy (TEM). Moreover, the outstanding therapeutic efficacy of CDDP and VTPF co-loaded micelles is validated both and . This research not only provides a new strategy to fabricate CDDP delivery systems by supramolecular self-assembly, but also presents an innovative way to enhance cisplatin-based chemotherapy autophagy inhibition.
Junwei Ye, Bo Yu, Haitao Hu, Dongfang Zhou, Qiao Jin, Jian Ji, Zhe Tang

2792 related Products with: Verteporfin-loaded supramolecular micelles for enhanced cisplatin-based chemotherapy autophagy inhibition.

One 96-Well Microplate Ki250 mg96 Tests0.1 mg10ìg100 mg 1000 ml 125 ml 100 mg0.2 mg

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#35043697   2022/01/19 To Up

Herceptin-conjugated magnetic polystyrene-Agsbox nanoparticles as a theranostic agent for breast cancer.

Breast cancer is a malignant tumor, which has derived from cells of the breast. Further, a relatively rapid metastasis, and resistance development against all the conventional drug combinations are major clinical issues in breast cancer patients as well as limitations like toxicity, genetic mutation, and metastasis make difficult the use of conventional therapy methods such as chemotherapy, radiotherapy, and local surgery. Therefore, considering the urgent needs, and high death rate in breast cancer cases, the development of new diagnosis and treatment regimens which diagnosed at the early stage and protected normal tissues required for clinical applications. Recently, the combination of tumor diagnosis and treatment within a single platform is a novel perspective, and magnetic nanoparticles are potential candidate owing to their low toxic effect, biocompatibility, biological degradability, superior magnetic properties, and targeting ability to overcome the problems of conventional diagnosis and therapy techniques. Considering these restrictions and requirements, the goal of this research was to investigate the potential of an innovative theranostic agent, which is soybean oil-based polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox) for treatment and MRI-based diagnosis of cancer. Herein, we designed targeted magnetic PS-Agsbox nanoparticles carrying thymoquinone (TQ) that is known for its anticancer potential against breast cancer, and herceptin (HER), which is to bind to the HER2 receptor protein on the surface of HER2-positive tumor cells, and acts by blocking the effects of it. We have successfully demonstrated selective binding, effective uptake of HER-conjugated magnetic PS-Agsbox nanoparticles into MDA-MB-231 (human breast carcinoma cells, a HER2-underexpressing cell line) and SKBR-3 (human breast cancer cells, a HER2-overexpressing breast cancer cell line) cell lines while no effect against L929 (mouse fibroblast cell line). Moreover, the magnetic resonance (MRI) properties of HER-conjugated magnetic PS-Agsbox nanoparticles were also confirmed.
Zeynep Karahaliloğlu, Ebru Kilicay, Baki Hazer

1686 related Products with: Herceptin-conjugated magnetic polystyrene-Agsbox nanoparticles as a theranostic agent for breast cancer.

100ug Lyophilized100ug100ul100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#35043633   2022/01/19 To Up

Wash-Free, Sandwich-Type Protein Detection Using Direct Electron Transfer and Catalytic Signal Amplification of Multiple Redox Labels.

Direct electron transfer (DET) between a redox label and an electrode has been used for sensitive and selective sandwich-type detection without a wash step. However, applying DET is still highly challenging in protein detection, and a single redox label per probe is insufficient to obtain a high electrochemical signal. Here, we report a wash-free, sandwich-type detection of thrombin using DET and catalytic signal amplification of multiple redox labels. The detection scheme is based on (i) the redox label-catalyzed oxidation of a reductant, (ii) the conjugation of multiple redox labels per probe using a poly-linker, (iii) the low nonspecific adsorption of the conjugated poly-linker due to uncharged, reduced redox labels, and (iv) a facile DET using long, flexible poly-linker and spacer DNA. Amine-reactive phenazine ethosulfate and NADH were used as the redox label and reductant, respectively. N-terminated polylysine was used as the poly-linker for the conjugation between an aptamer probe and multiple redox labels. Approximately 11 redox labels per probe and rapid catalytic NADH oxidation enable high signal amplification. Thrombin in urine could be detected without a wash step with a detection limit of ∼50 pM, which is practically promising for point-of-care testing of proteins.
Gyeongho Kim, Hyejin Cho, Ponnusamy Nandhakumar, Jin Kyoon Park, Kwang-Sun Kim, Haesik Yang

2128 related Products with: Wash-Free, Sandwich-Type Protein Detection Using Direct Electron Transfer and Catalytic Signal Amplification of Multiple Redox Labels.

31mg100ug Lyophilized100ul500 50100ug Lyophilized

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