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#34130366   2021/05/31 To Up

A Network Meta-Analysis Comparing Osteoporotic Fracture among Different Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Atrial Fibrillation.

There are limited studies comparing the risk of osteoporosis and fractures between different direct oral anticoagulants (DOACs) and vitamin K antagonists (VKA) in non-valvular atrial fibrillation (AF). Using a network meta-analysis (NMA), we compared osteoporotic fractures among 5 different treatment arms, viz. dabigatran, rivaroxaban, apixaban, edoxaban, and VKA.
Dibbendhu Khanra, Anindya Mukherjee, Saurabh Deshpande, Hassan Khan, Sanjeev Kathuria, Danesh Kella, Deepak Padmanabhan

2649 related Products with: A Network Meta-Analysis Comparing Osteoporotic Fracture among Different Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Atrial Fibrillation.

100 μg100 μg50μg1 Set48 samples100 μg100 μg

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#34130351   2021/06/15 To Up

Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats.

Acute lung injury (ALI) features dysregulated pulmonary inflammation. Ultrashort waves (USWs) exert anti-inflammatory effects but no studies have evaluated their activity in ALI. Herein, we used an in vivo lipopolysaccharide (LPS)-induced ALI model to investigate whether the anti-inflammatory activity of USWs is mediated by altering the polarization of M1 to M2 macrophages. Twenty-four male Sprague-Dawley rats were randomly divided into control, untreated ALI, and ALI treated with USW groups (n = 8 in each group). ALI was induced by intratracheal LPS instillation. Rats in the USW group were treated for 15 min at 0, 4, and 8 h after a single LPS intratracheal instillation. Histopathologic examination, wet/dry lung weight ratio, enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and western blot analyses were performed to evaluate the degree of lung injury and to determine macrophage phenotypes. Histopathologic examination disclosed attenuation of ALI, with reduced alveolar hemorrhage and neutrophilic infiltration in the USW group. Serum levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were significantly decreased after USW therapy. Moreover, the messenger RNA (mRNA) expressions of TNF-α and IL-1β were significantly decreased in the USW group, whereas the mRNA expression of Arginase 1 (Arg1) and the protein expression of mannose receptor significantly increased in comparison with the untreated ALI group. We conclude that USW therapy may attenuate inflammation in LPS-induced ALI through the modulation of macrophage polarization. © 2021 Bioelectromagnetics Society.
Lan Li, Mengjian Qu, Lu Yang, Jing Liu, Qian Wang, Peirui Zhong, Yahua Zeng, Ting Wang, Hao Xiao, Danni Liu, Xiarong Huang, Jinling Wang, Jun Zhou

1274 related Products with: Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats.

1 mg8 Sample Kit16-22 Sample Kit2ug

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#34130330   2021/06/15 To Up

Expression of the fructose transporter GLUT5 in patients with fructose malabsorption.

 Patients with abdominal symptoms are frequently diagnosed with fructose malabsorption (FM). Fructose is absorbed by monosaccharide transporters located in the brush border of the human small intestine. The aim of this study was to investigate the histoanatomical distribution of the main fructose transporter GLUT5.
Pia Staubach, Anna Katharina Koch, Jost Langhorst, Stefan Schreiber, Christoph Röcken, Ulf Helwig

1302 related Products with: Expression of the fructose transporter GLUT5 in patients with fructose malabsorption.

10 mg300 units1 mg250 MG100 assays100tests110 mg

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#34130317   2021/06/15 To Up

Cue-Based Feeding as Intervention to Achieve Full Oral Feeding in Preterm Infants Primarily Managed with Bubble CPAP.

 Cue-based feeding aims at matching introduction of per oral (PO) feeding with physiological readiness of preterm infants to facilitate PO intake and avoid oral aversion. It was claimed that cue-based feeding may lead to delay in the initiation or achieving full PO feeding in clinical setting primarily using bubble nasal continuous positive airway pressure (CPAP). The study aimed to examine the association of cue-based feeding with time of introduction and completing oral feeding in infants primarily managed with bubble CPAP.
Mohamed A Mohamed, Kirsten K Teumer, Mariana Leone, Nabi Akram, Mohamed H Rahamn, Dinan Abdelatif, Kimberly Condie

2952 related Products with: Cue-Based Feeding as Intervention to Achieve Full Oral Feeding in Preterm Infants Primarily Managed with Bubble CPAP.

1 kit1 kit500 tests100 assays96 samples1 kit(96 Wells)100 100 assays100 tests

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#34130289   2021/06/15 To Up

Cariogenic Potential of Human and Bovine Milk on Enamel Demineralization.

The higher cariogenicity of human milk when compared with bovine milk is still a debatable subject. Therefore, we evaluated the effect of human or bovine milk exposure on biofilm composition and enamel demineralization using a validated cariogenic biofilm model. Streptococcus mutans UA159 biofilms (n = 8) were grown on human saliva-coated bovine enamel slabs of known surface hardness. The biofilms were exposed 8×/day to 0.9% NaCl (negative control), human milk, bovine milk, 7.0% lactose (active human milk control), 4.5% lactose (active bovine milk control), or 10% sucrose (positive control). The culture medium was changed twice daily, and the pH was analyzed as an indicator of biofilm acidogenicity. After 120 h of growth, biofilms were harvested to evaluate viable cells, and soluble and insoluble extracellular polysaccharides (EPS). Enamel demineralization was assessed by the percentage of surface hardness loss (%SHL). Data were analyzed by one-way ANOVA/Tukey's test (α = 5%). In terms of %SHL, negative control (7.7 ± 3.1), human milk control (13.3 ± 7.5), bovine milk control (15.3 ± 8.2), human milk (7.5 ± 5.0), and bovine milk (8.7 ± 6.3) did not differ among them (p > 0.05) but differed (p < 0.05) from sucrose (55.1 ± 5.4). The findings of enamel demineralization (%SHL) were statistically supported by the data of biofilm acidogenicity, bacterial counts and EPS biofilm composition. This experimental study suggests that human and bovine milk have low cariogenic potential to provoke caries lesions in enamel.
Antonio P Ricomini Filho, Ana Camila M de Assis, Bárbara E Costa Oliveira, Jaime A Cury

2958 related Products with: Cariogenic Potential of Human and Bovine Milk on Enamel Demineralization.

100ug Lyophilized100ug Lyophilized1 kit(96 Wells)100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized 100 UG100ug Lyophilized100ug Lyophilized1 mg

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#34130274   2021/06/15 To Up

A bionic soft tongue driven by shape memory alloy and pneumatics.

Soft grippers have exhibited considerable advantages owing to their flexible deformation, compliant operation, and safe interaction with the objects. The ability to grip solid and liquid objects can greatly expand the application range of the soft grippers. Dogs stick out their tongues and then curl backward to form a ladle shape for eating food and drinking water. The large extension ratio and the ladling motion of the tongues endow dogs with flexible operations for both solids and liquids. In this work, inspired by both extending and ladling motions of dog tongues, a bionic soft tongue with capabilities of operating solid and liquid objects was designed. The bionic soft tongue was composed of a tongue base and a tongue tip which were driven by pneumatics and shape memory alloy (SMA) wires, respectively. The tongue base was capable of linearly elongating and contracting with a considerable scale, while the tongue tip could be curled into a ladle shape to grasp objects. The dynamic model of the tongue base was developed and then extended to build the model-based feedback controller for the motion control. A phase dynamic model of the tongue tip was simulated for the structural optimization. With the model-based feedback controller, the bionic soft tongue could achieve a fast step response and a precise position control. Experimental results showed that the bionic soft tongue could grasp different kinds of objects including of water, rice, and gel balls. This work is expected to expand the application scope of soft grippers.
Ning Gong, Hu Jin, Shuaishuai Sun, Shixin Mao, Weihua Li, Shiwu Zhang

2675 related Products with: A bionic soft tongue driven by shape memory alloy and pneumatics.

1 module50 ug 10 mg1 module1000 TESTS/0.65ml100 mg100ul200ul1 module100 mg

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#34130267   2021/06/15 To Up

Online detection of movement during natural and self-initiated reach-and-grasp actions from EEG signals.

Movement intention detection using electroencephalography (EEG) is a challenging but important component of brain-computer interfaces (BCIs) for people with motor disabilities. Objective​: The goal of this study is to exploit low-frequency time-domain EEG signals, concretely movement-related cortical potentials (MRCPs), to perform asynchronous online detection of movement. The experimental paradigm must be easily transferable to people without any residual upper-limb movement function. To achieve that goal, the BCI must be independent of upper-limb movement onset measurements and external cues. ​Approach​: In a study with non-disabled participants, we evaluated a novel BCI paradigm to detect self-initiated reach-and-grasp movements. Two experimental conditions were involved. In one condition, participants performed reach-and-grasp movements to a target and simultaneously shifted their gaze towards it. In a control condition, participants solely shifted their gaze towards the target (oculomotor task). The participants freely decided when to initiate the tasks. The saccade onset was used to label the EEG features, which were exploited on a hierarchical classification approach to detect movement asynchronously. ​Main results​: After correcting eye artifacts, movement information was mapped to sensorimotor, posterior parietal and occipital areas. With regards to BCI performance, 54.1% (14.4% SD) of the movements were correctly identified, and all participants achieved a performance above chance-level (around 12%). An average of 21.5% (14.1% SD) of the oculomotor tasks were falsely detected as upper-limb movement. In an additional rest condition, 1.7 (1.6 SD) false positives per minute were measured. ​Significance​: We present a new approach for movement detection which does not rely on upper-limb movement onset measurements or on the presentation of external cues. The task is intuitive and corresponds to the natural behavior of goal-directed movements, which also constitutes an advantage with respect to current BCI protocols.
Joana Pereira, Reinmar Josef Kobler, Patrick Ofner, Andreas Schwarz, Gernot R Müller-Putz

2088 related Products with: Online detection of movement during natural and self-initiated reach-and-grasp actions from EEG signals.

2x96 well plate1 mg0.1 mg2x96 well plate96 wells1,000 tests100ul100ug

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#34130262   2021/06/15 To Up

Anisotropic compliance of robot legs improves recovery from swing-phase collisions.

Uneven terrain in natural environments challenges legged locomotion by inducing instability and causing limb collisions. During the swing phase, the limb releases from the ground and arcs forward to target a secure next foothold. In natural environments leg-obstacle collisions may occur during the swing phase which can result in instability, and may require contact sensing and trajectory re-planning if a collision occurs. However, collision detection and response often requires computationally- and temporally-expensive control strategies. Inspired by low stiffness limbs that can pass past obstacles in small insects and running birds, we investigated a passive method for overcoming swing-collisions. We implemented virtual compliance control in a robot leg that allowed us to systematically vary the limb stiffness and ultimately its response to collisions with obstacles in the environment. In addition to applying a standard positional control during swing motion, we developed two virtual compliance methods: 1) an isotropic compliance for which perturbations in the $x$ and $y$ directions generated the same stiffness response, and 2) a vertical anisotropic compliance in which a decrease of the upward $y$ vertical limb stiffness enabled the leg to move upwards more freely. The virtual compliance methods slightly increased variability along the limb's planned pathway, but the anisotropic compliance control improved the successful negotiation of step obstacles by over 70\% compared to isotropic compliance and positional control methods. We confirmed these findings in simulation and using a self-propelling bipedal robot walking along a linear rail over bumpy terrain. While the importance of limb compliance for stance interactions have been known, our results highlight how limb compliance in the swing-phase can enhance walking performance in naturalistic environments.
Henry Chang, Justin Chang, Glenna Clifton, Nick Gravish

1705 related Products with: Anisotropic compliance of robot legs improves recovery from swing-phase collisions.

1 mg100 5 G96tests96testsBox of 250 Tubes/Unit x20

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