Search results for: Converting
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#34130299 2021/06/15 To Up
Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-Î± Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.The objective of this study is to examine the role of the tumour necrosis factor-Î± converting enzyme-epidermal growth factor receptor (TACE-EGFR) pathway in human neutrophil elastase (HNE)-induced MUC5AC mucin expression in mice.
Junmei Zhao, Tian Yang, Wei Qiao, Yu Ye, Jian Zhang, Qing Luo
2371 related Products with: Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-Î± Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.2 Pieces/Box100 μg4 Membranes/Box100 μg1 kit(96 Wells)5ug5 x 50 ug20ug5 x 50 ug1 kit(96 Wells)1 mg50 ug
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#34129234 2021/06/15 To Up
The association between neurohormonal therapy and mortality in older adults with heart failure with reduced ejection fraction.Neurohormonal therapy, which includes beta-blockers and angiotensin-converting enzyme inhibitor/angiotensin receptor blockers (ACEi/ARBs), is the cornerstone of heart failure with reduced ejection fraction (HFrEF) treatment. While neurohormonal therapies have demonstrated efficacy in randomized clinical trials, older patients, which now comprise the majority of HFrEF patients, were underrepresented in those original trials. This study aimed to determine the association between short- (30âday) and long-term (1Â year) mortality and the use of neurohormonal therapy in HFrEF patients, across the age spectrum.
Lauren Gilstrap, Andrea M Austin, Barbara Gladders, Parag Goyal, A James O'Malley, Amber Barnato, Anna N A Tosteson, Jonathan S Skinner
1550 related Products with: The association between neurohormonal therapy and mortality in older adults with heart failure with reduced ejection fraction.110025mg 100 UG100
#34128633 2021/06/15 To Up
N, P-Codoped Carbon Film Derived from Phosphazenes and Its Printing Integration with a Polymer Carpet "Molecular Welding" for Flexible Electronics.Although high-performance graphene-based micro/nano flexible electronic devices have shown promising applications in numerous fields, there are still many problems in converting graphene into practical applications. Heteroatom-doped graphene materials are of huge importance because heteroatom doping can significantly change the electronic structure and introduce the active site, which benefits the integration with a promising substrate and achieves nondestructive transfer of carbon materials. Herein, we analyze in detail the pyrolysis gas composition of heteroatom-enriched phosphazenes with different structures and prepare a series of high-quality N, P-codoped carbon-based films from phosphazene solid sources on a low-cost glass substrate by a convenient one-step method. The N, P-codoped carbon film shows reflectivity, good conductivity, and transparency. In addition, with the help of "molecular welding", we achieve nondestructive transfer of a conductive carbon-based film from a glass substrate to promising layer-polyimide (PI) and prepare a flexible free-standing carbon/PI hybrid film with an excellent binding interface. The flexible conductive hybrid film shows excellent durability under an extremely low temperature environment and superior bending stability after 800 bending cycles. The results suggest that a phosphazene precursor is an amazing choice for constructing high-quality heteroatom-doped conductive carbon films. Besides, this work provides a promising way for nondestructive transfer of the conductive carbon-based films and large-scale preparation of large-area patterned conductive thin films.
Fan Yang, Munan Qiu, Zhenwei Miao, Teng Zhang, Shuangkun Zhang, Zhanpeng Wu
1142 related Products with: N, P-Codoped Carbon Film Derived from Phosphazenes and Its Printing Integration with a Polymer Carpet "Molecular Welding" for Flexible Electronics.20 ug50 ul100 mg0.1 mg100ug Lyophilized100ug100ug 25 MG100ug Lyophilized100ug1 g25 mg
#34127973 2021/06/07 To Up
Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core.The molecular events that permit the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to bind, fuse, and enter cells are important to understand for both fundamental and therapeutic reasons. Spike proteins consist of S1 and S2 domains, which recognize angiotensin-converting enzyme 2 (ACE2) receptors and contain the viral fusion machinery, respectively. Ostensibly, the binding of spike trimers to ACE2 receptors promotes the preparation of the fusion machinery by dissociation of the S1 domains. We report the development of bottom-up coarse-grained (CG) models validated with cryo-electron tomography (cryo-ET) data, and the use of CG molecular dynamics simulations to investigate the dynamical mechanisms involved in viral binding and exposure of the S2 trimeric core. We show that spike trimers cooperatively bind to multiple ACE2 dimers at virion-cell interfaces. The multivalent interaction cyclically and processively induces S1 dissociation, thereby exposing the S2 core containing the fusion machinery. Our simulations thus reveal an important concerted interaction between spike trimers and ACE2 dimers that primes the virus for membrane fusion and entry.
Alexander J Pak, Alvin Yu, Zunlong Ke, John A G Briggs, Gregory A Voth
1730 related Products with: Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core.200ul1250ul5 200ul100 ul200ul200ul200ul250ul200ug
#34127431 2021/06/11 To Up
AI-guided discovery of the invariant host response to viral pandemics.Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune response, a.k.a, the "cytokine storm" that has been implicated in fatal COVID-19 using an AI-based approach.
Debashis Sahoo, Gajanan D Katkar, Soni Khandelwal, Mahdi Behroozikhah, Amanraj Claire, Vanessa Castillo, Courtney Tindle, MacKenzie Fuller, Sahar Taheri, Thomas F Rogers, Nathan Beutler, Sydney I Ramirez, Stephen A Rawlings, Victor Pretorius, Davey M Smith, Dennis R Burton, Laura E Crotty Alexander, Jason Duran, Shane Crotty, Jennifer M Dan, Soumita Das, Pradipta Ghosh200 ug100 ug100 ug200 ug100 ug0.25 mg0.1ml (1.3mg/ml)200 ug200 ug200 ug
#34127266 2021/06/11 To Up
Derivation of the maintenance energy requirements and efficiency of metabolizable energy utilization for dry and lactating Jersey cows.Maintenance energy is the energy required to conserve the state of an animal when no work is completed. Dietary energy must be supplied to meet maintenance requirements before milk can be produced. The objectives of the current experiment were to quantify the maintenance energy requirement of Jersey cows when lactating or dry. Energetic measures were collected on 8 Jersey cows and evaluated across 3 physiological phases and nutritional planes: lactation, dry cows fed at maintenance, and fasted dry cows. Through total collection of feces and urine as well as using headbox-style indirect calorimeters, energy balance and heat production data were measured across all phases. Lactation data were collected across four 28-d periods. Data for cows fed at maintenance were collected after 14 d and fasting heat production was measured during the last 24 h of a 96-h fast. Net energy for maintenance (NE) requirements, and the efficiency of converting metabolizable energy (ME) into net energy were compared between lactating and dry (maintenance or fasting phase) cows. Heat production of dry cows fed at maintenance, which represents ME for maintenance, was 0.146 Â± 0.0087 Mcal per unit of metabolic body weight (BW, MBW). Fasting heat production, which represents NE, was 0.102 Â± 0.0071 Mcal/MBW. Energy balance was calculated as tissue energy plus milk energy. When estimated via regressing energy balance on ME intake, NE was not different between dry and lactating cows (0.120 Â± 0.32 vs. 0.103 Â± 0.0052 Mcal/MBW). However, the slope of the regression of energy balance on ME intake was greater for dry compared with lactating cows (0.714 Â± 0.046 vs. 0.685 Â± 0.010) when evaluated with a fixed intercept. This suggests that dry cows were more efficient at converting ME into net energy and that the efficiency of utilizing ME for maintenance may be greater than for lactation. Our measurements of NE and the slope of ME on energy balance were greater than the value used by the National Research Council (2001), which are 0.080 Mcal/MBW for NE and approximately 0.64 for the slope. Results of this study suggest that NE and the efficiency of converting ME into NE of modern lactating Jersey cows are similar to recent measurements on modern Holstein cows and greater than previous measurements.
D L Morris, P J Kononoff
1416 related Products with: Derivation of the maintenance energy requirements and efficiency of metabolizable energy utilization for dry and lactating Jersey cows.5 G0.05 mg10 mg500 mg25 mg50 ug 5 G100ul25 mg 5 G96 wells (1 kit)100ug
#34126900 2021/06/11 To Up
COVID-19 and diabetes mellitus: potential metabolic associations.The COVID-19 pandemic turned the SARS-CoV-2 into the main target of scientific research all around the world. Many advances have already been made, but there is still a long way to go to solve the molecular mechanisms related to the process of the SARS-CoV-2 infection, as well as the particularities of the disease, its course and the complex host-pathogen relationships. However, a lot has been theorized and associated with COVID-19, like the worst prognosis of the disease among individuals with some comorbidities, like diabetes mellitus. In this perspective, diabetic patients are repeatedly associated with more severe cases of COVID-19 when compared to non-diabetic patients. Even though ACE2 (angiotensin-converting enzyme 2) was recognized as the host cell receptor for both binding and entering of SARS-CoV-2 particles, it was also pointed out that this enzyme plays an important protective role against pulmonary damage. Therefore, paradoxically as it may seem, the low baseline level of this receptor in people with diabetes is directly linked to a more expressive loss of ACE2 protective effect, which could be one of the possible factors for the worst prognosis of COVID-19. Still, COVID-19 may also have a diabetogenic effect. From this point of view, the main topics that will be highlighted are (i) the mechanism of the viral entry, with special attention to the cellular receptor (ACE2) and the viral binding protein (spike), (ii) the relationship among the renin-angiotensin system, the infection process and the patients' prognosis, (iii) the glucose control and the medicines used in this event, and (iv) a brief analysis on diabetes triggered by COVID-19.
Pedro Henrique Abreu da Silva, Andressa Santos Garcia, FÃ¡bio Aguiar Alves, AndrÃ© Luis Souza Dos Santos, CÃ¡tia Lacerda SodrÃ© 1 G1000 tests1 kit1 g50 mg1 mg5mg100ug5 g100ug Lyophilized 1 G10 mg
#34126881 2021/06/14 To Up
Efficacy and Safety of Angiotensin-Converting Enzyme Inhibitors in Combination with Angiotensin II Receptor Blockers in Non-diabetic Chronic Kidney Disease: a Systematic Review and Meta-Analysis.It is unclear whether angiotensin-converting enzyme inhibitors (ACEIs) in combination with angiotensin II receptor blockers (ARBs) are superior to ACEIs or ARBs alone in the treatment of nondiabetic chronic kidney disease (CKD). The present meta-analysis was designed to assess the efficacy and safety of ACEIs in combination with ARBs in nondiabetic CKD.
Mingming Zhao, Hanwen Zhang, Yi Yu, Rumeng Wang, Meiying Chang, Sijia Ma, Hua Qu, Yu Zhang
2014 related Products with: Efficacy and Safety of Angiotensin-Converting Enzyme Inhibitors in Combination with Angiotensin II Receptor Blockers in Non-diabetic Chronic Kidney Disease: a Systematic Review and Meta-Analysis.96T100ug100ug100 ug 50 UG100 ug100ul100.00 ug100 ug100ul100ug
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