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#35045584   2022/01/19 To Up

Principles for Designing and Developing a Workflow Monitoring Tool to Enable and Enhance Clinical Workflow Automation.

 Automation of health care workflows has recently become a priority. This can be enabled and enhanced by a workflow monitoring tool (WMOT).
Danny T Y Wu, Lindsey Barrick, Mustafa Ozkaynak, Katherine Blondon, Kai Zheng

2137 related Products with: Principles for Designing and Developing a Workflow Monitoring Tool to Enable and Enhance Clinical Workflow Automation.

1000 TESTS/0.65ml1 module100ul25 mg1 module1 module1000 tests3 modules1 module100.00 ul

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#35045581   2022/01/19 To Up

New Isoquinoline Alkaloids from Paraphaeosphaeria sporulosa F03, a Fungal Endophyte Isolated from Paepalanthus planifolius.

As part of our continuing efforts to discover new bioactive compounds from endophytic fungal sources, we have investigated the extract of the F03 strain. The study led to the isolation of four new 3-methyl-isoquinoline alkaloids (1:  - 4: ) and four known polyketides (5:  - 8: ). The structures of compounds 1:  - 4: were elucidated by 1D and 2D NMR experiments and HRMS analysis. The absolute configuration of 4: was determined by comparison of its experimental electronic circular dichroism spectrum with calculated data. Compounds 1:  - 4: exhibited antifungal activity with minimal inhibitory concentration values ranging from 6.25 - 50 µg/mL against six species but they did not present any cytotoxic activity against the human tumor cell lines A549 (lung), MCF-7 (breast), and HepG2 (hepatocellular). In addition, compound 4: exhibited antiplasmodial activity in the low micromolar range (IC = 4 µM).
Marcelo R de Amorim, Tiago A Paz, Luciano da S Pinto, Felipe Hilário, Camila L Zanini, Anna Caroline C Aguiar, Débora E S Silva, Maysa Furlan, Rafael V C Guido, Taís M Bauab, Adelino V de G Netto, Lourdes C Dos Santos

1409 related Products with: New Isoquinoline Alkaloids from Paraphaeosphaeria sporulosa F03, a Fungal Endophyte Isolated from Paepalanthus planifolius.

50 ul25 mg100 mg 25 G250 mg1 mg100 ug5 mg1 g 5 MG1 mg100 ul

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#35045577   2022/01/19 To Up

Racial and ethnic disparities in maternal and neonatal outcomes among women with chronic hypertension.

To compare maternal and neonatal outcomes in women with chronic hypertension by maternal race and ethnicity.
Kristen Stearns, Shirng-Wern Tsaih, Anna Palatnik

2675 related Products with: Racial and ethnic disparities in maternal and neonatal outcomes among women with chronic hypertension.

1,000 tests100ul 50 UG1 mg1000 tests100ug200 100 mg10 mg100ug

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#35045573   2022/01/19 To Up

External Validation of Postpartum Hemorrhage Prediction Models Using Electronic Health Record Data.

A recent study leveraging machine learning methods found that postpartum hemorrhage (PPH) can be predicted accurately at the time of labor admission in the U.S. Consortium for Safe Labor (CSL) dataset, with a C-statistic as high as 0.93. These CSL models were developed in older data (2002-2008) and used an estimated blood loss (EBL) of ≥1000 mL to define PPH. We sought to externally validate these models using a more recent cohort of births where blood loss was measured using quantitative blood loss (QBL) methods.
Sean R Meyer, Alissa Carver, Hyeon Joo, Kartik Kailas Venkatesh, J Eric Jelovsek, Thomas T Klumpner, Karandeep Singh

2091 related Products with: External Validation of Postpartum Hemorrhage Prediction Models Using Electronic Health Record Data.

1x 5

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#35045569   2022/01/19 To Up

Validation of the Khorana score for predicting venous thromboembolism in 40 218 cancer patients initiating chemotherapy.

The Khorana score is recommended for guiding primary venous thromboembolism prophylaxis in cancer patients, but its clinical utility overall and across cancer types remains debatable. Also, some previous validation studies have ignored competing risk of death, hereby potentially overestimating venous thromboembolism risk. We identified ambulatory cancer patients initiating chemotherapy without other indications for anticoagulation using Danish health registries and estimated six-month cumulative incidence of venous thromboembolism stratified by Khorana levels. Analyses were conducted with and without considering death as competing risk using the Kaplan-Meier method versus the cumulative incidence function. Analyses were performed overall and stratified by cancer types. Of 40,218 patients, 35.4% were categorized by Khorana as low risk (score 0), 53.6% as intermediate risk (score 1-2) and 10.9% as high risk (score ≥3). Considering competing risk of death, the corresponding six-month risks of venous thromboembolism were 1.5% (95% CI 1.3-1-7), 2.8% (95% CI 2.6-3.1), and 4.1% (95% CI 3.5-4.7), respectively. Among patients recommended anticoagulation by guidelines (Khorana score ≥2), six-month risk was 3.6% (95% CI 3.3-3.9). Kaplan-Meier analysis overestimated incidence up to 23% compared with competing risk analyses. Using the guideline-recommended threshold of ≥2, the Khorana score did not risk stratify patients with hepatobiliary or pancreatic cancer, lung cancer, and gynecologic cancer. In conclusion, the Khorana score was able to stratify ambulatory cancer patients according to risk of venous thromboembolism, but not for all cancer types. Absolute risks varied by methodology but were lower than in key randomized trials. Thus, although certain limitations with outcome identification using administrative registries apply, the absolute benefit of implementing routine primary thromboprophylaxis in an unselected cancer population may be smaller than seen in randomized trials.
Thure Overvad, Anne Ording, Peter B Nielsen, Flemming Skjøth, Ida E Albertsen, Simon Noble, Anders Krog Vistisen, Inger Lise Gade, Marianne Tang Severinsen, Gregory Piazza, Torben B Larsen

2942 related Products with: Validation of the Khorana score for predicting venous thromboembolism in 40 218 cancer patients initiating chemotherapy.



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#35045568   2022/01/20 To Up

Television viewing and venous thrombo-embolism: a systematic review and meta-analysis.


Setor K Kunutsor, Richard S Dey, Jari A Laukkanen

1036 related Products with: Television viewing and venous thrombo-embolism: a systematic review and meta-analysis.

1,000 tests100ug1 mg1000 tests50 ug 100ug100 mg25 mg10 mg5mg100ul

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#35045563   2022/01/18 To Up

Comparison of Logarithmic Reading Charts for Visual Assessment in Normally Sighted Participants.

Logarithmic reading charts provide standardised measures of reading performance. Here we show that existing charts provide equivalent assessments of visual aspects of reading that are in good agreement with traditional measures of visual acuity and appear uninfluenced by cognitive (linguistic) factors.
Yahya A Maeni, Kevin B Paterson, John Maltby, Victoria A McGowan, Claire V Hutchinson

1274 related Products with: Comparison of Logarithmic Reading Charts for Visual Assessment in Normally Sighted Participants.

5 G500 MG 100 G250 mg 1 G 1 G5096 wells (1 kit)100

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#35045557   2022/01/18 To Up

Trends and Disparities in Pediatric Nonalcoholic Fatty Liver Disease-Associated Hospitalizations in the United States.

Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of disease characterized by accumulation of fat in the liver and is associated with co-morbidities linked to metabolic syndrome. The prevalence of NAFLD in children has increased in the U.S. over time and with marked racial differences observed in geographically limited studies. This study aims to provide a current, nation-wide analysis of temporal trends of pediatric NAFLD-related hospitalizations and associated co-morbidities as well as assess for racial/ethnic disparities.
Eric Dybbro, Deepa Dongarwar, Hamisu M Salihu, Faith D Ihekweazu

1326 related Products with: Trends and Disparities in Pediatric Nonalcoholic Fatty Liver Disease-Associated Hospitalizations in the United States.

900 tests 50 UG

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