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#33080490   2020/09/22 To Up

Periprocedural vascular access complications associated with percutaneous femoral arterial access using the modified Seldinger's technique in dogs during cardiac catheterization: a single-center experience.

The primary objective of this study is to evaluate the peri-procedural major and minor complications associated with percutaneous femoral arterial access using modified Seldinger's technique in dogs that underwent cardiac catheterization.
D J Stern, T Gunasekaran, R A Sanders

2188 related Products with: Periprocedural vascular access complications associated with percutaneous femoral arterial access using the modified Seldinger's technique in dogs during cardiac catheterization: a single-center experience.

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#33080489   2020/09/19 To Up

Acute effects of intravenous pimobendan administration in dog models of chronic precapillary pulmonary hypertension.

Pulmonary hypertension (PH) is a progressive and potentially life-threatening disease. Several drugs are used for the treatment of dogs with precapillary PH. Pimobendan is an inotropic drug with phosphodiesterase 3 inhibitory and calcium-sensitizing effects. Pimobendan administration improved right ventricular (RV) function and lowered pulmonary arterial pressure in some human patients with precapillary PH. However, the efficacy of pimobendan in dogs with precapillary PH is unknown.
T Morita, K Nakamura, T Osuga, S Kawamoto, S Miki, K Sasaoka, M Takiguchi

1606 related Products with: Acute effects of intravenous pimobendan administration in dog models of chronic precapillary pulmonary hypertension.

5 G 50 UG50ug25 mg100ug100ug Lyophilized1 Set1 Set4 Arrays/Slide1 Set1 Set

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#33079588   2020/10/20 To Up

Letter by Simonato and Altmayer Regarding Article, "Dog Ownership and Survival: A Systematic Review and Meta-Analysis".


Matheus Simonato, Stephan Altmayer

1974 related Products with: Letter by Simonato and Altmayer Regarding Article, "Dog Ownership and Survival: A Systematic Review and Meta-Analysis".

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#33079587   2020/10/20 To Up

Response by Kramer et al to Letters Regarding Article, "Dog Ownership and Survival: A Systematic Review and Meta-Analysis".


Caroline K Kramer, Sadia Mehmood, Renée S Suen

2178 related Products with: Response by Kramer et al to Letters Regarding Article, "Dog Ownership and Survival: A Systematic Review and Meta-Analysis".

5 G1 module1 module1 module1 module 25 G500 mg51 module25 mg1 module

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#33079586   2020/10/20 To Up

Letter by Owen et al Regarding Article, "Dog Ownership and Survival: A Systematic Review and Meta-Analysis".


Katherine B Owen, Adrian Bauman, Magnhild Oust Torske

1290 related Products with: Letter by Owen et al Regarding Article, "Dog Ownership and Survival: A Systematic Review and Meta-Analysis".

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#33079585   2020/10/20 To Up

Does Dog Ownership Really Prolong Survival?: A Revised Meta-Analysis and Reappraisal of the Evidence.


Adrian Bauman, Katherine B Owen, Magnhild Oust Torske, Ding Ding, Steinar Krokstad, Emmanuel Stamatakis

2393 related Products with: Does Dog Ownership Really Prolong Survival?: A Revised Meta-Analysis and Reappraisal of the Evidence.

15 ml 1 module1 module10 mg1 ml1 module1000 tests100ug1 module1 module

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#33079268   2020/10/20 To Up

Usual or unusual presentations of Dirofilaria repens in two sibling dogs: a case report.

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Giulia Barlozzari, Tiziana Felice, Laura Salvato, Raffaella Conti, Claudio De Liberato, Federica Furzi, Simona Gabrielli, Manuela Scarpulla

1283 related Products with: Usual or unusual presentations of Dirofilaria repens in two sibling dogs: a case report.



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#33078965   2020/10/20 To Up

Preclinical and pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy.

Dilated cardiomyopathy (DCM) is a disease of the myocardium defined by left ventricular enlargement and systolic dysfunction leading to heart failure. Danicamtiv, a new targeted myosin activator designed for the treatment of DCM, was characterized in and preclinical studies. Danicamtiv human hepatic clearance was predicted to be 0.5 mL/min/kg from metabolic stability studies in human hepatocytes. For human, plasma protein binding was moderate with a fraction unbound of 0.16, whole blood-to-plasma partitioning ratio was 0.8, and danicamtiv showed high permeability and no efflux in a Caco-2 cell line. Danicamtiv metabolism pathways included CYP-mediated amide-cleavage, -demethylation, as well as isoxazole- and piperidine-ring-opening. Danicamtiv clearance was low across species with 15.5, 15.3, 1.6, and 5.7 mL/min/kg in mouse, rat, dog, and monkey, respectively. Volume of distribution ranged from 0.24 L/kg in mouse to 1.7 L/kg in rat. Oral bioavailability ranged from 26% in mouse to 108% in dog. Simple allometric scaling prediction of human plasma clearance, volume of distribution, and half-life was 0.64 mL/min/kg, 0.98 L/kg, and 17.7 h, respectively. Danicamtiv preclinical attributes and predicted human pharmacokinetics supported advancement toward clinical development.
Mark P Grillo, Svetlana Markova, Marc Evanchik, Marc Trellu, Patricia Moliner, Priscilla Brun, Anne Perreard-Dumaine, Pascale Vicat, Jim Driscoll, Tim J Carlson

1444 related Products with: Preclinical and pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy.

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#33078825   2020/10/20 To Up

Machine learning application identifies novel gene signatures from transcriptomic data of spontaneous canine hemangiosarcoma.

Angiosarcomas are soft-tissue sarcomas that form malignant vascular tissues. Angiosarcomas are very rare, and due to their aggressive behavior and high metastatic propensity, they have poor clinical outcomes. Hemangiosarcomas commonly occur in domestic dogs, and share pathological and clinical features with human angiosarcomas. Typical pathognomonic features of this tumor are irregular vascular channels that are filled with blood and are lined by a mixture of malignant and nonmalignant endothelial cells. The current gold standard is the histological diagnosis of angiosarcoma; however, microscopic evaluation may be complicated, particularly when tumor cells are undetectable due to the presence of excessive amounts of nontumor cells or when tissue specimens have insufficient tumor content. In this study, we implemented machine learning applications from next-generation transcriptomic data of canine hemangiosarcoma tumor samples (n = 76) and nonmalignant tissues (n = 10) to evaluate their training performance for diagnostic utility. The 10-fold cross-validation test and multiple feature selection methods were applied. We found that extra trees and random forest learning models were the best classifiers for hemangiosarcoma in our testing datasets. We also identified novel gene signatures using the mutual information and Monte Carlo feature selection method. The extra trees model revealed high classification accuracy for hemangiosarcoma in validation sets. We demonstrate that high-throughput sequencing data of canine hemangiosarcoma are trainable for machine learning applications. Furthermore, our approach enables us to identify novel gene signatures as reliable determinants of hemangiosarcoma, providing significant insights into the development of potential applications for this vascular malignancy.
Nuojin Cheng, Ashley J Schulte, Fadil Santosa, Jong Hyuk Kim

1172 related Products with: Machine learning application identifies novel gene signatures from transcriptomic data of spontaneous canine hemangiosarcoma.

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#33078734   // To Up

Change in jaw occlusive power by paralysis of masseter muscle with a neuromuscular blocker: Sion's masseter muscle paralysis.

We aimed to determine whether jaw occlusive power decreases with the injection of neuromuscular blocking agents in masseter muscle - a method we named Sion's masseter muscle paralysis (SMP).
Sion Jo, Jae Baek Lee, Youngho Jin, Taeoh Jeong, Jae Chol Yoon, Boyoung Park

2617 related Products with: Change in jaw occlusive power by paralysis of masseter muscle with a neuromuscular blocker: Sion's masseter muscle paralysis.

100ul 6 ml Ready-to-use 100ug Lyophilized200ul 2 ml Ready-to-use 900 tests200ul100ul100 μg1 ml

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