Search results for: Goat D-Dimer
#38088960 2023/11/27 To Up
Epidemiology, clinical manifestations, and laboratory findings of 1,590 human brucellosis cases in Ningxia, China.
Epidemiological and clinical analyses of brucellosis are vital for public health leaders to reinforce disease surveillance and case management strategies.Bofei Liu, Guangtian Liu, Xueping Ma, Fang Wang, Ruiqing Zhang, Pan Zhou, Zhiguo Liu, Zhenjun Li, Xuefeng Jiang
2711 related Products with: Epidemiology, clinical manifestations, and laboratory findings of 1,590 human brucellosis cases in Ningxia, China.
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#30199124 2018/07/09 To Up
Reference intervals for coagulation variables in healthy adult domestic goats (Capra aegagrus hircus).
Coagulation has not been studied extensively in adult goats, and reference intervals (RIs) for coagulation variables have not yet been established and would be clinically useful.Kristin M Zersen, A Russell Moore, Christine S Olver, Justin C Mathis
1342 related Products with: Reference intervals for coagulation variables in healthy adult domestic goats (Capra aegagrus hircus).
5 G500 MG 100 G250 mg 1 G 1 G18 kgs100ìg5mg2 Pieces/BoxRelated Pathways
#16096931 // To Up
Transgenic antithrombin III (Genzyme).
ATIII LLC, a joint venture between Genzyme Transgenics (GTC) and Genzyme General, is developing transgenic recombinant human antithrombin III (rhAT-III) as a potential treatment for sepsis and other disorders involving thrombosis. It is in phase III clinical trials in the US and Europe as an anticoagulant in patients undergoing elective cardiac surgery requiring cardiopulmonary bypass (CPB). GTC has a license from Behringwerke (Hoechst Marion Roussel; now Aventis Pharma) to develop transgenic AT-III. Behringwerke retains exclusive worldwide marketing rights to the product, but has to purchase its entire supply of transgenic AT-III from GTC [156364]. In March 1997, GTC signed an agreement with SMIG, a joint venture formed by GTC and Sumitomo Metals, under which SMIG has the rights to develop rhAT-III in Asia in return for US dollar 4.4 million in additional funding for the continued transgenic development of rhAT-III. The dollar 4.4 million will be paid upon reaching certain milestones, which GTC expected to complete in 1997 [240202]. In December 1998, US-05843705 was issued covering rhAT-III production in transgenic goats [302263]. In January 2000, the results of the European phase III trial, which were significant in meeting the trial's primary endpoint of reduction in the use of fresh frozen plasma were reported. The trial was also significant in two of three secondary endpoints, maintenance of normal AT-III levels and changes in D-dimer and fibrin monomer [352041,353372]. Three phase III trials were initiated in the second quarter of 1998. Two identical trials, one in Europe and one in the US, evaluated the safety and efficacy of rhAT-III compared to placebo in restoring heparin sensitivity to heparin-resistant patients scheduled for elective cardiac surgery requiring CPB. The third trial, in both the US and Europe, will determine whether rhAT-III matches, at equivalent doses, the ability of plasma-derived AT-III to restore heparin sensitivity among heparin-resistant patients undergoing CPB [292235,292861]. Full enrollment onto the US trial was complete by the end of first quarter 2000 [363589], and the companies aim to complete trials and submit a filing by the end of 2000 [353372]. Clinical trials of the proteins in Japan were expected to begin in 1998 [286086].P K Yeung
1292 related Products with: Transgenic antithrombin III (Genzyme).
96T1mg100 Tests100μg1.0mg1 kit(96 Wells)1 mg100μg100μg1mg10mg100μgRelated Pathways
#11423054 // To Up
Elevated plasma tissue plasminogen activator and anti-THP-1 antibodies are independently associated with decreased graft survival in cardiac transplant recipients.
Hemostatic and immunologic factors have been implicated in future cardiac events in patients with coronary artery disease. The role of these factors and their interaction is less established in cardiac transplant recipients. We sought to characterize the role of these factors in these patients. Cardiac transplant patients who presented for surveillance coronary angiography and/or endomyocardial biopsy were eligible for enrollment. Ninety-nine consecutive patients were enrolled. Plasma levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1, von Willebrand factor, fibrin D-dimer, and anti-t-PA antibody were determined by enzyme-linked immunosorbent assays. Anti-THP-1 cell antibodies directed against a monocytic leukemia cell line were detected by incubating patient plasma with THP-1 cells. Bound antibody was detected using goat peroxidase-labeled immunoglobulin G directed against human immunoglobulins. Lipids were measured by enzymatic methods. Multivariate analysis identified the presence of anti-THP-1 cell antibodies (risk ratio 4.41, p = 0.002), t-PA antigen (risk ratio 1.10, p = 0.033), donor age 20 to 26 years (risk ratio 8.83, p = 0.042), and donor age >36 years (risk ratio 15.53, p = 0.009) as predictors of allograft failure. Altered hemostatic function, as demonstrated by elevated plasma t-PA antigen levels, is predictive of subsequent allograft failure in cardiac transplant recipients. In addition, the presence of anti-THP-1 cell antibodies in these patients is predictive of allograft failure.M K Warshofsky, M Dominguez, M S Eisenberg, H S Wasserman, R Sciacca, W Wang, A D Simon, J H Morse, A Schwartz, E Anglés-Cano, L E Rabbani
2617 related Products with: Elevated plasma tissue plasminogen activator and anti-THP-1 antibodies are independently associated with decreased graft survival in cardiac transplant recipients.
200 200 200 100 μg100.00 ug100.00 ug100.00 ug1.0mg96 Tests/kit100 μg1.0mg1000 TESTS/0.65mlRelated Pathways
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