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Search results for: Estrogen receptor IHC control array, 3 cases 3 cores

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#26711328   2015/12/28 To Up

Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium.

Classification of breast cancer into intrinsic subtypes has clinical and epidemiologic importance. To examine accuracy of IHC-based methods for identifying intrinsic subtypes, a three-biomarker IHC panel was compared with the clinical record and RNA-based intrinsic (PAM50) subtypes.
Emma H Allott, Stephanie M Cohen, Joseph Geradts, Xuezheng Sun, Thaer Khoury, Wiam Bshara, Gary R Zirpoli, C Ryan Miller, Helena Hwang, Leigh B Thorne, Siobhan O'Connor, Chiu-Kit Tse, Mary B Bell, Zhiyuan Hu, Yan Li, Erin L Kirk, Traci N Bethea, Charles M Perou, Julie R Palmer, Christine B Ambrosone, Andrew F Olshan, Melissa A Troester

2124 related Products with: Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium.



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#17268818   2007/02/01 To Up

Clinical and pathological correlations in male breast cancer: intratumoral aromatase expression via tissue microarray.

Male breast cancer (MBC) commonly expresses hormone receptors and there is anecdotal evidence of disease responsivity to aromatase inhibitors in the metastatic setting. Our objectives were to: (i) assess clinical-pathologic characteristics in a consecutive cohort of MBC (ii) evaluate intratumoral aromatase (ITA) expression via tissue microarray (TMA) and (iii) assess the prognostic impact of ITA METHODS: A retrospective review was conducted to identify all cases of MBC seen at the Nova Scotia Cancer Center between 1985 and 2005. Specimens were reviewed for standard pathologic characteristics and tumor blocks were incorporated into three TMA's (four 1 mm cores per tumor). Immunohistochemistry (IHC) for ER, PR, Her2-neu and ITA was performed blinded to clinical outcomes. ITA staining intensity was compared to control, benign hepatic tissue and if greater than or equal to liver was scored positive and if less than liver was scored negative. The log-rank test was used for survival comparisons and Kaplan-Meyer curves were used to estimate 3- and 5-year progression-free and overall survival probabilities.
Kelly Dakin Haché, Samantha Gray, Penny J Barnes, Ron Dewar, Tallal Younis, Daniel Rayson

2864 related Products with: Clinical and pathological correlations in male breast cancer: intratumoral aromatase expression via tissue microarray.



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