Search results for: ERK
#38652214 
2024/04/23
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Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p.
CXiaodan Jiang, Zhejun Liu, Hongjie You, Zuoqing Tang, Yun Ma, Ruifang Nie, Zheng Yang, Niancong Che, Wenlan Liu
1063 related Products with: Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p.
5 x 10A5 cells/vial1 x 10^6 cells/vial1 vial1.00 flask900 tests1.00 flask100 ug/vial1.00 flask24 wells
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#38650175 2024/04/22
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Kinase activities in pancreatic ductal adenocarcinoma with prognostic and therapeutic avenues.
PAndrea Vallés-Martí, Richard R de Goeij-de Haas, Alex A Henneman, Sander R Piersma, Thang V Pham, Jaco C Knol, Joanne Verheij, Frederike Dijk, Hans Halfwerk, Elisa Giovannetti, Connie R Jiménez, Maarten F Bijlsma
2337 related Products with: Kinase activities in pancreatic ductal adenocarcinoma with prognostic and therapeutic avenues.
400Tests100100 ug5mg
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#38650142 2024/03/31
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Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway.
PMinggen Yang, Miaolin Guo, Chenqiang Su, Weiping Hao, Zhenqiang Xu
2515 related Products with: Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway.
2 Pieces/Box5ug50 ug10ug5ug5 x 50 ug20 ug2 Pieces/Box20 ug2ug x 20
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#38650011 2024/04/22
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ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
Osteosarcoma is a diverse and aggressive bone tumor. Driver genes regulating osteosarcoma initiation and progression remains incompletely defined. Zinc finger protein 692 (ZNF692), a kind of Krüppel C2H2 zinc finger transcription factor, exhibited abnormal expression in different types of malignancies and showed a correlation with the clinical prognosis of patients as well as the aggressive characteristics of cancer cells. Nevertheless, its specific role in osteosarcoma is still not well understood.Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu, Weichun Guo
2461 related Products with: ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
500 assays96 tests0.5 mg0.5 mg24 tests
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#38649932 2024/04/22
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Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis.
Postoperative cognitive dysfunction (POCD) is a common neurological complication of anesthesia and surgery in aging individuals. Neuroinflammation has been identified as a hallmark of POCD. However, safe and effective treatments of POCD are still lacking. Itaconate is an immunoregulatory metabolite derived from the tricarboxylic acid cycle that exerts anti-inflammatory effects by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. In this study, we investigated the effects and underlying mechanism of 4-octyl itaconate (OI), a cell-permeable itaconate derivative, on POCD in aged mice.Xiangyi Kong, Wenyuan Lyu, Xiaojie Lin, Chunlong Lin, Hao Feng, Lin Xu, Kaiyue Shan, Penghui Wei, Jianjun Li
1326 related Products with: Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis.
100ug Lyophilized100 ug/vial100ug100 100ug/vial100ug Lyophilized100 μg100ug Lyophilized0.1 mg100ug Lyophilized100 ug/vial
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#38647664 2024/04/22
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HMGB1 regulates autophagy of placental trophoblast through ERK signaling pathway.
The purpose of this study is to investigate the role of high mobility group protein B1 (HMGB1) in placental development and fetal growth.Ming-Rui Li, En-Xiang Chen, Zhuo-Hang Li, Hong-Lan Song, Yi Zhang, Fang-Fang Li, You-Long Xie, Jing Tang, Yu-Bin Ding, Li-Juan Fu
2673 related Products with: HMGB1 regulates autophagy of placental trophoblast through ERK signaling pathway.
2 Pieces/Box1.5x10(6) cells1 mg2 Pieces/Box2 Pieces/Box2 Pieces/BoxInhibitors2 Pieces/Box2 Pieces/Box2 Pieces/Box1.5 x 10^6 cells2 Pieces/Box
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#38647434 //
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Correction for: MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition.
Anbang He, Shiming He, Cong Huang, Zhicong Chen, Yucai Wu, Yanqing Gong, Xuesong Li, Liqun Zhou
2740 related Products with: Correction for: MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition.
25 TESTS
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#38647418 2024/04/22
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Therapeutic efficacy of RAS inhibitor trametinib using a juvenile myelomonocytic leukemia patient-derived xenograft model.
JAlex Q Lee, Hiroaki Konishi, Masami Ijiri, Yueju Li, Arun Panigrahi, Jeremy Chien, Noriko Satake
1274 related Products with: Therapeutic efficacy of RAS inhibitor trametinib using a juvenile myelomonocytic leukemia patient-derived xenograft model.
1 Set100 μg250 ug100 assays1mg100 assays100ug Lyophilized50ug1 mg96tests1 mg
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#38645557 2024/04/05
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Decoding the research landscape of drug resistance and therapeutic approaches in head and neck cancer: a bibliometric analysis from 2000 to 2023.
Head and neck cancer is one of the most common tumors worldwide. However, drug resistance in its treatment has become a major factor limiting the efficacy. This study aims to comprehensively understand the current status of research in this field.Qi Han, Junqi Shi, Jiaojiao Liu, Yang Fu, Zhongxun Li, Huina Guo, Xiaoya Guan, Xuting Xue, Hongliang Liu, Liting Zhao, Chunming Zhang
1967 related Products with: Decoding the research landscape of drug resistance and therapeutic approaches in head and neck cancer: a bibliometric analysis from 2000 to 2023.
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#38645496 //
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Effect of miR-412-5p-loaded exosomes in H9c2 cardiomyocytes via the MAPK pathway.
MicroRNAs (miRNAs) are small non-coding RNAs that function in all biological processes. Recent findings suggest that exosomes, which are small vesicles abundantly secreted by various cell types, can transport miRNAs to target cells. Here, we elucidated the effect of miRNA-loaded exosomes on lipopolysaccharide (LPS)-induced inflammation in H9c2 cardiomyocytes.Jin Hee Kim, June Hwan Lee