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#33246306   2020/11/24 To Up

Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities.

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Shuiyao Hu, Wern Chern Chai, Lintao Xu, Shaoqiang Li, Cuirong Jin, Rongxiu Zhu, Luping Yang, Ranran Zhang, Kaijun Tang, Ping Li, Erlan Yang, Wenqiang Chang, Tao Shen, Susan Semple, Henrietta Venter, Lan Xiang

2320 related Products with: Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities.

100ul100ul0.1 mg1 ml100.00 ul200 1000 TESTS/0.65ml1000 100 ul100ug50 ug 10 mg

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#33246284   2020/11/17 To Up

Development and validation of samples stabilization strategy and LC-MS/MS method for simultaneous determination of clevidipine and its primary metabolite in human plasma: Application to clinical pharmacokinetic study in Chinese healthy volunteers.

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Yujia Zhang, Shunbo Zhao, Huan Zhou, Li Ding

1994 related Products with: Development and validation of samples stabilization strategy and LC-MS/MS method for simultaneous determination of clevidipine and its primary metabolite in human plasma: Application to clinical pharmacokinetic study in Chinese healthy volunteers.

100 μg 100ul50ul 100ul16 Arrays/Slide100ul 100ul0.05 mg

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#33246283   2020/10/22 To Up

A rapid and highly sensitive UPLC-ESI-MS/MS method for the analysis of the fatty acid profile of edible vegetable oils.

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Suresh K Nagumalli, Cristina C Jacob, Gonçalo Gamboa da Costa

2372 related Products with: A rapid and highly sensitive UPLC-ESI-MS/MS method for the analysis of the fatty acid profile of edible vegetable oils.

100tests100tests100.00 ul50ul1KG 1 G 100ul25 g96 tests

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#33245661   2020/11/27 To Up

Improvement in the Palladium-Catalyzed Miyaura Borylation Reaction by Optimization of the Base: Scope and Mechanistic Study.

Aryl boronic acids and esters are important building blocks in API synthesis. The palladium-catalyzed Suzuki-Miyaura borylation is the most common method for their preparation. This paper describes an improvement of the current reaction conditions. By using lipophilic bases such as potassium 2-ethyl hexanoate, the borylation reaction could be achieved at 35 °C in less than 2 h with very low palladium loading (0.5 mol %). A preliminary mechanistic study shows a hitherto unrecognized inhibitory effect by the carboxylate anion on the catalytic cycle, whereas 2-ethyl hexanoate minimizes this inhibitory effect. This improved methodology enables borylation of a wide range of substrates under mild conditions.
Santiago Barroso, Markus Joksch, Pim Puylaert, Sergey Tin, Stephen J Bell, Luke Donnellan, Stewart Duguid, Colin Muir, Peichao Zhao, Vittorio Farina, Duc N Tran, Johannes G de Vries

1933 related Products with: Improvement in the Palladium-Catalyzed Miyaura Borylation Reaction by Optimization of the Base: Scope and Mechanistic Study.

1100.00 ul10000 Units

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#33244945   2020/11/27 To Up

The effect of caffeic acid phenethyl ester and Ankaferd blood stopper® on the diabetic and non-diabetic gingival wound healing: an experimental study.

Healthy wound healing is very important for patient comfort. Diabetes is one of the factors that negatively affect wound healing. Ankaferd blood stopper (ABS) and caffeic acid phenethyl ester (CAPE) are anti-inflammatory and antimicrobial agents and may have positive effects on wound healing.
Mehmet GÜl, Serkan DÜndar, GÖkhan ArtaŞ, Akin YİĞİn, Abdulsamet Tanik, Mehmet Emrah Polat, Erhan Cahİt Özcan

2784 related Products with: The effect of caffeic acid phenethyl ester and Ankaferd blood stopper® on the diabetic and non-diabetic gingival wound healing: an experimental study.

10 mg100ug10 mg1 g100.00 ul1000 tests100ug2.5 mg200ul25 mg

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#33244922   // To Up

[Progress in improving the properties of dissolving pulp by enzymes].

Dissolving pulp consists of high purity cellulose and is widely used to as raw materials for the production of regenerated cellulose fiber, cellulose ester and cellulose ether. The characteristic of dissolving pulp affects greatly the production and processing performance of subsequent products. The α-cellulose content, hemicellulose content, pulp viscosity, ash, transition metal ion content, fiber morphology, molecular weight distribution of cellulose and the reactivity are the important properties. Because of its green, mild and high efficiency, the application of enzymes in improving the properties of dissolving pulp has a promising application prospect and has been researched significantly. In this review, the main properties of dissolving pulp are presented first, followed by a recommendation of the enzymes to improve these properties. The application and current research of cellulase and xylanase in improving the properties of dissolving pulp are emphasized. The main problems and the future research areas in improving the properties of dissolving pulp by enzymes are revealed. Finally, the technology prospects in this field are proposed.
Xutao Zhang, Lefan Ma, Kunpeng Zhou, Hongbing Li, Faxing Qin, Wufei Xie, Yingsheng Xu

2009 related Products with: [Progress in improving the properties of dissolving pulp by enzymes].

1

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#33244785   2020/11/26 To Up

Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats.

The effects of a Cratoxylum formosum (Jack) Dyer ssp. (CF) extract on testicular damage were assessed in hypertensive rats. N -nitro-L-arginine methyl ester hydrochloride (L-NAME; 40 mg kg  day ) was administered for 5 weeks to induce hypertension in male Sprague-Dawley rats, and treated with CF extract (100, 300 or 500 mg kg  day ) or sildenafil (5 mg kg  day ) during the final 2 weeks (n = 8/group). Biochemical components of the CF extract were identified and mainly contained phenolic compounds. The CF extract significantly reduced systolic blood pressure and alleviated impaired sperm quality and seminiferous tubular morphology in hypertensive rats. CF extract restored reduced serum testosterone and protein expression of steroidogenic acute regulatory protein (StAR), nuclear factor erythroid-related factor 2 (Nrf2), and haem oxygenase 1 (HO-1) in L-NAME rats. Hypertensive rats presented decreased antioxidant enzyme activities, and increased testicular and plasma malondialdehyde (MDA) levels and superoxide production, all of which were normalised by CF extract. Furthermore, endothelial nitric oxide synthase (eNOS) expression in testicular tissue and plasma nitrate/nitrite levels were restored in hypertensive rats administered CF extract. Conclusion: CF extract alleviated testicular damage in hypertensive rats. Potential molecular mechanisms may involve suppression of oxidative stress and restoration of StAR, Nrf2, HO-1 and eNOS expression in hypertensive rats.
Anuson Poasakate, Putcharawipa Maneesai, Petcharat Chiangsaen, Sarawoot Bunbupha, Wannapa Settheetham-Ishida, Poungrat Pakdeechote

1272 related Products with: Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats.

1 mg96 assays1 mg400 ug400 ug100 assays1 mg100 μg100 MG4 Membranes/Box100 μg100ug

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#33244299   2020/11/10 To Up

Identification of Caffeic Acid Phenethyl Ester (CAPE) as a Potent Neurodifferentiating Natural Compound That Improves Cognitive and Physiological Functions in Animal Models of Neurodegenerative Diseases.

Cell-based screening of bioactive compounds has served as an important gateway in drug discovery. In the present report, using human neuroblastoma cells and enrolling an extensive three-step screening of 57 phytochemicals, we have identified caffeic acid phenethyl ester (CAPE) as a potent neurodifferentiating natural compound. Analyses of control and CAPE-induced neurodifferentiated cells revealed: (i) modulation of several key proteins (NF200, MAP-2, NeuN, PSD95, Tuj1, GAP43, and GFAP) involved in neurodifferentiation process; and (ii) attenuation of neuronal stemness (HOXD13, WNT3, and Msh-2) and proliferation-promoting (CDC-20, CDK-7, and BubR1) proteins. We anticipated that the neurodifferentiation potential of CAPE may be beneficial for the treatment of neurodegenerative diseases and tested it using the model of Alzheimer's disease (AD) and mice model of amnesia/loss of memory. In both models, CAPE exhibited improved disease symptoms and activation of physiological functions. Remarkably, CAPE-treated mice showed increased levels of neurotrophin-BDNF, neural progenitor marker-Nestin, and differentiation marker-NeuN, both in the cerebral cortex and hippocampus. Taken together, we demonstrate the differentiation-inducing and therapeutic potential of CAPE for neurodegenerative diseases.
Arpita Konar, Rajkumar Singh Kalra, Anupama Chaudhary, Aashika Nayak, Kanive P Guruprasad, Kapaettu Satyamoorthy, Yoshiyuki Ishida, Keiji Terao, Sunil C Kaul, Renu Wadhwa

1870 related Products with: Identification of Caffeic Acid Phenethyl Ester (CAPE) as a Potent Neurodifferentiating Natural Compound That Improves Cognitive and Physiological Functions in Animal Models of Neurodegenerative Diseases.

25 mg10 mg10 mg10 mg430 tests 5 G1 g250 mg5 mg900 tests

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#33243655   2020/11/16 To Up

Biofilm development of Bacillus siamensis ATKU1 on pristine short chain low-density polyethylene: A case study on microbe-microplastics interaction.

A low-density polyethylene (LDPE) degrading bacterial strain (ATKU1) was isolated (99.86% similar with Bacillus siamensis KCTC 13613) from a plastic dumping site to study interactions between microplastics (< 5 mm) and microorganisms. The strain was found (by scanning electron microscopy) to form biofilm on the microplastic surface after its interaction with LDPE (avg. M~4,000 Da and avg. M~1,700 Da) as a sole carbon source. Atomic force microscopy (AFM) showed the biofilm's 3-D developmental patterns and significantly increased Young's modulus of the LDPE surface after microbial treatment. Most of the viable bacteria attached to biofilms rather than media, which suggested their ability to utilize LDPE. Absorption bands of carbonyl, alkenyl, acyl, ester, primary-secondary alcohol, alkene groups and nitric oxides were found on the treated LDPE particles using Fourier-transform infrared spectroscopy. Fourier transform-ion cyclotron resonance mass spectrometry of the media indicated compositional shifts of the compounds after treatment (i.e., increase in the degree of unsaturation and increment in oxygen-to-carbon ratio) and presence of unsaturated hydrocarbons, polyketides, terpenoids, aliphatic/peptides, dicarboxylic acids, lipid-like compounds were hinted. The plastic degrading abilities of Bacillus siamensis ATKU1 suggest its probable application for large scale plastic bioremediation facility.
Abhrajyoti Tarafdar, Jae-Ung Lee, Ji-Eun Jeong, Hanbyul Lee, Yerin Jung, Han Bin Oh, Han Young Woo, Jung-Hwan Kwon

1038 related Products with: Biofilm development of Bacillus siamensis ATKU1 on pristine short chain low-density polyethylene: A case study on microbe-microplastics interaction.

1 mL

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