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Search results for: Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy.

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#34494427   2021/09/08 To Up

Virus-Inspired Gold Nanorod-Mesoporous Silica Core-Shell Nanoparticles Integrated with tTF-EG3287 for Synergetic Tumor Photothermal Therapy and Selective Therapy for Vascular Thrombosis.

Synergetic therapy includes the combination of two or more conventional therapeutic approaches and can be used for tumor treatment by combining the advantages and avoiding the drawbacks of each type of treatment. In the present study, truncated tissue factor (tTF)-EG3287 fusion protein-encapsulated gold nanorod (GNR)-virus-inspired mesoporous silica core-shell nanoparticles (vinyl hybrid silica nanoparticles; VSNP) ([email protected]) were synthesized to achieve synergetic therapy by utilizing selective vascular thrombosis therapy (SVTT) and photothermal therapy (PTT). By integrating the targeted coagulation activity of tTF-EG3287 and the high tumor ablation effect of [email protected], local hyperthermia could induce a high percentage of apoptosis of vascular endothelial cells by using near-infrared light. This provided additional phospholipid sites for tTF-EG3287 and enhanced its procoagulant activity . In addition, the nanoparticles, which had unique topological viral structures, exhibited superior cellular uptake properties leading to significant antitumor efficacy. The antitumor results further demonstrated an interaction between SVTT and PTT, whereas the synergetic therapy (SVTT and PTT) achieved an enhanced effect, which was superior to the respective treatment efficacy of each modality or the additive effect of their individual efficacies. In summary, the synthesized [email protected] exerted synergetic effects and enhanced the antitumor efficiency by avoiding multiple injections and suboptimal administration. These effects simultaneously affected both tumor blood supply and cancer cell proliferation. The data suggested that the integration of SVTT induced by tTF-EG3287 and PTT could provide potential strategies for synergetic tumor therapy.
Xian Luo, Jun Xie, Zonglang Zhou, Sihan Ma, Li Wang, Mengqi Li, Jiajing Liu, Peiyuan Wang, Yang Li, Fanghong Luo, Jianghua Yan

2429 related Products with: Virus-Inspired Gold Nanorod-Mesoporous Silica Core-Shell Nanoparticles Integrated with tTF-EG3287 for Synergetic Tumor Photothermal Therapy and Selective Therapy for Vascular Thrombosis.

0.25 mg25 g1 LITRE500 ug 100ul200 mg0.1ml (1mg/ml)25 μg25 mg 5 G

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#34130212   2021/06/08 To Up

Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy.

Recently, natural exosomes have attracted attention as an ideal drug carrier to overcome the limitations of existing drug delivery systems which are toxicity induction and low cancer-targeting performance. In this study, we propose an exosome-based hybrid nanostructure (EHN) with improved targeting ability and therapeutic efficacy against colorectal cancer by using exosomes isolated from the tumor cell line as a drug carrier. The proposed EHN can have high biocompatibility by using exosomes, a biologically derived material, and show improved targeting performance by adding a tumor-targeting ligand (folic acid). In addition, the proposed EHN is capable of chemotherapy because doxorubicin, an anticancer drug, is encapsulated by the exosome with high efficiency, and it can induce hyperthermia therapy because of the magnetic nanoparticles (MNPs) attached to the surface of exosomes. Through in vitro and in vivo experiments using a xenograft tumor mouse model, it was confirmed that the proposed EHN could exhibit increased apoptosis and excellent tumor growth inhibition ability. Therefore, the proposed EHN is expected to overcome the limitations of existing drug delivery systems and be utilized as an effective drug delivery system in cancer treatment.
Su-Hyun Kwon, Hasan Al Faruque, Hyeonwoo Kee, Eunjoo Kim, Sukho Park

1734 related Products with: Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy.

1 bottle 1 GOne 96-Well Microplate Ki100 TESTS1000 tests 96T/Kit

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#34093871   2021/05/13 To Up

Macrophage-mediated tumor homing of hyaluronic acid nanogels loaded with polypyrrole and anticancer drug for targeted combinational photothermo-chemotherapy.

Development of nanosystems that can be integrated with macrophages (MAs), an emerging carrier system, for effective tumor therapy remains to be challenging. We report here the development of MAs specifically loaded with hyaluronic acid (HA) nanogels (NGs) encapsulated with a photothermal agent of polypyrrole (PPy) and anticancer drug doxorubicin (DOX) (HA/[email protected] NGs) for tumor homing and combination photothermo-chemotherapy. Cystamine dihydrochloride-crosslinked HA NGs were first prepared through a double emulsification method, then loaded with PPy via an oxidization polymerization and physically encapsulated with DOX. The created HA/[email protected] NGs were well characterized and subjected to be endocytosed by MAs (MAs-NGs). The MAs-mediated tumor-homing property, phenotype changes and photothermal performance of MAs-NGs were investigated , and a subcutaneous tumor model was also established to confirm their targeting capability and enhanced antitumor therapy effect . The generated hybrid NGs possess a size around 77 nm and good colloidal stability, and can be specifically endocytosed by MAs without appreciably affecting their normal biofunctionalities. In particular, NG-loaded MAs display excellent cancer cell and tumor homing property. Systemic administration of the MAs-NGs leads to the significant inhibition of a subcutaneous tumor model through combination photothermo-chemotherapy under laser irradiation. The developed hybrid HA-based NG nanosystem incorporated with PPy and DOX fully integrates the coordination and heating property of PPy to regulate the optimized DOX release in the tumor region with the assistance of MA-mediated tumor homing, providing a promising cell therapy strategy for enhanced antitumor therapy.
Tingting Xiao, Wei Hu, Yu Fan, Mingwu Shen, Xiangyang Shi

1490 related Products with: Macrophage-mediated tumor homing of hyaluronic acid nanogels loaded with polypyrrole and anticancer drug for targeted combinational photothermo-chemotherapy.

1 G 1 G10 mg 1 G10 mg 1 G 1 G5 g50 ug 1 G25 g1 ml

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#34041901   2021/05/27 To Up

Self-promoted Albumin-Based Nanoparticles for Combination Therapy against Metastatic Breast Cancer via a Hyperthermia-Induced "Platelet Bridge".

It has been a great challenge to simultaneously inhibit the outgrowth of both the primary tumor and metastasis in metastatic cancer treatment. Substantial studies have evidenced that the interaction of platelets and cancer cells supports tumor metastasis, and platelets are considered to have metastasis-targeting property. Inspired by injury-targeting and metastasis-targeting properties of platelets, we constructed a photothermal therapy strategy with activated platelet-targeting albumin-based nanoparticles, PSN-HSA-PTX-IR780, to amplify drug delivery in the primary tumor at mild temperatures and simultaneously inhibit metastasis via a "platelet bridge". Human serum albumin (HSA) was premodified with a P-selectin-targeting peptide (PSN peptide) or IR780 serving as a photosensitizer. Hybrid albumin nanoparticles were assembled via the disulfide reprogramming method and encapsulated paclitaxel (PTX) to formulate PSN-HSA-PTX-IR780. The PSN-modified albumin nanoparticles could bind with upregulated P-selectin on activated platelets and subsequently target cancer cells by using platelets as a "bridge". In addition, nanoparticle-generated hyperthermia induced tissue injury and increased tumor-infiltrating platelets, thereby recruiting more nanoparticles into the tumor in a self-promoted way. studies showed that the drug accumulation of PSN-HSA-PTX-IR780 was 2.86-fold higher than that of HSA-PTX-IR780 at the optimal temperature (45 °C), which consequently improved the therapeutic outcome. Moreover, PSN-HSA-PTX-IR780 also effectively targets and inhibits lung metastasis by binding with metastasis-infiltrating platelets. Altogether, the self-promoted nanoplatform provides a unique and promising strategy for metastatic cancer treatment with enhanced drug delivery efficacy.
Wei Zhao, Ting Li, Yang Long, Rong Guo, Qinglin Sheng, Zhengze Lu, Man Li, Jiaxin Li, Shuya Zang, Zhirong Zhang, Qin He

1541 related Products with: Self-promoted Albumin-Based Nanoparticles for Combination Therapy against Metastatic Breast Cancer via a Hyperthermia-Induced "Platelet Bridge".



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#33762822   2021/03/17 To Up

Doxorubicin (DOX) Gadolinium-Gold-Complex: A New Way to Tune Hybrid Nanorods as Theranostic Agent.

In this paper, we have designed and formulated, a novel synthesis of doxorubicin (DOX) loaded bimetallic gold nanorods in which gold salt (HAuCl) is chelated with anthracycline (DOX), diacid polyethylene-glycol (PEG-COOH) and gadolinium salt (GdCl * 6 HO) to form DOX IN-Gd-AuNRs compared with DOX ON-Gd-AuNRs in which the drug was grafted onto the bimetallic pegylated nanoparticle surface by electrostatic adsorption.
Memona Khan, Sarah Boumati, Celia Arib, Amadou Thierno Diallo, Nadia Djaker, Bich-Thuy Doan, Jolanda Spadavecchia

2168 related Products with: Doxorubicin (DOX) Gadolinium-Gold-Complex: A New Way to Tune Hybrid Nanorods as Theranostic Agent.

1 kit(96 Wells)100 assays1 kit(96 Wells)1 kit(96 Wells)96430 tests1 kit(96 Wells)1 kit(96 Wells)100 assays1 kit(96 Wells)

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#33594402   // To Up

Biomineralized iron oxide-polydopamine hybrid nanodots for contrast-enhanced -weighted magnetic resonance imaging and photothermal tumor ablation.

Iron oxide nanoparticles (IO NPs) have become the focus of molecular imaging probes for contrast enhanced magnetic resonance (MR) imaging due to their intrinsic magnetic and biodegradable properties, as well as long blood half-lives and low toxicity. Massive efforts have been made to explore the IO NPs as T2-weighted MR contrast agents, which have high susceptibility to induce a long-range magnetic field that interferes with diagnosis. Thus, the development of IO NPs with potent T1 relaxivity might help in providing an alternative for clinically applied gadolinium chelates. Herein, biomineralized iron oxide-polydopamine hybrid nanodots (IO/PDA-NDs) have been constructed using albumin as the nanoreactors to induce nanoprecipitation and polymerization simultaneously, facilitating T1-weighted contrast-enhancement as well as photothermal therapeutic capability. The IO nanoclusters in IO/PDA-NDs have an r1 relaxivity of 5.79 mM-1 s-1 with a relatively low r2/r1 ratio of 1.71, demonstrating the preferable iron oxide based T1 contrast agents. The high photothermal conversion coefficient and tumor targeting effect of the hybrid nanodots could result in complete tumor ablation efficacy. The biomineralization method provides a promising approach for the integration of tumor diagnosis and treatment to achieve efficient cancer theranostics.
Ze'ai Wang, Yanfeng Wang, Yuan Wang, Chaogang Wei, Yibin Deng, Huabing Chen, Junkang Shen, Hengte Ke

2556 related Products with: Biomineralized iron oxide-polydopamine hybrid nanodots for contrast-enhanced -weighted magnetic resonance imaging and photothermal tumor ablation.

100ug Lyophilized 1 G1 kit1 kit(96 Wells)100ug1 ml1 mg 500 Slides

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#33452397   2021/01/15 To Up

Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids.

Colorectal cancer (CRC) treatment is currently hindered by micrometastatic relapse that cannot be removed completely during surgery and is often chemotherapy resistant. Targeted theranostic nanoparticles (NPs) that can produce heat for ablation and enable tumor visualization via their fluorescence offer advantages for detection and treatment of disseminated small nodules. A major hurdle in clinical translation of nanoparticles is their interaction with the 3D tumor microenvironment. To address this problem tumor organoid technology was used to evaluate the ablative potential of CD44-targeted polymer nanoparticles using hyaluronic acid (HA) as the targeting agent and coating it onto hybrid donor acceptor polymer particles (HDAPPs) to form HA-HDAPPs. Additionally, nanoparticles composed from only the photothermal polymer, poly[4,4-bis(2-ethylhexyl)-cyclopenta[2,1-b;3,4-b']dithiophene-2,6-diyl-alt-2,1,3-benzoselenadiazole-4,7-diyl] (PCPDTBSe), were also coated with HA, to form HA-BSe NPs, and evaluated in 3D. Monitoring of nanoparticle transport in 3D organoids revealed uniform diffusion of non-targeted HDAPPs in comparison to attenuated diffusion of HA-HDAPPs due to nanoparticle-matrix interactions. Computational diffusion profiles suggested that HA-HDAPPs transport may not be accounted for by diffusion alone, which is indicative of nanoparticle/cell matrix interactions. Photothermal activation revealed that only HA-BSe NPs were able to significantly reduce tumor cell viability in the organoids. Despite limited transport of the CD44-targeted theranostic nanoparticles, their targeted retention provides increased heat for enhanced photothermal ablation in 3D, which is beneficial for assessing nanoparticle therapies prior to in vivo testing.
Bryce McCarthy, Amit Cudykier, Ravi Singh, Nicole Levi-Polyachenko, Shay Soker

1838 related Products with: Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids.

Each5000 Units10 ml

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#33447034   2021/01/08 To Up

Gene Therapy for Drug-Resistant Glioblastoma via Lipid-Polymer Hybrid Nanoparticles Combined with Focused Ultrasound.

Therapy for glioblastoma (GBM) has always been very challenging, not only because of the presence of the blood-brain barrier (BBB) but also due to susceptibility to drug resistance. Recently, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR/Cas9) has revolutionized gene editing technology and is capable of treating a variety of genetic diseases, including human tumors, but there is a lack of safe and effective targeting delivery systems in vivo, especially in the central nervous system (CNS).
Qiang Yang, Yanghao Zhou, Jin Chen, Ning Huang, Zhigang Wang, Yuan Cheng

2063 related Products with: Gene Therapy for Drug-Resistant Glioblastoma via Lipid-Polymer Hybrid Nanoparticles Combined with Focused Ultrasound.



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#33393530   // To Up

Photothermal effect and cytotoxicity of CuS nanoflowers deposited over folic acid conjugated nanographene oxide.

Herein, we present the rational synthesis of a multimode photothermal agent, NGO-FA-CuS, for the advancement of photothermal therapy of cancer. The hierarchical architecture created in NGO-FA-CuS was attained by the covalent conjugation of folic acid (FA) to nanographene oxide (NGO) through amide bonding, followed by the hydrothermal deposition of CuS nanoflowers. In this approach, instead of mere mixing or deposition, FA was covalently bonded to NGO, which helped in retaining their intrinsic properties after binding and allowed to access them in the resulting hybrid nanostructure. In this specifically designed photothermal agent, NGO-FA-CuS, each component has an explicit task, i.e., NGO, FA and CuS act as the quencher, cancer cell-targeting moiety and photothermal transduction agent, respectively. Prior to the grafting of FA molecules and the deposition of CuS nanoflowers, sulfonic acid groups were introduced into NGO to provide stability under physiological conditions. Under irradiation using a 980 nm laser, NGO-FA-CuS was able to attain a temperature of 63.1 °C within 5 min, which is far beyond the survival temperature for cancer cells. Therefore, the resulting temperature recorded for NGO-FA-CuS was sufficient to induce hyperthermia in cancer cells to cause their death. When coming into contact with cancer cells, NGO-FA-CuS can cause a rapid increase in the temperature of their nucleus, destroy the genetic substances, and ultimately lead to exhaustive apoptosis under illumination using a near-infrared (NIR) laser. An excellent photothermal efficiency of 46.2% under illumination using a 980 nm laser and outstanding cytotoxicity against HeLa, SKOV3 and KB cells were attained with NGO-FA-CuS. Moreover, NGO-FA-CuS displays exceptional persistent photo-stability without photo-corrosiveness. The photothermal effect of NGO-FA-CuS was found to be dependent on its concentration and the power density of the laser source. It was found that its cytotoxicity toward cancer cells was enhanced with an increase in the concentration of NGO-FA-CuS and the incubation period.
Gururaj M Neelgund, Aderemi Oki, Subhani Bandara, Laura Carson

2112 related Products with: Photothermal effect and cytotoxicity of CuS nanoflowers deposited over folic acid conjugated nanographene oxide.

100ug Lyophilized100ug Lyophilized100ug Lyophilized100 μg100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#32805591   2020/07/29 To Up

Labeled-protein corona-coated BiS nanorods targeted to lysosomes for bioimaging and efficient photothermal cancer therapy.

One of the main diseases contributing to human death are malignant tumors. Phototherapy is a promising approach for cancer therapy, and functional nanoparticles with targeting ligands are commonly used to improve the therapeutic efficiency. However, recent studies have shown that nanoparticles in contact with a biological fluid can rapidly form a "protein corona" on their surface, which will remarkably decrease the targeting ability. Here, we describe the preparation of hybrid nanomaterials with BiS nanorods as the core, and fluorescein-isothiocyanate and folic acid-modified human serum albumin (HSA-FITC-FA) as the shell. By using fluorescent binding label (FITC) and imaging techniques, we discovered the image of the cell lysosomes, indicating that the photothermal therapy agent was predominantly targeted to and accumulated in lysosomes. Combined with photothermal therapy agent (BiS nanorods) and targeting ligand (FA), the obtained product shows enhanced photothermal therapy under near-infrared region laser irradiation. Additionally, SDS-PAGE shows that the modified HSA shell could remarkably reduce the reabsorption of protein corona from blood serum, minimized the adverse effect of protein corona on targetability. Taken together, the results indicate that our strategy has the potential for preparing efficient photothermal nanomaterials with image-guided subcellular organelle-targeting cancer cell ablation ability.
Shouning Yang, Yanmin Zhang, Sijia Lu, Lihong Liu, Lin Yang, Yuming Guo, Shaoning Yu, Huayan Yang

1004 related Products with: Labeled-protein corona-coated BiS nanorods targeted to lysosomes for bioimaging and efficient photothermal cancer therapy.

10 1mg0.5mg1mg1mg100ul0.5mg1mg1mg1mg5XPlates

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