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Translation, Cross-Culture Adaptation and Measurement Properties of the Simplified Chinese Version of the Osteoarthritis Knowledge Scale.
The aim of this study was to culturally adapt the Osteoarthritis Knowledge Scale (OAKS) into a simplified Chinese version and to evaluate its measurement properties among Chinese-speaking populations.Ziru Wang, Ben Darlow, Huili Deng, Guoxin Ni
1765 related Products with: Translation, Cross-Culture Adaptation and Measurement Properties of the Simplified Chinese Version of the Osteoarthritis Knowledge Scale.
500 Units111mg2000 IU100.00 ul500 Units
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#39375818 2024/10/07
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Preparation of a nanoemulsion containing active ingredients of cannabis extract and its application for glioblastoma: in vitro and in vivo studies.
Recently, the anti-tumor effects of cannabis extract on various cancers have attracted the attention of researchers. Here, we report a nanoemulsion (NE) composition designed to enhance the delivery of two active components in cannabis extracts (∆9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)) in an animal model of glioblastoma. The efficacy of the NE containing the two drugs (NED) was compared with the bulk drugs and carrier (NE without the drugs) using the C6 tumor model in rats. Hemocompatibility factors (RBC, MCV, MCH, MCHC, RDW, PPP, PT and PTT) were studied to determine the potential in vivo toxicity of NED. The optimized NED with mean ± SD diameter 29 ± 6 nm was obtained. It was shown that by administering the drugs in the form of NED, the hemocompatibility increased. Cytotoxicity studies indicated that the NE without the active components (i.e. mixture of surfactants and oil) was the most cytotoxic group, while the bulk group had no toxicity. From the in vivo MRI and survival studies, the NED group had maximum efficacy (with ~4 times smaller tumor volume on day 7 of treatment, compared with the control. Also, survival time of the control, bulk drug, NE and NED were 9, 4, 12.5 and 51 days, respectively) with no important adverse effects. In conclusion, the NE containing cannabis extract could be introduced as an effective treatment in reducing brain glioblastoma tumor progression.Houra Mobaleghol Eslam, Fatemeh Hataminia, Fariba Esmaeili, Seyed Alireza Salami, Hossein Ghanbari, Amir Amani
2182 related Products with: Preparation of a nanoemulsion containing active ingredients of cannabis extract and its application for glioblastoma: in vitro and in vivo studies.
0.1ml (1mg/ml)100ug Lyophilized 100ul0.1ml50 ug100ug Lyophilized50ul 100ul50ul (1mg/ml) 100ul
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#39375812 2024/10/07
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Transcriptome analysis reveals a new virulence-associated trimeric autotransporter responsible for Glaesserella parasuis autoagglutination.
Capsular polysaccharide is an important virulence factor of Glaesserella parasuis. An acapsular mutant displays multiple phenotype variations, while the underlying mechanism for these variations is unknown. In this study, we created an acapsular mutant by deleting the wza gene in the capsule locus. We then used transcriptome analysis to compare the gene expression profiles of the wza deletion mutant with those of the parental strain to understand the possible reasons for the phenotypic differences. The mutant Δwza, which has a deleted wza gene, secreted less polysaccharide and lost its capsule structure. The Δwza exhibited increased autoagglutination, biofilm formation and adherence to eukaryotic cells, while the complementary strain C-Δwza partially restored the phenotype. Transcriptome analysis revealed several differentially expressed genes (DEGs) in Δwza, including up-regulated outer membrane proteins and proteins involved in peptidoglycan biosynthesis, suggesting that wza deletion affects the cell wall homeostasis of G. parasuis. Transcriptome analysis revealed the contribution of non-coding RNAs in the regulation of DEGs. Moreover, a new virulence-associated trimeric autotransporter, VtaA31 is upregulated in Δwza. It is responsible for enhanced autoagglutination but not for enhanced biofilm formation and adherence to eukaryotic cells in Δwza. In conclusion, these data indicate that wza affects the expression of multiple genes, especially those related to cell wall synthesis. Furthermore, they provide evidence that vtaA31 is involved in the autoagglutination of G. parasuis.Junxing Li, Shiyi Ye, Fei Su, Bin Yu, Lihua Xu, Hongchao Sun, Xiufang Yuan
1161 related Products with: Transcriptome analysis reveals a new virulence-associated trimeric autotransporter responsible for Glaesserella parasuis autoagglutination.
0.1 mg0.1 mg1 module1 module 15 ml 100μg1 module 1 G1 module 100 G
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#39375805 2024/10/07
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New insights on genetic background of major diabetic vascular complications.
By 2045, it is expected that 693 million individuals worldwide will have diabetes and with greater risk of morbidity, mortality, loss of vision, renal failure, and a decreased quality of life due to the devastating effects of macro- and microvascular complications. As such, clinical variables and glycemic control alone cannot predict the onset of vascular problems. An increasing body of research points to the importance of genetic predisposition in the onset of both diabetes and diabetic vascular complications.Zuira Tariq, Salah Abusnana, Bashair M Mussa, Hala Zakaria
1283 related Products with: New insights on genetic background of major diabetic vascular complications.
25 ml Ready-to-use 50 UG2 0.5 mg1ml5ug500 6 ml 1 mg 25 MG180 Tests / Kit
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#39375800 2024/10/07
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Characterizing best practices for tonsil-oral-scrubbing (TOSc) collection for PRRSV RNA detection in sows.
A Tonsil-Oral-Scrubbing (TOSc) method was developed to sample the sow's oropharyngeal and tonsillar area without snaring and has shown comparable porcine reproductive and respiratory syndrome virus (PRRSV) RNA detection rates with tonsil scraping in infected sows. This study investigated the effect of specific TOSc collection factors on the PRRSV RT-rtPCR results (detection rates and Ct values). Those factors include whether the sow was snared or not snared at TOSc collection ("snared" vs. "not snared"); whether the sow was laying down or standing at collection ("laying down" vs. "standing"); and type of collectors used for TOSc collection ("TOSc prototype" vs. "Spiral-headed AI catheter (SHAC)"). Volume of fluid was compared between "snared" and "not snared" groups, and collection time was compared between "laying down" and "standing" groups as well.Peng Li, Ana Paula Poeta Silva, Hao Tong, Paul Yeske, Laura Dalquist, Jason Kelly, Matt Finch, Amanda V Anderson Reever, Darwin L Reicks, Joseph F Connor, Phillip C Gauger, Derald J Holtkamp, Gustavo S Silva, Giovani Trevisan, Daniel C L Linhares
1210 related Products with: Characterizing best practices for tonsil-oral-scrubbing (TOSc) collection for PRRSV RNA detection in sows.
2x96 well plate 5 G500 MG250 mg 100 G 1 G 1 G 1000 ml
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#39375798 2024/10/07
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Residual disease is the main, but not the only factor impacting satisfaction in psoriatic patients undergoing biological therapies.
Despite advancements in psoriasis treatment, a gap remains in aligning patient satisfaction with clinical outcomes. Our study aimed to evaluate which clinical and psychological factors may impact treatment satisfaction in psoriatic patients undergoing long-term biological therapies.Giacomo Caldarola, Eleonora De Luca, Gennaro Marco Falco, Lucia Di Nardo, Enrico Bocchino, Magda D'Agostino, Ketty Peris, Clara De Simone
1156 related Products with: Residual disease is the main, but not the only factor impacting satisfaction in psoriatic patients undergoing biological therapies.
100 ul100 ul150 ul0.1ml (1mg/ml)50 ul
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#39375797 2024/10/07
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Association between parental educational involvement and adolescent depressive symptoms: a systematic review and meta-analysis.
Adolescents in their school-age period undergo rapid changes in various aspects, such as physiological development, academic pressure, and interpersonal relationships, constitute a high-risk group for depression. Parental educational involvement, as a critical family variable, influences not only children's academic achievement but also their psychological well-being. However, previous research has shown significant discrepancies regarding the relationship between parental educational involvement and adolescent depressive symptoms.Ying Liu, Yidan Song, Yanlin Wu, Hongbo Lu, Yu Gao, Jing Tang, Xifu Zheng
2377 related Products with: Association between parental educational involvement and adolescent depressive symptoms: a systematic review and meta-analysis.
25 mg1000 tests100ug10 mg 5 G2.5 mg50 ug 200ug1 ml1 mg1,000 tests
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