Search results for: Floxacillin CAS: [5250-39-5]
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[A case of pyroglutamic metabolic acidosis after cotreatment by flucloxacillin and paracetamol].
We report on the case of a 73-year-old man, who was referred to our emergency department for confusion and dyspnea. He had been under a treatment of flucloxacillin for six weeks because of a possible methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis that was complicated by an acute late infection of a knee prosthesis. The laboratory work-up revealed a metabolic acidosis with a high anion gap. After exclusion of the other explanations, we retained a pyroglutamic metabolic acidosis due to concomitant intake of paracetamol and flucloxacillin, favoured by several risk factors. This diagnosis was confirmed by an organic acid dosage in the urine. After discontinuation of the drugs and a treatment with N-acetylcysteine, the evolution was favourable with correction of the metabolic acidosis and the confusional state.Adlija Desgranges, Ketty Hu, Carole Monney Chaubert
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#28293337 2016/12/06
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[Gangrene of the hand due to accidental intra-arterial injection of floxacilline: about a case].
Floxacilline is a beta-lactam antibiotic of the penicillin class. In our context it is used to fight against infections caused by gram-positive bacteria, including staphylococcus aureus. However, floxacilline should be administered with great caution due to its possible side-effects. Our study reports the case of a 6-year old boy who underwent surgery for the treatment of a humeral fracture. The child was treated with injectable floxacilline following a suspected orthopaedic device infection 2 months after surgery. The day after starting antibiotic treatment, the child presented with acute ischemia of the right hand. Then, he was referred to us. Explorations objectified occlusion of the radial artery. The patient underwent relieving fasciotomy and received postoperative heparin. The evolution was marked by gangrene affecting the whole hand. The aim of our study was to educate caregivers about the risk of occurrence of this disastrous complication and about the measures to prevent it.Tarik Salama, El Mohtadi Aghoutane, Rédouane El Fezzazi
1988 related Products with: [Gangrene of the hand due to accidental intra-arterial injection of floxacilline: about a case].
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#21067956 2010/10/19
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[Fingers necrosis after an accidental intra-arterial injection of flucloxacilline: case report].
Accidental intra-arterial injection of drugs is rare in pediatric patients. It is a source of considerable morbidity. Vessel proximity, aberrant vasculature, difficult procedures, and clerical errors can contribute to accidental intra-arterial injection. We report a case of a 7-year-old girl who had an accidental intra-arterial injection of 500 mg of floxacillin in her right elbow for open wound of the index. Initial signs and symptoms consisted of intense forearm pain and cyanosis. Two to 3 hours later, discoloration and nail bed pallor became evident, with no radial pulse. Rapid development of signs of acute ischemia prompted urgent brachial artery embolectomy and exploration and forearm fasciotomy. Postoperative heparin was administered. Postoperatively gangrene of the five fingers of the right hand developed. We present a comprehensive review of literature, highlighting available information on symptoms, pathogenesis, sequelae and management strategies for accidental intra-arterial injection. We believe that all physicians and ancillary personnel who administer intravenous therapy should be aware of this serious risk.E M Aghoutane, R Fezzazi, R Elhaouati, D Boumzebra