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#39356215 
2024/10/02
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Selective, Intrinsically Fluorescent Trk Modulating Probes.
Neurotrophins (NTs) elicit the growth, survival, and differentiation of neurons and other neuroectoderm tissues via activation of Trk receptors. Hot spots for NT·Trk interactions involve three neurotrophin loops. Mimicry of these using "-organopeptides" comprising loop sequences cyclized onto endocyclic organic fragments accounts for a few of the low molecular mass Trk agonists or modulators reported so far; the majority are nonpeptidic small molecules accessed without molecular design and identified in random screens. It has proven difficult to verify activities induced by low molecular mass substances are due to Trk activation (rather than via other receptors), enhanced Trk expression, enhanced NT expression, or other pathways. Consequently, identification of selective probes for the various Trk receptors (e.g., A, B, and C) has been very challenging. Further, a key feature of probes for early stage assays is that they should be easily detectable, and none of the compounds reported to date are. In this work, we designed novel -organopeptide derivatives where the organic fragment is a BODIPY fluor and found ones that selectively, though not specifically, activate TrkA, B, or C. One of the assays used to reach this conclusion (binding to live Trk-expressing cells) relied on intrinsic fluorescence in the tested materials. Consequently, this work established low molecular mass Trk-selective probes exhibiting neuroprotective effects.Thitima Pewklang, Tye Thompson, Arthur Sefiani, Cédric G Geoffroy, Anyanee Kamkaew, Kevin Burgess
1681 related Products with: Selective, Intrinsically Fluorescent Trk Modulating Probes.
10reactions 10reactions 10reactions 10reactions 10reactions 100 reactions1x96 well plate
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#39347917 2024/09/30
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Comparative fluorophotometric evaluation of the ocular surface retention time of cross-linked and linear hyaluronic acid ocular eye drops on healthy dogs.
Evaluate and compare the retention time on the canine ocular surface of crosslinked hyaluronic acid (X-HA), linear hyaluronic acid (L-HA) and saline solution using fluorescent compounds (fluorescein sodium salt, Alexa Fluor 488 cadaverine and Alexa Fluor 488 maleimide).Andressa Lopes Grego, Andy D Fankhauser, Emily K Behan, Sarah K Atzet, D J Haeussler, Franz Riegler Mello, Mariza Bortolini, Fabiano Montiani Ferreira
1897 related Products with: Comparative fluorophotometric evaluation of the ocular surface retention time of cross-linked and linear hyaluronic acid ocular eye drops on healthy dogs.
50 ug 5 G10 mg1 ml1 mg1200 mg1 g250 mg1 g1 mg
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#39337881 2024/08/30
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Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models.
Repairing or reconstructing significant bone defects is typically challenging. In the present study, two composite cements were used as scaffolds in a sub-critical femoral defect in rats. A control group and two experimental batches were used to compare the outcomes. This research aimed to investigate the osteogenic potential and toxicological tolerance of the bioproducts through histopathology and computed tomography imaging analysis at 14, 28, 56, and 90 days post-implantation. The biomaterials used in the investigation consisted of a 65% bioactive salinized inorganic filler and a 25% weight organic matrix. The organic part of the biomaterial was composed of Bis-GMA (bisphenol A-glycidyl methacrylate), UDMA (urethane dimethacrylate), HEMA (2-Hydroxyethyl methacrylate), and TEGDMA (triethylene glycol dimethacrylate), while the inorganic filler was composed of silica, barium glass, hydroxyapatite, and fluor aluminosilicate glass. The first findings of this research are encouraging, revealing that there is a slight difference between the groups treated with biomaterials, but it might be an effective approach for managing bone abnormalities. Material C1 exhibited a faster bone defect healing time compared to material C2, where bone fractures occurred in some individuals. It is unclear if the fractures were caused by the presence of the biomaterial C2 or whether additional variables were to blame. By the end of the research, the mice appeared to tolerate the biomaterials without exhibiting any inflammatory or rejection responses.Alina Ioana Ardelean, Sorin Marian Mârza, Raluca Marica, Mădălina Florina Dragomir, Alina Oana Rusu-Moldovan, Mărioara Moldovan, Paula Maria Pașca, Liviu Oana
2484 related Products with: Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models.
500 MG 100 G250 mg 100 UG 1 G10ìg900 tests
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#39309231 2024/08/14
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Plant-derived compounds normalize platelet bioenergetics and function in hyperglycemia.
Polyphenols have been shown to decrease oxidative stress and modulate glycemic response. Nevertheless, their effect on platelet bioenergetics and clot structure in diabetes and hyperglycemia is unknown.Julia S Gauer, Abigail Ajanel, Lutale M Kaselampao, Isabel Candir, Amanda D V MacCannell, Lee D Roberts, Robert A Campbell, Robert A S Ariëns
2993 related Products with: Plant-derived compounds normalize platelet bioenergetics and function in hyperglycemia.
2ug4/120 Packing /sleeve/bo2ug100 µg2ug4/120 Packing /sleeve/bo2ug12ug96 tests10 µg96tests
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#39275674 2024/09/04
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Area-Efficient Mixed-Signal Time-to-Digital Converter Integration for Time-Resolved Photon Counting.
Digital histogram generation for time-resolved measurements with single-photon avalanche diode (SPAD) sensors requires the storage of many timestamp signals. This work presents a mixed-signal time-to-digital converter (TDC) that uses analog storage to achieve an area-efficient design that can be integrated in large SPAD arrays. Fabricated using a 150 nm CMOS process, the prototype occupies an area of only 18.3 µm × 36.5 µm, a notable size reduction compared to conventional designs. The experimental results demonstrated high performance, with an integral nonlinearity (INL) of 0.35/0.14 least significant bit (LSB) and a differential nonlinearity (DNL) of 0.14/-0.12 LSB. In addition, the proposed TDC can support the construction of histograms comprising up to 512 bins, making it an effective solution to accommodate a wide range of resolution requirements. Validated in a point-of-care (PoC) device for fluorescence lifetime measurements, it distinguished between lifetimes of approximately 4.1 ns, 3.6 ns and 80 ns with the Alexa Fluor (AF) 546 and 568 dyes and Quantum Dot (QD) 705, respectively. The analog storage design and area-efficient architecture offer a novel approach to integrating TDCs in SPAD-based systems, with potential applications in medical diagnostics and beyond.Sergio Moreno, Victor Moro, Joan Canals, Angel Diéguez
1095 related Products with: Area-Efficient Mixed-Signal Time-to-Digital Converter Integration for Time-Resolved Photon Counting.
25252525252525252596 wells2525
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#39273016 2024/08/28
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Enhanced Performance of the Optimized Dye CF583R in Stochastic Optical Reconstruction Microscopy of Active Zones in .
Super-resolution single-molecule localization microscopy (SMLM) of presynaptic active zones (AZs) and postsynaptic densities contributed to the observation of protein nanoclusters that are involved in defining functional characteristics and in plasticity of synaptic connections. Among SMLM techniques, stochastic optical reconstruction microscopy (STORM) depends on organic fluorophores that exert high brightness and reliable photoswitching. While multicolor imaging is highly desirable, the requirements necessary for high-quality STORM make it challenging to identify combinations of equally performing, spectrally separated dyes. Red-excited carbocyanine dyes, e.g., Alexa Fluor 647 (AF647) or Cy5, are currently regarded as "gold standard" fluorophores for STORM imaging. However, a recent study introduced a set of chemically modified rhodamine dyes, including CF583R, that promise to display similar performance in STORM. In this study, we defined CF583R's performance compared to AF647 and CF568 based on a nanoscopic analysis of Bruchpilot (Brp), a nanotopologically well-characterized scaffold protein at AZs. We demonstrate equal suitability of AF647, CF568 and CF583R for basal AZ morphometry, while in Brp subcluster analysis CF583R outperforms CF568 and is on par with AF647. Thus, the AF647/CF583R combination will be useful in future STORM-based analyses of AZs and other subcellularly located marker molecules and their role in physiological and pathophysiological contexts.Marvin Noß, Dmitrij Ljaschenko, Achmed Mrestani
2469 related Products with: Enhanced Performance of the Optimized Dye CF583R in Stochastic Optical Reconstruction Microscopy of Active Zones in .
20 ul50 ul50 ul20 ul20 ul50 ul20 ul20 ul50 ul
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#39259254 2024/09/11
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Reversible Addition-Fragmentation Chain-Transfer Polymerization in Supercritical CO: A Review.
The development of cleaner, more environmentally friendly processes in polymerization technology is crucial due to the prevalent use of volatile organic solvents (VOCs), which are harmful and toxic. Future regulations are likely to limit or ban VOCs. This review explores the use of supercritical solvents, specifically supercritical CO (scCO), in polymerization processes. The study focuses on reversible addition-fragmentation chain-transfer (RAFT) induced homo-polymerization of various monomers using specific chain transfer agents (CTAs) in scCO. RAFT polymerization, a reversible deactivation radical polymerization (RDRP) polymerization, relies heavily on the choice of CTA, which significantly influences the dispersity and molar mass of the resulting polymers. Stabilizers are also crucial in controlling product specifications for polymerizations in supercritical CO, except for fluor-based polymers, although they must be removed and preferably recycled to ensure product purity and sustainability. The review notes that achieving high molar mass through RAFT polymerization in scCO is challenging due to solubility limits, which lead to polymer precipitation. Despite this, RAFT polymerization in scCO shows promise for sustainable, circular production of low molar mass polymers, although these cannot yet be fully considered green products.Friso G Versteeg, Francesco Picchioni
1982 related Products with: Reversible Addition-Fragmentation Chain-Transfer Polymerization in Supercritical CO: A Review.
2 100 ug1mg1 mg10 100ug Lyophilized100.00 ug4 Membranes/Box100 μg
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#39240539 2024/09/06
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Plasmonic nanoparticle sensors: current progress, challenges, and future prospects.
Plasmonic nanoparticles (NPs) have played a significant role in the evolution of modern nanoscience and nanotechnology in terms of colloidal synthesis, general understanding of nanocrystal growth mechanisms, and their impact in a wide range of applications. They exhibit strong visible colors due to localized surface plasmon resonance (LSPR) that depends on their size, shape, composition, and the surrounding dielectric environment. Under resonant excitation, the LSPR of plasmonic NPs leads to a strong field enhancement near their surfaces and thus enhances various light-matter interactions. These unique optical properties of plasmonic NPs have been used to design chemical and biological sensors. Over the last few decades, colloidal plasmonic NPs have been greatly exploited in sensing applications through LSPR shifts (colorimetry), surface-enhanced Raman scattering, surface-enhanced fluorescence, and chiroptical activity. Although colloidal plasmonic NPs have emerged at the forefront of nanobiosensors, there are still several important challenges to be addressed for the realization of plasmonic NP-based sensor kits for routine use in daily life. In this comprehensive review, researchers of different disciplines (colloidal and analytical chemistry, biology, physics, and medicine) have joined together to summarize the past, present, and future of plasmonic NP-based sensors in terms of different sensing platforms, understanding of the sensing mechanisms, different chemical and biological analytes, and the expected future technologies. This review is expected to guide the researchers currently working in this field and inspire future generations of scientists to join this compelling research field and its branches.Krishna Kant, Reshma Beeram, Yi Cao, Paulo S S Dos Santos, Lara González-Cabaleiro, Daniel García-Lojo, Heng Guo, Younju Joung, Siddhant Kothadiya, Marta Lafuente, Yong Xiang Leong, Yiyi Liu, Yuxiong Liu, Sree Satya Bharati Moram, Sanje Mahasivam, Sonia Maniappan, Daniel Quesada-González, Divakar Raj, Pabudi Weerathunge, Xinyue Xia, Qian Yu, Sara Abalde-Cela, Ramon A Alvarez-Puebla, Rizia Bardhan, Vipul Bansal, Jaebum Choo, Luis C C Coelho, José M M M de Almeida, Sergio Gómez-Graña, Marek Grzelczak, Pablo Herves, Jatish Kumar, Theobald Lohmueller, Arben Merkoçi, José Luis Montaño-Priede, Xing Yi Ling, Reyes Mallada, Jorge Pérez-Juste, María P Pina, Srikanth Singamaneni, Venugopal Rao Soma, Mengtao Sun, Limei Tian, Jianfang Wang, Lakshminarayana Polavarapu, Isabel Pastoriza Santos