Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors. productsSearch results for: Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors.
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Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors.
Photodynamic therapy (PDT) is a minimally invasive form of cancer therapy, and the development of a novel photosensitizer (PS) with optimal properties is important for enhancing PDT efficacy. Folate receptor (FR) membrane protein is frequently overexpressed in 40% of human cancer and a good candidate for tumor-specific targeting. Specific active targeting of PS to FR can be achieved by conjugation with the folate moiety. A folate-linked, near-infrared (NIR)-sensitive probe, folate-Si-rhodamine-1 (FolateSiR-1), was previously developed and is expected to be applicable to NIR-PDT.Winn Aung, Atsushi B Tsuji, Kenjiro Hanaoka, Tatsuya Higashi
