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#32232285   // Save this To Up

"Watson-Crick G[triple bond, length as m-dash]C"-inspired supramolecular nanodrug of methotrexate and 5-fluorouracil for tumor microenvironment-activatable self-recognizing synergistic chemotherapy.

Carrier-free nanodrugs, generated via the straightforward small-molecule self-assembly of anticancer drugs, provide a promising route for cancer chemotherapy. However, their low structural stability, lack of targeting specificity, and poor stimulus responsiveness are still limiting their therapeutic effect. Inspired by Watson-Crick G[triple bond, length as m-dash]C base pairing, the FDA-approved chemo-drug methotrexate (MTX, which can bind with folate receptors) and 5-fluorouracil (5-FU, a DNA/RNA synthetase inhibitor) were adopted for direct assembly into self-recognizing MTX-5-FU nanoparticles via "Watson-Crick-like base pairing"-driven precise supramolecular assembly. Sequentially, our synthesized weak acidity-responsive polyethylene glycol (PEG) was inserted onto the nanoparticle surface to temporarily shield the self-targeting function of MTX and prolong the blood circulation time. Once PEG-MTX-5-FU nanoparticles reached the weakly acidic tumor microenvironment, the PEG corona could be cleaved from their surface and then MTX could be re-exposed to recover its self-recognition ability and significantly elevate tumor cell uptake; furthermore, the de-PEGylated MTX-5-FU nanoparticles could respond to the stronger acidity of lysosome, triggering core disassembly and thus the burst release of both MTX and 5-FU. Further in vitro and in vivo studies consistently confirmed that the nanodrugs exhibited preferable accumulation at the tumor sites with highly synergistic chemotherapeutic effects. The supramolecular recognition-inspired, cascade-triggered self-targeting and controlled release of nanodrugs could be a promising strategy to improve synergistic chemotherapy.

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Cultrex In Vitro Angiogen MarkerGeneTM Fluorescent QuantiChrom™ Formaldehy MarkerGene™ LysoLive™ Endothelial Tube Formatio Brain tumor (meningioma, Glucose Assay With the La QuantiChrom™ Formaldehy Formate Assay Kit Brain primary tumor high Brain tumor tissue array Active ASK1

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Targeted delivery of Auristatin PE to Hep G2 cells using folate - conjugated boron nitride nanotubes.

Auristatin PE (PE) as an anti-microtubule agent possesses good anticancer activity. However, the poor target effect and strong side effect limit its clinical applications. Targeted delivery of PE may overcome the disadvantages associated with PE, being very conducive to continuing clinical trials of PE. Boron nitride nanotubes (BNNTs) with unique physical and chemical properties have attracted considerable attention in drug delivery. Herein, a targeted drug delivery strategy based on folate-conjugated boron nitride nanotubes (BNNTs-FA) was used to improve the efficacy of PE. It was found that PE was successfully loaded onto BNNTs-FA via π-π stacking and hydrogen bonding interactions. [email protected] exhibited stronger cytotoxicity to Hep G2 cells than free PE and [email protected] complexes due to the increased cellular uptake of PE mediated by the FA receptor. [email protected] showed excellent antiproliferative activities in a dose- and time-dependent manner. Furthermore, [email protected] induced apoptosis of Hep G2 cells via an intrinsic mitochondria-mediated pathway by reducing the mitochondrial membrane potential, activating Caspase-9 and Caspase-3. The construction of [email protected] system successfully improves the target effect of PE and may be very promising for the treatment of liver cancer in the future.

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Rabbit Anti-Hepatitis C V Anti human Apolipoprotein Rabbit Anti-CBFb PEBP2B P Rabbit Anti-CD31 PECAM-1 Rabbit Anti-Hepatitis C V Rabbit Anti-CBFb PEBP2B P NWLSS™ TAC Peroxyl Assa Rabbit Anti-Hepatitis C V Rabbit Anti-Phospho-PEA15 Mouse Anti-B. pertussis T Rabbit Anti-Phospho-PEA15 Rabbit Anti-Polyprotein(H

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Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development.

An extracellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate development. Here, we find that the bilaterally symmetric interfaces between the zebrafish neural tube and paraxial mesoderm function as optimally engineered adhesive lap joints with rounded edges, graded Fibronectin 'adhesive' and an arced adhesive spew filet. Fibronectin is a 'smart adhesive' that remodels to the lateral edges of the neural tube-paraxial mesoderm interfaces where shear stress is highest. Fibronectin remodeling is mechanically responsive to contralateral variation morphogenesis, and Fibronectin-mediated inter-tissue adhesion is required for bilaterally symmetric morphogenesis of the paraxial mesoderm. Strikingly, however, perturbation of the Fibronectin matrix rescues the neural tube convergence defect of mutants. Therefore, Fibronectin-mediated inter-tissue adhesion dynamically coordinates bilaterally symmetric morphogenesis of the vertebrate trunk but predisposes the neural tube to convergence defects that lead to spina bifida.

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FDA Standard Frozen Tissu Clostridum difficile toxi Mouse Anti-Human Fibronec Analysis Tool for Custom Clostridum difficile toxi Rabbit Anti-FN Fibronecti Rabbit Anti-FN Fibronecti anti-Fibronectin (16E5), Rabbit Anti-Clostridium b Shiga Toxin 2 antibody, M Rabbit Anti-FN Fibronecti Diphtheria toxin antibody

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