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#34525465   2021/09/15 To Up

Rationale for developing tunable laser spectroscopy (TLS) technology for high resolution real-time carbon dioxide monitoring (capnography) in human breath.

Real-time monitoring of exhaled carbon dioxide (CO2), also known as capnography, is a valuable hospital tool for assessing patient health during anesthesia and in both the emergency department and critical care units. The fundamental measurement is referred to as end-tidal carbon dioxide (ETCO2) concentration that reflects pulmonary gas exchange of CO2 representing systemic metabolism. The shape of the exhaled CO2 concentration for individual inhalation/exhalation breath cycles can offer additional information regarding lung function, airway obstruction, alveolar ventilation, and worsening disease. The most frequent use is to indicate appropriate placement of an endotracheal tube but and it is also employed in the assessment of disease severity and response to treatment (e.g. asthma). Other applications include outpatient monitoring with oxygen supplementation (nasal cannula) and continuous positive airway pressure (CPAP) control for sleep apnea. As technology has evolved, CO2 measurements have become more mobile; capnography systems are now used by emergency medical services (EMS) personnel for verifying proper placement of airway devices in "pre-hospital" environments. The use of CO2 diagnostics has evolved to identify breathing system disruptions in "on-demand" regulator/masks equipment, both in medical and occupational settings. Most recently, miniaturized TLS sensors have been implemented for assessing pilot breathing in high-performance military aircraft. This editorial describes the use of CO2 breath sensors and proposes some new applications based on miniaturized sensors that can be directly inserted into breathing masks.
Joachim D Pleil, Lance Christensen

2660 related Products with: Rationale for developing tunable laser spectroscopy (TLS) technology for high resolution real-time carbon dioxide monitoring (capnography) in human breath.

5 G25 µg4 Arrays/Slide4 Membranes/Box254 Membranes/Box25 μg4 Membranes/Box20 ug10 4 Arrays/Slide1.0 mg

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#34525462   2021/09/15 To Up

A highly transparent tri-polymer complexhydrogel of HA, Collagen and 4-arm-PEG as potential vitreous substitute.

There is a requirement of removal and replacement of vitreous for various ophthalmic diseases, e.g., retinopathy and retinal detachment. Clinical tamponades, e.g., silicone oil and fluorinated gases are used but limited due to their toxicity and some complications. A lot of polymer-based materials have been tested and proposed as vitreous substitute, but till date, there is no ideal vitreous substitute available. Thus, it requires to develop an improved vitreous substitute which will be highly suitable for vitreous replacement. We have developed tri-polymer complex in situ hydrogels by crosslinking among hyaluronic acid (HA), collagen (Coll) and 4-arm-polyethylene glycol (PEG). All the developed hydrogels are biocompatible with NIH 3T3 mouse fibroblast cells, having pH in the range 7-7.44 and refractive index in the range 1.333-1.345. The developed hydrogels are highly transparent, showing transmittance >97%. FTIR study shows that the hydrogel was crosslinked by amide bond formation between HA and PEG, and between collagen and PEG. The rheological study shows that all the developed hydrogels exhibit viscoelastic behavior and all the hydrogels have storage modulus values (>100 pa) which is greater than loss modulus values-indicating sufficient elasticity for vitreous application. The elastic nature of the hydrogel increases with the increase in PEG concentration. The gel is formed in between 2 to 3 min-indicating its application in situ. The viscosity of the developed hydrogels shows shear thinning behavior. The pre-gel solution of the hydrogel is injectable through a 22 G needle -indicating its application in situ through vitrectomy surgery. All the hydrogels are hydrophilic and have water content of 96% approximately. Thus, the results show the positive properties for its application as a potential vitreous substitute.
Indu Yadav, Shiv Dutt Purohit, Hemant Singh, Neeladri Singha Das, Partha Roy, Narayan Chandra Mishra

2008 related Products with: A highly transparent tri-polymer complexhydrogel of HA, Collagen and 4-arm-PEG as potential vitreous substitute.

10 plates

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#34525444   2021/08/12 To Up

Effect of marketable age on proximate composition and nutritional profile of breast meat from Cherry Valley broiler ducks.

Marketable age is an important determinant of meat quality. Cherry Valley duck (SM3 medium) is the most efficient Pekin-type duck and is the most widely farmed breed globally. However, whether marketable age determines the meat quality of Cherry Valley ducks is not well documented. The objective of this study was to investigate the effect of marketable age on the proximate composition and nutritional profile of breast meat from Cherry Valley broiler ducks. Ducks at 28, 38, 42, and 45 days old were selected and slaughtered, and their proximate composition, cholesterol and essential mineral compositions, and amino acids and fatty acid profile of breast meat lipid were determined. The results showed higher protein content and lower intramuscular fat content were observed in the 38-day-old ducks than in the 28-day-old birds (P < 0.05). Additionally, 38-day-old ducks contained higher Fe and Mg contents (P < 0.05), whereas 28-day-old birds had higher Zn and Ca contents (P < 0.05). The essential amino acid content in 38-day-old was about 95.29 g/kg, higher than that in 28-day-old birds (P < 0.05). The contents of C20:5 n-3, omega-6 polyunsaturated fatty acids, and polyunsaturated fatty acids were the highest in 38-day-old birds (P < 0.05), whereas the content of C20:4 n-6, DHA (C22:6 n-3), and saturated fatty acids in 28-day-old birds was the lowest (P < 0.05). Finally, a comprehensive evaluation model of multiple traits was developed by applying principal component analysis, and the meat nutrition of 38-day-old ducks was identified as the optimal. Taken together, the meat of 38-day-old ducks had an advantage in proximate composition, minerals content, essential amino acids, and fatty acids, and 38 d might be recommended as an appropriate marketable age to provide duck meat of high nutrition value.
Zhengfeng Cao, Wen Gao, Yang Zhang, Weiran Huo, Kaiqi Weng, Yu Zhang, Bichun Li, Guohong Chen, Qi Xu

1641 related Products with: Effect of marketable age on proximate composition and nutritional profile of breast meat from Cherry Valley broiler ducks.

5 G1000 tests 100 UG 25 MG 100ul100ug

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#34525361   // To Up

Pro-inflammatory and proliferative microglia drive progression of glioblastoma.

Scant understanding of the glioblastoma microenvironment and molecular bases hampers development of efficient treatment strategies. Analyses of gene signatures of human gliomas demonstrate that the SETD2 mutation is correlated with poor prognosis of IDH1/2 wild-type (IDH-WT) adult glioblastoma patients. To better understand the crosstalk between SETD2 mutant (SETD2-mut) glioblastoma cells and the tumor microenvironment, we leverage single-cell transcriptomics to comprehensively map cellular populations in glioblastoma. In this study, we identify a specific subtype of high-grade glioma-associated microglia (HGG-AM). Further analysis shows that transforming growth factor (TGF)-β1 derived from SETD2-mut/IDH-WT tumor cells activates HGG-AM, exhibiting pro-inflammation and proliferation signatures. Particularly, HGG-AM secretes interleukin (IL)-1β via the apolipoprotein E (ApoE)-mediated NLRP1 inflammasome, thereby promoting tumor progression. HGG-AM present extensive proliferation and infiltration to supplement the activated microglia pool. Notably, TGF-β1/TβRI depletion dramatically reduces HGG-AM density and suppresses tumor growth. Altogether, our studies identify a specific microglia subpopulation and establish the cellular basis of interactions between HGG-AM and glioblastoma cells.
Hailong Liu, Youliang Sun, Qian Zhang, Wei Jin, Renata E Gordon, Yanyang Zhang, Jian Wang, Caihong Sun, Zeyuan John Wang, Xueling Qi, Junping Zhang, Boyuan Huang, Qiuping Gui, Hongyu Yuan, Ling Chen, Xiaodong Ma, Chuan Fang, Yong-Qiang Liu, Xinguang Yu, Shiyu Feng

2628 related Products with: Pro-inflammatory and proliferative microglia drive progression of glioblastoma.

1000 tests100ug2ug200ul200 25 mg1000 TESTS/0.65ml10 mg

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#34525343   2021/09/07 To Up

Social interaction is a catalyst for adult human learning in online contexts.

Human learning is highly social. Advances in technology have increasingly moved learning online, and the recent coronavirus disease 2019 (COVID-19) pandemic has accelerated this trend. Online learning can vary in terms of how "socially" the material is presented (e.g., live or recorded), but there are limited data on which is most effective, with the majority of studies conducted on children and inconclusive results on adults. Here, we examine how young adults (aged 18-35) learn information about unknown objects, systematically varying the social contingency (live versus recorded lecture) and social richness (viewing the teacher's face, hands, or slides) of the learning episodes. Recall was tested immediately and after 1 week. Experiment 1 (n = 24) showed better learning for live presentation and a full view of the teacher (hands and face). Experiment 2 (n = 27; pre-registered) replicated the live-presentation advantage. Both experiments showed an interaction between social contingency and social richness: the presence of social cues affected learning differently depending on whether teaching was interactive or not. Live social interaction with a full view of the teacher's face provided the optimal setting for learning new factual information. However, during observational learning, social cues may be more cognitively demanding and/or distracting, resulting in less learning from rich social information if there is no interactivity. We suggest that being part of a genuine social interaction catalyzes learning, possibly via mechanisms of joint attention, common ground, or (inter-)active discussion, and as such, interactive learning benefits from rich social settings..
Sara De Felice, Gabriella Vigliocco, Antonia F de C Hamilton

2733 related Products with: Social interaction is a catalyst for adult human learning in online contexts.

100 μg100 μg100 ul100ug Lyophilized100 μg 100ul100ug Lyophilized25 µg100ug Lyophilized25 µg100 μg100ug Lyophilized

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#34525320   2021/09/15 To Up

How to make the use of recycled paperboard fit for food contact? A contribution to the discussion.

Recycled paperboard contains hundreds of non-evaluated or even unidentified substances that could endanger human health if they turn out to be highly toxic. It seems as unrealistic to evaluate each of them as it is to phase out the use of the problematic ones or sort out the papers and boards introducing them into the recyclate. Therefore, measures should be taken that generally reduce migration into food, such as functional barriers or functional sorbents. A general approach is used for the recycling of plastics, particularly poly(ethylene terephthalate), PET: as not every potential contaminant can be regulated, a pragmatic approach is applied, for PET mainly on the required decontamination efficiency. Criteria are required on the required efficacy of the measures to be taken. Recycled paperboard is used for various types of food contact: mostly contact is through the gas phase (evaporation and recondensation), often indirect through other layers (e.g. internal bags or for transport boxes), seldom in wetting contact. Numerous factors have to be considered. For typical folding boxes and at least strongly dominating gas phase contact, it was proposed that no more than 1% of each contaminant in the recycled paperboard should enter the food. The efficiency of the measures required to comply with this criterion depends on the application. The three main measures are reviewed with regard to this criterion: (i) internal bags with an incorporated functional barrier (successfully used for some time), (ii) a barrier layer on the internal wall of the box (for which the design of the closures might be most critical) and (iii) functional sorbents added to the paperboard (for which the sorbent capacity is critical). For transport boxes, commonly of corrugated board (quantitatively the most important use of recycled paperboard in food contact), an adjusted or different criterion is needed.
Koni Grob

1327 related Products with: How to make the use of recycled paperboard fit for food contact? A contribution to the discussion.

0.1 mg1 module 25 G600 Tests / Kit5 mg100 µg1 mg

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