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#39535875   2024/11/13 To Up

Collaborative Care to Improve Quality of Life for Anxiety and Depression in Posttraumatic Epilepsy (CoCarePTE): Protocol for a Randomized Hybrid Effectiveness-Implementation Trial.

Anxiety and depression in people with epilepsy are common and associated with poor outcomes; yet, they often go untreated due to poor mental health specialist access. Collaborative care is an integrated care model with a strong evidence base in primary care and medical settings, but it has not been evaluated in neurology clinics. Evaluating implementation outcomes when translating evidence-based interventions to new clinical settings to inform future scaling and incorporation into real-world practice is important.
Heidi M Munger Clary, Beverly M Snively, Christian Cagle, Richard Kennerly, James N Kimball, Halley B Alexander, Gretchen A Brenes, Justin B Moore, Robin A Hurley

2189 related Products with: Collaborative Care to Improve Quality of Life for Anxiety and Depression in Posttraumatic Epilepsy (CoCarePTE): Protocol for a Randomized Hybrid Effectiveness-Implementation Trial.

100ug100 mg 5 G0.2 mg 100ul 1 G 1 G10 mg

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#39535861   2024/11/13 To Up

Network hub gene detection using the entire solution path information.

Gene co-expression networks typically comprise modules and their associated hub genes, which are regulating numerous downstream interactions within the network. Methods for hub screening, as well as data-driven estimation of hub co-expression networks using graphical models, can serve as useful tools for identifying these hubs. Graphical model-based penalization methods typically have one or multiple regularization terms, each of which encourages some favorable characteristics (e.g., sparsity, hubs, power-law) to the estimated complex gene network. It is common practice to find a single optimal graphical model corresponding to a specific value of the regularization parameter(s). However, instead of doing this, one could aggregate information across several graphical models, all of which depend on the same data set, along the solution path in the hub gene detection process. We propose a novel method for detecting hub genes that utilizes the information available in the solution path. Our procedure is related to stability selection, but we replace resampling with a simple statistic. This procedure amalgamates information from each node of the data-driven graphical models into a single influence statistic, similar to Cook's distance. We call this statistic the Mean Degree Squared Distance (MDSD). Our simulation and empirical studies demonstrate that the MDSD statistic maintains a good balance between false positive and true positive hubs. An R package MDSD is publicly available on GitHub under the General Public License https://github.com/markkukuismin/MDSD.
Markku Kuismin, Mikko J Sillanp

2208 related Products with: Network hub gene detection using the entire solution path information.

200 units200 units 6 ml Ready-to-use 1000 ml 1 mL50 ug

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#39535858   2024/11/13 To Up

Outcome of Ultrasonography-Guided Percutaneous Nephrolithotomy for the Management of Pediatric Urolithiasis.

This study aims to assess the outcomes of ultrasonography (US)-guided minimally invasive percutaneous nephrolithotomy (PCNL) in the treatment of pediatric urolithiasis. A retrospective analysis was conducted on 176 patients with pediatric renal and upper ureteral lithotripsy who underwent PCNL between August 2006 and July 2022. The cohort comprised 110 men and 66 women, with ages ranging from 6 months to 16 years. Postoperative stone clearance was evaluated using kidney, ureter, and bladder radiograph or US, categorizing stones less than 4 mm as clear. Postoperative complications were graded according to the Clavien-Dindo classification, with grades I and II considered minor and III and IV classified as major. Among the patients, 152 underwent unilateral renal operation, whereas 24 underwent bilateral renal operation. The average operation duration was 67.41 minutes (range: 15-195 minutes). The mean duration of nephrostomy tube removal was 3.79 days, and the mean postsurgical hospital stay was 5.97 days. A total of 146 patients experienced a decrease in hemoglobin concentration post operation, with an average drop of 10.57 g/dL (range: 0.5-37.8 g/dL). Initial stone-free rate (SFR) was achieved in 85.5% (171/200) of cases, and the final SFR was 92.50% (185/200). The postoperative rate of minor complications was 8.54% (17/199), whereas major complications occurred in 12.06% (24/199) of cases. During the 6-month to 11-year follow-up period, 19 patients presented with combined stones, and of these 4 presented with ipsilateral stone recurrence who underwent PCNL treatment. Calcium oxalate was identified as the most common stone component. US-guided minimally invasive PCNL demonstrated excellent SFR and an acceptable complication rate in the management of pediatric urolithiasis. Furthermore, it offers the advantage of minimizing potential risks associated with radiation exposure during the procedure.
Yang Hong, Luping Yu, Xiaobo Huang, Lizhe An, Liulin Xiong, Tao Xu, QingQuan Xu

1312 related Products with: Outcome of Ultrasonography-Guided Percutaneous Nephrolithotomy for the Management of Pediatric Urolithiasis.

5 G96 Well 1 G 1L1500 MG25 µg1mg50 ml100 tests

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#39535846   2024/11/13 To Up

Enhanced Charge Transfer in Poly(Heptazine Imide) Synergistically Induced by Donor-Acceptor Motifs and Ohmic Junctions for Efficient Photocatalytic CO2 Reduction.

Poly(heptazine imide) (PHI) has received widely interest in the photocatalytic CO2 reduction due to its good crystallinity and complete in-plane structure. However, its poor photo-induced carrier separation and migration efficiency and insufficient active sites results in undesirable photocatalytic CO2 reduction performance. Herein, we designed and constructed a novel ohmic junction photocatalyst by integrating melamine edge-modified PHI (mel-PHI) with extended π-conjugated system with TiN (TiN/mel-PHI) for enhancing the photocatalytic CO2 reduction activity. Strikingly, the photocayalytic CO2 reduction yield of the optimal TiN/mel-PHI is 62.64 µmol·g-1·h-1, which is 5.6 and 2.8 times higher than PHI (11.26 µmol·g-1·h-1) and mel-PHI (22.32 µmol·g-1·h-1), respectively. The superior photocatalytic CO2 reduction activity is attributed not only to the formation of D-A structure by the introduction of melamine, which extends the π-conjugation system, alters the electronic structure of PHI, and accelerates the charge separation and migration, but also to the induced internal electric field by ohmic junction further enhances the charge separation and migration efficiency. Meanwhile, the synergistic effect of mel-PHI and TiN enriched the electron number of TiN, reducing the CO2 reduction potential. This work highlights the synergistic enhancement of charge transfer between D-A motifs and ohmic junctions, confirming their potential in optimizing photocatalysts.
Qin Li, Ran Yang, Zhanzhen Ma, Sirui Liu, Di Li, Dan Tian, Deli Jiang

2727 related Products with: Enhanced Charge Transfer in Poly(Heptazine Imide) Synergistically Induced by Donor-Acceptor Motifs and Ohmic Junctions for Efficient Photocatalytic CO2 Reduction.

100 ul 100ul 5 G400 ug50 ul96 assays500 MG1 mg

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#39535839   2024/11/13 To Up

The role of surface and structural similarities in the retrieval of realistic perceptual events.

This study investigated whether structural similarities (i.e. abstract frames, e.g. once bitten twice shy) can prevail over surface similarities (i.e. contexts, e.g. restaurant) in driving the retrieval of realistic events involving dynamic, multimodal and perceptually crowded data. After watching an initial set of video clips, participants had to indicate whether a new video clip, that shared surface similarities with an initial event and structural similarities with another one, elicited a retrieval. The results of Experiment 1A showed that retrieval was more likely to be elicited by structural rather than by surface similarities. Experiment 1B confirmed that the surface similarities manipulated in this study were strong enough to elicit substantial retrievals when the competing structural match was neutralized. The pattern of results obtained in Experiment 1A remained unchanged when the number of unrelated video clips within the initial set was increased. The findings suggest that structurally based retrievals still prevail when familiar structures underlie realistic perceptual events. They open new perspectives regarding the settings that promote structurally based retrievals in educational contexts where unfamiliar principles are introduced.
Lucas Raynal, Evelyne Clément, Emmanuel Sander

2120 related Products with: The role of surface and structural similarities in the retrieval of realistic perceptual events.

1100.00 ul100 U

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#39535757   // To Up

[Not Available].

This review summarises the current knowledge of posterior reversible encephalopathy syndrome which is an acute and severe neurological condition characterised by headache, encephalopathy, epileptic seizures, and visual disturbances. Typical radiological findings are cerebral vasogenic oedema, predominantly localised in the posterior cerebral circulation. The exact pathophysiological mechanisms remain unknown but involve dysfunction of the blood-brain barrier. There are several well-documented causes for the syndrome, the most important being acute hypertension. Management is aimed at identifying and eliminating the underlying cause and preventing secondary brain injury from, e.g., epileptic seizures.
Mikkel Bundgaard Skotting, Anders Vedel Holst, Daniel Kondziella, Peter Birkeland

1201 related Products with: [Not Available].

100 µg25 Tests100 μg25 50 100 100 μg1000 unit1.5 x 10^6 cells100 μg200 unit50 ug

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#39535725   2024/11/13 To Up

Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL.

Prostate cancer and its treatment, particularly androgen deprivation therapy (ADT), can profoundly impact patients' quality of life. The aim of the prospective observational study reported here was to evaluate the effects of ADT on various aspects of quality of life in men with prostate cancer at a community-based hospital in Southern Italy.
Francesca Cappuccio, Carlo Buonerba, Luca Scafuri, Rossella Di Trolio, Pasquale Dolce, Serena Orsola Trabucco, Filomena Erbetta, Elvira Tulimieri, Antonella Sciscio, Concetta Ingenito, Antonio Verde, Giuseppe Di Lorenzo

1969 related Products with: Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL.

1100.00 ulmin 2 cartons1200 units500 Units1

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#39535708   // To Up

Transcriptome-Wide Analysis of the 5' Cap Status of RNA Using 5' Monophosphate-Dependent Exonuclease Digestion and RNA Sequencing.

Eukaryotic mRNAs carry an N7-methylguanosine (mG) cap structure at their 5' extremity, which protects them from the degradation by 5'-3' exoribonucleases and plays a pivotal role in mRNA metabolism, promoting splicing, nuclear export, and translation. Decapping, the enzymatic process that removes this structure, is a key event during cytoplasmic mRNA 5'-3' decay, leading to the degradation of the transcript body by Xrn1. In this chapter, we describe a procedure to assess the cap status of RNA at the transcriptome level. It is based on a treatment of total RNA extracts with a 5' monophosphate-dependent exonuclease, which like Xrn1 specifically degrades decapped RNAs harboring 5' monophosphate extremities, but not RNAs with intact mG cap. The digested RNAs are then analyzed by RNA sequencing.
Maxime Wery, Ugo Szachnowski, Sara Andjus, Antonin Morillon

1813 related Products with: Transcriptome-Wide Analysis of the 5' Cap Status of RNA Using 5' Monophosphate-Dependent Exonuclease Digestion and RNA Sequencing.

1000 units10 nmol200ul25ul1000 units10 nmol5 X 1000 U100 μg250ul50 mg1ml

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#39535690   2024/11/13 To Up

Adjuvant Immune Checkpoint Inhibitors for Muscle-Invasive Urothelial Carcinoma: An Updated Systematic Review, Meta-analysis, and Network Meta-analysis.

Adjuvant immune checkpoint inhibitors (ICIs) have recently emerged as guideline-recommended treatments of high-risk muscle-invasive urothelial carcinoma (MIUC). However, there is limited evidence regarding the optimal candidates and the differential efficacy of adjuvant ICI regimens.
Takafumi Yanagisawa, Keiichiro Mori, Akihiro Matsukawa, Tatsushi Kawada, Satoshi Katayama, Ekaterina Laukhtina, Pawel Rajwa, Fahad Quhal, Benjamin Pradere, Wataru Fukuokaya, Kosuke Iwatani, Luca Afferi, Gautier Marcq, Laura S Mertens, Andrea Gallioli, Karl H Tully, Jorge Caño-Velasco, José Daniel Subiela, Yasmin Abu-Ghanem, Elisabeth Grobet-Jeandin, Francesco Del Giudice, Renate Pichler, Jeremy Yuen-Chun Teoh, Marco Moschini, Wojciech Krajewski, Jun Miki, Shahrokh F Shariat, Takahiro Kimura,

2728 related Products with: Adjuvant Immune Checkpoint Inhibitors for Muscle-Invasive Urothelial Carcinoma: An Updated Systematic Review, Meta-analysis, and Network Meta-analysis.

1 module1 module1 module1 module1 module1 module1 module1 module1 module1 module1 module

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#39535661   2024/11/13 To Up

Switching treatment to cipaglucosidase alfa plus miglustat positively affects patient-reported outcome measures in patients with late-onset Pompe disease.

Late-onset Pompe disease (LOPD), a rare autosomal recessive multisystemic disorder, substantially impacts patients' day-to-day activities, outcomes, and health-related quality of life (HRQoL). The PROPEL trial compared cipaglucosidase alfa plus miglustat (cipa+mig) with alglucosidase alfa plus placebo (alg+pbo) in adult patients with LOPD over 52 weeks and showed improved motor and respiratory function in patients switching treatment from standard-of-care enzyme replacement therapy (ERT) to cipa+mig at baseline. This study evaluated the impact of cipa+mig on patient-reported outcomes (PROs), including HRQoL in ERT-experienced patients, using data from PROPEL.
Priya S Kishnani, Barry J Byrne, Kristl G Claeys, Jordi Díaz-Manera, Mazen M Dimachkie, Hani Kushlaf, Tahseen Mozaffar, Mark Roberts, Benedikt Schoser, Noemi Hummel, Agnieszka Kopiec, Fred Holdbrook, Simon Shohet, Antonio Toscano,

1287 related Products with: Switching treatment to cipaglucosidase alfa plus miglustat positively affects patient-reported outcome measures in patients with late-onset Pompe disease.

100 1 mg1-99 mg/ml/ea price x 296 tests500 gm.

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