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#33951534 2021/04/23 To Up
Bioactive naphthoquinones and triterpenoids from the fruiting bodies of Taiwanofungus salmoneus.Drug resistance of cancer cells stands for the major problem of the treatment failure for chemotherapy or target therapy. Overexpression of efflux pumps leading to multidrug resistance (MDR) is still an important issue needed to be solved. In the present study, Taiwanofungus salmoneus was selected as the topic and eleven undescribed constituents including four naphthoquinones salmonones A-D (1-4) and seven triterpenoids salmoneatins A-G (5-11), along with one chromanone (12) and two benzenoids (13 and 14) reported from the natural sources for the first time, as well as twenty-one known compounds were characterized. The structures of undescribed compounds were established by the spectroscopic and spectrometric analyses. In addition, the plausible biosynthetic mechanism of purified naphthoquinones was proposed and these compounds may be the excellent chemotaxonomic markers. Moreover, the isolates were evaluated for their P-gp inhibitory effects and the results showed that most of the examined compounds were effective. Among the tested compounds, 5, 10, 2,3-dimethoxy-5-(2',5'-dimethoxy-3',4'-methylenedioxyphenyl)-7-methyl-[1,4]naphthoquinone, zhankuic acid A methyl ester, and camphoratin F can reverse the resistance of paclitaxel or vincristine with the reversal folds in the range of 51093.3 and 259.5. These experimental data would initiate the possible development of Taiwanofungus salmoneus for the cancer therapy in the future.
Kun-Ching Cheng, Chin-Fu Chen, Chin-Chuan Hung, Sio-Hong Lam, Hsin-Yi Hung, Yue-Chiun Li, Fu-An Chen, Po-Chuen Shieh, Ping-Chung Kuo, Tian-Shung Wu
1423 related Products with: Bioactive naphthoquinones and triterpenoids from the fruiting bodies of Taiwanofungus salmoneus.200 units2.5 mg1000 tests11 ml100ug1100 mg25 mg500 Units50 ug 10 mg
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#33951329 // To Up
Drp1-dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia.Friedreich ataxia is an autosomal recessive, neurodegenerative disease characterized by the deficiency of the iron-sulfur cluster assembly protein frataxin. Loss of this protein impairs mitochondrial function. Mitochondria alter their morphology in response to various stresses; however, such alterations to morphology may be homeostatic or maladaptive depending upon the tissue and disease state. Numerous neurodegenerative diseases exhibit excessive mitochondrial fragmentation, and reversing this phenotype improves bioenergetics for diseases in which mitochondrial dysfunction is a secondary feature of the disease. This paper demonstrates that frataxin deficiency causes excessive mitochondrial fragmentation that is dependent upon Drp1 activity in Friedreich ataxia cellular models. Drp1 inhibition by the small peptide TAT-P110 reverses mitochondrial fragmentation but also decreases ATP levels in frataxin-knockdown fibroblasts and FRDA patient fibroblasts, suggesting that fragmentation may provide a homeostatic pathway for maintaining cellular ATP levels. The cardiolipin-stabilizing compound SS-31 similarly reverses fragmentation through a Drp1-dependent mechanism, but it does not affect ATP levels. The combination of TAT-P110 and SS-31 does not affect FRDA patient fibroblasts differently from SS-31 alone, suggesting that the two drugs act through the same pathway but differ in their ability to alter mitochondrial homeostasis. In approaching potential therapeutic strategies for FRDA, an important criterion for compounds that improve bioenergetics should be to do so without impairing the homeostatic response of mitochondrial fragmentation.
Joseph Johnson, Elizabeth Mercado-Ayón, Elisia Clark, David Lynch, Hong Lin
1493 related Products with: Drp1-dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia.96 tests50 250 TESTS50 200ul200ul96 assays20 100 UG50 200ul100 μg
#33951300 2021/05/05 To Up
Photobiomodulation therapy promotes the ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage to ameliorate atherosclerosis.A
Qianxia Yin, Haocai Chang, Qi Shen, Da Xing
1213 related Products with: Photobiomodulation therapy promotes the ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage to ameliorate atherosclerosis.4 Membranes/Box0.1mg2ug5ug2ug96 wells (1 kit)100.00 ug100
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#33951269 2021/05/05 To Up
The impact of aging on innate and adaptive immunity in the human female genital tract.Mucosal tissues in the human female reproductive tract (FRT) are primary sites for both gynecological cancers and infections by a spectrum of sexually transmitted pathogens, including human immunodeficiency virus (HIV), that compromise women's health. While the regulation of innate and adaptive immune protection in the FRT by hormonal cyclic changes across the menstrual cycle and pregnancy are being intensely studied, little to nothing is known about the alterations in mucosal immune protection that occur throughout the FRT as women age following menopause. The immune system in the FRT has two key functions: defense against pathogens and reproduction. After menopause, natural reproductive function ends, and therefore, two overlapping processes contribute to alterations in immune protection in aging women: menopause and immunosenescence. The goal of this review is to summarize the multiple immune changes that occur in the FRT with aging, including the impact on the function of epithelial cells, immune cells, and stromal fibroblasts. These studies indicate that major aspects of innate and adaptive immunity in the FRT are compromised in a site-specific manner in the FRT as women age. Further, at some FRT sites, immunological compensation occurs. Overall, alterations in mucosal immune protection contribute to the increased risk of sexually transmitted infections (STI), urogenital infections, and gynecological cancers. Further studies are essential to provide a foundation for the development of novel therapeutic interventions to restore immune protection and reverse conditions that threaten women's lives as they age.
Marta Rodriguez-Garcia, Mickey V Patel, Zheng Shen, Charles R Wira
1643 related Products with: The impact of aging on innate and adaptive immunity in the human female genital tract.100ul1mg1012
#33951076 2021/05/05 To Up
Incidence of dengue illness in Mexican people aged 6 months to 50 years old: A prospective cohort study conducted in Jalisco.The burden of dengue virus (DENV), a mosquito-borne pathogen, remains difficult to assess due to misdiagnosis and underreporting. Moreover, the large proportion of asymptomatic dengue cases impairs comprehensive assessment of its epidemiology even where effective surveillance systems are in place. We conducted a prospective community-based study to assess the incidence of symptomatic dengue cases in Zapopan and neighboring municipalities in the state of Jalisco, Mexico.
Rodrigo DeAntonio, Gerardo Amaya-Tapia, Gabriela Ibarra-Nieto, Gloria Huerta, Silvia Damaso, Adrienne Guignard, Melanie de Boer
1091 related Products with: Incidence of dengue illness in Mexican people aged 6 months to 50 years old: A prospective cohort study conducted in Jalisco.100 μg50ul50ug1 kit1 1 G10 mg50ul (1mg/ml)10 mg1 kit
#33951059 2021/05/05 To Up
Reverse engineering of ceramic anthropomorphic figurines from the Tumaco archaeological tradition in southwest Colombia.Traditional studies of archaeological ceramics in Colombia have been largely based on visual and stylistic analyses. Here we introduce frameworks and concepts of reverse engineering as a complementary strategy to develop hypotheses about ceramic manufacture, as a first step to the address possible cross-craft relationships and broader sociocultural parameters affecting technical traditions. Our case study is focused on ceramic figurines recovered from two archaeological sites in southwest Colombia (Inguapí and La Cocotera), both dated to the period of greatest cultural and technological development of the Tumaco tradition (350 BC-AD 350). The results of the analyses including microscopy, XRF, SEM-EDS and XRD revealed two manufacturing pathways within the broader tradition, developed locally and adapted to the natural resources available to each site. These are shown through chemical and mineralogical differences in the raw materials, as well as differences in their preparation and shaping, molding, and modeling processes as observed at the microstructural level. Estimated firing temperatures are under 600°C for La Cocotera, and under 800°C for those of Inguapí, with an inhomogeneous, oxidizing atmosphere probably related to firing in a pit. The superficial characterization shows that all the figurines were painted, with those from Inguapí externally smoothed and polished, and those from La Cocotera covered with a slip. Notwithstanding differences between sites, the ceramic figurines illustrate a particular technical style that undoubtedly conveyed a shared ideological message of cultural affiliation. These results contribute in an innovative way to archaeological ceramic studies in Colombia from a different perspective that is complementary to the more common typological studies.
Nohora Alba Bustamante, Jairo Arturo Escobar, Marcos Martinón-Torres
2134 related Products with: Reverse engineering of ceramic anthropomorphic figurines from the Tumaco archaeological tradition in southwest Colombia.1100ug100 ug
#33951037 2021/05/05 To Up
Estimating poaching risk for the critically endangered wild red wolf (Canis rufus).T
Suzanne W Agan, Adrian Treves, Lisabeth L Willey
2401 related Products with: Estimating poaching risk for the critically endangered wild red wolf (Canis rufus).
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#33950689 2021/05/05 To Up
Corn Stalk-Derived Carbon Quantum Dots with Abundant Amino Groups as a Selective-Layer Modifier for Enhancing Chlorine Resistance of Membranes.Low permeability and chlorine resistance of normal thin-film composite (TFC) membranes restrict their practical applications in many fields. This study reports the preparation of a high chlorine-resistant TFC membrane for forward osmosis (FO) by incorporating corn stalk-derived N-doped carbon quantum dots (N-CQDs) into the selective polyamide (PA) layer to construct a polydopamine (PDA) sub-layer (PTFC). Membrane modification is characterized by surface morphology, hydrophilicity, Zeta potential, and roughness. Results show that TFC (without PDA pretreatment) and PTFC membranes possess greater negative surface charges and thinner layer-thickness (less than 68 nm). With N-CQDs and PDA pretreatment, the surface roughness of the PTFC membrane decreases significantly with the co-existence of microsized balls and flocs with a dense porous structure. With the variation of concentration and type of draw solution, the PTFC membrane exhibits an excellent permeability with low / values (0.1-0.25) due to the enhancement of surface hydrophilicity and the shortening of permeable paths. With 16,000 ppm·h chlorination, reverse salt flux of the PTFC membrane (8.4 g m h) is far lower than those of TFC (136.2 g m h), PTFC (127.6 g m h), and TFC (132 g m h) membranes in FO processes. The decline of salt rejection of the PTFC membrane is only 8.2%, and the normalized salt rejection maintains 0.918 in the RO system (16,000 ppm·h chlorination). Super salt rejection is ascribed to the existence of abundant N-H bonds (N-CQDs), which are preferentially chlorinated by free chlorine to reduce the corrosion of the PA layer. The structure of the PA layer is stable during chlorination also due to the existence of various active groups grafted on the surface. This study may pave a new direction for the preparation of durable biomass-derivative (N-CQD)-modified membranes to satisfy much more possible applications.
Di Wang, Ying Zhang, Zhuang Cai, Shijie You, Yubo Sun, Ying Dai, Rongyue Wang, Siliang Shao, Jinlong Zou
1773 related Products with: Corn Stalk-Derived Carbon Quantum Dots with Abundant Amino Groups as a Selective-Layer Modifier for Enhancing Chlorine Resistance of Membranes.100 tests1 g200 mg1 mg5 mg1 kit100 assays10 mg2.5 mg1 kit100 assays1 mg
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