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#34129433   2021/06/15 To Up

Autoimmune Pulmonary Alveolar Proteinosis: Evidence of the pathogenicity of GM-CSF antibodies.


Aurélie Le Gal, Alexandre Chabrol, Anne-Laure Brun, Séverine Fraboulet, Louis-Jean Couderc, Hélène Salvator

1904 related Products with: Autoimmune Pulmonary Alveolar Proteinosis: Evidence of the pathogenicity of GM-CSF antibodies.

0.5 mg500100 5000.1 mg0.1 mg1mg0.5 mg1 ml0.5 mg1 mg500

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#34129185   2021/06/15 To Up

Enhanced matrix production by cocultivated human stem cells and chondrocytes under concurrent mechanical strain.

Conventional treatments of osteoarthritis have failed to re-build functional articular cartilage. Tissue engineering clinical treatments for osteoarthritis, including autologous chondrocyte implantation, provides an alternative approach by injecting a cell suspension to fill lesions within the cartilage in osteoarthritic knees. The success of chondrocyte implantation relies on the availability of chondrogenic cell lines, and their resilience to high mechanical loading. We hypothesize we can reduce the numbers of human articular chondrocytes necessary for a treatment by supplementing cultures with human adipose-derived stem cells, in which stem cells will have protective and stimulatory effects on mixed cultures when exposed to high mechanical loads, and in which coculture will enhance production of requisite extracellular matrix proteins over those produced by stretched chondrocytes alone. In this work, adipose-derived stem cells and articular chondrocytes were cultured separately or cocultivated at ratios of 3:1, 1:1, and 1:3 in static plates or under excessive cyclic tensile strain of 10% and results were compared to culturing of both cell types alone with and without cyclic strain. Results indicate 75% of chondrocytes in engineered articular cartilage can be replaced with stem cells with enhanced collagen over all culture conditions and glycosaminoglycan content over stretched cultures of chondrocytes. This can be done without observing adverse effects on cell viability. Collagen and glycosaminoglycan secretion, when compared to chondrocyte alone under 10% strain, was enhanced 6.1- and 2-fold, respectively, by chondrocytes cocultivated with stem cells at a ratio of 1:3.
Haneen A Abusharkh, Alia H Mallah, Mahmoud M Amr, Juana Mendenhall, Bulent A Gozen, Edwin M Tingstad, Nehal I Abu-Lail, Bernard J Van Wie

1791 related Products with: Enhanced matrix production by cocultivated human stem cells and chondrocytes under concurrent mechanical strain.

11 mg10 ug1.00 flask1.00 flask1.00 flask100 50 ug1.00 flask200 12

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#34129148   2021/06/15 To Up

Current Knowledge on the Biology of Lysophosphatidylserine as an Emerging Bioactive Lipid.

Lysophosphatidylserine (LysoPS) is an emerging lysophospholipid (LPL) mediator, which acts through G protein-coupled receptors, like lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). LysoPS is detected in various tissues and cells and thought to be produced mainly by the deacylation of phosphatidylserine. LysoPS has been known to stimulate degranulation of mast cells. Recently, four LysoPS-specific G protein-coupled receptors (GPCRs) were identified. These GPCRs belong to the P2Y family which covers receptors for nucleotides and LPLs and are predominantly expressed in immune cells such as lymphocytes and macrophages. Studies on knockout mice of these GPCRs have revealed that LysoPS has immune-modulatory functions. Up-regulation of a LysoPS-producing enzyme, PS-specific phospholipase A, was frequently observed in situations where the immune system is activated including autoimmune diseases and organ transplantations. Therefore, modulation of LysoPS signaling appears to be a promising method for providing therapies for the treatment of immune diseases. In this review, we summarize the biology of LysoPS-producing enzymes and receptors, recent developments in LysoPS signal modulators, and prospects for future therapeutic applications.
Jumpei Omi, Kuniyuki Kano, Junken Aoki

1406 related Products with: Current Knowledge on the Biology of Lysophosphatidylserine as an Emerging Bioactive Lipid.

1000 assays100ul100ug400 assays100μl200ul100ug Lyophilized

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#34128447   2021/06/15 To Up

Effect of morning versus evening exercise training on sleep, physical activity, fitness, fatigue and quality of life in overweight and obese adults.

This study compares the effectiveness of a 12-week moderate exercise training program (METP), performed in the morning versus the evening, on sleep, physical activity, physical fitness, sleepiness, fatigue and health-related quality of life (HRQoL) in overweight and obese patients. Sedentary and inactive overweight/obese adults (n = 36) were included in METP and randomized into two groups: morning group (GM) and evening group (GE). Twenty-eight participants successfully completed METP (3 × 90 min exercise session per week for 12 weeks, completion rates >80%). Sleep, physical activity, and bedtime temperature were measured using accelerometry and infrared tympanic temperature during 3 separate weeks of the study (Week1, Week6, and Week12). Participants also took part in baseline and endpoint assessments including physical fitness as well as subjective physical activity, chronotype, sleep quality, sleepiness, fatigue and HRQoL. METP did not impact objective sleep quality differently between the two groups (morning vs evening). Bedtime and mid-sleep were advanced when METP was done in the morning whereas they were delayed when METP was practiced in the early evening ( = .003). Beside this finding, no valuable differences between the two groups were noted in all the remaining measures. METP resulted in improvements of body composition, cardiorespiratory and muscular endurance, as well as a favorable impact on subjective sleep quality, diurnal sleepiness, fatigue and HRQoL in both groups (all < .05). Evening METP could be an effective alternative for overweight/obese adults when morning METP is not possible.
Oussama Saidi, Etienne Colin, Mélanie Rance, Eric Doré, Bruno Pereira, Pascale Duché

1974 related Products with: Effect of morning versus evening exercise training on sleep, physical activity, fitness, fatigue and quality of life in overweight and obese adults.

100ug500 MG25 mg10 mg0.1 mg96T100ul50 mg25 mg50 ug 48 assays

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#34128329   2021/06/14 To Up

Unique phage-bacterium interplay in sponge holobionts from the southern Okinawa Trough hydrothermal vent.

Deep-sea hydrothermal vents harbour diverse and abundant animals and their symbiotic microorganisms, which together comprise holobionts. The interplay between bacterial members of holobionts and their viruses (phages) is important for maintaining these symbiotic systems; however, phage-bacterium interactions in deep-sea vent holobionts are not well understood. Marine sponges serve as good models for such studies and are used to unveil phage-bacterium interplay via metagenomic analysis. In three demosponges from deep-sea hydrothermal vent fields in the southern Okinawa Trough, the genomes of a diverse array of symbiotic bacteria, including 10 bacterial phyla, were found to lack intact prophages. Genes related to diverse anti-viral defence systems, for example, the restriction-modification and toxin-antitoxin systems, were abundant in the bacterial communities. We also detected phage genes that could complement or compensate host bacterial metabolism, indicating beneficial roles of phage infection. Our findings provide insight into phage-bacterium interplay in sponges from deep-sea hydrothermal vents.
Kun Zhou, Pei-Yuan Qian, Ting Zhang, Ying Xu, Rui Zhang

2249 related Products with: Unique phage-bacterium interplay in sponge holobionts from the southern Okinawa Trough hydrothermal vent.

11 g10 mg2 mg

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#34128245   2021/06/14 To Up

Overcoming stochastic variations in culture variables to quantify and compare growth curve data.

The comparison of growth, whether it is between different strains or under different growth conditions, is a classic microbiological technique that can provide genetic, epigenetic, cell biological, and chemical biological information depending on how the assay is used. When employing solid growth media, this technique is limited by being largely qualitative and low throughput. Collecting data in the form of growth curves, especially automated data collection in multi-well plates, circumvents these issues. However, the growth curves themselves are subject to stochastic variation in several variables, most notably the length of the lag phase, the doubling rate, and the maximum expansion of the culture. Thus, growth curves are indicative of trends but cannot always be conveniently averaged and statistically compared. Here, we summarize a simple method to compile growth curve data into a quantitative format that is amenable to statistical comparisons and easy to graph and display.
Christopher W Sausen, Matthew L Bochman

2986 related Products with: Overcoming stochastic variations in culture variables to quantify and compare growth curve data.

0.1ml (1mg/ml)case100 4/120 Packing /sleeve/bo100.00 ug96 wells (1 kit)20ug10ug

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#34128115   2021/06/15 To Up

The impact of device-assisted therapies on the gut microbiome in Parkinson's disease.

Microbiome feedbacks are proposed to influence Parkinson's disease (PD) pathophysiology. A number of studies have evaluated the impact of oral medication on the gut microbiome (GM) in PD. However, the influence of PD device-assisted therapies (DATs) on the GM remains to be investigated.
Michal Lubomski, Xiangnan Xu, Andrew J Holmes, Jean Y H Yang, Carolyn M Sue, Ryan L Davis

1619 related Products with: The impact of device-assisted therapies on the gut microbiome in Parkinson's disease.

1200 units96 tests

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