Search results for: Globulin
#39373813 
2024/10/07
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Deciphering the impact of stickwater hydrolysate on growth performance, immune response, and IGF-1/PI3K/AKT/mTOR signaling pathway in Siberian sturgeon (Acipenser baerii) fingerlings.
A feeding trial lasting 56 days was carried out to assess how the inclusion of stickwater hydrolysate (SWH) in the diet of Siberian sturgeon (Acipenser baerii) fingerlings affected their growth performance, immunity, digestive enzyme activity, and gene expression linked to the IGF-1/PI3K/AKT/mTOR signaling pathway. Siberian sturgeon fingerlings were acclimatized and fed isonitrogenous, isoenergetic diets with varying SWH concentrations (0%, 0.5%, 1.5%, and 2.5%). Growth parameters, serum proteins, immunological and digestive enzyme activities, and gene expression levels were assessed post-trial. Results demonstrated that 0.5%, and 1.5% SWH treatments significantly improved weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio. Notably, these diets also elevated serum protein and plasma globulin levels, reduced albumin-to-globulin ratios, and enhanced lysozyme, myeloperoxidase (MPO) activities, and immunoglobulin (Ig) M levels, indicating an immunostimulatory effect. Digestive enzyme activities were markedly increased in the SWH groups, particularly at 1.5%. Gene expression analyses revealed upregulation of mtorc1, s6K, akt, pi3k, and igf1, with concurrent downregulation of 4e-bp1 in the muscle of fish, signifying activation of the IGF-1/PI3K/AKT/mTOR pathway, which is central to protein synthesis and muscle growth. In conclusion, SWH at appropriate levels significantly enhances growth, digestive efficiency, and immune function in Siberian sturgeon fingerlings, while also activating key metabolic pathways.Mahdad Mahdabi, Mehdi Shamsaie Mehrgan, Houman Rajabi Islami
1068 related Products with: Deciphering the impact of stickwater hydrolysate on growth performance, immune response, and IGF-1/PI3K/AKT/mTOR signaling pathway in Siberian sturgeon (Acipenser baerii) fingerlings.
2 Pieces/Box11 inhibitors8 inhibitors2 Pieces/Box5mg2 Pieces/Box50mg14 inhibitors5mg2 Pieces/Box7 inhibitors2 Pieces/Box
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#39373796 2024/10/07
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Clinical Findings, Laboratory Results, Electrocardiography and Echocardiography Findings in Dairy Buffaloes with Theileriosis.
Tropical theileriosis is a tick-borne haemoprotozoan disease, and cardiac function assessment in buffaloes with theileriosis was poorly documented.Kambala Swetha, Bhavanam Sudhakara Reddy, Bollam Shobhamani, Sirigireddy Sivajothi
2674 related Products with: Clinical Findings, Laboratory Results, Electrocardiography and Echocardiography Findings in Dairy Buffaloes with Theileriosis.
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#39373596 //
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Mysterious Allergy Caused by Tick Bite: Alpha-Gal Syndrome.
Alpha-Gal syndrome (AGS) manifests as an intricate allergic response characterised by the formation of specific immunoglobulin E (IgE) antibodies targeting a carbohydrate termed galactose-a-1.3-galactose (a-Gal). Alpha-Gal antigens, which play a role in AGS, have been detected in the salivary glands and saliva of various tick species, especially . Identifying these antigens in tick saliva underlines the potential role of tick bites in sensitising individuals to a-Gal and contributes to the complex immunological processes associated with AGS. When people with a-Gal allergy eat beef, pork, lamb, or the flesh of other mammals, they experience an allergic reaction that causes various symptoms, including rash, nausea, vomiting, and diarrhoea. In some cases, AGS can be life-threatening requiring emergency medical attention. Moreover, these reactions do not occur only due to red meat; intake of medical drugs, vaccines, and antidotes containing a-Gal epitopes can also trigger allergies. The fact that the symptoms causing IgE antibodies are directed against a carbohydrate moiety the unusual delay between food consumption and the onset of symptoms, and the differences in the reactions shown by a-Gal allergy make a-Gal syndrome an unprecedented allergic disease and distinguish it from other food allergies. Interestingly, a-Gal antigens involved in the development of AGS have been discovered in salivary secretions of different tick species in several continents. However, the underlying causes of a-Gal-specific IgE production and immune responses to tick bites are not fully understood. This complex system is crucial for identifying and developing new therapies for the disease. This article reviews the evolution of a-Gal, the current understanding of AGS and its relationship to tick species.Muhammed Nalçacı
2604 related Products with: Mysterious Allergy Caused by Tick Bite: Alpha-Gal Syndrome.
25 G100 MG100 MG 1 G250 MG5 mg50 100ul100ug Lyophilized100ug0.1 mgOne 96-Well Strip Micropl
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#39373591 //
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Investigation of Seropositivity of Anti- Antibodies and Possible Risk Factors in Pregnant Women with Diabetes at Risk.
Toxoplasmosis is a parasitic infection caused by . Immunocompromised individuals and pregnant women are at risk, with the latter group being susceptible to miscarriages. This study aimed to determine the seropositivity of antibodies and potential risk factors in pregnant women diagnosed with diabetes mellitus.Nazlı Aksoy Sanay, Neriman Mor, Dilek Şahin
2812 related Products with: Investigation of Seropositivity of Anti- Antibodies and Possible Risk Factors in Pregnant Women with Diabetes at Risk.
100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg1 ml100 μg
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#39373573 2024/10/07
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Associations of Serum Testosterone and Sex Hormone-Binding Globulin with Incident Fractures in Middle-Aged to Older Men.
As men age, circulating testosterone (T) decreases, circulating sex-hormone binding globulin (SHBG) increases, and risk of fracture increases. It is unclear if circulating T, independently of comorbidities, is associated with fracture risk in men.Louise Grahnemo, Ross J Marriott, Kevin Murray, Lauren T Tyack, Maria Nethander, Alvin M Matsumoto, Eric S Orwoll, Dirk Vanderschueren, Bu B Yeap, Claes Ohlsson
2608 related Products with: Associations of Serum Testosterone and Sex Hormone-Binding Globulin with Incident Fractures in Middle-Aged to Older Men.
1 kit0.1 mg1 kit1 ml100.00 ug100 ml10 Inserts of 96 Tips/Uni96T1x96 well plate10ml
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#39373532 2024/10/07
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Improvement in health-related quality of life questionnaires with biologic treatment in severe asthma and comorbid chronic rhinosinusitis with or without nasal polyposis: a real-life experience.
Patients with severe asthma frequently have comorbid chronic rhinosinusitis (CRS) with or without nasal polyps, that can increase the symptom burden and complicate treatment. Real-life clinical data on the impact of biologic treatments on CRS-specific quality-of-life questionnaires are still lacking.Pierachille Santus, Marina Saad, Anna Casartelli, Rosaria Lorusso, Lisa Milani, Fiammetta Danzo, Paolo Busatto, Dejan Radovanovic
2826 related Products with: Improvement in health-related quality of life questionnaires with biologic treatment in severe asthma and comorbid chronic rhinosinusitis with or without nasal polyposis: a real-life experience.
252 Pieces/Box
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#39373303 2024/10/04
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A challenging case of hemolytic disease of the fetus and newborn (HDFN) due to anti-Ku in a K (Kell) mother.
Hemolytic disease of the fetus and newborn (HDFN) due to an antibody in the Kell blood group system can be associated with severe fetal anemia. This case report details the challenges of managing a Kell mother with anti-Ku that affected her fetus/newborn. A gravida 4 para 3 woman at term underwent an emergency lower caesarean section because of fetal distress. The baby was intubated because of low oxygen saturation. An urgent request for a hematology workup showed severe anemia and erythroblastosis fetalis. Unfortunately, no compatible blood was found, and the baby died. The case was referred to the National Blood Centre, and anti-Ku was confirmed in a sample sent from the mother. When she presented with her fifth pregnancy, meticulous planning was used to manage this pregnancy. Her family screening revealed one brother with a matching phenotype. Three blood donations were planned for the brother-for freezing, for intrauterine transfusion, and for standby during delivery. Serial anti-Ku titrations of maternal samples were performed, and the fetus was monitored for anemia through middle cerebral artery Doppler scans. Although the anti-Ku titers reached as high as 1024, fetal anemia was never diagnosed. The neonate was delivered safely but was diagnosed with severe pathologic jaundice and anemia secondary to HDFN and congenital pneumonia. The baby was transfused with K packed red blood cells and later discharged to home.Siti A Wan Mohd Hasni, Nor H Ahmad, Muniswaran Ganeshan, Soon L Yong, Pei P Tan, Rahimah Abdul Wahab, Rozi H Musa, Gunaseelan Muniandi, Ambika Nakulan, Afifah Hassan
1423 related Products with: A challenging case of hemolytic disease of the fetus and newborn (HDFN) due to anti-Ku in a K (Kell) mother.
100 μg100 μg
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#39373302 2024/10/04
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The American Rare Donor Program: 25 years supporting rare blood needs.
Rare donor programs are critically important for those patients with rare phenotypes who have produced the associated alloantibodies that necessitate the provision of rare blood components. We describe the American Rare Donor Program (ARDP) and its establishment, members, and policies. The specific phenotypes meeting the ARDP criteria for inclusion are described. Data on the number of rare donors registered by year, and the number of requests for rare blood components received and fulfilled over the 25 years of the program (1998-2023) are provided, along with a description of some notable cases and discussion of how the program supports patients with sickle cell disease.Margaret A Keller, Sandra T Nance, Joan Maurer, Victoria Kavitsky, Shraddha P Babariya
1203 related Products with: The American Rare Donor Program: 25 years supporting rare blood needs.
25ml25ml25ml25ml
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#39373190 //
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Expression of thyroid antigens in the female reproductive system.
Thyroid autoimmunity (TAI) has been linked to fertility disorders and pregnancy complications, even in euthyroid women. However, the exact pathophysiological mechanism underlying this association is not fully understood. This study seeks to investigate the expression of thyroid antigens within the human female reproductive system, potentially identifying targets for thyroid antibodies. Human biopsies of endometrium and follicular granulosa cells were collected and thyroperoxidase (TPO) and thyroglobulin (TG) expression was evaluated in these tissues by immunohistochemistry. Results showed, for the first time, the expression of TG protein and confirmed the presence of thyroid TPO in human endometrium and granulosa cells. Results suggest that TPO antibodies (TPOAbs) and TG antibodies (TGAbs) could interact with TPO and TG expressed in the reproductive system in patients with positive thyroid antibodies, thereby disrupting the function of TPO and TG and generating an inflammatory response, leading to fertility disorders and pregnancy complications.Selma Aissiou, Nadjia Boucekkine, Eoghan M Cunnane, Nasrin G Gashti, Amina Oumeziane, Naima Kaci
2456 related Products with: Expression of thyroid antigens in the female reproductive system.
1-99 mg/ml/ea price x 21-99 mg/ml/ea price x 21-99 mg/ml/ea price x 2
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#39373132 //
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Detection of Neutralizing Antibodies in Serum Samples Using a SARS-CoV-2 Pseudotyped Virus Assay.
Conventional live virus research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease-19 (COVID-19), requires Biosafety Level 3 (BSL-3) facilities. SARS-CoV-2 pseudotyped viruses have emerged as valuable tools in virology, mimicking the entry process of the SARS-CoV-2 virus into human cells by expressing its spike glycoprotein in a surrogate system using recombinant plasmids. One significant application of this tool is in functional assays for the evaluation of neutralizing antibodies. Pseudotyped viruses have the advantage of being competent for only a single cycle of infection, providing better safety and versatility and allowing them to be studied in BSL-2 laboratories. Here, we describe three protocols for the detection of SARS-CoV-2 neutralizing antibodies through a pseudotyped virus assay. First, SARS-CoV-2 S pseudotyped viruses (PV SARS-CoV-2 S) are produced using a Moloney murine leukemia virus (MuLV) three-plasmid system. The plasmids are designed to express the GagPol packing proteins, enhanced green fluorescent protein (eGFP) as a readout system, and the SARS-CoV-2 S protein modified to remove the endoplasmic reticulum retention domain and to improve infection. Next, the internalization of PV SARS-CoV-2 S protein in human embryonic kidney 293T (HEK-293T) cells overexpressing angiotensin-converting enzyme 2 (HEK-293T-ACE2) is confirmed by fluorescence microscopy and quantified using flow cytometry. Finally, PV SARS-CoV-2 S is used to screen neutralizing antibodies in serum samples from convalescent COVID-19 patients; it can also be used for studying the cell entry mechanisms of different SARS-CoV-2 variants, evaluating antiviral agents, and designing vaccines. © 2024 Wiley Periodicals LLC. Basic Protocol 1: Generation of PV SARS-CoV-2 S pseudotyped virus Basic Protocol 2: Assay of PV SARS-CoV-2 S internalization in target cells. Basic Protocol 3: Detection of neutralizing antibodies in serum samples.Sol Ferrero, María Victoria Batto, Matías Iván Gatto, Federico Dimase, Gustavo Helguera