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#39374070   2024/10/07 To Up

Trace Dual-Salt Electrolyte Additive Enabling a LiF-Rich Solid Electrolyte Interphase for High-Performance Lithium Metal Batteries.

The composition and physiochemical properties of the solid electrolyte interphase (SEI) significantly impact the electrochemical cyclability of the Li metal. Here, we introduce a trace dual-salt electrolyte additive (TDEA) that accelerates LiF production from FEC decomposition and improves the LiF distribution, resulting in earlier LiF precipitation and the formation of a LiF-rich SEI on the Li anode. TDEA at a millimolar-level concentration was found to alter the morphology of deposited Li, suppress Li dendrite formation, and increase the cycling time and operating current density for Li anodes. Li∥NCM811 full cells using TDEA-based electrolytes exhibited approximately two times longer lifespan than those without additives. Additionally, the TDEA-based electrolytes enabled a high energy density of 347 Wh kg for 500-mAh pouch cells, maintaining stable cycling over 180 cycles under stringent conditions (N/P = 1.26 and E/C = 2.2 g A h). Our findings suggest that the proposed TDEA strategy offers a promising path to achieving high-performance Li metal batteries.
Yingchun Xia, Wenhui Hou, Pan Zhou, Yu Ou, Guangyu Cheng, Chong Guo, Fengxiang Liu, Weili Zhang, Shuaishuai Yan, Yang Lu, Yunxiong Zeng, Kai Liu

1666 related Products with: Trace Dual-Salt Electrolyte Additive Enabling a LiF-Rich Solid Electrolyte Interphase for High-Performance Lithium Metal Batteries.

100 Tests / Kit1100μg100μg100μg20 ug 5 G1 g 25 G10ìg100 MG 100 G

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#39374064   2024/10/07 To Up

Micron-Scale Vertical MoS/Porous g-CN Piezocatalyst via a Precursor's Supramolecular Self-Template Architecture: Degradation and Hydrogen Evolution.

Piezocatalysis can effectively harvest various kinds of mechanical energy with high entropy from the environment and drive some redox reactions without light irradiation, where MoS- and g-CN-based piezocatalysts are recent research hotspots. This study constructs an architecture of ordered melamine hydrochloride-cyanuric acid/MoO supramolecular precursor via self-assembly, serving as a self-template for in situ tight growth of vertically aligned micron-scale MoS on porous foam-like g-CN(CM) under S vapor with a bioinspired rooting and sprouting-like process. Experiments, DFT calculations, and finite element simulations collectively confirm the high piezoresponse of the CM with high exposure of active sites and enhanced mechanical energy collection. The vertical interfaces and built-in electric fields in the composite induce efficient charge carrier separation and transfer. The optimized CM0.77 efficiently degrades various organic dyes and antibiotic under dark ultrasound [rhodamine B (RhB): 0.47 s, methyl orange (MO): 0.05 s, methylene blue (MB): 0.21 s, and tetracycline hydrochloride (TC): 0.03 s] and achieves hydrogen evolution (2431 μmol·g·h). Under simulated water flow (10 L/min), the expanded CM0.77/AlO porous foam ceramic (CM/alumina ceramic) purifier device degrades 95% of 400 mL of RhB within 25 min. The developed ordered vertical MoS/g-CN piezocatalyst demonstrates rapid pollutant degradation and efficient hydrogen evolution under water flow and ultrasound, providing new insights for constructing multidimensional piezoelectric composites for environmental remediation and clean energy production.
Yimeng Wang, Hecheng Ma, Jianjun Liu, Yingchun Yu, Shengli Zuo

1884 related Products with: Micron-Scale Vertical MoS/Porous g-CN Piezocatalyst via a Precursor's Supramolecular Self-Template Architecture: Degradation and Hydrogen Evolution.

100ul96T 100ul100ug 100ul1000pcs100μg50 ug 100ug/vial100ug100 ug/vial

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#39374010   // To Up

The Impact of Spliceosome Inhibition in SF3B1-Mutated Uveal Melanoma.

Unfortunately, treatment of patients with uveal melanoma (UM) with metastatic disease is limited. Twenty percent of patients with UM harbor a mutation in the splicing factor gene SF3B1, suggesting that aberrant spliceosome function plays a vital role in tumorigenesis. Splicing inhibitors exploit the preferential sensitivity of spliceosome-compromised leukemic cells to these compounds.
Josephine Q N Nguyen, Wojtek Drabarek, Aïsha M C H J Leeflang, Tom Brands, Thierry P P van den Bosch, Robert M Verdijk, Harmen J G van de Werken, Job van Riet, Dion Paridaens, Annelies de Klein, Erwin Brosens, Emine Kiliç,

2224 related Products with: The Impact of Spliceosome Inhibition in SF3B1-Mutated Uveal Melanoma.

96 assays 148 assays

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#39373990   2024/10/07 To Up

Barriers to Tofersen Therapy for Variant SOD1-Mediated ALS.


Stanley H Appel, Jason R Thonhoff

2017 related Products with: Barriers to Tofersen Therapy for Variant SOD1-Mediated ALS.

100ug 1 G 25 MG10 mg100 mg1 module 1000 ml 1 mg25 mg0.5mg200 ug 50G

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#39373979   2024/10/07 To Up

Two-dimensional viologen-based lanthanide coordination polymers as multi-stimuli responsive materials to light and amines with a fluorescence response.

Integrating multi-stimuli response properties in one molecule is challenging. This study presents two 2D polymers, [(Bpydp)Ln(HO)(BDC)]·NO·2HO (Ln = Eu(1), Tb(2)), exhibiting rapid photo-responsiveness and the ability to detect specific small-molecule amines. In particular, complex 1 combines the functions of inkless printing, amine detection, anti-counterfeiting, and fluorescence recognition.
Hao Wang, Xiao-Han Sun, Tian-Tian Wang, Yu-Xin Li, Ying-Ming Xu, Wen-Bin Sun

2369 related Products with: Two-dimensional viologen-based lanthanide coordination polymers as multi-stimuli responsive materials to light and amines with a fluorescence response.

1 kit1 kit1 kit1 kit1 kit(96 Wells)25 Tests1 kit1 kit1 kit1 kit1 kit

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#39373974   2024/10/07 To Up

Luminescence Modulation in Boron-Cluster-Based Luminogens via Boron Isotope Effects.

Recent advances in luminescent materials highlight the significant impact of hydrogen isotope effects on improving optoelectronic properties. However, the research on the influence of the boron isotope effects on photophysical properties remains underdeveloped. This study focused on exploring the boron isotope effects in boron-cluster-based luminogens. In doing so, we designed and synthesized carborane-based luminogens containing 98% 10B and 95% 11B, respectively, and observed distinct photophysical behaviors. Compared to the 10B-enriched luminogens, the 11B-enriched counterparts can significantly enhance luminescence efficiency, prolong emission lifetime, and reduce full-width at half-maximum. Additionally, increased thermal stability, redshifted B-H vibrations, and a fourfold enhanced electrochemiluminescence intensity have also been observed. On the other hand, the biological assessments of a 10B-enriched luminogen reveals low cytotoxicity, high boron uptake, and excellent fluorescence imaging capability, indicating the potential application in boron neutron capture therapy (BNCT). This work presents the first comprehensive exploration on the boron isotope effects in boron clusters, and provides valuable insights into the rational design of organic luminogens for advanced optoelectronic and biomedical applications.
Wenli Ma, Jianyu Zhang, Jibo Zong, Hongyuan Ren, Deshuang Tu, Qinfeng Xu, Ben Zhong Tang, Hong Yan

1485 related Products with: Luminescence Modulation in Boron-Cluster-Based Luminogens via Boron Isotope Effects.

100 G 1L100 μg100ug 1 G100 μg1 Set1000 Units100 μg1 Set5

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#39373945   2024/10/07 To Up

Molecular detection and phylogenetic analysis of ovine herpesvirus-2 in subclinical infections of cattle and sheep.

Ovine herpesvirus-2 (OvHV-2) is the causative agent of malignant catarrhal fever (MCF), a serious and often fatal disease that affects cattle and other ruminants. This study aimed to investigate the molecular epidemiology and genetic diversity of OvHV-2 strains circulating in sheep and cattle populations in the Jammu and Kashmir region of India. Screening of 150 sheep and 57 cattle blood samples revealed the presence of the OvHV-2 polymerase (pol) gene in 8.6% of sheep, 10% of apparently healthy cattle, and 29.7% of cattle exhibiting MCF-like symptoms. The full-length glycoprotein B (gB) gene (2800 bp) and an 875 bp internal fragment were successfully amplified, cloned, and sequenced from pol-positive samples. Comparative sequence analysis of the deduced gB amino acid sequences identified seven substitutions at positions 278, 341, 390, 440, 468, 539, and 566 compared to reference strains. Phylogenetic analysis based on the gB nucleotide sequences clustered the OvHV-2 strains from this study within the Indian clade, distinct from strains reported in the UK and US. These findings provide insights into the genetic diversity of OvHV-2 strains circulating in Jammu and Kashmir, with the identified mutations potentially influencing virus-host interactions. Further investigations into the functional implications of these mutations are warranted to understand their role in viral pathogenesis and tropism.
A S Kumar, Z A Kashoo, A Rasool, M N Mir, S Farooq, S Qureshi, M A Bhat, M I Hussain, G A Badroo

1516 related Products with: Molecular detection and phylogenetic analysis of ovine herpesvirus-2 in subclinical infections of cattle and sheep.

200ug200ug200ul10 mg200ul200ul2.5 mg5mg20ug5mg10 mg

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#39373944   2024/10/07 To Up

Bio-adsorption of Fe (II) by dry biomass of metal-tolerant haloarchaeon Haloferax alexandrinus GUSF-1.

Mining-associated activities result in iron pollution exceeding the acceptable limit of 0.3 mg L and are rampant in estuarine soil and water bodies that harbor halophilic microorganisms. Biotechnologies are underway to unveil the concentrations and recover the metals that skip existing physico-chemical methods. Concerning this, the present study describes for the first time the development of a bio-adsorption batch system using dried cells of Haloferax alexandrinus GUSF-1 for Fe (II) from saline water under microaerophilic conditions. A maximum of 99.5% Fe (II) was adsorbed at pH 6.0, 30 ºC in 3 h with 92% efficiency over three adsorption-desorption cycles with saturation and pseudo-second-order kinetics and heterogeneity of Freundlich model having K of 1.38 mg g with the n value of 0.96. Adsorbed Fe (II) by the cells was detected by scanning electron microscopy. The involvement of the carboxyl, amino, hydroxyl, and phosphate groups of the cells in interaction with the metal ions was detected by infrared spectroscopy. Conclusively, the study is the first report of whole dried cells mediated metal adsorption by the haloarcheon Haloferax alexandrinus GUSF-1 which acts as promising candidate for metal clean-up strategy and bioremediation in hypersaline ecosystems.
Sanika Naik-Samant, Sanket Gaonkar, Irene Furtado

2135 related Products with: Bio-adsorption of Fe (II) by dry biomass of metal-tolerant haloarchaeon Haloferax alexandrinus GUSF-1.

5 G50mg 25 ml Ready-to-use 100ug Lyophilized 1 G100 ul0.2 mg0.25 mg100ug Lyophilized250 ug500 ml100ug Lyophilized

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#39373939   2024/10/07 To Up

Severe bleeding events among critically ill patients with haematological malignancies.

Bleeding events are common complications in critically ill patients with haematological malignancies. The objective of this study was to assess the incidence and identify determinants of ICU-acquired severe bleeding events in critically ill patients with haematological malignancies. We conducted a single-center retrospective study including all adult patients with a history of haematological malignancy requiring unplanned ICU admission over a 12-year period (2007-2018). The primary endpoint was the occurrence of ICU-acquired (i.e. after the first 24 h in the ICU) severe bleeding events, as defined as grades 3 or 4 of the World Health Organization classification.
Clara Vigneron, Clément Devautour, Julien Charpentier, Rudy Birsen, Matthieu Jamme, Frédéric Pène

1032 related Products with: Severe bleeding events among critically ill patients with haematological malignancies.



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#39373937   2024/10/07 To Up

A Novel Bifunctional Chelating Agent for Tyrosine-Specific Radiolabeling of Peptides and Proteins.

Site-specific radiolabeling is utilized for the development of antibody- or peptide-based radiotheranostic agents. Although tyrosine can be exploited as one of the target residues for site-specific radiolabeling of peptides and proteins, a tyrosine-specific radiolabeling method has not been established. In this study, we newly designed and synthesized a novel bifunctional chelating agent, TBD-DO3A, consisting of a triazabutadiene (TBD) scaffold and metal chelator, 1,4,7,10-tetraazacyclododecane 1,4,7-triacetic acid (DO3A). Conjugation of TBD-DO3A with Ac-Tyr-NHMe followed by In-labeling afforded [In]In-Tyr-DO3A, which showed high-level stability in mouse plasma. Then, we selected the tyrosine-containing cyclic peptide c(RGDyK) as a model ligand and synthesized [In]In-RYD. [In]In-RYD showed binding properties for integrin αβ equivalent to those of [In]In-RKD, a lysine residue-labeled control compound. In biodistribution and SPECT/CT imaging studies using U87MG/PC-3 tumor-bearing mice, [In]In-RYD and [In]In-RKD were selectively accumulated and facilitated U87MG tumor visualization at 24 h postinjection. These results indicate that TBD-DO3A has fundamental properties as a bifunctional chelator for tyrosine-specific radiolabeling of peptides and proteins.
Daiki Nakano, Hiroyuki Watanabe, Saito Kosuke, Masahiro Ono

1863 related Products with: A Novel Bifunctional Chelating Agent for Tyrosine-Specific Radiolabeling of Peptides and Proteins.

25 µg100 ml1 mg1 ml0.25 mg0.1 ml25 µg2 Pieces/Box0.1 mg100 TESTS100ul0.2 mg

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