Search results for: H2
#38015427 2023/11/28 To Up
Perylene diimide-based radical anions for the rapid detection of picomolar HO in an aqueous medium.The formation of radical anions (PDI 1˙) using HS as a sacrificial electron donor in 50% HEPES buffer-THF solution is reported. PDI 1˙ was confirmed by optical, - plot, CV, DPV, NOBF and EPR studies. PDI 1˙ has a half-life of 96 minutes in solution and 11 days in the solid state without any additive. The formation of PDI 1˙ was confirmed by AFM and SEM. PDI 1˙ can be used for the detection of 26.6 pM of HO supported by optical and CV data.
Navdeep Kaur, Sagar Sardana, Aman Mahajan, Subodh Kumar, Prabhpreet Singh
2026 related Products with: Perylene diimide-based radical anions for the rapid detection of picomolar HO in an aqueous medium.250 ml0.1 ml0.1ml25 µg0.1ml100 μg0.2 mg100 ul100 ul0.1ml100 μg
#38015337 2023/11/28 To Up
Metals stress on soil enzyme activities and herbs defense in the vicinity of high traffic roadways.This study has investigated the impact of vehicle sourced heavy metals (HMs) on soil enzyme activities and plants in and around high traffic roadways near the metropolitan area. In detail, the defense response against HM pollution was studied by considering the commonly available herbs around the roadside area namely Alternanthera paronychioides, Ageratum conyzoides, Spilanthes acmella, and Parthenium hysterophorus. The study reported that the HM concentrations such as Cu, Ni, Zn, Mn, and Cr were observed in the range of 6.05 ± 0.1 to 309 ± 0.5 mg/kg in roadside soil and 5.2 ± 0.1to 451 ± 4.2 mg/kg in the herbs collected from roadside area. The soil enzyme (urease, dehydrogenase, amylase, catalase, peroxidase, and polyphenol oxidase) activities decreased by 22.56 to 77.84% in roadside soil and lower IC values were observed for DPPH (2.32-4.67) and HO (1.59-2.15) free radical scavenging activities in plants collected from roadside area. The flavonoid and phenolic content in plants collected from the roadside area ranges from 12.65 ± 0.2 to 15.75 ± 0.3 mg quercitin/g and 0.61 ± 0.04 to 1.16 ± 0.1 mg gallic acid/g respectively while in plant collected from the control areas ranges from 7.96 ± 0.1 to 11.24 ± 0.05 and 0.47 ± 0.01 to 0.61 ± 0.1. In addition, the contamination factor (CF) (1.53-11.92) and geo-accumulation index (I) (0.031-2.99) in soil and bioaccumulation factor (BAF) (0.72-2.73) of Cu, Ni, Zn, Mn, and Crin plants indicated that the soil and plants growing along the highway were heavily contaminated with HM. Finally, Pearson correlation matrix confirmed the inhibition effect of HM on soil enzymatic activities and enzymatic defense of plants in response to the HM stress.
Mridulina Hazarika, Glory Borah, W James Singha, Hemen Deka
1311 related Products with: Metals stress on soil enzyme activities and herbs defense in the vicinity of high traffic roadways.4 Membranes/Box4 Arrays/Slide4 Arrays/Slide2 Pieces/Box4 Membranes/Box2 Pieces/Box2 Pieces/Box4 Arrays/Slide96T
#38015303 2023/11/28 To Up
Tauroursodeoxycholic Acid Inhibited Apoptosis and Oxidative Stress in HO-Induced BMSC Death via Modulating the Nrf-2 Signaling Pathway: the Therapeutic Implications in a Rat Model of Spinal Cord Injury.S
Jiaxian Weng, Le Wang, Kai Wang, Haitao Su, Dan Luo, Haimei Yang, Yaqian Wen, Qiduan Wu, Xing Li
1976 related Products with: Tauroursodeoxycholic Acid Inhibited Apoptosis and Oxidative Stress in HO-Induced BMSC Death via Modulating the Nrf-2 Signaling Pathway: the Therapeutic Implications in a Rat Model of Spinal Cord Injury.12 Pieces/Box2 Pieces/Box 500 G
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#38015094 2023/11/28 To Up
Oxygen Dependent Switchable Selectivity during Ruthenium Catalyzed Selective Synthesis of -Alkylated Indoles and Bis(indolyl)methanes.Herein, we report a ligand-centered redox-controlled oxygen-dependent switchable selectivity during ruthenium-catalyzed selective synthesis of -alkylated indoles and bis(indolyl)methanes (BIMs). A wide variety of -alkylated indoles and BIMs were prepared selectively in moderate to good isolated yields by coupling a wide variety of indoles and alcohols, catalyzed by a well-defined, air-stable, and easy-to-prepare Ru(II)-catalyst () bearing a redox-active tridentate pincer (). Catalyst efficiently catalyzed the -alkylation of indoles under an argon atmosphere while, under an oxygen environment, exclusively producing the BIMs. A few drug molecules containing BIMs were also synthesized efficiently. exhibited excellent chemoselectivity with alcohols containing internal carbon-carbon double bonds. Mechanistic investigation revealed that the coordinated azo-aromatic ligand actively participates during the catalysis. During the dehydrogenation of alcohols, the azo-moiety of the ligand stores the hydrogen removed from the alcohols and subsequently transfers the hydrogen to the alkylideneindolenine intermediate, forming the -alkylated indoles. While under an oxygen environment, the transfer of hydrogen from the ligand scaffold to the molecular oxygen generates HO, leaving no scope for hydrogenation of the alkylideneindolenine intermediate, rather than it undergoing 1,4-Michael-type addition forming the BIMs.
Amit Kumar Guin, Subhasree Pal, Subhajit Chakraborty, Santana Chakraborty, Nanda D Paul
2477 related Products with: Oxygen Dependent Switchable Selectivity during Ruthenium Catalyzed Selective Synthesis of -Alkylated Indoles and Bis(indolyl)methanes.200ul100ug Lyophilized25 mg50 96T100ul100 mg250ul50 mg10 mg50 ug
#38014993 2023/11/28 To Up
Filamentous actin destabilization by HO favors DnmA aggregation, with crucial roles of cysteines 450 and 776 in mitochondrial and peroxisomal division in .Mitochondria constitute major sources of HO and other reactive oxygen species in eukaryotic cells. The division of these organelles is crucial for multiple processes in cell biology and relies on highly regulated mechano-GTPases that are oligomerization dependent and belong to the dynamin-related protein family, like DnmA. Our previous work demonstrated that HO induces mitochondrial constriction, division, and remodeling of the outer membrane. Here, we show that HO also induces a DnmA aggregation consistent with higher-order oligomerization and its recruitment to mitochondria. The study of this response uncovered that HO induces the depolymerization and reorganization of actin as well as the critical role that cysteines 450 and 776 play in DnmA function. Our results provide new insights into the mechanisms of reactive oxygen species cell signaling and how they can regulate the dynamics of the actin cytoskeleton and the division of mitochondria and peroxisomes.
Verónica Garrido-Bazán, Dulce C Guzmán-Ocampo, Laura Domínguez, Jesús Aguirre
1396 related Products with: Filamentous actin destabilization by HO favors DnmA aggregation, with crucial roles of cysteines 450 and 776 in mitochondrial and peroxisomal division in .0.1ml50 ug 50ul0.1ml (1mg/ml)
#38014876 2023/11/28 To Up
Unraveling the Unimolecular Ion Chemistry of Protonated Isoprene and Prenol.The atmospheric chemistries of isoprene and prenol have been studied extensively; however, much of that research has focused on neutral or radical chemistry. Recent studies have demonstrated that under acidic conditions, isoprene and prenol can become protonated in the atmosphere, and we have explored the unimolecular chemistry of protonated isoprene and prenol with tandem mass spectrometry (using a triple-quadrupole mass spectrometer) and density functional theory. The collision-induced dissociation of protonated isoprene revealed two product ion channels: the neutral losses of CH and H, the former dominating over the latter. Protonated prenol dissociates by four product ion channels: the neutral losses of water, formaldehyde, methanol, and propene, with the former two being minor channels and the latter two being major channels. Density functional theory supplemented with CBS-QB3 single-point calculations revealed the underlying mechanisms to explain the breakdown behavior. The two competing channels from protonated isoprene could easily be rationalized due to the relative energy difference between key transition states along the reaction coordinates. However, in the case of protonated prenol, it was revealed that the minor products observed in the breakdown of protonated prenol had significantly lower reaction barriers when compared to the major products, an apparent contradiction. This could be rationalized if the initial ion population entering the collision cell is comproed of several isomeric species on the minimum energy reaction pathway, species populated by collisional excitation in the ion source region.
Edgar White Buenger, Paul M Mayer
1677 related Products with: Unraveling the Unimolecular Ion Chemistry of Protonated Isoprene and Prenol.500IU2.5 mg100ug10 mg100.00 ul2.5 mg 5 G100.00 ul 1 MG
#38014813 2023/11/28 To Up
Lithium-Modified TiO Surface by Anodization for Enhanced Protein Adsorption and Cell Adhesion.Promoting osseointegration is an essential step in improving implant success rates. Lithium has gradually gained popularity for promoting alkaline phosphatase activity and osteogenic gene expression in osteoblasts. The incorporation of lithium into a titanium surface has been reported to change its surface charge, thereby enhancing its biocompatibility. In this study, we applied anodization as a novel approach to immobilizing Li on a titanium surface and evaluated the changes in its surface characteristics. The objective of this study was to determine the effect of Li treatment of titanium on typical proteins, such as albumin, laminin, and fibronectin, in terms of their adsorption level as well as on the attachment of osteoblast cells. Titanium disks were acid-etched by 66 wt % HSO at 120 °C for 90 s and set as the control group. The etched samples were placed in contact with an anode, while a platinum bar served as the counter electrode. Both electrodes were mounted on a custom electrochemical cell filled with 1 M LiCl. The samples were anodized at constant voltages of 1, 3, and 9 V. Scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM) results showed no significant differences in the topography. However, the ζ potentials of the 3 V group were higher than those of the control group at a physiological pH of 7.4. Interestingly, the adsorption level of the extracellular matrix protein was mostly enhanced on the 3 V-anodized surface. The number of attached cells on the Li-anodized surfaces increased. The localization of vinculin at the tips of the stretching cytoplasmic projections was observed more frequently in the osteoblasts on the 3 V-anodized surface. Although the optimal concentration or voltage for Li application should be investigated further, this study suggests that anodization could be an effective method to immobilize lithium ions on a titanium surface and that modifying the surface charge characteristics enables a direct protein-to-material interaction with enhanced biological adhesion.
Huaze Wu, Takeshi Ueno, Kosuke Nozaki, Huichuan Xu, Yuki Nakano, Peng Chen, Noriyuki Wakabayashi
2710 related Products with: Lithium-Modified TiO Surface by Anodization for Enhanced Protein Adsorption and Cell Adhesion.100ug100ug Lyophilized100ul20500 ml1 kit(96 Wells)100ug Lyophilized200 10100 mg
#38014787 // To Up
Hydroxypyridinate-bridged paddlewheel-type dirhodium complex as a catalyst for photochemical and electrochemical hydrogen evolution.Electrochemical and photochemical hydrogen (H2) evolution activities of a 6-fluoro-2-hydroxypyridinate (fhp-)-bridged paddlewheel-type dirhodium (Rh2) complex, [Rh2(fhp)4], were investigated through experimental and theoretical approaches. In DMF, the [Rh2(fhp)4] underwent a one-electron reduction (assigned to Rh24+/3+) at -1.31 V vs SCE in the cathodic region. Adding trifluoroacetic acid as a proton source to the electrochemical cell containing [Rh2(fhp)4], the significant catalytic current, i.e., electrochemical H2 evolution, was observed; the turnover frequency and overpotential of electrochemical H2 evolution were 18 244 s-1 and 732 mV, respectively. The reaction mechanism of electrochemical H2 evolution catalyzed by [Rh2(fhp)4] in DMF was examined in detail by theoretically predicting the redox potentials and pKa values of the reaction intermediates using density functional theory calculations. The calculations revealed that (i) the formation of a one-electron reduced species, [Rh2(fhp)4]-, triggered for H2 evolution and (ii) the protonation and reduction processes of [Rh2(fhp)4]- to further reduced hydride intermediates proceeded directly via a concerted proton-electron transfer mechanism. Moreover, [Rh2(fhp)4] was shown to be a highly efficient H2 evolution catalyst (HEC) for photochemical proton reduction reactions when combined with an artificial photosynthetic (AP) system containing [Ir(ppy)2(dtbbpy)]PF6 and triethylamine, which served as a photosensitizer and a sacrificial electron donor, respectively. Under visible light irradiation, the total amount of H2 evolved and its turnover number (per Rh ion) were 1361.0 µmol and 13 610, respectively, which are superior to those of previously reported AP systems with rhodium complexes as HEC.
Yusuke Kataoka, Kozo Sato, Natsumi Yano
2293 related Products with: Hydroxypyridinate-bridged paddlewheel-type dirhodium complex as a catalyst for photochemical and electrochemical hydrogen evolution.1 ml1 kit
#38014756 2023/11/28 To Up
Application of engineered myoglobins for biosynthesis of clofazimine by integration with chemical synthesis.Significant efforts have been made in the design of artificial metalloenzymes. Myoglobin (Mb), an O carrier, has been engineered to exhibit different functions. Herein, we applied a series of engineered Mb mutants with peroxidase activity for biosynthesis of clofazimine (CFZ), a potential drug with a broad-spectrum antiviral activity, by integration with chemical synthesis. Two of those mutants, F43Y Mb and F43Y/T67R Mb, have been shown to efficiently catalyze the oxidative coupling of 2--(4-chlorophenyl) benzene-1,2-diamine (-4-CPBDA) in the presence of HO, with 97% yields. The overall catalytic efficiency (/) is 46-fold and 82-fold higher than that of WT Mb, respectively. By further combination of this reaction with chemical synthesis, the production of CFZ was accomplished with an isolated yield of 72%. These results showed that engineered Mbs containing the Tyr-heme cross-link (F43Y Mb and F43Y/T67R Mb) exhibit enhanced activity in the oxidative coupling reaction. This study also indicates that the combination of biocatalysis and chemical synthesis avoids the need for the separation of intermediate products, which offers a convenient approach for the total synthesis of the biological compound CFZ.
Shuai Tang, Li-Juan Sun, Ai-Qun Pan, Jun Huang, Huamin Wang, Ying-Wu Lin
1360 related Products with: Application of engineered myoglobins for biosynthesis of clofazimine by integration with chemical synthesis.1 ml0.1 mg0.1 mg0.1 ml 100ul250 ml25 µg0.2 mg 100ul1 LITRE0.25 mg100 ml
#38014751 2023/11/28 To Up
FODMAP meal challenge test: a novel investigation to predict response to low-FODMAP diet in non-constipating irritable bowel syndrome.Though a low-FODMAP diet improves 50% irritable bowel syndrome (IBS) patients, regional dietary variations, vegetarianism, and long-term nutritional consequences challenge its implementation. We aimed developing a FODMAP meal challenge test (FMCT). We prospectively studied whether (i) high- than low-FODMAP foods produce more breath H among IBS patients than controls; (ii) post-meal symptoms relate to breath H ; and (iii) novel FMCT predicts response to a low-FODMAP diet?
Uday C Ghoshal, Uzma Mustafa, Subhra K Mukhopadhyay
2569 related Products with: FODMAP meal challenge test: a novel investigation to predict response to low-FODMAP diet in non-constipating irritable bowel syndrome.100 25 1 mg100 μg1 mL1 kit
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