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Search results for: Hepatocellular

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#32791547   2020/08/13 To Up

[Liver transplantation - current trends].

 There is an ongoing change in the indications of orthotopic liver transplantation (OLT) with non-alcoholic and alcoholic liver disease and hepatocellular carcinoma (HCC) becoming the main indications whereas the numbers of cirrhosis due to chronic viral hepatitis are declining. 6-MONTH ABSTINENCE RULE: : The directive of the German Federal Medical Association requires absolute abstinence from alcohol for at least 6 months. New data show that patients with severe alcoholic hepatitis for the first time who do not show a response to medical treatment may benefit from OLT. For these patients an individual exception for OLT listing can be requested.
Niklas F Aehling, Daniel Seehofer, Thomas Berg

1772 related Products with: [Liver transplantation - current trends].

96T250ul10 mgEach10

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#32791447   2020/07/28 To Up

Living donor liver transplantation for combined hepatocellular-cholangiocarcinoma: A case series of four patients.

Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma whose components include both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Indications for liver transplantation for cHCC-CCA remain controversial.
Takashi Ito, Takamichi Ishii, Shinji Sumiyoshi, Satoshi Ogiso, Ken Fukumitsu, Takashi Ito, Shintaro Yagi, Satoru Seo, Koichiro Hata, Kojiro Taura, Shinji Uemoto

1071 related Products with: Living donor liver transplantation for combined hepatocellular-cholangiocarcinoma: A case series of four patients.



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#32791397   2020/07/13 To Up

Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents.

As a continuation of earlier works, a series of novel quinazolinone derivatives (5a-s) were synthesized and evaluated for their in vitro anti-HBV and anti-hepatocellular carcinoma cell (HCC) activities. Among them, compounds 5j and 5k exhibited most potent inhibitory effect on HBV DNA replication in both drug sensitive and resistant (lamivudine and entecavir) HBV strains. Interestingly, besides the anti-HBV effect, compound 5k could significantly inhibit the proliferation of HepG2, HUH7 and SK- cells, with IC values of 5.44, 6.42 and 6.75 μM, respectively, indicating its potential anti-HCC activity. Notably, the in vitro anti-HCC activity of 5k were more potent than that of positive control 5-fluorouracil and sorafenib. Further studies revealed that compound 5k could induce HepG2 cells apoptosis by dose-dependently upregulating Bad and Bax expression and decreasing Bcl-2 and Bcl-xl protein level. Considering the potent anti-HBV and anti-HCC effect, compound 5k might be a promising lead to develop novel therapeutic agents towards HBV infection and HBV-induced HCC.
Jingying Qiu, Qingqing Zhou, Yinpeng Zhang, Mingyu Guan, Xin Li, Yueting Zou, Xuan Huang, Yali Zhao, Wang Chen, Xiaoke Gu

2965 related Products with: Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents.

100μl100ug100μl100μl100ug Lyophilized100μl100ug Lyophilized100μl20 mg

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#32791232   2020/08/10 To Up

Repeated stereotactic body radiotherapy for hepatocellular carcinoma.

In clinical practice, it remains unclear whether cirrhotic livers in patients with hepatocellular carcinoma (HCC) can withstand repeated stereotactic body radiotherapy (SBRT). This study aimed to evaluate outcomes and toxicities in such patients.
Takahisa Eriguchi, Nobuhiro Tsukamoto, Nobuko Kuroiwa, Takafumi Nemoto, Takeru Ogata, Yusuke Okubo, Shigeru Nakano, Akitomo Sugawara

2506 related Products with: Repeated stereotactic body radiotherapy for hepatocellular carcinoma.



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#32790956   2020/08/13 To Up

Serum copeptin level is a biomarker associated with ascites retention and the formation of a portosystemic shunt in chronic liver disease.

Copeptin is a stable cleavage product of the arginine vasopressin (AVP) precursor and is equimolarly secreted with AVP. We aimed to assess whether copeptin is the surrogate marker for complications related chronic liver disease (CLD) such as ascites, hepatic encephalopathy (HE), portosystemic shunts (PSS) and all causes of mortality in CLD.
Ryuta Shigefuku, Motoh Iwasa, Akiko Eguchi, Yasuyuki Tamai, Kyoko Yoshikawa, Ryosuke Sugimoto, Yoshiyuki Takei

1468 related Products with: Serum copeptin level is a biomarker associated with ascites retention and the formation of a portosystemic shunt in chronic liver disease.

50 UG100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized50ul (1mg/ml)100 ul100ug Lyophilized100ug Lyophilized

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#32790935   2020/08/13 To Up

Extrahepatic autoimmune diseases in primary biliary cholangitis: prevalence, significance for clinical presentation and disease outcome.

The prevalence and clinical significance of extrahepatic autoimmune diseases (EHAID) have not been evaluated in a large cohort of primary biliary cholangitis (PBC).
Cumali Efe, Murat Torgutalp, Ida Henriksson, Fatema Alalkim, Ellina Lytvyak, Hirsh Trivedi, Fatih Eren, Janett Fischer, Maneerat Chayanupatkul, Claudia Coppo, Tugrul Purnak, Luigi Muratori, Mårten Werner, Paolo Muratori, Fredrik Rorsman, Kristina Onnerhag, Emma Nilsson, Alexandra Heurgué-Berlot, Nurhan Demir, David Semela, Murat Kıyıcı, Thomas D Schiano, Aldo J Montano-Loza, Thomas Berg, Ersan Ozaslan, Eric M Yoshida, Alan Bonder, Hanns-Ulrich Marschall, Benedetta Terziroli Beretta-Piccoli, Staffan Wahlin

1477 related Products with: Extrahepatic autoimmune diseases in primary biliary cholangitis: prevalence, significance for clinical presentation and disease outcome.

500 tests500 tests500 tests500 tests500 tests

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#32790882   2020/08/13 To Up

Planning Dosimetry for Y Radioembolization with Glass Microspheres: Evaluating the Fidelity of Tc-MAA and Partition Model Predictions.

Tc-MAA-SPECT/CT may be used in Y glass microsphere radioembolization treatment planning to assess perfused liver volumes and absorbed dose distributions. The partition model (PM) offers a more detailed planning dosimetry option beyond the single compartment MIRD model more traditionally used in Y radioembolization. As Y radioembolization treatments shift toward activities and doses that aim to achieve tumor eradication, accurate and reliable treatment planning dosimetry for both tumors and normal liver (NL) becomes more critical. In this work, we explore the accuracy and precision of Y dosimetry predictions from pre-therapy Tc-MAA and PM.
M Allan Thomas, Armeen Mahvash, Mohamed Abdelsalam, Ahmed O Kaseb, S Cheenu Kappadath

2631 related Products with: Planning Dosimetry for Y Radioembolization with Glass Microspheres: Evaluating the Fidelity of Tc-MAA and Partition Model Predictions.

10 100ug 100ul4 Arrays/SlideOne 96-Well Microplate Ki100 ug 100 G100 μg1 Set10100ug

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#32790866   2020/08/13 To Up

Extracellular vesicles-derived OncomiRs mediate communication between cancer cells and cancerassociated hepatic stellate cells in hepatocellular carcinoma microenvironment.


Jiang Li, Yan Yan, Lin Ang, Xiaoya Li, Chunying Liu, Bin Sun, Xuejing Lin, Zhangxiao Peng, Xiaofeng Zhang, Qin Zhang, Hongping Wu, Min Zhao, Changqing Su

1032 related Products with: Extracellular vesicles-derived OncomiRs mediate communication between cancer cells and cancerassociated hepatic stellate cells in hepatocellular carcinoma microenvironment.

-1x10e7 cells96 wells96 tests1.00 flask4 x 96-well plate

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#32790728   2020/08/13 To Up

Hypovascular tumors developed into hepatocellular carcinoma at a high rate despite the elimination of hepatitis C virus by direct-acting antivirals.

Direct-acting antivirals (DAAs) against hepatitis C virus (HCV) exert high anti-HCV activity and are expected to show anti-inflammatory effects associated with HCV elimination. Furthermore, hepatocellular carcinoma (HCC) is known to dedifferentiate from hypovascular tumors, such as dysplastic nodules or well-differentiated HCC, to hypervascular tumors. We therefore explored whether or not DAAs can suppress the growth and hypervascularization of hypovascular tumors.
Kazuaki Tabu, Seiichi Mawatari, Kohei Oda, Kotaro Kumagai, Yukiko Inada, Hirofumi Uto, Akiko Saisyoji, Yasunari Hiramine, Masafumi Hashiguchi, Tsutomu Tamai, Takeshi Hori, Kunio Fujisaki, Dai Imanaka, Takeshi Kure, Ohki Taniyama, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kazuhiro Sakurai, Akihiro Moriuchi, Shuji Kanmura, Akio Ido

1363 related Products with: Hypovascular tumors developed into hepatocellular carcinoma at a high rate despite the elimination of hepatitis C virus by direct-acting antivirals.

100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized

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#32790706   2020/08/13 To Up

Differences in healthcare expenditure estimates according to statistical approach: A nationwide claims database study on patients with hepatocellular carcinoma.

Disease-associated healthcare expenditures are generally calculated using matched comparisons or regression-based analyses, but little is known about their differences in estimates. This aim of this study was to compare the differences between disease-associated healthcare expenditures estimated using these 2 methods.
Haruhisa Fukuda, Daisuke Sato, Kensuke Moriwaki, Haku Ishida

2423 related Products with: Differences in healthcare expenditure estimates according to statistical approach: A nationwide claims database study on patients with hepatocellular carcinoma.

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