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Identifying critical states of hepatocellular carcinoma based on landscape dynamic network biomarkers.

Hepatocellular carcinoma (HCC) is the major histological form of primary liver cancer. It has usually reached the disease state once the patient is diagnosed since there are no specific symptoms in the early stages of HCC. This fact increases the difficulty of curing HCC. Recently, quantities of evidence have shown that many mathematical methods (such as dynamic network biomarkers, DNB) can be used to detect critical states or tipping points of complex diseases. However, it is difficult to apply the DNB theory to the clinic since multiple samples are generally unavailable for individual patient. This paper constructs a novel method based on landscape dynamic network biomarkers (L-DNB), which aims to detect early warning signals from cirrhosis state to very advanced HCC state in individual patient. The selected dataset contains multiple samples for each HCC state. A score that indicates the disease characteristics is calculated for each sample by RNA-seq data, and several scores constitute a distribution in the same state. Quantifying the statistical characteristics of these distributions and determining that low-grade dysplastic and high-grade dysplastic are the critical states of HCC. These results can provide scientific advice for early warning indicators and optimal treatment time for HCC.

1846 related Products with: Identifying critical states of hepatocellular carcinoma based on landscape dynamic network biomarkers.

Hepatocellular carcinoma Liver hepatocellular carc Hepatocellular carcinoma Hepatocellular carcinoma Hepatocellular carcinoma Hepatocellular carcinoma Normal liver and hepatoce Hepatocellular carcinoma Hepatocellular carcinoma Liver cancer (hepatocellu Hepatocellular carcinoma Hepatocellular carcinoma

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Multifunctionality and cytotoxicity of a layered coordination polymer.

This work reports the synthesis and multifunctionality of 2D layered coordination polymers formulated as [Ln2(H3nmp)2]·xH2O (1, where Ln = Sm3+, Eu3+, Tb3+, Dy3+, Ho3+, Er3+ and Y3+) (x = 1 to 4). We describe detailed synthesis of the materials using various methods [typical hydrothermal reaction (HT), microwave-assisted synthesis (MWAS) and one-pot method (OP)], while discussing the various crystal morphologies which can be fine tuned by varying systematically the conditions. We further explore the multifunctionality of this material by studying its heterogeneous catalytic activity in the ring opening of styrene oxide, its photoluminescence behaviour and its cytotoxicity. A conversion of 88%/100% yield at 4 h/24 h reaction respectively, with excellent selectivity towards 2-methoxy-2-phenylethanol product (100%) was observed. Photoluminescence properties of the optically-active [Eu2(H3nmp)2]·xH2O (1Eu) and the mixed-lanthanide [(Gd0.95Eu0.5)2(H3nmp)2]·xH2O (1GdEu), on the other hand, show potential use for UV-to-visible light converters, with lifetimes of 2.31 ± 0.01 and 2.61 ± 0.01 ms at ambient temperature for 1Eu and 1GdEu samples. Preliminary cytotoxic studies showed no effects on metabolic activity of both in vitro human epithelial kidney (HK-2) and human hepatocellular carcinoma (HepG2) cell lines. A reduction of NR uptake was, however, observed indicating some cytotoxic effect on lysosomal activity.

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Combination of Probiotics and Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice.

Nonalcoholic fatty liver disease (NAFLD) increases the risk of hepatocellular carcinoma, which is currently the leading cause of obesity-related cancer deaths in middle-aged men.

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Application of Isothermal Nucleic Acid Signal Amplification in the Detection of Hepatocellular Carcinoma-Associated MicroRNA.

Hepatocellular carcinoma (HCC) is a common type of malignant tumor with high incidence and mortality, and is the third leading cause of cancer-related death in human. High-precision detection of tumor markers, such as microRNA (miRNA), is expected to contribute to the early diagnosis of HCC as well as improve the survival rate of HCC patients. In recent years, great effort has been made to develop different methods to detect HCC-associated miRNA, in which signal amplification strategies are incorporated to realize high sensitivity. Among them, isothermal nucleic acid signal amplification is an emerging signal amplification technology which has the advantages of high amplification efficiency, good reproducibility, and easy operation for real-time analysis. Herein, we provide an overview of the advances in the application of isothermal nucleic acid signal amplification in HCC-associated miRNA detection by highlighting several representative works in recent years.

1582 related Products with: Application of Isothermal Nucleic Acid Signal Amplification in the Detection of Hepatocellular Carcinoma-Associated MicroRNA.

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Application of new ultrasound techniques for focal liver lesions.

Ultrasonography (US) has the overwhelming advantages of not entailing radiation exposure and being a noninvasive, real-time, convenient, easy-to-perform, and relatively inexpensive imaging modality. It is used as the first-line imaging modality for screening, detection, and diagnosis of focal liver lesions (FLLs) [small hepatocellular carcinomas (HCCs), in particular]. However, with the increasing demand for accurate and early diagnosis of small HCCs, newer radiologic methods need to be explored to overcome certain limitations of US. For example, the imaging is easily negatively affected by the presence of gas, rib cage, and subcutaneous fat, and is insensitive for capturing the subtle but vital information on the blood flow. It was in response to this need that new promising technologies such as contrast-enhanced ultrasound and fusion imaging were introduced for the detection of liver lesions. This paper presents an overview of the epidemiology and mechanisms of the development of HCCs, with an emphasis on the application of US in the diagnosis and treatment of FLLs. The aim of this article is to provide the state-of-the-art developments in the imaging diagnosis of FLLs and evaluation of ablation treatment of early HCCs. By keeping abreast of these recent advances, we hope that doctors and researchers working in the field of diagnosis/treatment of liver diseases will be able to discriminate benign FLLs such as regenerative nodules and focal nodular hyperplasia from HCCs, so as to avoid unnecessary repeated tumor biopsies and overtreatment. In particular, we expect that small HCCs or precancerous nodules (such as dysplastic nodules) can be accurately diagnosed and appropriately treated even at an early stage.

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Single-excited double-emission [email protected] quantum dots for use in a fluorometric hybridization assay for multiple tumor-related microRNAs.

A method is described for the simultaneous determination of hepatocellular carcinoma-associated microRNA-122 and microRNA-199a/b-3p. This probe consists of two kinds of nanomaterials. The first comprises [email protected] core-shell quantum dots which, on excitation at 375 nm give two emissions, with peak wavelengths at 543 (g-QDs) and at 627 nm (r-QDs). The second comprises gold nanoparticles acting as a quencher. In the absence of the target, g-QD-N1 and r-QD-N2 are stable due to the fluorescence stability. With the addition of microRNA-122 and microRNA-199a/b-3p, g-QD-N1 and r-QD-N2 are conjugated to the surface of AuNP-S1/S2 through base complementary pairing. As a result, fluorescence resonance energy transfer (FRET) occurs, resulting in a decrease at 550 nm and 635 nm respectively, which can realize the simultaneous detection of two different microRNAs. Detection is achieved within 50 min. The detection limits (3σ/k) are 0.2 nM for microRNA-122 and 0.5 nM for microRNA-199a/b-3p. The clinical applicability of the assay was demonstrated by detecting microRNAs in human serum and different cell lysates. Graphical abstractSchematic for the simultaneous determination of microRNA-122 and microRNA-199a/b-3p by FRET.

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Is hepatic resection better than transarterial chemoembolization in hepatocellular carcinoma with portal vein tumor thrombosis?

The management of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) remains controversial. We compared the outcomes of hepatic resection (HR) and transarterial chemoembolization (TACE).

1275 related Products with: Is hepatic resection better than transarterial chemoembolization in hepatocellular carcinoma with portal vein tumor thrombosis?

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Preoperative elevated plasma fibrinogen level predicts tumor recurrence and poor prognosis in patients with hepatocellular carcinoma.

Elevated plasma fibrinogen has been reported to be associated with poor prognosis in several cancers. The aim of present study was to investigate the prognostic value of preoperative plasma fibrinogen in hepatocellular carcinoma (HCC) patients.

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Hepatocellular carcinoma Normal liver and hepatoce Hepatocellular carcinoma Hepatocellular carcinoma Liver hepatocellular carc Liver cancer (hepatocellu Hepatocellular carcinoma High density (188 cases 2 Kidney tumor tissue array Multiple organ tumor and Cancer Samples: Cervix C Skin squamous cell carcin

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Increased expression of osteopontin indicates poor prognosis in hepatocellular carcinoma.

To investigate the potential prognostic value of osteopontin (OPN) in hepatocellular carcinoma (HCC) patients after hepatectomy.

2013 related Products with: Increased expression of osteopontin indicates poor prognosis in hepatocellular carcinoma.

Liver cancer (hepatocellu Hepatocellular carcinoma Liver hepatocellular carc Hepatocellular carcinoma Hepatocellular carcinoma Normal liver and hepatoce Hepatocellular carcinoma Breast invasive ductal ca Liver carcinoma and norma Hepatocellular carcinoma Colon carcinoma tissue ar pCAMBIA0105.1R Vector, (G

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