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#36725743 2023/02/01 To Up
Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells.Mast cells utilize SNAREs (soluble-N-ethyl-maleimide sensitive factor attachment protein receptors) and SM (Sec1/Munc18) proteins to secrete/exocytose a variety of proinflammatory mediators. However, whether a common SNARE-SM machinery is responsible remains unclear.
Pratikshya Adhikari, Tolulope E Ayo, John C Vines, Shuzo Sugita, Hao Xu
2721 related Products with: Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells.0.1ml (1mg/ml)10 assays10 assays96 tests- 0.1 mg 100ug100ml500 rxns 100 TESTS
#36724975 // To Up
Promoting Activity of Terpenes on Skin Permeation of Famotidine.Famotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion cell, and skin permeation experiment of FMT hydrogel was carried out. The results suggested that the thermodynamic activity influenced the permeability of the drug, and the main mechanism of terpenes to enhance skin permeation of the drug was based on increasing the fluidity of the intercellular lipids. Moreover, it was revealed that l-menthol simultaneously relaxed the packing structure and lamellar structure, whereas geraniol had a great influence on the lamellar structure only. Collectively, all terpenes had a promoting effect on skin permeation of FMT, indicating their potential as chemical enhancers to change the microstructure of stratum corneum and improve the permeation of FMT through the skin, and it has great potential to be used in transdermal formulations of FMT.
Qihui Xu, Yifan Wu, Hiroki Saito, Yuki Ofuchi, Haruna Setoyama, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi, Yasuko Obata