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Search results for: Human Insulin ELISA Kit

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#32761879   2020/08/06 To Up

Opposite Association of Adropin Concentrations with Obesity in Prepubertal Children Compared with Adolescents.

The aim of this study was to evaluate the association between obesity and plasma adropin levels in two cohorts of children at two different ages.
Leticia Herrero, Olaya de Dios, Teresa Gavela-Pérez, Pía Riestra, Asha Jois, Leandro Soriano-Guillén, Carmen Garcés

2326 related Products with: Opposite Association of Adropin Concentrations with Obesity in Prepubertal Children Compared with Adolescents.

4 Arrays/Slide4 Membranes/BoxInhibitor100 μg96/kit100 μg10 mg50 ug 100 μg

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#32479251   2020/06/01 To Up

Positive Correlation between Circulating Fetuin A and Severity of Coronary Artery Disease in Men

Fetuin-A serves a dual function; its high levels are associated with metabolic syndrome, type 2 diabetes, obesity, insulin resistance, and nonalcoholic fatty liver disease, and on the other hand, it serves as a potent inhibitor of ectopic vascular calcification. Due to the opposing findings, the aim of the current study was to investigate serum fetuin-A levels in men with coronary artery disease (CAD).
Reza Afrisham, Maliheh Paknejad, Davod Ilbeigi, Sahar Sadegh-Nejadi, Sattar Gorgani-Firuzjaee, Mahmoud Vahidi

1903 related Products with: Positive Correlation between Circulating Fetuin A and Severity of Coronary Artery Disease in Men

500 tests1.00 flask500 tests96 tests1-99 mg/ml/ea price x 2

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#32322309   2020/04/15 To Up

Effect of circulating exosomes derived from normal-weight and obese women on gluconeogenesis, glycogenesis, lipogenesis and secretion of FGF21 and fetuin A in HepG2 cells.

It is generally accepted that obesity can lead to metabolic disorders such as NAFLD and insulin resistance. However, the underlying mechanism has been poorly understood. Moreover, there is evidence to support the possible role of exosomes in the metabolic homeostasis regulation. Accordingly, we aimed to determine the effect of plasma circulating exosomes derived from obese and normal-weight women on insulin signaling and the secretion of hepatokines in human liver cells.
Reza Afrisham, Sahar Sadegh-Nejadi, Reza Meshkani, Solaleh Emamgholipour, Maliheh Paknejad

2802 related Products with: Effect of circulating exosomes derived from normal-weight and obese women on gluconeogenesis, glycogenesis, lipogenesis and secretion of FGF21 and fetuin A in HepG2 cells.

200 1,000 tests1 mg100ug1000 tests1 ml100 mg96 assays25 mg100ul10 mg

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#32275937   2020/04/08 To Up

Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover.

This study was conducted to determine the relationship between mesencephalic astrocyte-derived neurotrophic factor (MANF), autophagy and endoplasmic reticulum (ER) stress, and whether liraglutide (LRG) can protect β cells, promote autophagy and alleviate ER stress by regulating MANF expression.
Jili Fu, Kija Malale Nchambi, Hao Wu, Xie Luo, Xizhou An, Dongfang Liu

2102 related Products with: Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover.

100ul0.25 mL1.00 flask100 extractions96 tests1.00 flask250 25UG1 kit(96 Wells)100 2.00 flask1 mg

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#31979994   2020/01/24 To Up

Effects of concurrent training on irisin and fibronectin type-III domain containing 5 (FNDC5) expression in visceral adipose tissue in type-2 diabetic rats.

Evidence suggests that myokines could have clinical implications for metabolic diseases such as type-2 diabetes. We investigated the effects of concurrent training (CT) on irisin and fibronectin type-III domain containing five (FNDC5) expressions in visceral adipose tissue (VAT) in type-2 diabetic rats. Eighteen male Wistar rats (ages four to eight weeks) became diabetic using nicotinamide and streptozotocin and were assigned to either a control (CON) or a CT group using a randomised block design. The CT group exercised on a motor-driven treadmill at 60 to 75 per cent of VO (0% grade) for 10-40 min/day (aerobic training) and performed 10 climbs on a 1-meter ladder utilising weighted resistance of 30-100% of body mass (resistance exercise) for 5 days/week over 8 weeks. Forty-eight hours after the last training session, the VAT of rats was removed and washed. FNDC5-relative gene expression and irisin were measured by the reverse transcription polymerase chain reaction (RT-PCR) method and enzyme-linked immunosorbent assay (ELISA) kit. Additionally, insulin resistance and plasma insulin and glucose levels were determined. Our findings revealed that CT significantly increased FNDC5-relative gene expression in the VAT of type-2 diabetic rats compared to controls. Furthermore, eight weeks of CT improved insulin resistance and insulin and glucose levels but did not significantly alter irisin levels in type-2 diabetic rats. The results of this study demonstrated that CT increased FNDC5 mRNA and improved insulin resistance, insulin, and glucose levels. Also observed were increased trends (non-significant,  = .051) in irisin levels. Hence, CT may play a role in attenuating metabolic disorders such as obesity and type-2 diabetes.
Ahmad Abdi, Javad Mehrabani, Michael Nordvall, Alexei Wong, Abbas Fallah, Reza Bagheri

1149 related Products with: Effects of concurrent training on irisin and fibronectin type-III domain containing 5 (FNDC5) expression in visceral adipose tissue in type-2 diabetic rats.

50ul96 wells (1 kit)50 10 96tests96 wells (1 kit)96T96T10

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#31930835   // To Up

FICK-3 Score Combining Fibrosis-4, Insulin Resistance and Cytokeratin-18 in Predicting Non-alcoholic Steatohepatitis in NAFLD Egyptian Patients.

As liver biopsy had multiple procedure-related complications, the introduction of reliable noninvasive tests for accurate discrimination of NASH and liver fibrosis in patients with NAFLD are mandatory. The aim was to elucidate the diagnostic value of fibrosis-4 index (FIB-4), Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and Cytokeratin-18 fragments (CK18-Fs) in the prediction of NASH and liver fibrosis.
Mohammed Amin Mohammed, Nesreen Moustafa Omar, Soad Amin Mohammed, Ahmed Mohammed Amin, Doaa Farouk Gad

1492 related Products with: FICK-3 Score Combining Fibrosis-4, Insulin Resistance and Cytokeratin-18 in Predicting Non-alcoholic Steatohepatitis in NAFLD Egyptian Patients.

100ug Lyophilized100ug1 g100ug200ul100ug100 1 mg100ug Lyophilized250ul100ug200

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#31841752   2019/12/13 To Up

Long non-coding RNA SNHG16 promotes lipopolysaccharides-induced acute pneumonia in A549 cells via targeting miR-370-3p/IGF2 axis.

Pneumonia is an infectious lung inflammation in children with high mortality and morbidity rates. Small nucleolar RNA host gene 16 (SNHG16) has been verified to accelerate the progression of acute pneumonia. However, the role of SNHG16 in acute pneumonia has not yet been fully elucidated. The study was aimed to explore the regulatory mechanism of SNHG16 in LPS-induced acute pneumonia in A549 cells.
Ju Zhang, Fengxia Mao, Gai Zhao, Haixia Wang, Xiaomin Yan, Qian Zhang

1174 related Products with: Long non-coding RNA SNHG16 promotes lipopolysaccharides-induced acute pneumonia in A549 cells via targeting miR-370-3p/IGF2 axis.

1x10e7 cells400 ug50 ulOne Vial: 5 X 10^6 Cells100ug1 vial100 μg100 µg1.00 flask1 mg

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#31756289   2019/12/24 To Up

Increased diagnosis of autoimmune childhood-onset Japanese type 1 diabetes using a new glutamic acid decarboxylase antibody enzyme-linked immunosorbent assay kit, compared with a previously used glutamic acid decarboxylase antibody radioimmunoassay kit.

We compared the results of testing for glutamic acid decarboxylase antibodies (GADAb) using a radioimmunoassay (RIA) and an enzyme-linked immunosorbent assay (ELISA) in individuals with childhood-onset type 1 diabetes mellitus.
Shigetaka Sugihara, Ichiro Yokota, Tokuo Mukai, Takahiro Mochizuki, Masashi Nakayama, Emiko Tachikawa, Yasumasa Kawada, Kinship Minamitani, Nobuyuki Kikuchi, Tatsuhiko Urakami, Tomoyuki Kawamura, Eiji Kawasaki, Toru Kikuchi, Shin Amemiya,

2445 related Products with: Increased diagnosis of autoimmune childhood-onset Japanese type 1 diabetes using a new glutamic acid decarboxylase antibody enzyme-linked immunosorbent assay kit, compared with a previously used glutamic acid decarboxylase antibody radioimmunoassay kit.

100 μl100μg100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized1 kit

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#31594568   2019/09/09 To Up

Reflectance aptasensor based on metal salphen label for rapid and facile determination of insulin.

An optical aptasensor-based sensing platform for rapid insulin detection was fabricated. Aminated porous silica microparticles (PSiMPs) were synthesized via a facile mini-emulsion method to provide large surface area for covalent immobilization of insulin-binding DNA aptamer (IGA3) by glutaraldehyde cross-linking protocol. A Nickel-salphen type complex with piperidine side chain [Ni(II)-SP] was synthesized with a simple one-pot reaction, and functionalized as an optical label due to strong π-π interaction between aromatic carbons of G-quadruplex DNA aptamer and planar aromatic groups of Ni(II)-SP to form the immobilized IGA3-Ni(II)-SP complex, i.e. the dye-labeled aptamer, thereby bringing yellow colouration to the immobilized G-quartet plane. Optical characterization of aptasensor towards insulin binding was carried out with a fiber optic reflectance spectrophotometer. The maximum reflectance intensity of the immobilized IGA3-Ni(II)-SP complex at 656 nm decreased upon binding with insulin as aptasensor changed to brownish orange colouration in the background. This allows optical detection of insulin as the colour change of aptasensor is dependent on the insulin concentration. The linear detection range of the aptasensor is obtained from 10 to 50 μIU mL (R = 0.9757), which conformed to the normal fasting insulin levels in human with a limit of detection (LOD) at 3.71 μIU mL. The aptasensor showed fast response time of 40 min and long shelf life stability of >3 weeks. Insulin detection using healthy human serums with informed consent provided by participants suggests the DNA aptamer biosensor was in good agreement with ELISA standard method using BIOMATIK Human INS (Insulin) ELISA Kit.
Mahirah Taib, Ling Ling Tan, Nurul Huda Abd Karim, Goh Choo Ta, Lee Yook Heng, Bahariah Khalid

1494 related Products with: Reflectance aptasensor based on metal salphen label for rapid and facile determination of insulin.

400Tests100μg100tests100μg100Tests1 x 96100μg1 x 9625 1.0mg

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#31560471   // To Up

Relationship of adiponectin, leptin, visfatin and IGF-1 in cow's venous blood and venous cord blood with calf birth weight.

The Intrauterine fetal development process is complicated and affected by many regulating factors such as maternal nutritional status, transcription factors and adipokines. Adipokines are kinds of active substances secreted by adipose tissue, including more than 50 kinds of molecules. To explore the correlation between calf birth weights and adipokines including adiponectin, leptin, visfatin, and IGF-1 in cows venous and venous cord blood. Fifty-four healthy multiparous Chinese Holstein cows were used; in which, cows with a calf weight less than 40 kg were included in group A (n=9); those with a calf weight between 40 kg~45 kg were included in group B (n=25) and ≥45 kg were included in group C (n=20), venous blood and cord venous blood was collected. An ELISA kit was used to evaluate the concentration of adiponectin, leptin, visfatin, and IGF-1, correlations between index-index and index-calf birth weight were analysed. In both cows venous and cord venous blood, adiponectin, leptin, visfatin, and IGF-1 levels were significantly correlated with each other (p⟨0.01), and levels of these adipokines in venous blood were significantly higher than cord venous blood (p⟨0.01). Adiponectin, leptin, visfatin, and IGF-1 in venous cord blood were positively correlated with calf birth weights, and significantly correlated with calf birth weights respectively (p⟨0.01). Our study showed that adiponectin, leptin, and IGF-1 were found in venous blood and cord venous blood, and adiponectin, leptin, and IGF-1 in venous and cord venous blood potentially inter-regulated each other; adiponectin, leptin, and IGF-1 in venous blood were not significantly correlated with calf birth weights, while adiponectin, leptin, visfatin, and IGF-1 in venous cord blood were significantly correlated with calf birth weights, respectively.
L Shen, Y Zhu, J Xiao, J Deng, G Peng, Z Zuo, S Yu, X Ma, Z Zhong, Z Ren, Z Zhou, H Liu, X Zong, S Cao

1360 related Products with: Relationship of adiponectin, leptin, visfatin and IGF-1 in cow's venous blood and venous cord blood with calf birth weight.

15ml100ug1000ml10x96 blood spots

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