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#39392675 
2024/10/11
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Intervention for the Management of Neuropsychiatric Symptoms to Reduce Caregiver Stress: Protocol for the Mindful and Self-Compassion Care Intervention for Caregivers of Persons Living With Dementia.
Stress related to Alzheimer disease and related dementias (ADRD) is common, particularly among those who care for persons with challenging behaviors and personality or mood changes. Mindfulness and self-compassion programs are efficacious for managing stress. The skills of mindfulness and self-compassion, however, must be integrated with behavioral management skills in order to effectively improve caregiver stress.Aniyah Travis, Arden O'Donnell, Natalia Giraldo-Santiago, Sarah M Stone, Daniel Torres, Shelley R Adler, Ana-Maria Vranceanu, Christine S Ritchie
1360 related Products with: Intervention for the Management of Neuropsychiatric Symptoms to Reduce Caregiver Stress: Protocol for the Mindful and Self-Compassion Care Intervention for Caregivers of Persons Living With Dementia.
1 G1 LITRE 100ul100 ug250 mg0.1ml (1mg/ml) 1L500 MG25 µg
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#39392674 //
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Microbiome-derived metabolite effects on intestinal barrier integrity and immune cell response to infection.
The gut microbiota exerts a significant influence on human health and disease. While compositional changes in the gut microbiota in specific diseases can easily be determined, we lack a detailed mechanistic understanding of how these changes exert effects at the cellular level. However, the putative local and systemic effects on human physiology that are attributed to the gut microbiota are clearly being mediated through molecular communication. Here, we determined the effects of gut microbiome-derived metabolites l-tryptophan, butyrate, trimethylamine (TMA), 3-methyl-4-(trimethylammonio)butanoate (3,4-TMAB), 4-(trimethylammonio)pentanoate (4-TMAP), ursodeoxycholic acid (UDCA), glycocholic acid (GCA) and benzoate on the first line of defence in the gut. Using models of intestinal barrier integrity and studying the interaction of macrophages with pathogenic and non-pathogenic bacteria, we could ascertain the influence of these metabolites at the cellular level at physiologically relevant concentrations. Nearly all metabolites exerted positive effects on barrier function, but butyrate prevented a reduction in transepithelial resistance in the presence of the pathogen , despite inducing increased apoptosis and exerting increased cytotoxicity. Induction of IL-8 was unaffected by all metabolites, but GCA stimulated increased intra-macrophage growth of and tumour necrosis-alpha (TNF-α) release. Butyrate, 3,4-TMAB and benzoate all increased TNF-α release independent of bacterial replication. These findings reiterate the complexity of understanding microbiome effects on host physiology and underline that microbiome metabolites are crucial mediators of barrier function and the innate response to infection. Understanding these metabolites at the cellular level will allow us to move towards a better mechanistic understanding of microbiome influence over host physiology, a crucial step in advancing microbiome research.Lauren Adams, Xiang Li, Richard Burchmore, Richard J A Goodwin, Daniel M Wall
2591 related Products with: Microbiome-derived metabolite effects on intestinal barrier integrity and immune cell response to infection.
100ul4 x 96-well plate96 assays100 extractions2ug12ug500 gm.1.00 flask1.00 flask
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#39392671 2024/10/14
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Nursing students' experience of a transformative approach to teaching cross cultural clinical decision making.
This study reveals the learning gained by Canadian and Rwandan nursing students from a course to enhance cross cultural clinical decision-making skills using a collaborative approach across two countries.Carole A Orchard, Marilyn K Evans, Germaine Tuyisenge, Sibylle Ugirase, Yvonne Kasine, Benoite Umubyeyi, Pauline Uwajeneza
1831 related Products with: Nursing students' experience of a transformative approach to teaching cross cultural clinical decision making.
1 kit1 g1 kit1 mL
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#39392670 2024/06/22
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Dynamic changes in aromas and precursors of edible fungi juice: mixed lactic acid bacteria fermentation enhances flavor characteristics.
Lactic acid bacteria (LAB) fermentation technology has been increasingly used in the deep processing of edible fungi. However, the flavor profiles of edible fungi products after mixed LAB fermentation have received less attention and how aromas changes during the mixed LAB fermentation are still open questions. In the present study, fermented Hericium erinaceus and Tremella fuciformis compound juice (FHTJ) was prepared by mixed LAB strains. We aimed to systematically monitor the dynamic changes of aromas and precursors throughout the fermentation process and a data-driven association network analysis was used to tentatively illustrate the mechanisms of formation between aromas and their precursors.Hailan Sun, Jiaxin Du, Xingyue Yan, Xiao Chen, Liyan Zhao
1487 related Products with: Dynamic changes in aromas and precursors of edible fungi juice: mixed lactic acid bacteria fermentation enhances flavor characteristics.
1 G100ug Lyophilized100ug Lyophilized 1 G25 mg96tests 5 G100tests10 mg100ug 1 G
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Kongresskalender 2024.
1074 related Products with: Kongresskalender 2024.
100 G
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#39392667 2024/10/11
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Knot data analysis using multiscale Gauss link integral.
In the past decade, topological data analysis has emerged as a powerful algebraic topology approach in data science. Although knot theory and related subjects are a focus of study in mathematics, their success in practical applications is quite limited due to the lack of localization and quantization. We address these challenges by introducing knot data analysis (KDA), a paradigm that incorporates curve segmentation and multiscale analysis into the Gauss link integral. The resulting multiscale Gauss link integral (mGLI) recovers the global topological properties of knots and links at an appropriate scale and offers a multiscale geometric topology approach to capture the local structures and connectivities in data. By integration with machine learning or deep learning, the proposed mGLI significantly outperforms other state-of-the-art methods across various benchmark problems in 13 intricately complex biological datasets, including protein flexibility analysis, protein-ligand interactions, human Ether-à-go-go-Related Gene potassium channel blockade screening, and quantitative toxicity assessment. Our KDA opens a research area-knot deep learning-in data science.Li Shen, Hongsong Feng, Fengling Li, Fengchun Lei, Jie Wu, Guo-Wei Wei
2069 related Products with: Knot data analysis using multiscale Gauss link integral.
1 module 100ul1 module 15 ml 1 module1 module 5 G
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#39392665 2024/10/11
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Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells.
Tumors can induce systemic disturbances in distant organs, leading to physiological changes that enhance host morbidity. In Drosophila cancer models, tumors have been known for decades to cause hypervolemic "bloating" of the abdominal cavity. Here we use allograft and transgenic tumors to show that hosts display fluid retention associated with autonomously defective secretory capacity of fly renal tubules, which function analogous to those of the human kidney. Excretion from these organs is blocked by abnormal cells that originate from inappropriate activation of normally quiescent renal stem cells (RSCs). Blockage is initiated by IL-6-like oncokines that perturb renal water-transporting cells and trigger a damage response in RSCs that proceeds pathologically. Thus, a chronic inflammatory state produced by the tumor causes paraneoplastic fluid dysregulation by altering cellular homeostasis of host renal units.Sze Hang Kwok, Yuejiang Liu, David Bilder, Jung Kim
1982 related Products with: Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells.
1 mg10 ug
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#39392661 2024/06/22
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A novel cellobiose 2-epimerase from anaerobic halophilic Iocasia fonsfrigidae and its ability to convert lactose in fresh goat milk into epilactose.
Cellobiose 2-epimerase (CE) has received great attention due to its potential applications in the food and pharmaceutical industries. In this study, a novel CE from mesophilic anaerobic halophilic bacterium Iocasia fonsfrigidae strain SP3-1 (IfCE) was successfully expressed in Escherichia coli and characterized.Sokhoeun Eat, Shinta Wulansari, Prattana Ketbot, Rattiya Waeonukul, Patthra Pason, Ayaka Uke, Akihiko Kosugi, Khanok Ratanakhanokchai, Chakrit Tachaapaikoon
1595 related Products with: A novel cellobiose 2-epimerase from anaerobic halophilic Iocasia fonsfrigidae and its ability to convert lactose in fresh goat milk into epilactose.
100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 100 μg100 μg100 μg100 μg
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#39392653 2024/06/22
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Simultaneous determination of semi-essential nutrients taurine, l-carnitine and choline in infant formulas and adult/pediatric nutritional formulas by hydrophilic interaction liquid chromatography-electrospray ionization-tandem mass spectrometry.
The nutritional intake of formula-fed newborns is often limited to a single source, so it must be supplemented with essential nutrients for the growth and proper development of infants. Taurine, l-carnitine, and choline are considered conditionally essential nutrients especially in newborns and infants.Myriam Bustamante-Rangel, Encarnación Rodríguez-Gonzalo, José Luis Pérez-Pavón