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#34118794   2021/06/14 To Up

Urinary bisphenol A in women with polycystic ovary syndrome - a possible suppressive effect on steroidogenesis?

There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Second aim was to assess the relationship of U-BPA to ovarian steroidogenesis in the group with PCOS.
Zora Lazúrová, Jana Figurová, Beáta Hubková, Jana Mašlanková, Ivica Lazúrová

2990 related Products with: Urinary bisphenol A in women with polycystic ovary syndrome - a possible suppressive effect on steroidogenesis?

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#34118792   2021/06/11 To Up

Physiological and pathological functions of βB2-crystallins in multiple organs: a systematic review.

Crystallins, the major constituent proteins of mammalian lenses, are significant not only for the maintenance of eye lens stability, transparency, and refraction, but also fulfill various physiopathological functions in extraocular tissues. βB2-crystallin, for example, is a multifunctional protein expressed in the human retina, brain, testis, ovary, and multiple tumors. Mutations in the βB2 crystallin gene or denaturation of βB2-crystallin protein are associated with cataracts, ocular pathologies, and psychiatric disorders. A prominent role for βB2-crystallins in axonal growth and regeneration, as well as in dendritic outgrowth, has been demonstrated after optic nerve injury. Studies in βB2-crystallin-null mice revealed morphological and functional abnormalities in testis and ovaries, indicating βB2-crystallin contributes to male and female fertility in mice. Interestingly, although pathogenic significance remains obscure, several studies identified a clear correlation between βB2 crystallin expression and the prognosis of patients with breast cancer, colorectal cancer, prostate cancer, renal cell carcinoma, and glioblastoma in the African American population. This review summarizes the physiological and pathological functions of βB2-crystallin in the eye and other organs and tissues and discusses findings related to the expression and potential role of βB2-crystallin in tumors.
Meihui Li, Shengnan Liu, Wei Huang, Junjie Zhang

1307 related Products with: Physiological and pathological functions of βB2-crystallins in multiple organs: a systematic review.



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#34118764   2021/05/27 To Up

Postexercise hypotension due to resistance exercise is not mediated by autonomic control: A systematic review and meta-analysis.

Changes in autonomic control have been suggested to mediate postexercise hypotension (PEH). We investigated through meta-analysis the after-effects of acute resistance exercise (RE) on blood pressure (BP) and autonomic activity in individuals with normal and elevated BP. Electronic databases were searched for trials including: adults; exclusive RE interventions; and BP and autonomic outcomes measured pre- and postintervention for at least 30 min. Analyses incorporated random-effects assumptions. Thirty trials yielded 62 interventions (N = 480). Subjects were young (33.6 ± 15.6 yr), with systolic BP (SBP)/diastolic BP (DBP) of 124.2 ± 8.9/71.5 ± 6.6 mm Hg. Overall, RE moderately reduced SBP (normal BP: ~1 to 4 mm Hg, p < 0.01; elevated BP: ~1 to 12 mm Hg, p < 0.01) and DBP (normal BP: ~1 to 4 mm Hg, p < 0.03; elevated BP: ~0.5 to 7 mm Hg, p < 0.01), which was in general parallel to sympathetic increase (normal BP: g = 0.49 to 0.51, p < 0.01; elevated BP: g = 0.41 to 0.63, p < 0.01) and parasympathetic decrease (normal BP: g = -0.52 to -0.53, p < 0.01; elevated BP: g = -0.46 to -0.71, p < 0.01). The meta-regression showed inverse associations between the effect sizes of BP vs. sympathetic (SBP: slope - 0.19 to -3.45, p < 0.01; DBP: slope - 0.30 to -1.60, p < 0.01), and direct associations vs. parasympathetic outcomes (SBP: slope 0.17 to 2.59, p < 0.01; DBP: slope 0.21 to 1.38, p < 0.01). In conclusion, changes in BP were concomitant to sympathetic increase and parasympathetic decrease, which questions the role of autonomic fluctuations as potential mechanisms of PEH after RE.
Paulo Farinatti, Marcos D Polito, Renato Massaferri, Walace D Monteiro, Denilson Vasconcelos, Blair T Johnson, Linda S Pescatello

1483 related Products with: Postexercise hypotension due to resistance exercise is not mediated by autonomic control: A systematic review and meta-analysis.

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#34118760   2021/06/05 To Up

Highly permselective uric acid detection using kidney cell membrane-functionalized enzymatic biosensors.

Abnormal blood uric acid (UA) levels can lead to its crystallization in the joints, consequently resulting in gout. Accurate detection of UA in the blood is imperative for the early diagnosis of gout. However, electrochemical UA biosensors are vulnerable to antioxidants in the blood, limiting accurate UA detection. To address this issue, we focused on the function of uric acid transporter 1 (URAT1), which is selectively permeable to UA. URAT1 is abundant in the kidney cell membrane (KCM). To apply URAT1 to a sensor, we developed a KCM-coated UA biosensor (called the KCM sensor) that could selectively detect UA through URAT1. The KCM coating in the fabricated KCM sensor was verified via scanning electron microscopy, atomic force microscopy, and confocal microscopy. The KCM sensor enabled the detection of UA in the range of 0-1000 μM, with a limit of detection of 8.5 μM, suggesting that it allows the diagnosis of the early stages of gout. On the other hand, the UA permeability of the KCM sensor was significantly reduced in the presence of a URAT1 inhibitor, implying that URAT1 is a key factor for UA detection. The selectivity of the KCM sensor was demonstrated by measuring the amount for UA in the presence of various antioxidants. Finally, the KCM sensor was capable of measuring UA in human serum and was reproducible with 0.5-1.6% deviation. The UA permeability and selectivity of the KCM sensor were maintained even after 3 weeks of storage.
Insu Kim, Young Im Kim, Sang Won Lee, Hyo Gi Jung, Gyudo Lee, Dae Sung Yoon

2249 related Products with: Highly permselective uric acid detection using kidney cell membrane-functionalized enzymatic biosensors.

4 Membranes/Box100tests 25 G4 Membranes/Box4 Membranes/Box430 Tests / Kit4 Membranes/Box4 Membranes/Box1.00 flask

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#34118758   2021/06/07 To Up

Impact of environmental chemicals on craniofacial skeletal development: Insights from investigations using zebrafish embryos.

Craniofacial skeletal anomalies are among the most common structural birth defects around the world. Various studies using human populations and experimental animals have shown that genetic and environmental factors play significant roles in the causation and progression of these anomalies. Environmental factors, such as teratogens and toxin mixtures, induce craniofacial anomalies are gaining heightened attention. Among experimental investigations, the use of the zebrafish (Danio rerio) has been increasing. A major reason for the increased use is that the zebrafish boast a simple craniofacial structure, and facial morphogenesis is readily observed due to external fertilization and transparent embryo, making it a valuable platform to screen and identify environmental factors involved in the etiology of craniofacial skeletal malformation. This review provides an update on harmful effects from exposure to environmental chemicals, involving metallic elements, nanoparticles, persistent organic pollutants, pesticides and pharmaceutical formulations on craniofacial skeletal development in zebrafish embryos. The collected data provide a better understanding for induction of craniofacial skeletal anomalies and for development of better prevention strategies.
Wenlong Huang, Tianjie Wu, William W Au, Kusheng Wu

2902 related Products with: Impact of environmental chemicals on craniofacial skeletal development: Insights from investigations using zebrafish embryos.

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#34118750   2021/05/17 To Up

The time course of speaker-specific language processing.

Listeners are sensitive to a speaker's individual language use and generate expectations for particular speakers. It is unclear, however, how such expectations affect online language processing. In the present EEG study, we presented thirty-two participants with auditory sentence stimuli of two speakers. Speakers differed in their use of two particular syntactic structures, easy subject-initial SOV structures and more difficult object-initial OSV structures. One speaker, the SOV-Speaker, had a high proportion of SOV sentences (75%) and a low proportion of OSV sentences (25%), and vice-versa for the OSV-Speaker. Participants were exposed to the speakers' individual language use in a training session followed by a test session on the consecutive day. ERP-results show that early stages of sentence processing are driven by syntactic processing only and are unaffected by speaker-specific expectations. In a late stage, however, an interaction between speaker and syntax information was observed. For the SOV-Speaker condition, the classical P600-effect reflected the effort of processing difficult and unexpected sentence structures. For the OSV-Speaker condition, both structures elicited different responses on frontal electrodes, possibly indexing effort to switch from a local speaker model to a global model of language use. Overall, the study identifies distinct neural mechanisms related to speaker-specific expectations.
Leon O H Kroczek, Thomas C Gunter

2693 related Products with: The time course of speaker-specific language processing.

2 Pieces/Box1 mg25 µg4 Membranes/Box100.00 ul2 Pieces/Box96 tests/kit 6 ml Ready-to-use 25

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#34118749   2021/05/25 To Up

MicroRNA-383-5p regulates osteogenic differentiation of human periodontal ligament stem cells by targeting histone deacetylase 9.

Human periodontal ligament stem cells (hPDLSCs) play an important role in regenerative engineering technology for periodontal therapy. The mechanism of microRNA (miR)-383-5p in osteogenic differentiation needs further exploration. This study aimed at investigating the potential role of miR-383-5p in the osteogenic differentiation of hPDLSCs.
Lan Ma, Di Wu

2583 related Products with: MicroRNA-383-5p regulates osteogenic differentiation of human periodontal ligament stem cells by targeting histone deacetylase 9.

5 x 50 ug1 mg10 ug24 wells50 ug11001.00 flask50ul1.00 flask0.5 ml 100ul

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#34118747   2021/06/09 To Up

Zinc oxide nanoparticles alleviates the adverse effects of cadmium stress on Oryza sativa via modulation of the photosynthesis and antioxidant defense system.

Cadmium (Cd) is a trace element causing severe toxicity symptoms in plants, besides posing hazardous fitness issue due to its buildup in the human body through food chain. Nanoparticles (NPs) are recently employed as a novel strategy to directly ameliorate the Cd stress and acted as nano-fertilizers. The intend of the current study was to explore the effects of zinc oxide nanoparticles (ZnO-NPs; 50 mg/L) on plant growth, photosynthetic activity, elemental status and antioxidant activity in Oryza sativa (rice) under Cd (0.8 mM) stress. To this end, the rice plants are treated by Cd stress at 15 days after sowing (DAS), and the treatment was given directly into the soil. Supply of ZnO-NPs as foliar spray was given for five consecutive days from 30 to 35 DAS, and sampling was done at 45 DAS. However, rice plants supplemented with ZnO-NPs under the Cd toxicity revealed significantly increased shoot length (SL; 34.0%), root fresh weight (RFW; 30.0%), shoot dry weight (SDW; 23.07%), and root dry weight (RDW; 12.24%). Moreover, the ZnO-NPs supplement has also positive effects on photosynthesis related parameters, SPAD value (40%), chloroplast structure, and qualitatively high fluorescence observed by confocal microscopy even under Cd stress. ZnO-NPs also substantially prevented the increases of hydrogen peroxide (HO) and malondialdehyde (MDA) triggered by Cd. Physiological and biochemical analysis showed that ZnO-NPs increased enzymatic activities of superoxide dismutase (SOD; 59%), catalase (CAT; 52%), and proline (17%) that metabolize reactive oxygen species (ROS); these increases coincided with the changes observed in the HO and MDA accumulation after ZnO-NPs application. In conclusion, ZnO-NPs application to foliage has great efficiency to improve biomass, photosynthesis, protein, antioxidant enzymes activity, mineral nutrient contents and reducing Cd levels in rice. This can be attributed mainly from reduced oxidative damage resulted due to the ZnO-NPs application.
Mohammad Faizan, Javaid Akhter Bhat, Kamel Hessini, Fangyuan Yu, Parvaiz Ahmad

2031 related Products with: Zinc oxide nanoparticles alleviates the adverse effects of cadmium stress on Oryza sativa via modulation of the photosynthesis and antioxidant defense system.

500 Units1 ml1mg112000 IU100.00 ul1500 Units

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#34118746   2021/06/04 To Up

Sampling rate influences the regularity analysis of temporal domain measures of walking more than spatial domain measures.

The spatiotemporal dynamics of stepping can provide useful information about walking performance. Most often, the identification of gait motion is performed using 3-D cinematography. The sampling rate of motion capture systems may influence the accuracy of these measures albeit in varying degrees for measures within the spatial versus temporal domain.
Farahnaz Fallahtafti, Shane R Wurdeman, Jennifer M Yentes

1041 related Products with: Sampling rate influences the regularity analysis of temporal domain measures of walking more than spatial domain measures.

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