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Extending the spectrum of CLRN1- and ABCA4-associated inherited retinal dystrophies caused by novel and recurrent variants using exome sequencing.Inherited retinal dystrophies (IRDs) are characterized by extreme genetic and clinical heterogeneity. There are many genes that are known to cause IRD which makes the identification of the underlying genetic causes quite challenging. And in view of the emergence of therapeutic options, it is essential to combine molecular and clinical data to correctly diagnose IRD patients. In this study, we aimed to identify the disease-causing variants (DCVs) in four consanguineous Jordanian families with IRDs and describe genotype-phenotype correlations.
2367 related Products with: Extending the spectrum of CLRN1- and ABCA4-associated inherited retinal dystrophies caused by novel and recurrent variants using exome sequencing.Epiandrosterone (3 beta H Androstane-3a,17b-diol Gl 4 Androstene 3,17 dione C Androgen Receptor (Ab 650 Androgen Receptor Antibod Androgen Receptor Antibod 5α-N-Acetyl-2'H-androst- Rabbit Anti-Rat Androgen Androsta-1,4,6-triene-3,1 1,4 Androstadiene 3,17 di ELISA 5α-Androstane-3α, ∆1-Androstene-3α,17β-
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Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii.The treatment of vitiligo includes the combination of psoralens and ultraviolet type A exposure. Psoralens belong to a group of natural furanocoumarins that cause the skin to become sensitive temporarily to ultraviolet type A. The aim of this study was to develop a physiologically based pharmacokinetic model of 5-MOP from to support psoralen and ultraviolet type A therapy. A study of rats was used to establish and validate rat tissue distribution. The same chemical-specific parameters used in the rat model were also employed in the human model to project human pharmacokinetics. The highest exposures in the rats were in the brain and skin. Following a single dose of 1.2 mg/kg 5-MOP in humans, the model predicted a maximum concentration of 20 ng/mL and an area under the curve of 125 ng.h/mL, matching clinical results. The half-maximum melanogenesis concentrations in B16F10 cells were 29.5, 18.5, 11.5, and 6.5 ng/mL for synthetic 5-MOP, synthetic 5-MOP with ultraviolet type A, alone, and plus ultraviolet type A, respectively. Physiologically based pharmacokinetic model prediction in humans supported a once-every-two-day regimen for optimal melanin production. This type of framework can be applied to support strategies for dose selection and to investigate the impact of drugs on melanocyte recovery.
1031 related Products with: Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii.MarkerGeneTM Fluorescent QuantiChrom™ LDH Cytoto Creatinine Assay Creatini MarkerGene™ Multiple Dr Human Phospho-EGFR (Activ Analysis Tool for AAH-INF Androgen Receptor (Ab 650 (5α)-2'H-Androst-2-eno[3 Clostridum difficile toxi Plant DNA Preparation Kit Mouse Anti-Clostridium bo Di p toluoyl L tartaric a
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Aqueous Root Extract from Ononis spinosa Exerts Anti-adhesive Activity against Uropathogenic Escherichia coli.Extracts from are traditionally used for urinary tract infections due to diuretic and anti-inflammatory activity. A potential influence on the virulence of uropathogenic has not been investigated until now. The following study aimed to investigate the influence of an aqueous extract on uropathogenic and uropathogenic host cell interaction. A hot water extract from the roots of ( extract) was characterized by LC-qTOF-MS. The influence of extract on the proliferation of uropathogenic UTI89 and on cell viability against human T24 bladder cells was investigated. Anti-adhesive activity of extract was assessed by flow cytometry, evaluating the adhesion of fluorescent-labelled UTI89 to T24 bladder cells. Internalization of uropathogenic into T24 cells was monitored by an invasion assay. extract was characterized by the presence of isoflavones, isoflavanones, licoagrosides, pterocarpans, tartaric acid derivatives, and saponines. extract had no influence on the proliferation of uropathogenic (125 - 1000 µg/mL) and did not influence the cell viability of T24 cells. Bacterial adhesion to T24 cells was significantly (p > 0.001) inhibited by extract in a concentration-dependent manner (125 - 1000 µg/mL) during coincubation. Preincubation of uropathogenic or T24 cells with extract reduced bacterial adhesion, but to a lower extent than during coincubation. Consequently, the reduced bacterial adhesion also leads to a reduced internalization of uropathogenic uropathogenic into the host cell. extract does not interact with FimH-mediated uropathogenic adhesion to host cells. From these data, the traditional use of extracts for urinary tract infections seems to be rationalized.
2310 related Products with: Aqueous Root Extract from Ononis spinosa Exerts Anti-adhesive Activity against Uropathogenic Escherichia coli.Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Goat Anti-Escherichia col Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Anti-mouse adenomatous po
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[Keratoplasty in Germany: Systematic Analysis of the Quality Reports of German Hospitals between 2006 and 2017].Keratoplasty is considered the most frequently performed type of transplantation in humans. Traditionally, penetrating keratoplasty has been the most common procedure. However, over the last 15 years, the importance of posterior lamellar keratoplasty has increased for the treatment of Fuchs endothelial dystrophy and bullous keratopathy. In Germany, based on national surveys, it was suggested that there was a trend towards lamellar keratoplasty.
2793 related Products with: [Keratoplasty in Germany: Systematic Analysis of the Quality Reports of German Hospitals between 2006 and 2017].Multiple organ tumor tiss FDA Standard Frozen Tissu Thermal Shaker with cooli FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu MultiGene Gradient therm Ofloxacin CAS Number [824 FDA Standard Frozen Tissu Apoptosis (Human) Antibod FGFR1 & PIK3R1 Protein Pr
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A reference library for assigning protein subcellular localizations by image-based machine learning.Confocal micrographs of EGFP fusion proteins localized at key cell organelles in murine and human cells were acquired for use as subcellular localization landmarks. For each of the respective 789,011 and 523,319 optically validated cell images, morphology and statistical features were measured. Machine learning algorithms using these features permit automated assignment of the localization of other proteins and dyes in both cell types with very high accuracy. Automated assignment of subcellular localizations for model tail-anchored proteins with randomly mutated C-terminal targeting sequences allowed the discovery of motifs responsible for targeting to mitochondria, endoplasmic reticulum, and the late secretory pathway. Analysis of directed mutants enabled refinement of these motifs and characterization of protein distributions in within cellular subcompartments.
2985 related Products with: A reference library for assigning protein subcellular localizations by image-based machine learning.Anti daf 2(Abnormal dauer NATIVE HUMAN PROLACTIN, P Bone Morphogenetic Protei NATIVE HUMAN PROLACTIN, P Anti-daf-2(Abnormal dauer MarkerGeneTM Fluorescent Anti-BMP-1 (Bone Morphoge Recombinant Human Inhibin MID1 interacting G12-like Recombinant Human ANXA1 P Rabbit Anti-14-3-3 family HSPB1 & EGFR Protein Prot
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Thioredoxin1 Inactivation Mediates the Impairment of Ischemia-Induced Angiogenesis and Further Injury in Diabetic Myocardium.Diabetes mellitus (DM)-induced impairment of collateral formation has been demonstrated in subjects with coronary artery disease, which contributes to unfavorable prognosis among diabetic individuals. In our previous studies, thioredoxin1 (Trx1) activity was shown to be decreased in diabetic cardiac tissues, but the reason of Trx1 inactivation and whether it mediates the impaired angiogenesis in ischemic myocardium is still to be identified. As thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of Trx, is overexpressed in DM due to carbohydrate response element within its promoter, we hypothesized that inhibition of Trx1 by enhanced TXNIP expression in endothelial cells may play a role in hyperglycemia-induced impairment of angiogenesis. In the present study, we found that high glucose-mediated increase of TXNIP expression and TXNIP-Trx1 interaction induced the impairment in endothelial cell function and survival, since these detrimental effects are rescued by silencing TXNIP with small interfering RNA. In diabetic mice, TXNIP knockdown or recombinant human Trx1 treatment counteracted the impairment of angiogenesis, alleviated myocardial ischemic injury, and improved survival rate. All these data implicate that TXNIP upregulation and subsequently the increased formation of TXNIP-Trx1 complex is a novel pathologic pathway by which DM induces insufficient angiogenesis and thereby exacerbates myocardial ischemia injury.
1823 related Products with: Thioredoxin1 Inactivation Mediates the Impairment of Ischemia-Induced Angiogenesis and Further Injury in Diabetic Myocardium.Anti AGO2 Human, Monoclon Jurkat Cell Extract (Indu FDA Standard Frozen Tissu Angiogenesis (Human) Anti Bovine prolactin-induced MultiGene Gradient therm Human Epstein-Barr Virus Directed In Vivo Angiogen FDA Standard Frozen Tissu Anti AGO2 Human, Monoclon Mouse Epstein-Barr Virus Angiogenesis (Human) Anti
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Interactions between Auditory and Vestibular Modalities during Stimulation with a Combined Vestibular and Cochlear Prosthesis.A combined vestibular and cochlear prosthesis may restore hearing and balance to patients who have lost both. To do so, the device should activate each sensory system independently.
2669 related Products with: Interactions between Auditory and Vestibular Modalities during Stimulation with a Combined Vestibular and Cochlear Prosthesis.Androgen Receptor (Ab 650 5α-N-Acetyl-2'H-androst- Androgen Receptor (Phosph Androgen Receptor , Mouse Androsta-1,4,6-triene-3,1 Epiandrosterone (3 beta H Androstane-3a,17b-diol Gl 4 Androstene 3,17 dione C Rabbit Anti-Human Androge Androgen Receptor (Phosph (5α,16β)-N-Acetyl-16-[2 Androgen Receptor Ab-1 An
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Efficacy of Long-Term Feeding of α-Glycerophosphocholine for Aging-Related Phenomena in Old Mice.α-Glycerophosphocholine (GPC) is a natural source of choline. It reportedly prevents aging-related decline in cognitive function, but the underlying mechanism remains unclear. Although it is understood that aging influences taste sensitivity and energy regulation, whether GPC exerts antiaging effects on such phenomena requires further elucidation. Here, we used old C57BL/6J mice that were fed a GPC-containing diet, to investigate the molecular mechanisms underlying the prevention of a decline in cognitive function associated with aging and examine the beneficial effects of GPC intake on aging-related phenomena, such as taste sensitivity and energy regulation. We confirmed that GPC intake reduces the aging-related decline in the expression levels of genes related to long-term potentiation. Although we did not observe an improvement in aging-related decline in taste sensitivity, there was a notable improvement in the expression levels of β-oxidation-associated genes in old mice. Our results suggest that the prevention of aging-related decline in cognitive function by GPC intake may be associated with the improvement of gene expression levels of long-term potentiation. Furthermore, GPC intake may positively influence lipid metabolism.
2739 related Products with: Efficacy of Long-Term Feeding of α-Glycerophosphocholine for Aging-Related Phenomena in Old Mice.Tyrosine Kinase Adaptors Interleukin-34 IL34 (N-t (7’-Benzyloxy-indolymet Goat Anti- Glucogon recep Goat Anti-Mouse ATG16L1, Goat Anti-Human CACNB4 (i Goat Anti-Human TRPV3 (aa Goat Anti-Human Cathepsin Goat Anti-Human NAT10 hAL EGF Phospho-Specific Arra Indole 5 carboxaldehyde ( Anti-BMP-1 (Bone Morphoge
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What We Can Find Beyond the Classic Neuroimaging Findings of Congenital Zika Virus Syndrome?In 1947, Zika virus (ZIKV) was first discovered in Monkeys, in Zika Forest, in Uganda, Africa. Five years later, (1952) the first human Zika infection was detected in Nigeria, Africa. After this date, only sporadic cases happened, until the first 3 epidemics occurred, all outside Africa. The first epidemic was in Yap Island in 2007, the second in French Polynesia in 2013, and the third in 2015 in the northeast of Brazil, and then the spread to the Americas in 2015 and 2016. However, it was only after the epidemic in the northeast of Brazil, in the first half of 2015, that many babies were born with microcephaly in the second semester of that same year and in 2016. Until now, every year, some babies are still born with congenital ZIKV syndrome (CZVS).
2191 related Products with: What We Can Find Beyond the Classic Neuroimaging Findings of Congenital Zika Virus Syndrome?Rabbit Anti-polyprotein[C West Nile virus Real Time Mouse Anti-Canine Distemp Canine Alpha 1-Antitrypsi Rabbit Anti-polyprotein[C Rabbit Anti-polyprotein[C Human Ovarian Cancer Anti Rabbit Anti-polyprotein[C Rabbit Anti-polyprotein[C West Nile virus Real Time West Nile Virus (Pre-M), West Nile Virus Pre M rec
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