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#38015614 
2023/11/28
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A prospective cohort study evaluating exclusive breastfeeding in late preterm infants.
Breastfeeding can be challenging in neonates born between 34 and 36 weeks gestation (late preterm).Daniela Menichini, Katia Rossi, Eleonora Bonini, Maria L Deicco, Francesca Monari, Simona DI Mario, Alberto Berardi, Fabio Facchinetti, Isabella Neri
1293 related Products with: A prospective cohort study evaluating exclusive breastfeeding in late preterm infants.
100 μg100 2 Pieces/Box100 μg100 μg50 ug 100 μg
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#38015610 2023/11/28
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Applications of the Natural Language Processing Tool ChatGPT in Clinical Practice: Comparative Study and Augmented Systematic Review.
This research integrates a comparative analysis of the performance of human researchers and OpenAI's ChatGPT in systematic review tasks and describes an assessment of the application of natural language processing (NLP) models in clinical practice through a review of 5 studies.Nikolas Schopow, Georg Osterhoff, David Baur
1393 related Products with: Applications of the Natural Language Processing Tool ChatGPT in Clinical Practice: Comparative Study and Augmented Systematic Review.
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#38015602 2023/11/28
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Predictive Dispatch of Volunteer First Responders: Algorithm Development and Validation.
Smartphone-based emergency response apps are increasingly being used to identify and dispatch volunteer first responders (VFRs) to medical emergencies to provide faster first aid, which is associated with better prognoses. Volunteers' availability and willingness to respond are uncertain, leading in recent studies to response rates of 17% to 47%. Dispatch algorithms that select volunteers based on their estimated time of arrival (ETA) without considering the likelihood of response may be suboptimal due to a large percentage of alerts wasted on VFRs with shorter ETA but a low likelihood of response, resulting in delays until a volunteer who will actually respond can be dispatched.Michael Khalemsky, Anna Khalemsky, Stephen Lankenau, Janna Ataiants, Alexis Roth, Gabriela Marcu, David G Schwartz
2084 related Products with: Predictive Dispatch of Volunteer First Responders: Algorithm Development and Validation.
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#38015588 2023/11/28
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Patient Information Summarization in Clinical Settings: Scoping Review.
Information overflow, a common problem in the present clinical environment, can be mitigated by summarizing clinical data. Although there are several solutions for clinical summarization, there is a lack of a complete overview of the research relevant to this field.Daniel Keszthelyi, Christophe Gaudet-Blavignac, Mina Bjelogrlic, Christian Lovis
2532 related Products with: Patient Information Summarization in Clinical Settings: Scoping Review.
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#38015560 2023/11/21
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Targeted PCR of in pediatric bronchoalveolar lavage samples indicates low prevalence of airway colonization and sample contamination.
are a large order of ubiquitous saprophytic zygomycete fungi and act as opportunistic pathogens in humans. In pediatric patients, little is known about the role of in airway colonization and infection or their role as contaminants of respiratory samples. Currently, polymerase chain reaction (PCR) is the most sensitive mode of detection in clinical specimen. In this study, we aimed to determine the prevalence of in bronchoalveolar lavage samples (BAL) from a large, diverse group of pediatric patients. We performed commercial PCR (MucorGenius®, Pathonostics, Maastricht, NL, USA) on 102 thawed BAL samples of 100 patients. PCR was negative in all samples. Our data suggest that have a low prevalence in paediatric airways and do not frequently contaminate pediatric BAL samples.Alexandra Kavvalou, Florian Stehling, Sarah Christina Goretzki, Christian Dohna-Schwake, Peter-Michael Rath, Mathis Steindor
1241 related Products with: Targeted PCR of in pediatric bronchoalveolar lavage samples indicates low prevalence of airway colonization and sample contamination.
500 samples96 samples16 Arrays/Slide16 Arrays/Slide96 samples16 Arrays/Slide96 samples96 samples16 Arrays/Slide
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#38015547 2023/11/15
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Biochemical and gene expression studies reveal the potential of Aspergillus oryzae-fermented broken rice and brewers' rice water extracts as anti-photoageing agents.
In this study, UVA- and UVB-irradiated human fibroblasts were used to investigate the anti-photoaging efficacy of two aqueous extracts from Aspergillus oryzae-fermented broken rice (FBR) and brewers' rice (FBrR). As UVA and UVB can damage the dermal and epidermal layers, respectively, two UV radiation approaches were utilised: i) direct UVA irradiation on fibroblasts, and ii) UVB-irradiated keratinocytes indirectly co-cultured with fibroblasts to observe their epithelial-mesenchymal interaction during UVB-induced photoaging. The anti-photoaging properties were tested utilising biochemical tests and quantitative polymerase chain reaction (qPCR). The treatment of UV-irradiated human fibroblasts with FBR and FBrR dramatically downregulates MMP-1 and SFE gene expression. Nonetheless, MMP-1 secretion was inhibited by FBR and FBrR, with more substantial decreases in UVB-treated co-cultures, ranging from 0.76- to 1.89-fold relative to the untreated control. In UVA-treated fibroblasts, however, the elastase-inhibiting activity of FBR and FBrR is up to 1.63-fold and 2.13-fold more potent, respectively. In addition, post-UV irradiation treatment with FBR and FBrR was able to repair and enhance collagen formation in UVA-irradiated fibroblasts. Both FBR and FBrR were able to upregulate elastin gene expression in fibroblasts under both culture conditions, especially at 50 µg/mL. The pro-inflammatory cytokines TNF-, IL-1ß, and IL-6 were likewise lowered by FBR and FBrR, which may have contributed to the anti-photoaging effect of the UVB-treated co-culture. These results reveal that FBR and FBrR inhibit photoaging in human fibroblasts under both UV induction conditions. In conclusion, FBR and FBrR may be attractive bio-ingredients for usage in the cosmetic sector as cosmeceuticals.Anisah Jamaluddin, Siti Muneerah Mohd Abd Rahman, Musaalbakri Abd Manan, Dang Lelamurni Abd Razak, Nur Yuhasliza Abd Rashid, Amsal Abd Ghani, Nurul Yuziana Mohd Yusof
1454 related Products with: Biochemical and gene expression studies reveal the potential of Aspergillus oryzae-fermented broken rice and brewers' rice water extracts as anti-photoageing agents.
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#38015544 2023/11/15
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Activin suppresses the expression of inflammatory genes and signaling proteins in human leukemia monocytic THP-1 cells.
Activin regulates inflammation, cell proliferation, immune response, wound repair, and endocrine function. In this study, we investigated the effect of activin on inflammatory genes in THP-1 cells and the involvement of NF-κB, AKT, and mitogen-activated protein kinase (MAPK) signaling. Cell viability was determined using a colorimetric assay with the MTS/PES solution. The mRNA levels were analyzed using reverse transcription-quantitative polymerase chain reaction. The expression of NF-κB, AKT, and MAPK signaling proteins was measured using immunoblot analysis. Activin A did not affect THP-1 cell viability at concentrations below 50 ng/ml. Activin decreased the mRNA expression of cytokines (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α), toll-like receptor 4 (TLR4), and matrix metallo-proteinases (MMP)-9 proteins but did not affect IL-8 expression. Activin increased the expression of TLR2 and MMP-2. In addition, activin inhibited the phosphorylation of NF-κB p65, AKT, and MAPK (c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 MAPK) signaling proteins. Our results suggest that activin may be involved in anti-inflammation by inhibiting inflammatory gene expression and regulating NF-κB and AKT/MAPK signaling.Sang Oh Yun, Young Il Kim, Hyung Joon Ahn, Sun Young Min
2554 related Products with: Activin suppresses the expression of inflammatory genes and signaling proteins in human leukemia monocytic THP-1 cells.
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#38015543 2023/11/15
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Determination of bone marrow cell morphology in rat.
The skeletal system of the body is responsible for important functions in the human body. In addition to causing movement, this system also plays a role in the production of blood cells and fat storage. Bone marrow is a spongy or viscous tissue that fills the inside of the body's bones. The basic structure of bone marrow is of two types. Red bone marrow and yellow bone marrow. Red bone marrow contains blood stem cells that can become red blood cells, white blood cells, or platelets. Yellow bone marrow is made mostly of fat and contains stem cells that can turn into cartilage, fat, or bone cells. Human bone marrow mesenchymal stem cells (HBMSCs) are widely used cell sources for clinical bone regeneration. Achieving a therapeutic effect depends on the osteogenic differentiation potential of the stem cells. The purpose of judging the morphology of bone marrow cells is to diagnose leukemia or bone marrow disorders, determine the cause of severe anemia or thrombocytopenia and low platelet count, identify abnormal chromosomes to prevent hereditary diseases, and plan their treatment. In this study, we examined the morphological characteristics of bone marrow cells, mesenchyme cells, and osteoblasts in a laboratory environment. The results of the morphological investigations showed changes such as the change of the position of the nucleus and the rounding of the cytoplasm in the differentiated cells compared to the mesenchyme cells. Therefore, to identify and diagnose as many of these cells as possible, molecular genetic techniques such as network algorithms and fluorescence staining can be used for hematological and cytomorphological investigations.Jun Ling Shan, Guang Yu Zhu, Li Hui Su, Xiao Song Liang, Jun Fu, Zhen Fen Zhang
1758 related Products with: Determination of bone marrow cell morphology in rat.
24 tests100ug Lyophilized1.00 flask1
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#38015537 2023/11/15
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Induced pluripotent stem cells (iPSCs): Where are we and where are we heading?
Induced Pluripotent Stem Cells (iPSCs) offer a unique therapeutic tool. The extent of the ongoing clinical studies substantiates the role of these cells in a highly promising area of personalized medicine. The employment of this technology in translational research is on the horizon. However, still, many questions remain unanswered. In this review, we discussed certain challenges and difficulties currently faced during the safe and stable clinical application of iPSCs. Furthermore, we describe the potential therapeutic scenarios employing iPSCs for the betterment of human health and the improvement of the health care sector.Arshad Jamal
2089 related Products with: Induced pluripotent stem cells (iPSCs): Where are we and where are we heading?
24 wells96 wells (1 kit)96 wells (1 kit)24 wells96 wells24 wells96 samples1 kit(96 Wells)1 kit(96 Wells)96 wells (1 kit) 250 ml
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#38015536 2023/11/15
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TGFβ1, SMAD2, CTNNβ1, and Wnt3a gene mutational status and serum concentrations in individuals with non-small cell lung cancer.
The objective of the current investigation was to investigate the diagnostic utility of the serum concentrations and mutational status of TGFβ1, SMAD2, CTNNβ1, and Wnt3a. and the expression levels of human‑related genes in patients with non-small cell lung cancer (NSCLC). The serum concentrations were determined using the ELISA technique, and PCR for genotype variations of TGFβ1, SMAD2, CTNNβ1, and Wnt3a were examined using Sanger sequencing in tissue samples obtained from 93 patients with NSCLC and 84 healthy individuals for blood, and 20 Formalin Fixed Paraffin Embedded (FFPE) from normal samples dissected adjacent to the tumour. The findings of the current investigation indicate that individuals diagnosed with NSCLC exhibited significant elevation in the serum levels of CEA and CYFRA21-1, as well as TGFβ1, SMAD2, CTNNβ1, and Wnt3a. In total, 325 mutations in four trialled genes (243 mutations in TGFβ1, 24 mutations in SMAD2,47 mutation Wnt3a and 11 mutations in CTNNβ1) were identified in patients with NSCLC. Furthermore, all mutations were recorded in adenocarcinoma, not squamous and normal adjacent tumour cells. CYFRA21-1 and CEA are more significant between NSCLC and HC, gender, and NSCLC types (p<0.001). In detail, TGFβ1 exhibited the highest rate of mutations among other genes and three types of genomic mutations. Elevated levels and genetic polymorphisms of TGFβ1, SMAD2, CTNNβ1, and Wnt3a may play crucial functions in the pathogenesis and angiogenesis of non-small cell lung cancer (NSCLC). These biomarkers might play a role in future immunologic response and pharmacologically targeted NSCLC therapy.Hemn Abdalla Omer, Kawa Amin