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Recombinant factor VIII Fc fusion protein for the treatment of severe haemophilia A: Final results from the ASPIRE extension study.

The efficacy and safety of recombinant factor VIII Fc fusion protein (rFVIIIFc) as an extended half-life treatment for severe haemophilia A were demonstrated in the Phase 3 A-LONG and Kids A-LONG studies. Eligible subjects who completed A-LONG and Kids A-LONG could enrol in ASPIRE (NCT01454739), an open-label extension study.

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Recombinant Human Factor Recombinant Human PKC the Recombinant Human PKC the Recombinant Human Factor Recombinant Human Factor Recombinant Human PKC the Recombinant EBV p18 [GST- Recombinant HIV Type-O gp Pfu DNA Polymerase protei Recombinant Human Intrins Recombinant Thermostable Bone Morphogenetic Protei

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Thoracoscopic surgery under local anesthesia for high-risk intractable secondary spontaneous pneumothorax.

To evaluate the outcomes of thoracoscopic surgery for intractable secondary spontaneous pneumothorax (SSP) under local anesthesia in high-risk patients and report intraoperative findings useful for identifying air leakage points.

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Uterine Cervix Cancer of ELISA Mouse , C-Reactive Cellufine Formyl Media Goat Anti-CYBB GP91-PHOX, High density uterine cerv High density liver cancer Stomach cancer and normal N-γ-Acetyl-N-2-formyl-5- Mitochondrial creatine ki Brain primary tumor high RubyGlowTM Luminescent Ba Anti- ADAM-12 (A Disintig

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Interprofessional Education on Medication Adherence: Peer-to-Peer Teaching of Osteopathic Medical Students.

Medication nonadherence is an important barrier to achieving optimal clinical outcomes. Currently, there are limited data on methods used to train medical students about medication adherence.

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Ofloxacin CAS Number [824 c-erbB-3 Oncoprotein; Cl c-erbB-3 Oncoprotein; Cl Mouse anti human Oncostat Bcl-2 Oncoprotein; Clone c-erbB-2 Oncoprotein; Cl Recombinant Human Oncosta Ondasetron CAS: [99614-02 RAP2C, member of RAS onco c-erbB-2 Oncoprotein; Cl c-erbB-2 Oncoprotein; Cl Ondansetron hydrochloride

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Treatment of Full-Thickness Skin Wounds with Blood-Derived CD34 Precursor Cells Enhances Healing with Hair Follicle Regeneration.

Epidermal CD34 stem cells located in the hair follicle (HF) bulge area are capable of inducing HF neogenesis and enhancing wound healing after transplantation. In this study, we observed CD34 cells derived from blood directly participate in dermal regeneration during full-thickness excisional wound healing. We isolated and expanded a subset of hematopoietic stem cell (HSC)-like precursor cells from the peripheral blood of adult mice with the surface markers: CD34, leucine rich repeat containing G protein-coupled receptor 5 (LGR5), CD44, c-kit, lineage negative (lin), and E-cadherin. These blood-derived precursor cells (BDPCs), can be further differentiated into epithelial-like cells (eBDPCs) and secret fibroblast growth factor 9 (Fgf9) protein. When transplanted into full-thickness skin wounds, eBDPC treatment produced accelerated healing and enhanced skin structure regeneration with less dermal scar formation. Also, HF neogenesis (HFN) was observed with incorporation of labeled BDPCs in the wound area. Nondermal-derived CD34 cells (BDPCs) from the adult unmobilized peripheral blood are capable of expansion and differentiation.Successful establishment of an technical platform for BDPCs expansion and differentiation.The expanded and differentiated epithelial-like cells (eBDPCs) enhance wound healing and directly contribute to skin regeneration and HFN. BDPCs isolated and expanded from adult peripheral blood may provide a possible new cell-based treatment strategy for HF neogenesis and skin wound regeneration.

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Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis.

: CD47 plays a vital role in the immune escape of tumor cells, but its role in regulating immune-unrelated biological processes such as proliferation and metastasis remains unclear. We seek to explore the immune-independent functions of CD47 in colorectal cancer (CRC). : The expression of CD47 in CRC was determined by immunohistochemistry. The biological effect of CD47 signaling on tumor cell proliferation and metastasis was evaluated and . RNA sequencing analysis was performed to identify pivotal signaling pathways modulated by CD47. The interaction between CD47 and ENO1 was verified by co-immunoprecipitation (co-IP). The effect of CD47 on glycolytic metabolites was analyzed by seahorse XF and targeted metabolomics. : The expression of CD47 was upregulated and correlated to poor prognosis in CRC patients. Functional assays revealed that CD47 promoted CRC cell growth and metastasis and . Our mechanistic investigations demonstrated that CD47 interacted with ENO1 and protected it from ubiquitin-mediated degradation, subsequently promoting glycolytic activity and phosphorylation of ERK in CRC cells. Inhibition of ENO1 diminished CD47-mediated cell growth and migration. Clinically, the combined expression of CD47 and ENO1 provided reliable predictive biomarkers for the prognosis of CRC patients. : CD47 is overexpressed in CRC, and its expression is associated with poor prognosis. Through stabilizing ENO1, CD47 enhances the aerobic glycolysis and ERK activity in CRC cells, thereby promoting the progression of CRC. Our studies reveal an unconventional role of CD47, suggesting that targeting the CD47-ENO1 axis may provide a novel therapeutic avenue for CRC.

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Optical properties of chain inverted pyramids on silicon.

Pyramidal structures, including upright pyramids and inverted pyramids (IPs), are commonly used as light-trapping structures for silicon solar cells and silicon photodetectors. In this paper, the possible ray propagation paths in a pyramidal structure are analyzed by establishing a mathematical model in which up to seven ray paths may exist either in a regular or random pyramidal structure. To reduce the reflectivity, the proportion of the quadruple bounce should be increased because of its lower reflectivity. Therefore, a chain IP structure with a quadruple bounce proportion of 10.33% is proposed, of which the overlap value $\Delta x/w$Δx/w is 0.4. According to theoretical ray-tracing calculations, the weighted average reflectivity is reduced by 0.75% compared to that of a random IP structure. Experimentally, chain IP structures are fabricated from the surface line damage produced by the diamond wire sawing of a silicon wafer as a mask, and the reflectivity of the structures is 0.80% lower than that of a random IP structure. The theoretical analysis and experimental results both show that the chain IP structure has better optical properties than the random IP structure, indicating promising prospects for the abovementioned applications.

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Mouse Anti-Ricin A Chain Mouse Anti-Lambda Light C Goat Anti-Human Kappa Lig Rabbit Anti-FGF3 Oncogene Rabbit Anti-Human CD98 Li c-erbB-2 Oncoprotein; Cl Kappa Light Chain Sheep Anti-Human Kappa Li Mouse Anti-HPV 16 Oncopro Mouse Anti-Human Ig Kappa Mouse anti human MSP beta Ondansetron CAS Number [9

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Two-Step Size-Exclusion Nanofiltration of Prothrombin Complex Concentrate Using Nanocellulose-Based Filter Paper.

Coagulation Factor IX-rich protrhombin complex concentrate (FIX-PCC) is a therapeutic biologic product that consists of a mixture of several human plasma-derived proteins, useful for treating hemophilia B. Due to its complex composition, FIX-PCC is very challenging to bioprocess through virus removing nanofilters in order to ensure its biosafety. This article describes a two-step filtration process of FIX-PCC using a nanocellulose-based filter paper with tailored porosity. The filters were characterized with scanning electron microscopy (SEM), cryoporometry with differential scanning calorimetry, and nitrogen gas sorption. Furthermore, in order to probe the filter's cut-off size rejection threshold, removal of small- and large-size model viruses, i.e., ΦX174 (28 nm) and PR772 (70 nm), was evaluated. The feed, pre-filtrate, and permeate solutions were characterized with mass-spectrometric proteomic analysis, dynamic light scattering (DLS), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and analytical size-exclusion high-performance liquid chromatography (SEHPLC). By sequential filtration through 11 μm pre-filter and 33 μm virus removal filter paper, it was possible to achieve high product throughput and high virus removal capacity. The presented approach could potentially be applied for bioprocessing other protein-based drugs.

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