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#34562263   2021/09/25 To Up

Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel.

The long-term course of immunity among individuals with a history of COVID-19, in particular among those who received a booster vaccination, has not been well defined so far.
Vivian Glück, Sonja Grobecker, Josef Köstler, Leonid Tydykov, Manuela Bertok, Tanja Weidlich, Christine Gottwald, Bernd Salzberger, Ralf Wagner, Florian Zeman, Michael Koller, André Gessner, Barbara Schmidt, Thomas Glück, David Peterhoff

2848 related Products with: Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel.

25 mg1 mg1 mg100ug0.1 mg 5 G 1 G 1 G50 ug

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#34561284   2021/09/24 To Up

Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies.

is the most common bacterial cause of pneumonia in children hospitalised for community-acquired pneumonia. Prevention of infection by vaccines may be an important strategy in the presence of emerging macrolide resistant However, knowledge of immune responses to is limited, complicating vaccine design. We therefore studied the antibody response during infection and asymptomatic carriage.In a nested case-control study (n=80) of carriers and matched controls we observed that carriage by does not lead to a rise in either mucosal or systemic specific antibodies, even after months of persistent carriage. We replicated this finding in a second cohort (n=69) and also found that during community-acquired pneumonia, mucosal levels of specific IgA and IgG did increase significantly. adhesion assays revealed that high levels of specific antibodies in nasal secretions of paediatric patients prevented the adhesion of to respiratory epithelial cells.In conclusion, our study demonstrates that specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells and are induced only during infection and not during asymptomatic carriage. This is strikingly different from carriage with bacteria such as where mucosal antibodies are induced by bacterial carriage.
Ruben Cornelis Anthonie de Groot, Silvia Cristina Estevão, Patrick Michael Meyer Sauteur, Aditya Perkasa, Theo Hoogenboezem, Emiel Benny Margriet Spuesens, Lilly Maria Verhagen, Anna Maria Christiane van Rossum, Wendy Wilhelmina Josephina Unger

2772 related Products with: Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies.

0.1 mg0.2 mg1mg1 ml1 mL0.2 mg100 1 mL96 Tests100 1 ml1 mL

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#34561239   // To Up

Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response.

To determine clinical and ethnodemographic correlates of serological responses against the SARS-CoV-2 spike glycoprotein following mild-to-moderate COVID-19.
Adrian M Shields, Sian E Faustini, Marisol Perez-Toledo, Sian Jossi, Joel D Allen, Saly Al-Taei, Claire Backhouse, Lynsey A Dunbar, Daniel Ebanks, Beena Emmanuel, Aduragbemi A Faniyi, Mark Garvey, Annabel Grinbergs, Golaleh McGinnell, Joanne O'Neill, Yasunori Watanabe, Max Crispin, David C Wraith, Adam F Cunningham, Mark T Drayson, Alex G Richter

1143 related Products with: Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response.

200ug200ul1

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#34561158   2021/09/10 To Up

Anti-SARS-CoV-2 immunoglobulin profile in patients with celiac disease living in a high incidence area.

How symptoms and antibodies related to SARS-CoV-2 infection develop in patients with celiac disease (CD) is unclear. We aimed to investigate the impact of SARS-CoV-2 infection in CD patients.
Luca Elli, Federica Facciotti, Vincenza Lombardo, Alice Scricciolo, David S Sanders, Valentina Vaira, Donatella Barisani, Maurizio Vecchi, Andrea Costantino, Lucia Scaramella, Bernardo dell'Osso, Luisa Doneda, Leda Roncoroni

2531 related Products with: Anti-SARS-CoV-2 immunoglobulin profile in patients with celiac disease living in a high incidence area.

100 ul100ug Lyophilized500 tests100 ul100ug Lyophilized 50 UG25mg100ug Lyophilized100 μg

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#34560320   2021/09/17 To Up

Protective efficacy of the peptide Subolesin antigen against the cattle tick Rhipicephalus microplus under natural infestation.

The cattle tick Rhipicephalus microplus affect animal health, welfare, and cattle production in tropical and subtropical zones of the world. Anti-tick vaccines have been an effective alternative for cattle tick control instead of traditional chemical products. To date, Subolesin antigen has shown efficacy for the control of tick infestation in cattle, and previous studies showed that one peptide derived from this protein has demonstrated to elicit a strong and specific humoral immune response. Based on these findings, herein we characterized the efficacy of the peptide Subolesin for the control of cattle tick, R. microplus infestation under field conditions. Twenty-four female calves were assigned to four experimental groups and immunized with three subcutaneous doses of the peptide Subolesin, Bm86, both antigens (dual vaccine) and adjuvant/saline alone, respectively. Serum antibody levels (IgG) were assessed by ELISA and confirmed by Western blot; also, reproductive performance of naturally infested R. microplus was determined. The results showed that immunizations with the experimental antigens reduced tick infestations with vaccine's efficacy of 67 % (peptide Subolesin), 56 % (Bm86), and 49 % (dual vaccine) based on adult tick numbers, oviposition, and egg fertility between vaccinated and control animals. Peptide Subolesin-immunized calves developed a strong humoral immune response expressed by high anti-pSubolesin IgG levels, and the Western blot analysis confirmed that it is immunogenic. Cattle receiving Bm86 and dual vaccine showed less protection, although Bm86 was within the range reported previously. The negative correlation between antibody levels and reduction of naturally infested R. microplus strongly suggested that the effect of the vaccine was the result of the antibody response in immunized cattle. In conclusion, it was demonstrated that the peptide Subolesin induced a specific immune response in cattle under field conditions, resulting in reduced R. microplus populations in subsequent generations. Finally, integrated tick control must consider anti-tick vaccines as a cost-effective, sustainable, and successful tool for controlling cattle tick infestations.
Nancy Mendoza-Martínez, Miguel Angel Alonso-Díaz, Octavio Merino, Agustín Fernández-Salas, Rodolfo Lagunes-Quintanilla

2919 related Products with: Protective efficacy of the peptide Subolesin antigen against the cattle tick Rhipicephalus microplus under natural infestation.

1 ml100 µg10100 IU10.1 mg500 Units 100 G

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#34560256   2021/09/21 To Up

Optimization strategies for expression of a novel bifunctional anti-PD-L1/TGFBR2-ECD fusion protein.

The novel anti-PD-L1/TGFBR2-ECD fusion protein (BR102) comprises an anti-PD-L1 antibody (HS636) which is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment. In the expression of TGFBR2-ECD wild-type fused protein (BR102-WT), a 50 kDa clipped species was confirmed to be induced by proteolytic cleavage at a "QKS" site located in the N-terminus of the ectodomain, which resulted in the formation of IgG-like clipping. The matrix metalloproteinase-9 was determined to be associated with BR102-WT digestion. In addition, it was observed that the N-glycosylation modifications of the fusion protein were tightly involved in regulating proteolytic activity and the levels of cleavage could be significantly suppressed by MMP-inhibitors. To avoid proteolytic degradation, eliminating protease-sensitive amino acid motifs and introducing potential glycosylation were performed. Three sensitive motifs were mutated, and the levels of clipping were strongly restrained. The mutant candidates exhibited similar binding affinities to hPD-L1 and hTGF-β1 as well as highly purified BR102-WT2. Furthermore, the mutants displayed more significant proteolytic resistance than that of BR102-WT2 in the lysate incubation reaction and the plasma stability test. Moreover, the bifunctional candidate Mu3 showed an additive antitumor effect in MC38/hPD-L1 bearing models as compared to that of with anti-PD-L1 antibody alone. In conclusion, in this study, the protease-sensitive features of BR102-WT were well characterized and efficient optimization was performed. The candidate BR102-Mutants exhibited advanced druggability in drug stability and displayed desirable antitumor activity.
Zhang-Zhao Gao, Cui Li, Gang Chen, Jun-Jie Yuan, Ya-Qiong Zhou, Jing-Yu Jiao, Lei Nie, Jian Qi, Yong Yang, Shu-Qing Chen, Hai-Bin Wang

2482 related Products with: Optimization strategies for expression of a novel bifunctional anti-PD-L1/TGFBR2-ECD fusion protein.

100ug100 0.1 mg100 0.1 mg0.1 mg0.2 mg100μg100ug1 mg0.1 mg1 mg

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