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Search results for: IgG

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#32745595   2020/07/31 To Up

Antibody response against SARS-CoV-2 spike protein and nucleoprotein evaluated by 4 automated immunoassays and 3 ELISAs.

To determine the antibody response against SARS-CoV-2 spike protein and nucleoprotein using 4 automated immunoassays and 3 ELISAs for the detection of total Ig antibodies (Roche) or IgG (Abbott, Diasorin, Snibe, Euroimmun, Mikrogen) in COVID-19 patients.
Jan Van Elslande, Bram Decru, Stijn Jonckheere, Eric Van Wijngaerden, Els Houben, Patricia Vandecandelaere, Christophe Indevuyst, Melissa Depypere, Stefanie Desmet, Emmanuel André, Marc Van Ranst, Katrien Lagrou, Pieter Vermeersch

2868 related Products with: Antibody response against SARS-CoV-2 spike protein and nucleoprotein evaluated by 4 automated immunoassays and 3 ELISAs.

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#32745569   2020/07/31 To Up

Autoantibody detection for diagnosis in direct immunofluorescence negative mucous membrane pemphigoid: ocular and other sites compared.

To assess whether a panel of serum pemphigoid autoantibody tests could be used to confirm an immunopathological diagnosis of mucous membrane pemphigoid (MMP) in direct immunofluorescent negative (DIF-) MMP patients.
John Dart, Jane Setterfield, Richard W Groves, John B Mee, Gilles F H Diercks, Hendri H Pas, Darwin Minassian,

1130 related Products with: Autoantibody detection for diagnosis in direct immunofluorescence negative mucous membrane pemphigoid: ocular and other sites compared.

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#32745496   2020/07/31 To Up

Anti-PEG antibodies: Properties, formation and role in adverse immune reactions to PEGylated nano-biopharmaceuticals.

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Gergely Kozma, Taro Shimizu, Tatsuhiro Ishida, Janos Szebeni

1763 related Products with: Anti-PEG antibodies: Properties, formation and role in adverse immune reactions to PEGylated nano-biopharmaceuticals.

100 μg100 100 μg100 μg100 μg100 μg100 μg100 μg100 μg100100 μg100.00 ug

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#32745316   2020/08/03 To Up

A natural oil increases specific anti-OVA IgG levels and induces a cellular immune response combined with aluminum hydroxide.

The efficacy of certain vaccines is improved by the use of adjuvants. Nowadays, the development of new, effective, and safe adjuvants that stimulate the innate immune response is researched. In this context, medicinal plants appear as a suitable alternative. Minthostachys verticillata essential oil (EO) has demonstrated the ability to modulate mechanisms of the innate immune response. Thus, the present work aimed to evaluate the EO adjuvant effect on humoral and cellular immunity, coadministered with OVA as antigen. The chemical analysis of EO by gas chromatography-mass spectrometry revealed a predominant pulegone-menthone chemotype. EO (1.25, 2.5, or 5.0 mg/ml) did not alter the viability of murine fibroblasts (3T3 cell line) neither showed signs of toxicity in Balb/c mice inoculated subcutaneously. The serum of mice immunized with OVA + EO showed increased levels of anti-OVA-specific antibodies of IgG1 subclass compared with the mice immunized with OVA alone revealing an adjuvant effect of EO. The delayed type hypersensitivity showed that the combination OVA + Al(OH)  + EO was the best to induce a cellular immune response that extended until 48 h postinjection of OVA. M. verticillata EO appears as a new, safe, and effective adjuvant, which should continue to be studied for their possible future incorporation into vaccine formulations.
Noelia Anahí Campra, Ivana Dalila Montironi, Elina Beatriz Reinoso, José Raviolo, Federico Ruiz Moreno, Belkys Maletto, Laura Noelia Cariddi

2687 related Products with: A natural oil increases specific anti-OVA IgG levels and induces a cellular immune response combined with aluminum hydroxide.

1 ml96 Tests/kit0.25 mg0.2 mg96 Tests/kit100 TESTS100 ul0.1ml (1mg/ml)100 ul1 mg

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#32745283   2020/08/03 To Up

IgG 4 Autoimmune hepatitis presenting as idiopathic hypereosinophilia syndrome.

Autoimmune Hepatitis (AIH) and Idiopathic Hypereosinophilia Syndrome (HES) are viewed as distinct diseases. Our patient presented with hepatic and serum IgG4+ plasma cell infiltration, in addition to a marked bone marrow and peripheral eosinophilia with colonic involvement, raising the diagnosis of IgG4-related disease (IgG4-RD) and HES. This is the first reported case of IgG4 - AIH presenting with HES, both of which resolved with immune suppressive therapy.
Darren Kastin, Matthew Siegel, Richard Anderson, Andrew Aronsohn

2991 related Products with: IgG 4 Autoimmune hepatitis presenting as idiopathic hypereosinophilia syndrome.

100 ul100 ug

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#32745196   2020/08/03 To Up

Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection.

Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed vaccine or specific antiviral agents for therapy. Little is known about the longitudinal dynamics of SARS-CoV-2-specific neutralizing antibodies (NAbs) in COVID-19 patients.
Kai Wang, Quan-Xin Long, Hai-Jun Deng, Jie Hu, Qing-Zhu Gao, Gui-Ji Zhang, Chang-Long He, Lu-Yi Huang, Jie-Li Hu, Juan Chen, Ni Tang, Ai-Long Huang

2230 related Products with: Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection.

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#32744925   2020/04/21 To Up

Spotted Fever Group Infection of Cats and Cat Fleas in Northeast Thailand.

species cause rickettsioses, which are zoonotic diseases found worldwide, and are transmitted by arthropods such as lice, fleas, ticks, and mites. In Thailand, flea infestations are common among cats and dogs. This study aimed at determining the exposure to spotted fever group rickettsiae (SFGR) of cats in surrounding areas of Rajabhat Maha Sarakham University, Muang district, Maha Sarakham province and rickettsial infection among cat fleas, collected from dogs of the surrounding area of Waeng Noi district, Khon Kaen province. Forty-two cat sera were assessed for IgG antibody titers against SFGR by a group-specific enzyme-linked immunosorbent assay. The prevalence of seroreactive cats was 4.76% (2/42). DNA preparations from 23 individual cat fleas from three dogs were assessed by genus-specific, group-specific, and species-specific quantitative real-time PCR (qPCR) assays. Positive results were confirmed by gene fragment sequencing. Twenty-one of 23 cat fleas were positive for , and the other two DNA preparations were negative for rickettsial DNA. This study's finding indicates that companion cats and dogs in Northeast Thailand are exposed to SFGR and that exposure may be due to infection with an organism known to infect humans, monkeys, and dogs. Clinicians for humans and animals in Northeast Thailand should be aware of rickettsial infections among their patients.
Sirirat Phomjareet, Prapansak Chaveerach, Fanan Suksawat, Ju Jiang, Allen L Richards

2295 related Products with: Spotted Fever Group Infection of Cats and Cat Fleas in Northeast Thailand.

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#32744608   2020/08/03 To Up

Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

Recognizing the presenting and immunopathological features of Kelch-like protein-11 immunoglobulin G seropositive (KLHL11 IgG+) patients may aid in early diagnosis and management.
Divyanshu Dubey, Michael R Wilson, Benjamin Clarkson, Caterina Giannini, Manish Gandhi, John Cheville, Vanda A Lennon, Scott Eggers, Michelle F Devine, Caleigh Mandel-Brehm, Thomas Kryzer, Shannon R Hinson, Khashayarsha Khazaie, Chadwick Hales, Jorge Kattah, Kevin D Pavelko, Patrick Andrews, James E Eaton, Jiraporn Jitprapaikulsan, John R Mills, Eoin P Flanagan, Anastasia Zekeridou, Bradley Leibovich, James Fryer, Matthew Torre, Charles Kaufman, James B Thoreson, Jessica Sagen, Jenny J Linnoila, Joseph L DeRisi, Charles L Howe, Andrew McKeon, Sean J Pittock

1214 related Products with: Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

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#32743610   2020/07/21 To Up

High Community SARS-CoV-2 Antibody Seroprevalence in a Ski Resort Community, Blaine County, Idaho, US. Preliminary Results.

Community-level seroprevalence surveys are needed to determine the proportion of the population with previous SARS-CoV-2 infection, a necessary component of COVID-19 disease surveillance. In May, 2020, we conducted a cross-sectional seroprevalence study of IgG antibodies for nucleocapsid of SARS-CoV-2 among the residents of Blaine County, Idaho, a ski resort community with high COVID-19 attack rates in late March and Early April (2.9% for ages 18 and older). Participants were selected from volunteers who registered via a secure web link, using prestratification weighting to the population distribution by age and gender within each ZIP Code. Participants completed a survey reporting their demographics and symptoms; 88% of volunteers who were invited to participate completed data collection survey and had 10 ml of blood drawn. Serology was completed via the Abbott Architect SARS-CoV-2 IgG immunoassay. Primary analyses estimated seroprevalence and 95% credible intervals (CI) using a hierarchical Bayesian framework to account for diagnostic uncertainty. Stratified models were run by age, sex, ZIP Code, ethnicity, employment status, and participant-reported COVID-19 status. Sensitivity analyses to estimate seroprevalence included base models with post-stratification for ethnicity, age, and sex, with or without adjustment for multi-participant households. IgG antibodies to the virus that causes COVID-19 were found among 22.7% (95% CI: 20.1%, 25.5%) of residents of Blaine County. Higher levels of antibodies were found among residents of the City of Ketchum 34.8% (95% CI 29.3%, 40.5%), compared to Hailey 16.8% (95%CI 13.7%, 20.3%) and Sun Valley 19.4% (95% 11.8%, 28.4%). People who self-identified as not believing they had COVID-19 had the lowest prevalence 4.8% (95% CI 2.3%, 8.2%). The range of seroprevalence after correction for potential selection bias was 21.9% to 24.2%. This study suggests more than 80% of SARS-CoV-2 infections were not reported. Although Blaine County had high levels of SARS-CoV-2 infection, the community is not yet near the herd immunity threshold.
Colleen C McLaughlin, Margaret K Doll, Kathryn T Morrison, William L McLaughlin, Terry O'Connor, Anton M Sholukh, Emily L Bossard, Khamsone Phasouk, Emily S Ford, Kurt Diem, Alexis M Klock, Keith R Jerome, Lawrence Corey

1010 related Products with: High Community SARS-CoV-2 Antibody Seroprevalence in a Ski Resort Community, Blaine County, Idaho, US. Preliminary Results.

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