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#32744608   2020/08/03 To Up

Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

Recognizing the presenting and immunopathological features of Kelch-like protein-11 immunoglobulin G seropositive (KLHL11 IgG+) patients may aid in early diagnosis and management.
Divyanshu Dubey, Michael R Wilson, Benjamin Clarkson, Caterina Giannini, Manish Gandhi, John Cheville, Vanda A Lennon, Scott Eggers, Michelle F Devine, Caleigh Mandel-Brehm, Thomas Kryzer, Shannon R Hinson, Khashayarsha Khazaie, Chadwick Hales, Jorge Kattah, Kevin D Pavelko, Patrick Andrews, James E Eaton, Jiraporn Jitprapaikulsan, John R Mills, Eoin P Flanagan, Anastasia Zekeridou, Bradley Leibovich, James Fryer, Matthew Torre, Charles Kaufman, James B Thoreson, Jessica Sagen, Jenny J Linnoila, Joseph L DeRisi, Charles L Howe, Andrew McKeon, Sean J Pittock

2967 related Products with: Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

1000 TESTS/0.65ml25 mg20050ug100ug100ug Lyophilized100ug Lyophilized1 Set2µg1 Set1 Set

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#32744145   // To Up

Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies.

Current combination therapies elicit high response rates in B cell malignancies, often using CD20 antibodies as the backbone of therapy. However, many patients eventually relapse or develop progressive disease. Therefore, novel CD20 antibodies combining multiple effector mechanisms were generated. To study whether neutrophil-mediated destruction of B cell malignancies can be added to the arsenal of effector mechanisms, we chimerized a panel of five previously described murine CD20 antibodies to the human IgG1, IgA1 and IgA2 isotype. Of this panel, we assessed antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and direct cell death induction capacity and studied the efficacy in two different mouse models. IgA antibodies outperformed IgG1 antibodies in neutrophil-mediated killing , both against CD20-expressing cell lines and primary patient material. In these assays, we observed loss of CD19 with both IgA and IgG antibodies. Therefore, we established a novel method to improve the assessment of B-cell depletion by CD20 antibodies by including CD24 as a stable cell marker. Subsequently, we demonstrated that only IgA antibodies were able to reduce B cell numbers in this context. Additionally, IgA antibodies showed efficacy in both an intraperitoneal tumor model with EL4 cells expressing huCD20 and in an adoptive transfer model with huCD20-expressing B cells. Taken together, we show that IgA, like IgG, can induce ADCC and CDC, but additionally triggers neutrophils to kill (malignant) B cells. We conclude that antibodies of the IgA isotype offer an attractive repertoire of effector mechanisms for the treatment of CD20-expressing malignancies.
Mitchell Evers, Toine Ten Broeke, J H Marco Jansen, Maaike Nederend, Firas Hamdan, Karli R Reiding, Saskia Meyer, Petra Moerer, Iris Brinkman, Thies Rösner, Robert Jan Lebbink, Thomas Valerius, Jeanette H W Leusen

2183 related Products with: Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies.

100 100 μg50 TESTS0.5 mg 6 ml Ready-to-use 100ug100ug Lyophilized0.1 mg0.1 mg1 ml100ug1 mg

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#32742570   // To Up

Changing delta hepatitis patient profile: A single center experience in Valencia region, Spain.

Delta hepatitis is a rare infection with an aggressive disease course. For almost three decades, however, there have been no epidemiological studies in our traditionally endemic area.
Helena Hernàndez-Èvole, Álvaro Briz-Redón, Marina Berenguer

2507 related Products with: Changing delta hepatitis patient profile: A single center experience in Valencia region, Spain.

100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg

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#32740810   2020/08/01 To Up

Adipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional study.

To establish the association between adipokine levels and markers of periodontal involvement as risk indicators of early stages of RA (eRA) and the interaction between the presence of markers of periodontal disease with adipokine in eRA individuals.
Jacqueline Rodríguez, Gloria Inés Lafaurie, Wilson Bautista-Molano, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero, Consuelo Romero-Sánchez

1795 related Products with: Adipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional study.

100μg100 assays96 samples10025 assays100 assays 5 G100ug Lyophilized200 assays

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#32739419   2020/07/30 To Up

Results of a nation-wide cohort study suggest favorable long-term outcomes of clone-targeted chemotherapy in immunotactoid glomerulopathy.

Immunotactoid glomerulopathy is a rare disease defined by glomerular microtubular immunoglobulin deposits. Since management and long-term outcomes remain poorly described, we retrospectively analyzed results of 27 adults from 21 departments of nephrology in France accrued over19 years. Inclusion criteria were presence of glomerular Congo red-negative monotypic immunoglobulin deposits with ultrastructural microtubular organization, without evidence for cryoglobulinemic glomerulonephritis. Baseline manifestations of this cohort included: proteinuria (median 6.0 g/day), nephrotic syndrome (70%), microscopic hematuria (74%) and hypertension (56%) with a median serum creatinine of 1.5 mg/dL. Nineteen patients had detectable serum and/or urine monoclonal gammopathy. A bone marrow and/or peripheral blood clonal disorder was identified in 18 cases (16 lymphocytic and two plasmacytic disorders). Hematologic diagnosis was chronic/small lymphocytic lymphoma in 13, and monoclonal gammopathy of renal significance in 14 cases. Kidney biopsy showed atypical membranous in 16 or membranoproliferative glomerulonephritis in 11 cases, with microtubular monotypic IgG deposits (kappa in 17 of 27 cases), most commonly IgG1. Identical intracytoplasmic microtubules were observed in clonal lymphocytes from five of ten tested patients. Among 21 patients who received alkylating agents, rituximab-based or bortezomib-based chemotherapy, 18 achieved a kidney response. After a median follow-up of 40 months, 16 patients had sustained kidney response, seven had reached end-stage kidney disease and six died. Chronic/small lymphocytic lymphoma appears as a common underlying condition in immunotactoid glomerulopathy but clonal detection remains inconstant with routine techniques in patients with monoclonal gammopathy of renal significance. Thus, early diagnosis and hematological response after clone-targeted chemotherapy was associated with favorable outcomes. Hence, thorough pathologic and hematologic workup is key to the management of immunotactoid glomerulopathy.
Vincent Javaugue, Léa Dufour-Nourigat, Estelle Desport, Audrey Sibille, Bruno Moulin, Pierre Bataille, Pascal Bindi, Cyril Garrouste, Christophe Mariat, Lionel Karlin, Mathilde Nouvier, Jean-Michel Goujon, Viviane Gnemmi, Jean-Paul Fermand, Guy Touchard, Frank Bridoux

2919 related Products with: Results of a nation-wide cohort study suggest favorable long-term outcomes of clone-targeted chemotherapy in immunotactoid glomerulopathy.

100 μg 0.1 mg 100 μg100100 μg100 μg100 μg100 100 μg100 μg

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#32739118   2020/07/29 To Up

Inactivated influenza vaccine formulated with single-stranded RNA-based adjuvant confers mucosal immunity and cross-protection against influenza virus infection.

Influenza vaccination is considered the most valuable means to prevent and control seasonal influenza infections, which causes various clinical symptoms, ranging from mild cough and fever to even death. Among various influenza vaccine types, the inactivated subunit type is known to provide improved safety with reduced reactogenicity. However, there are some drawbacks associated with inactivated subunit type vaccines, with the main ones being its low immunogenicity and the induction of Th2-biased immune responses. In this study, we investigated the role of a single-stranded RNA (ssRNA) derived from the intergenic region in the internal ribosome entry site of the Cricket paralysis virus as an adjuvant rather than the universal vaccine for a seasonal inactivated subunit influenza vaccine. The ssRNA adjuvant stimulated not only well-balanced cellular (indicated by IgG2a, IFN-γ, IL-2, and TNF-α) and humoral (indicated by IgG1 and IL-4) immune responses but also a mucosal immune response (indicated by IgA), a key protector against respiratory virus infections. It also increases the HI titer, the surrogate marker of influenza vaccine efficacy. Furthermore, ssRNA adjuvant confers cross-protective immune responses against heterologous influenza virus infection while promoting enhanced viral clearance. Moreover, ssRNA adjuvant increases the number of memory CD4 and CD8 T cells, which can be expected to induce long-term immune responses. Therefore, this ssRNA-adjuvanted seasonal inactivated subunit influenza vaccine might be the best influenza vaccine generating robust humoral and cellular immune responses and conferring cross-protective and long-term immunity.
Yun-Hee Kim, Yoo-Jin Bang, Hyo-Jung Park, Hae Li Ko, Sang-In Park, Kyung-Ah Hwang, Hun Kim, Jae-Hwan Nam

2614 related Products with: Inactivated influenza vaccine formulated with single-stranded RNA-based adjuvant confers mucosal immunity and cross-protection against influenza virus infection.

50 10 1 mg100 1 mg251 mL1001 mL50 ug10 1 mg

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#32736160   2020/07/04 To Up

Evaluation and comparison of automated and manual ELISA for diagnosis of chronic pulmonary aspergillosis (CPA) in Indonesia.

Pulmonary tuberculosis (TB) is one of the common risk factors for chronic pulmonary aspergillosis (CPA). A positive Aspergillus IgG is a key element of the diagnosis of CPA but this has not been studied in Indonesia. We conducted studies with patients at the end of TB therapy in Indonesia. We performed receiver operating curve (ROC) analysis to determine the optimum cutoff of the Aspergillus-specific IgG level (Immulite and Dynamiker ELISA) in those patients who met criteria of CPA in relation to control groups. In 203 TB patients, 26 (13%) patients had clinical and radiological features of CPA. We derived optimum cutoffs for Immulite Aspergillus-specific IgG of 11.5 mg/L and Dynamiker anti-galactomannan IgG of 106.8 AU/mL (sensitivity 89% and 83%, specificity 78% and 51%, respectively). The currently accepted Aspergillus-specific IgG cutoff of Immulite and Dynamiker assays for CPA diagnosis may require slight adjustment for the Indonesian population.
Findra Setianingrum, Anna Rozaliyani, Ridhawati Syam, Robiatul Adawiyah, Mulyati Tugiran, Cut Yulia I Sari, Erlina Burhan, Retno Wahyuningsih, Riina Rautemaa-Richardson, David W Denning

2645 related Products with: Evaluation and comparison of automated and manual ELISA for diagnosis of chronic pulmonary aspergillosis (CPA) in Indonesia.

96T96 wells (1 kit)1 Product tipe: Instrumen200ug96 wells (1 kit)1 kit(96 Wells)1 mg96 wells (1 kit) 5 G1000 100.00 ul

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#32735681   2020/07/31 To Up

Dengue epidemic in Malaysia: urban versus rural comparison of dengue immunoglobulin G seroprevalence among Malaysian adults aged 35-74 years.

A periodic serosurvey of dengue seroprevalence is vital to determine the prevalence of dengue in countries where this disease is endemic. This study aimed to determine the prevalence of dengue immunoglobulin G (IgG) seropositivity among healthy Malaysian adults living in urban and rural areas.
Nor Azila Muhammad Azami, Meng Ling Moi, Sharifah Azura Salleh, Hui-Min Neoh, Mohd Arman Kamaruddin, Nazihah Abdul Jalal, Norliza Ismail, Tomohiko Takasaki, Ichiro Kurane, Rahman Jamal

1581 related Products with: Dengue epidemic in Malaysia: urban versus rural comparison of dengue immunoglobulin G seroprevalence among Malaysian adults aged 35-74 years.

25100 μg100 μg100 μg100 μg100ug Lyophilized100 μg100 μg

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#32734203   2019/08/01 To Up

Proliferative Glomerulonephritis With Monoclonal IgG3λ Deposits: A Case Report of a Rare Cause of Monoclonal Gammopathy of Renal Significance.

Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits is a rare monoclonal gammopathy of renal significance with dense deposits on electron microscopy similar to polyclonal immune complex-mediated glomerulonephritis. 70% of patients with proliferative glomerulonephritis with monoclonal IgG are negative for a monoclonal (M) spike, and patients with this condition rarely develop an M spike during follow-up. We report a Chinese man in his 50s who presented with nephrotic syndrome and normal glomerular filtration rate. His first kidney biopsy showed masked IgG3 deposition, such that IgG3 staining was apparent only after digestion by enzyme on paraffin tissue, with a membranoproliferative pattern. During follow-up, his glomerular filtration rate worsened and proteinuria increased. 18 months after the first biopsy, the patient developed an M spike; a second kidney biopsy showed proliferative glomerulonephritis with monoclonal IgG deposits with unmasked IgG3λ deposition. The patient was successfully treated with bortezomib and dexamethasone, followed by lenalidomide and dexamethasone maintenance therapy.
Xiao-Juan Yu, Mang-Ju Wang, Zi-Hao Yong, Yi-Yi Ma, Su-Xia Wang, Fu-de Zhou, Ming-Hui Zhao

1098 related Products with: Proliferative Glomerulonephritis With Monoclonal IgG3λ Deposits: A Case Report of a Rare Cause of Monoclonal Gammopathy of Renal Significance.

100 ul100 ul100 ul100 ug100ul100ug Lyophilized100 ul100.00 ug100.00 ug200 ug100ul1 mg

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