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Habitual cigarette smoking attenuates shear-mediated dilation in the brachial artery but not in the carotid artery in young adults.In the present study, we hypothesized that habitual cigarette smoking attenuates endothelial function in the cerebral circulation as well as that of the peripheral circulation in young adults. To test this hypothesis, we measured cerebrovascular and peripheral flow-mediated dilation (FMD) in young smokers and nonsmokers in the present study. Ten healthy nonsmokers and 10 smokers participated in the study. We measured blood velocity and diameter in the brachial artery and internal carotid artery (ICA) using Doppler ultrasound. We identified shear-mediated dilation in the brachial artery and ICA by the percentage change in peak diameter during hyperemia stimulation (reactive hyperemia and hypercapnia). We measured the baseline diameter and the shear rate area under the curve from the onset of hyperemia to peak dilation in the brachial artery and ICA, finding the measurements of the smokers and those of the nonsmokers did not differ (p > .05). In contrast to brachial FMD (5.07 ± 1.79% vs. 7.92 ± 3.01%; smokers vs. nonsmokers, p = .019), FMD in the ICA was not attenuated in the smokers compared with that of the nonsmokers (5.46 ± 2.32% vs. 4.57 ± 2.70%; p = .442). These findings indicate that in young healthy smokers, cerebral endothelial function was preserved, and the response of cerebral endothelial function to smoking was different from that of peripheral vasculature.
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Clinico-pathological features, treatments and survival of malignant insulinomas: a multicenter study.management of malignant insulinomas is challenging due to the need to control both hypoglycaemic syndrome and tumor growth. Literature data is limited to small series.
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Kidney health for everyone everywhere-From prevention to detection and equitable access to care.
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Qualitative and Quantitative H NMR Spectroscopy for Determination of Divalent Metal Cation Concentration in Model Salt Solutions, Food Supplements and Pharmaceutical Products by Using EDTA as Chelating Agent.This paper introduces an H NMR method to identify individual divalent metal cations Be , Mg , Ca , Sr , Zn , Cd , Hg , Sn , and Pb in aqueous salt solutions through their unique signal shift and coupling after complexation with the salt of ethylenediamine tetraacetic acid (EDTA). Furthermore, quantitative determination applied for the divalent metal cations Ca , Mg , Hg , Sn , Pb and Zn (LOQ: 5-22 μg/mL) can be achieved using an excess of EDTA with aqueous model salt solutions. An internal standard is not required since a known excess of EDTA is added and the remaining free EDTA can be used to recalculate the quantity of chelated metal cations. The utility of the method is demonstrated for the analysis of divalent cations in some food supplements and in pharmaceutical products.
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Infective Endocarditis with mitral leaflet perforation and multiple embolic infarcts.
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High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolemia patients.Presentation of acute events in patients with atherosclerosis remains unpredictable even after controlling for classical risk factors. MicroRNAs (miRNAs) measured in liquid biopsies could be good candidate biomarkers to improve risk prediction. Here, we hypothesized that miRNAs could predict atherosclerotic plaque progression and clinical event presentation in familial hypercholesterolemia (FH) patients.
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