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#32471486   2020/05/29 To Up

Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation.

Immunotherapies targeting pathological tau have recently emerged as a promising approach for treatment of neurodegenerative disorders. We have previously showed that the mouse antibody DC8E8 discriminates between healthy and pathological tau, reduces tau pathology in murine tauopathy models and inhibits neuronal internalization of AD tau species in vitro.Here we show, that DC8E8 and antibodies elicited against the first-in-man tau vaccine, AADvac1, which is based on the DC8E8 epitope peptide, both promote uptake of pathological tau by mouse primary microglia. IgG1 and IgG4 isotypes of AX004, the humanized versions of DC8E8, accelerate tau uptake by human primary microglia isolated from post-mortem aged and diseased brains. This promoting activity requires the presence of the Fc-domain of the antibodies.The IgG1 isotype of AX004 showed greater ability to promote tau uptake compared to the IgG4 isotype, while none of the antibody-tau complexes provoked increased pro-inflammatory activity of microglia. Our data suggest that IgG1 has better suitability for therapeutic development.
Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J M Hoozemans

2199 related Products with: Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation.

4 Membranes/Box96T96T96T4 Arrays/Slide4 Membranes/Box4 Membranes/Box6 ml100 μg100 1 ml100 μg

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#32465044   2020/03/30 To Up

Complement Inhibition as Potential Novel Therapy for Antibody-Mediated Rejection after Lung Transplantation in Murine Antibody-Mediated Rejection Model.

Antibody-mediated rejection (AMR) can induce acute or chronic graft failure in organ transplantations. There are few reports regarding AMR in lung transplant, and no reports of effective therapy for AMR after lung transplant. This study aimed to verify the efficacy of anti-complement 5(anti-C5), which is reported to prevent AMR in kidney transplant, in an AMR-enhanced mouse model after lung transplant.
Y Shiina, H Suzuki, T Kaiho, H Matsumoto, A Hata, T Yamamoto, K Tanaka, Y Sakairi, H Wada, T Nakajima, S Motohashi, I Yoshino

1113 related Products with: Complement Inhibition as Potential Novel Therapy for Antibody-Mediated Rejection after Lung Transplantation in Murine Antibody-Mediated Rejection Model.

16 Arrays/Slide1 Set1 Set1 Set1 Set100 ug100ug100μg

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#32462058   2020/05/18 To Up

Imaging of lysophosphatidylcholine in an induced pluripotent stem cell-derived endothelial cell network.

Vascular endothelial cell disorders are closely related to cardiovascular disease (CVD) and pulmonary diseases. Abnormal lipid metabolism in the endothelium leads to changes in cell signalling, and the expression of genes related to immunity and inflammation. It is therefore important to investigate the pathophysiology of vascular endothelial disorders in terms of lipid metabolism, using a disease model of endothelium.
Yasuo Shimizu, Yusuke Nakamura, Yasuhiro Horibata, Mio Fujimaki, Keitaro Hayashi, Nobuhiko Uchida, Hiroko Morita, Ryo Arai, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto

2433 related Products with: Imaging of lysophosphatidylcholine in an induced pluripotent stem cell-derived endothelial cell network.

96 tests2 Pieces/Box100ug Lyophilized100ug Lyophilized100 μg1 mg1 mL100ug Lyophilized100ug Lyophilized

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#32461917   2020/05/05 To Up

Extreme elevations of alkaline phosphatase in pregnancy: A case report.

The normal serum concentration of alkaline phosphatase (ALP) in adults over the age of 18 ranges from 37 to 116 U/L, while in pregnant women levels of up to twice that upper limit can still be normal. There have been very few reports of extreme elevations in ALP, and here we present the case of a 29-year-old pregnant woman with an incidentally found 30-fold increase.
Zachary Stanley, Katherine Vignes, Miriam Marcum

2765 related Products with: Extreme elevations of alkaline phosphatase in pregnancy: A case report.

100ul1 kit900 tests100ul 100ul100ug

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#32452410   2020/04/30 To Up

Association of viral load with serum biomakers among COVID-19 cases.

Since SARS-CoV-2 spreads rapidly around the world, data have been needed on the natural fluctuation of viral load and clinical indicators associated with it. We measured and compared viral loads of SARS-CoV-2 from pharyngeal swab, IgM anti-SARS-CoV-2, CRP and SAA from serum of 114 COVID-19 patients on admission. Positive rates of IgM anti-SARS-CoV-2, CRP and SAA were 80.7%, 36% and 75.4% respectively. Among IgM-positive patients, viral loads showed different trends among cases with different severity, While viral loads of IgM-negative patients tended to increase along with the time after onset. As the worsening of severity, the positive rates of CRP and SAA also showed trends of increase. Different CRP/SAA type showed associations with viral loads in patients in different severity and different time after onset. Combination of the IgM and CRP/SAA with time after onset and severity may give suggestions on the viral load and condition judgment of COVID-19 patients.
Fengjuan Shi, Tao Wu, Xiaojuan Zhu, Yiyue Ge, Xiaoyan Zeng, Ying Chi, Xuefei Du, Liguo Zhu, Fengcai Zhu, Baoli Zhu, Lunbiao Cui, Bin Wu

2253 related Products with: Association of viral load with serum biomakers among COVID-19 cases.

100 extractions500 ml100 ml2ml25 mg

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