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#34130337   2021/06/15 To Up

Current and Evolving Indications for Simultaneous Liver Kidney Transplantation.

This review will discuss the etiologies of kidney disease in liver transplant candidates, provide a historical background of the prior evolution of simultaneous liver-kidney (SLK) transplant indications, discuss the current indications for SLK including Organ Procurement and Transplantation Network policies and Model for End Stage Liver Disease exception points, as well as provide an overview of the safety net kidney transplant policy. Finally, the authors explore unanswered questions and future research needed in SLK transplantation.
Kathy M Nilles, Josh Levitsky

1173 related Products with: Current and Evolving Indications for Simultaneous Liver Kidney Transplantation.

100ul 500 ml 25 mgN/A 100ul100 mg250ul

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#34130304   2021/06/15 To Up

Abdominal Panniculectomy Can Simplify Kidney Transplantation in Obese Patients.

Obesity is frequently present in patients suffering from end-stage renal disease (ESRD). However, overweight kidney transplant candidates are a challenge for the transplant surgeon. Obese patients tend to develop a large abdominal panniculus after weight loss creating an area predisposed to wound-healing disorders. Due to concerns about graft survival and postoperative complications after kidney transplantation, obese patients are often refused in this selective patient cohort. The study aimed to analyze the effect of panniculectomies on postoperative complications and transplant candidacy in an interdisciplinary setting.
Dominik Promny, Theresa Hauck, Aijia Cai, Andreas Arkudas, Katharina Heller, Bernd Wullich, Hendrik Apel, Raymund E Horch, Ingo Ludolph

2598 related Products with: Abdominal Panniculectomy Can Simplify Kidney Transplantation in Obese Patients.



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#34130301   2021/06/15 To Up

From Proteinuria to Fibrosis: An Update on Pathophysiology and Treatment Options.

Proteinuria is a key biomarker in nephrology. It is central to diagnosis and risk assessment and the primary target of many important therapies. Etiologies resulting in pathological proteinuria include congenital and acquired disorders, as well as both glomerular (immune/non-immune mediated) and tubular defects.
Sonia Sharma, Brendan Smyth

1512 related Products with: From Proteinuria to Fibrosis: An Update on Pathophysiology and Treatment Options.

200 0.2 mg1 mL200 1 module100ug1 ml0.2 mg100ug100 µg1 module

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#34130292   2021/06/15 To Up

Long-Term Outcomes of Kidney Transplants from Older/Marginal Donors: A Cohort Study.

To safely expand the donor pool, we introduced a strategy of biopsy-guided selection and allocation to single or dual transplantation of kidneys from donors >60 years old or with hypertension, diabetes, and/or proteinuria (older/marginal donors). Here, we evaluated the long-term performance of this approach in everyday clinical practice.
Boris Bikbov, Piero Ruggenenti, Annalisa Perna, Norberto Perico, Eliana Gotti, AnnaRita Plati, Flavio Gaspari, Fabiola Carrara, Vincenzo Gambara, Tobia Peracchi, Giuseppe Rossini, Giovanni Rota, Francesco Lacanna, Annalisa Amaduzzi, Michele Colledan, Giuseppe Remuzzi

2880 related Products with: Long-Term Outcomes of Kidney Transplants from Older/Marginal Donors: A Cohort Study.

1 mg100 100 μg100 μg100 μg100 μg0.1 mg50 100ug100 μg

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#34130291   2021/06/15 To Up

Calcineurin Inhibitor Toxicity in Solid Organ Transplantation.

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Andrea Karolin, Vera Genitsch, Daniel Sidler

1190 related Products with: Calcineurin Inhibitor Toxicity in Solid Organ Transplantation.

5 mg1 mg100 mg5 mg1 mg5 mg5 mg5 mg25 mg5 mg1 mg2 mg

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#34130288   2021/06/15 To Up

Indoleamine-2,3-Dioxygenase Activates Wnt/β-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.

As disorder of tryptophan metabolism is common in CKD, the rate-limiting enzyme of tryptophan, indoleamine-2,3-dioxygenase (IDO), has been reported to be involved in CKD, while the accurate mechanism remains unknown. This study was designed to explore correlations between IDO and kidney fibrosis after ischemia-reperfusion injury (IRI).
Binbin Pan, Hao Zhang, Yali Hong, Mengqing Ma, Xin Wan, Changchun Cao

1291 related Products with: Indoleamine-2,3-Dioxygenase Activates Wnt/β-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.

96T 100ul

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#34130287   2021/06/15 To Up

Association of Acute Kidney Injury with Outcomes in Patients Undergoing Transcatheter Mitral Valve Repair.

Although transcatheter mitral valve repair (TMVr) is a contrast-free procedure, prior single-center studies have demonstrated a high incidence of acute kidney injury (AKI) following TMVr. The main objective of this study was to examine risk factors for AKI, and its association with outcomes in patients undergoing TMVr.
Salik Nazir, Keerat Rai Ahuja, Dhaval Kolte, Tanush Gupta, Sahil Khera, Sammy Elmariah

1555 related Products with: Association of Acute Kidney Injury with Outcomes in Patients Undergoing Transcatheter Mitral Valve Repair.

96T

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#34130218   2021/06/12 To Up

Synthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles.

African trypanosomiasis is a zoonotic protozoan disease affecting the nervous system. Various natural products reportedly exhibit trypanocidal activity. Naturally occurring 2,5-diphenyloxazoles present in Oxytropis lanata, and their derivatives, were synthesized. The trypanocidal activities of the synthesized compounds were evaluated against Trypanosoma brucei brucei, T. b. gambiense, T. b. rhodesiense, T. congolense, and T. evansi. Natural product 1 exhibited trypanocidal activity against all the species/subspecies of trypanosomes, exhibiting half-maximal inhibitory concentrations (IC) of 1.1-13.5 μM. Modification of the oxazole core improved the trypanocidal activity. The 1,3,4-oxadiazole (7) and 2,4-diphenyloxazole (9) analogs exhibited potency superior to that of 1. However, these compounds exhibited cytotoxicity in Madin-Darby bovine kidney cells. The O-methylated analog of 1 (12) was non-cytotoxic and exhibited selective trypanocidal activity against T. congolense (IC = 0.78 µM). Structure-activity relationship studies of the 2,5-diphenyloxazole analogs revealed aspects of the molecular structure critical for maintaining selective trypanocidal activity against T. congolense.
Koichi Narita, Keisuke Suganuma, Toshihiro Murata, Ryutaro Kondo, Hiroka Satoh, Kazuhiro Watanabe, Kenroh Sasaki, Noboru Inoue, Yuichi Yoshimura

1630 related Products with: Synthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles.

5 G1 kit200ul100 assays192 samples25 mg40 assays100Tests1000 tests

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