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Search results for: KITLG

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#34114687   2021/06/11 To Up

Familial progressive hyper- and hypopigmentation caused by a novel mutation in site II of the KITLG gene.


Zhenfeng Liu, Zhenlai Zhu, Junjie Luo, Bin Yang

1495 related Products with: Familial progressive hyper- and hypopigmentation caused by a novel mutation in site II of the KITLG gene.

300 units11 Set

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#34093644   2021/05/20 To Up

The GWAS Analysis of Body Size and Population Verification of Related SNPs in Hu Sheep.

Body size is an important indicator of growth and health in sheep. In the present study, we performed Genome-Wide Association Studies (GWAS) to detect significant single-nucleotide polymorphisms (SNPs) associated with Hu sheep's body size. After genotyping parental (G1) and offspring (G2) generation of the nucleus herd for meat production of Hu sheep and conducting GWAS on the body height, chest circumference, body length, tail length, and tail width of the two groups, 5 SNPs associated with body height and 4 SNPs correlated with chest circumference were identified at the chromosomal significance level. No SNPs were significantly correlated to body length, tail length, and width. Four out of the 9 SNPs were found to be located within the 4 genes. and are considered as candidate functional genes related to body height; and are candidate functional genes related to chest circumference. The 9 SNPs found in GWAS were verified using the G3 generation of the nucleus herd for meat production. Nine products were amplified around the 9 sites, and 29 SNPs were found; 3 mutation sites, G > C mutation at 134 bp downstream of s554331, T > G mutation at 19 bp upstream of s26859.1, and A > G mutation at 81 bp downstream of s26859.1, were significantly correlated to the body height. Dual-luciferase reporter gene experiments showed that the 3 SNPs could significantly impact dual-luciferase and gene transcription activity.
Junfang Jiang, Yuhao Cao, Huili Shan, Jianliang Wu, Xuemei Song, Yongqing Jiang

2923 related Products with: The GWAS Analysis of Body Size and Population Verification of Related SNPs in Hu Sheep.

1 ml0.1 ml1 ml100 μg100 μg100 μg2ug0.1 mg1.0mg100 μg 100ul

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#34053447   2021/05/31 To Up

Highly heterogeneous-related genes of triple-negative breast cancer: potential diagnostic and prognostic biomarkers.

Triple-negative breast cancer (TNBC) is a highly heterogeneous subtype of breast cancer, showing aggressive clinical behaviors and poor outcomes. It urgently needs new therapeutic strategies to improve the prognosis of TNBC. Bioinformatics analyses have been widely used to identify potential biomarkers for facilitating TNBC diagnosis and management.
Yiduo Liu, Linxin Teng, Shiyi Fu, Guiyang Wang, Zhengjun Li, Chao Ding, Haodi Wang, Lei Bi

1833 related Products with: Highly heterogeneous-related genes of triple-negative breast cancer: potential diagnostic and prognostic biomarkers.

100ul 100ul2 Pieces/Box

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#33975729   2021/05/08 To Up

Pathways and factors regulated by bone marrow-derived stem cells in human ovarian tissue.

To describe molecular and paracrine signaling changes produced by human bone marrow-derived stem cells (BMDSC) in human ovarian cortex.
Anna Buigues, Patricia Diaz-Gimeno, Patricia Sebastian-Leon, Livia Pellegrini, Nuria Pellicer, Antonio Pellicer, Sonia Herraiz

1459 related Products with: Pathways and factors regulated by bone marrow-derived stem cells in human ovarian tissue.

1 mg10 ug1

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#33911192   2021/04/28 To Up

Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival.

The expanding targeted therapy landscape requires combinatorial biomarkers for patient stratification and treatment selection. This requires simultaneous exploration of multiple genes of relevant networks to account for the complexity of mechanisms that govern drug sensitivity and predict clinical outcomes. We present the algorithm, Digital Display Precision Predictor (DDPP), aiming to identify transcriptomic predictors of treatment outcome. For example, 17 and 13 key genes were derived from the literature by their association with MTOR and angiogenesis pathways, respectively, and their expression in tumor versus normal tissues was associated with the progression-free survival (PFS) of patients treated with everolimus or axitinib (respectively) using DDPP. A specific eight-gene set best correlated with PFS in six patients treated with everolimus: AKT2, TSC1, FKB-12, TSC2, RPTOR, RHEB, PIK3CA, and PIK3CB (r = 0.99, p = 5.67E-05). A two-gene set best correlated with PFS in five patients treated with axitinib: KIT and KITLG (r = 0.99, p = 4.68E-04). Leave-one-out experiments demonstrated significant concordance between observed and DDPP-predicted PFS (r = 0.9, p = 0.015) for patients treated with everolimus. Notwithstanding the small cohort and pending further prospective validation, the prototype of DDPP offers the potential to transform patients' treatment selection with a tumor- and treatment-agnostic predictor of outcomes (duration of PFS).
Vladimir Lazar, Shai Magidi, Nicolas Girard, Alexia Savignoni, Jean-François Martini, Giorgio Massimini, Catherine Bresson, Raanan Berger, Amir Onn, Jacques Raynaud, Fanny Wunder, Ioana Berindan-Neagoe, Marina Sekacheva, Irene Braña, Josep Tabernero, Enriqueta Felip, Angel Porgador, Claudia Kleinman, Gerald Batist, Benjamin Solomon, Apostolia Maria Tsimberidou, Jean-Charles Soria, Eitan Rubin, Razelle Kurzrock, Richard L Schilsky

1306 related Products with: Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival.

1 mg1 mg1 module50 mL1 module1 mL1 mg

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#33867398   2021/04/16 To Up

Alterations of transcriptome expression, cell cycle, and mitochondrial superoxide reveal foetal endothelial dysfunction in Saudi women with gestational diabetes mellitus.

Gestational diabetes mellitus (GDM) affects one in four Saudi women and is associated with high risks of cardiovascular diseases in both the mother and foetus. It is believed that endothelial cells (ECs) dysfunction initiates these diabetic complications. In this study, differences in the transcriptome profiles, cell cycle distribution, and mitochondrial superoxide (MTS) between human umbilical vein endothelial cells (HUVECs) from GDM patients and those from healthy (control) subjects were analysed. Transcriptome profiles were generated using high-density expression microarray. The selected four altered genes were validated using qRT-PCR. MTS and cell cycle were analysed by flow cytometry. A total of 84 altered genes were identified, comprising 52 upregulated and 32 downregulated genes in GDM.HUVECs. Our selection of the four interested altered genes (TGFB2, KITLG, NEK7, and IGFBP5) was based on the functional network analysis, which revealed that these altered genes are belonging to the highest enrichment score associated with cellular function and proliferation; all of which may contribute to ECs dysfunction. The cell cycle revealed an increased percentage of cells in the G2/M phase in GDM.HUVECs, indicating cell cycle arrest. In addition, we found that GDM.HUVECs had increased MTS generation. In conclusion, GDM induces persistent impairment of the biological functions of foetal ECs, as evidenced by analyses of transcriptome profiles, cell cycle, and MTS even after ECs culture in vitro for several passages under normal glucose conditions.
Samar Sultan, Farid Ahmed, Osama Bajouh, Hans-Juergen Schulten, Nadia Bagatian, Roaa Al-Dayini, Ohoud Subhi, Sajjad Karim, Sultanah Almalki

1642 related Products with: Alterations of transcriptome expression, cell cycle, and mitochondrial superoxide reveal foetal endothelial dysfunction in Saudi women with gestational diabetes mellitus.

1.00 flask2 Pieces/Box1.00 flask2 Pieces/Box1.00 flask2 Pieces/Box1.00 flask96 tests1x10e7 cells1.00 flask1.00 flask

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#33804589   2021/03/01 To Up

Correction: Weich, K., et al. Pigment Intensity in Dogs Is Associated with a Copy Number Variant Upstream of . 2020, , 75.

The authors wish to make the following corrections to this paper [...].
Danika L Bannasch, Verena K Affolter, Daniel York, Robert B Rebhun, Robert A Grahn, Kalie M Weich, Angelica Kallenberg

2926 related Products with: Correction: Weich, K., et al. Pigment Intensity in Dogs Is Associated with a Copy Number Variant Upstream of . 2020, , 75.

100 μg100ug Lyophilized0.1ml (1mg/ml)100 ul100ug Lyophilized100ug Lyophilized 5 G 5 G5 mg 1 G100ug Lyophilized100ug Lyophilized

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#33790969   2021/03/17 To Up

Machine Learning for Building Immune Genetic Model in Hepatocellular Carcinoma Patients.

Hepatocellular carcinoma (HCC) is the leading liver cancer with special immune microenvironment, which played vital roles in tumor relapse and poor drug responses. In this study, we aimed to explore the prognostic immune signatures in HCC and tried to construct an immune-risk model for patient evaluation.
Jun Liu, Zheng Chen, Wenli Li

1685 related Products with: Machine Learning for Building Immune Genetic Model in Hepatocellular Carcinoma Patients.



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#33575478   2020/11/26 To Up

Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of and genes in glioma SCs .

Cancer stem cells (CSCs) use their stemness properties to perpetuate their lineage and survive chemotherapy. Currently cell-based and cell-free therapies are under investigation to develop novel anti-cancer treatment modalities. We designed this study to investigate how cell extracts of mesenchymal stem cells affect the growth of glioma stem cells . Gliospheres were generated from the U87MG cell line and treated with conditioned media of Wharton's jelly and bone marrow mesenchymal stem cells. The effects were investigated at the functional and molecular levels. Our results showed that conditioned media from both types of mesenchymal stem cells changed the morphology of spheres and inhibited the proliferation, invasion, and self-renewal ability of glioma stem cells. At the molecular level, metabolism interruption at oxidative phosphorylation, cell cycle arrest, cell differentiation, and upregulation of the immune response were observed. Furthermore, this effect was mediated by the upregulation of the gene inhibiting the Wnt pathway mediated by growth factor activity and downregulation of the gene activated by growth factor and cytokine activity, inhibiting multiple pathways. We conclude that different types of mesenchymal stem cells possess antitumor properties and their paracrine factors, in combination with anti-immune modalities, can provide practical therapeutic targets for glioblastoma treatment.
Nazneen Aslam, Elham Abusharieh, Duaa Abuarqoub, Dema Ali, Dana Al-Hattab, Suha Wehaibi, Ban Al-Kurdi, Fatima Jamali, Walhan Alshaer, Hanan Jafar, Abdalla S Awidi

2139 related Products with: Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of and genes in glioma SCs .

200.00 ug100 μg500 100ug100ug Lyophilized100.00 ul

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