Search results for: Kit
#33079815 2020/10/19 To Up
COVID-19 and Nurse-Sensitive Indicators: Using Performance Improvement Teams to Address Quality Indicators During a Pandemic.Nurse-sensitive quality indicators have historically been used as a metric of nursing care quality in health care organizations.
Janet Stifter, Emily Sermersheim, Mary Ellsworth, Erin Dowding, Elizabeth Day, Karen Silvestri, Jessica Margwarth, Kerem Korkmaz, Nicole Walkowiak, Lisa Boudreau, Laura Hernandez, Bryce Harbert, Shirley Ambutas, Aney Abraham, Phil Shaw
2179 related Products with: COVID-19 and Nurse-Sensitive Indicators: Using Performance Improvement Teams to Address Quality Indicators During a Pandemic.1 module100ug1 module100 µg5 g1 kit(96 Wells)1 mg200 50 ug 100 1 module 50 UG
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#33079516 2020/10/20 To Up
Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip.A
Maha Alafeef, Ketan Dighe, Parikshit Moitra, Dipanjan Pan
1771 related Products with: Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip.250tests100tests2x96 well plate2x96 well plate200ug2x384 well plate250ul2x96 well plates100tests2x96 well plate250ul100tests
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#33079405 2020/10/20 To Up
Efficacy of axitinib in metastatic head and neck cancer with novel radiographic response criteria.There are limited treatment options for unresectable recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Vascular endothelial growth factor is of significant interest for targeted therapy in R/M HNSCC because of its central role in tumorigenesis and immunosuppression. Axitinib is a potent inhibitor of vascular endothelial growth factor receptor (VEGFR) 1 , VEGFR2, VEGFR3, platelet-derived growth factor receptor, as well as c-kit and offers such an approach.
Paul L Swiecicki, Emily L Bellile, Collin V Brummel, J Chad Brenner, Francis P Worden
1450 related Products with: Efficacy of axitinib in metastatic head and neck cancer with novel radiographic response criteria.
#33079389 2020/10/20 To Up
Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI™.Plasma specimens from COVID-19 patients were double-tested for anti-SARS-CoV-2 antibodies by two different batches of MAGLUMI™ 2019-nCov IgM/IgG assays to evaluate IgM/IgG levels, qualitative interpretation, antibody kinetics and linearity of diluted specimen. Here we show that (i) high-level IgM specimens need to be diluted with negative human plasma but not kit diluents and (ii) measured anti-SARS-CoV-2 IgM/IgG concentrations are substantially higher with later marketed immunoassay batch leading to (iii) the change of qualitative interpretation (positive vs. negative) in 12.3 % of specimens measured for IgM, (iv) the informative time-course pattern of antibody production only when data from different immunoassay batches are not combined. This article is protected by copyright. All rights reserved.
Iveta Selingerova, Dalibor Valik, Lenka Gescheidtova, Vladimir Sramek, Zdenka Cermakova, Lenka Zdrazilova-Dubska
1342 related Products with: Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI™.0.2 mg0.1ml0.1ml1 ml0.1ml100 TESTS0.1ml0.1ml (1mg/ml)1mg0.1ml0.25 mg100 ul
#33079215 2020/10/20 To Up
A diagnostic marker kit for Fusarium wilt and sterility mosaic diseases resistance in pigeonpea.Fusarium wilt (FW) and sterility mosaic diseases (SMD) are key biotic constraints to pigeonpea production. Occurrence of these two diseases in congenial conditions is reported to cause complete yield loss in susceptible pigeonpea cultivars. Various studies to elucidate genomic architecture of the two traits have revealed significant marker-trait associations for use in breeding programs. However, these DNA markers could not be used effectively in genomics-assisted breeding for developing FW and SMD resistant varieties primarily due to pathogen variability, location or background specificity, lesser phenotypic variance explained by the reported QTL and cost-inefficiency of the genotyping assays. Therefore, in the present study, a novel approach has been used to develop a diagnostic kit for identification of suitable FW and SMD resistant lines. This kit was developed with 10 markers each for FW and SMD resistance. Investigation of the diversity of these loci has shown the role of different alleles in different resistant genotypes. Two genes (C.cajan_03691 and C.cajan_18888) for FW resistance and four genes (C.cajan_07858, C.cajan_20995, C.cajan_21801 and C.cajan_17341) for SMD resistance have been identified. More importantly, we developed a customized and cost-effective Kompetitive allele-specific PCR genotyping assay for the identified genes in order to encourage their downstream applications in pigeonpea breeding programs. The diagnostic marker kit developed here will offer great strength to pigeonpea varietal development program, since the resistance against these two diseases is essentially required for nominating an improved line in varietal release pipeline.
Rachit K Saxena, Anil Hake, Abhishek Bohra, Aamir W Khan, Anupama Hingane, Rafat Sultana, Indra Prakash Singh, S J Satheesh Naik, Rajeev K Varshney
1117 related Products with: A diagnostic marker kit for Fusarium wilt and sterility mosaic diseases resistance in pigeonpea.500 tests540 tests500 tests500 tests
#33079022 2020/10/20 To Up
First Report of Garlic virus B infecting Garlic in India.Garlic (Allium sativum L.) is an economically important spice and vegetable crop grown throughout the world. Garlic viral disease complex caused by multiple virus infections is an important constraint in exploiting the potential yield of garlic. Among these viral pathogens, allexivirus (family Alphaflexiviridae) is the genus of viruses known for their degenerative effect on garlic yield. Their coexistence with other viruses, particularly potyviruses, has an adverse effect on garlic yield and quality (Perotto et al. 2010). During Sept 2018, while screening garlic germplasm accessions for the presence of allexiviruses, symptoms like foliar mosaic and curling were observed on accession G-204, planted at an experimental plot of ICAR-DOGR, Pune, India. A total of five samples comprised of five randomly selected G-204 garlic plants were collected from the experimental plot. Each sample contained leaves from the top, middle, and bottom portion of the individual garlic plants. These samples were subjected to RNA extraction using the RNeasy Plant Mini Kit (Qiagen, Germany) followed by reverse transcription (RT) using the Transcriptor cDNA synthesis kit (Roche Diagnostics, GmbH, Germany). The extracted RNA was then tested for allexiviruses such as garlic virus A (GarV-A), garlic virus B (GarV-B), garlic virus C (GarV-C), garlic virus D (GarV-D), and garlic virus X (GarV-X) by polymerase chain reaction (PCR) (Gawande et al. 2015; Roylawar et al. 2019; Baranwal et al. 2011; Gieck et al. 2009). Leaf samples tested through RT-PCR were found positive for garlic viruses GarV-A, GarV-B, GarV-C, GarV-D, and GarV-X. Allexiviruses other than GarV-B had been previously reported in India and hence further tests were conducted to confirm GarV-B infection. RT-PCR using primers, CF 5'- ATGGGAGACAGGTCGCAA-3' and CR5'- CTAAAATGTAAGCATGAGCGGT-3' designed specific to the coat protein yielded a 735-bp amplicon from all five G-204 plants. The amplified product was purified using QIAquick PCR Purification Kit (Qiagen, Germany) and cloned in pJET1.2 vector (Thermo Scientific, Lithuania). Two clones containing the CP gene were bidirectionally sequenced, and a consensus sequence was submitted to GenBank (MN650206). BLASTn results indicated that this consensus sequence showed 97.96% nucleotide (KP657919.1) and 100% amino acid sequence (AKN19940.1) identity with the CP sequence of GarV-B isolate from Poland. The presence of GarV-B was confirmed by enzyme-linked immunosorbent assay (ELISA) using a double-antibody sandwich ELISA kit (Arsh Biotech, Delhi, India) as per the manufacturer's protocol. An absorbance of reaction was read using a microplate reader at 405 nm. The mean OD values of negative and positive controls were 0.034 and 0.373, respectively. The OD values of five samples tested ranged from 0.210 to 0.296 indicating a positive reaction for GarV-B. To assess the presence of GarV-B in the available genetic stock, we tested 30 garlic germplasm accessions for GarV-B using RT-PCR. Out of these, 17 accessions were found positive for GarV-B. GarV-B has been reported from many countries (Gieck et al. 2009). This is the first report of GarV-B from India. Globally, allexiviruses are known for their adverse impact on garlic production (Oliveira et al. 2014). GarV-B together with other viruses can be a potential threat to garlic production in India. Further, detailed evaluations are needed to study the impact of GarV-B on garlic production in India.
Praveen Baliram Roylawar, Kiran S Khandagale, Pragati Randive, Gorakshnath E Atre, Suresh Janardhan Gawande, Major Singh50 ug2ug5ug96 tests100 2000 Units1 mg100 μg0.5 mg2
#33078756 // To Up
Rhabdoid melanoma: A diagnostic ordeal.A 64-year-old man presented with multiple, bilateral pulmonary nodules, considered clinically to be intrapulmonary metastasis from lung carcinoma. On histopathologic examination, a tumor with a solid growth pattern and rhabdoid neoplastic morphology was seen. Initially, a diagnosis of nonsmall cell carcinoma of lung was considered but the immunophenotype was not supportive. Further, extensive immunohistochemistry revealed SOX10, Melan-A, and HMB45 expression in the absence of S-100. Strong globular cytoplasmic staining for vimentin, SMA, Desmin, and WT1 were observed. A final diagnosis of rhabdoid melanoma was made. The immunoprofile of our case was unique from previously described rhabdoid melanoma in English literature. The globular staining for intermediate filaments such as desmin and SMA is a novel finding. The strong WT1 intracytoplasmic staining reported previously was also observed in this case, with intense globular characteristics.
Anurag Mehta, Abhimanyu Sharma, Garima Gupta100ug Lyophilized100ug Lyophilized100ug Lyophilized
#33078406 2020/10/20 To Up
β-Catenin signaling is important for osteogenesis and hematopoiesis recovery following methotrexate chemotherapy in rats.Cancer chemotherapy can significantly impair the bone formation and cause myelosuppression; however, their recovery potentials and mechanisms remain unclear. This study investigated the roles of the β-catenin signaling pathway in bone and bone marrow recovery potentials in rats treated with antimetabolite methotrexate (MTX) (five once-daily injections, 0.75 mg/kg) with/without β-catenin inhibitor indocyanine green (ICG)-001 (oral, 200 mg/kg/day). ICG alone reduced trabecular bone volume and bone marrow cellularity. In MTX-treated rats, ICG suppressed bone volume recovery on Day 11 after the first MTX injection. ICG exacerbated MTX-induced decreases on Day 9 osteoblast numbers on bone surfaces, their formation in vitro from bone marrow stromal cells (osteogenic differentiation/mineralization), as well as expression of osteogenesis-related markers Runx2, Osx, and OCN in bone, and it suppressed their subsequent recoveries on Day 11. On the other hand, ICG did not affect MTX-induced increased osteoclast density and the level of the osteoclastogenic signal (RANKL/OPG expression ratio) in bone, suggesting that ICG inhibition of β-catenin does nothing to abate the increased bone resorption induced by MTX. ICG also attenuated bone marrow cellularity recovery on Day 11, which was associated with the suppressed recovery of CD34 or c-Kit hematopoietic progenitor cell contents. Thus, β-catenin signaling is important for osteogenesis and hematopoiesis recoveries following MTX chemotherapy.
Jian Fan, Yu-Wen Su, Mohammadhossein Hassanshahi, Chia-Ming Fan, Yaser Peymanfar, Alessandro Piergentili, Fabio Del Bello, Wilma Quaglia, Cory J Xian
2389 related Products with: β-Catenin signaling is important for osteogenesis and hematopoiesis recovery following methotrexate chemotherapy in rats.100ug Lyophilized 1 G100ug Lyophilized100ug Lyophilized0.1 mg2 Pieces/Box100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized0.1ml
#33078103 2020/10/18 To Up
Anti-proliferation and apoptosis-inducing effects of sodium aescinate on retinoblastoma Y79 cells.To investigate the anti-proliferation and apoptosis-inducing effects of sodium aescinate (SA) on retinoblastoma Y79 cells and its mechanism.
Lei Li, Bing Xu, Cai-Rui Li, Miao-Miao Zhang, Sheng-Jun Wu, Wen-Jun Dang, Jing-Chen Liu, Shu-Guang Sun, Wei Zhao
2760 related Products with: Anti-proliferation and apoptosis-inducing effects of sodium aescinate on retinoblastoma Y79 cells.100ul100ul100.00 ug100ug Lyophilized1mg1 mg25 100ug Lyophilized100ug Lyophilized100ug200 100ug
#33078100 2020/10/18 To Up
Biosafety of a 3D-printed intraocular lens made of a poly(acrylamide-co-sodium acrylate) hydrogel and .To assess the biosafety of a poly(acrylamide-co-sodium acrylate) hydrogel (PAH) as a 3D-printed intraocular lens (IOL) material.
Jia-Wen Li, Yi-Jian Li, Xi-Su Hu, Yu Gong, Ben-Bin Xu, Hai-Wei Xu, Zheng-Qin Yin
2963 related Products with: Biosafety of a 3D-printed intraocular lens made of a poly(acrylamide-co-sodium acrylate) hydrogel and .1 g2.5 mg 500 G100ug10 mL 500 G96 wells (1 kit) 100 G10 mg100μl1 g 100 G
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