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#32746071   2020/07/24 To Up

Skill-oriented and Performance-driven Adaptive Curricula for Training in Robot-Assisted Surgery using Simulators: a Feasibility Study.

Virtual Reality (VR) simulators represent a remarkable educational opportunity in order to acquire and refine surgical practical skills. Nevertheless, there exists no consensus regarding a standard curriculum of simulation-based training. This study introduces an automatic, adaptive curriculum where the training session is real-time scheduled on the basis of the trainee's performances. An experimental study using the master console of the da Vinci Research Kit (Intuitive Surgical Inc., Sunnyvale, US) was carried out to test this approach. Tasks involving fundamental skills of robotic surgery were designed and simulated in VR. Twelve participants without medical background along with twelve medical residents were randomly and equally divided into two groups: a control group, self-managing the training session, and an experimental group, undergoing the proposed adaptive training. The performances of the experimental users were significantly better with respect to the ones of the control group after training (non-medical: p<0.01; medical: p=0.02). The analysis of the learning of the involved surgical skills highlighted how the adaptive training managed to better identify and compensate for the trainee's gaps. This trend was analogous in the non-medical and medical populations. No significant difference was identified between these classes in the baseline assessment: this underlines that robotic surgical devices require specific training before clinical practice.
Andrea Mariani, Edoardo Pellegrini, Elena De Momi

1626 related Products with: Skill-oriented and Performance-driven Adaptive Curricula for Training in Robot-Assisted Surgery using Simulators: a Feasibility Study.

18 kgs1,000 tests100 μg100ul100 μg100ug100 μg100ug Lyophilized100ug Lyophilized

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#32745408   // To Up

Cornering Spontaneous CP Violation with Charged-Higgs-Boson Searches.

Decades of precision measurements have firmly established the Kobayashi-Maskawa phase as the dominant source of the charge-parity (CP) violation observed in weak quark decays. However, it is still unclear whether CP violation is explicitly encoded in complex Yukawa matrices or instead stems from spontaneous symmetry breaking with underlying CP-conserving Yukawa and Higgs sectors. Here we study the latter possibility for the case of a generic two-Higgs-doublet model. We find that theoretical constraints limit the ratio t_{β} of the vacuum expectation values (vevs) to the range 0.22≤t_{β}≤4.5 and imply the upper bounds M_{H^{±}}≤435  GeV, M_{H_{2}^{0}}≤485  GeV and M_{H_{3}^{0}}≤545  GeV for the charged and extra neutral Higgs masses. We derive lower bounds on charged-Higgs couplings to bottom quarks which provide a strong motivation to study the nonstandard production and decay signatures pp→qbH^{±}(→q^{'}b) with all flavors q,q^{'}=u, c, t in the search for the charged Higgs boson. We further present a few benchmark scenarios with interesting discovery potential in collider analyses.
Ulrich Nierste, Mustafa Tabet, Robert Ziegler

1892 related Products with: Cornering Spontaneous CP Violation with Charged-Higgs-Boson Searches.

250ul100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized100ug100 μg100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug

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#32744765   2020/08/03 To Up

Synthesis and Reactivity of Bis(silylene)-Coordinated Calcium and Divalent Lanthanide Complexes.

Divalent lanthanide complexes of Eu ( 1 ) and Yb ( 2 ) coordinated by a chelating pyridine-based bis(silylene) ligand were isolated and fully characterized. Compared to the Eu(II) complex 1 , the Yb(II) complex 2 presents a lower thermal stability, resulting in the activation of one Si(II)-N bond and formation of an Yb(III) complex ( 3 ), which features a unique silylene-pyridyl-amido ligand. The different thermal stability of 1 and 2 points towards reduction-induced cleavage of one Si(II)-N bond of the bis(silylene) ligand. Successful isolation of the corresponding redox-inert bis(silylene) Ca(II) complex ( 5 ) was achieved at low temperature and thermal decomposition into a Ca(II) complex ( 4 ) bearing the same silylene-pyridyl-amido ligand was identified. In this case, the thermolysis reaction proceeds through another, non-redox induced, mechanism. An alternative higher yielding route to 4 was developed through an in situ generated silylene-pyridyl-amine proligand.
Peter Werner Roesky, Xiaofei Sun, Thomas Simler, Kevin Reiter, Florian Weigend

2740 related Products with: Synthesis and Reactivity of Bis(silylene)-Coordinated Calcium and Divalent Lanthanide Complexes.

50 ug 200ul10 mg1 ml100 mg100ug5mg25 mg100 mg 25 MG100ul200ug

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#32744384   2020/08/03 To Up

Diagnostic and Prognostic ability of salivary MMP-9 and S100A8 for periodontitis.

Salivary diagnostic using matrix metalloproteinase (MMP) and S100 for periodontitis is a promising issue. However, its prognostic effect is still unclear. This study aimed to evaluate the prognostic ability of salivary MMP-9 and S100A8 for periodontitis through non-surgical periodontitis treatment clinical trial.
Hyun-Duck Kim, Sungtae Kim, Sumin Jeon, Seon-Jip Kim, Hyun-Jae Cho, Young-Nim Choi

1837 related Products with: Diagnostic and Prognostic ability of salivary MMP-9 and S100A8 for periodontitis.

2.5 mg25 mg10 mg500 MG50 mg50 ug 25 mg96T100ul10 mg1000 tests100ug

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#32744363   2020/08/03 To Up

Isolation of Helicobacter pylori using leftover tissue in the rapid urease test kit.

Isolation of Helicobacter pylori is considered difficult because of the requirement of the additional biopsy tissue and the effort involved in the isolation of the bacterium. We investigated whether H pylori can be cultured from tissue samples used for the rapid urease test (RUT).
Eun Jeong Gong, Ji Yong Ahn, Da Kyung Jung, Sun Mi Lee, Gyu Young Pih, Ga Hee Kim, Hee Kyong Na, Jeong Hoon Lee, Hwoon-Yong Jung, Jung Mogg Kim

1014 related Products with: Isolation of Helicobacter pylori using leftover tissue in the rapid urease test kit.

96 tests96 tests900 tests

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#32744338   2020/08/03 To Up

Muscarinic cholinergic receptors in minor salivary gland tissues of patients with oral lichen planus: A case-control study.

Oral lichen planus (OLP) is a common, chronic immunological and inflammatory condition. Many of the OLP patients complain of xerostomia. The M3 muscarinic cholinergic receptors (MR3) are the main receptors in the salivary glands responsible for water secretion into the saliva. This study aimed to assess the level of M3 muscarinic cholinergic receptors in minor salivary glands of OLP patients.
Farzaneh Agha-Hosseini, Mahdieh-Sadat Moosavi, Iraj Mirzaii-Dizgah, Mohammad Samami

1348 related Products with: Muscarinic cholinergic receptors in minor salivary gland tissues of patients with oral lichen planus: A case-control study.



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#32744010   // To Up

[The cholestatic fibrosis induced by α-naphthylisothiocyanate in mice and the inflammation pathway].

To explore the development of cholestatic fibrosis induced by α-naphthylisothiocyanate (ANIT) and the inflammation pathways. Fifteen 129/Sv mice weighing (23±2) g were randomly divided into 2 groups: control group (=5) and experiment group (=10). The control group was fed commercial chow diet and the experiment group was fed the same diet supplemented with 0. 05% ANIT. Five mice in the experiment group were sacrificed on day 14 and 28 respectively. The gallbladder, serum and liver samples were collected. Biochemical indicators of cholestasis were detected following the procedures in the kit. Liver injury was evaluated by histopathological. Hepatic fibrosis and inflammatory response were analyzed by Q-PCR and WB. Compared with the control group, total bile acid (TBA), the main cholestasis biomarker, was increased from (3. 2±0. 9) μmol/L to (31. 6±4. 3) μmol/L in A-D14 group. AST and ALT, the biomarkers of liver injury, were also increased significantly (<0. 05). The expression levels of fibrotic factor tissue inhibitors of metalloproteinases 1 (), monocyte chemoattractant protein 1 () and collagen protein I () were higher than those of control group (<0. 05). The expressions of fibrosis protein Collagen I and α-SMA were also up-regulated. The collagen fibers of the liver were largely deposited and the liver fibrosis occurred (<0. 05). The expression of inflammatory factors was higher than the control group, JNK, c-Jun and STAT3 were activated (<0. 05). In A-D28 group, except AST, matrix metalloproteinases 2 () and indicators were slightly decreased, other indicators of cholestasis, liver injury, liver fibrosis and inflammation continued to be up-regulated or stable (<0. 05). After 14-day treatment with 0. 05% ANIT diet, significant cholestatic liver fibrosis occurred in mice. After 28 days of treatment, cholestasis liver fibrosis kept stable. The JNK inflammatory pathway played a crucial role in the development of liver fibrosis.
Yi-Shuang Luo, Xiu-Ting Zheng, Hao-Yue Zhang, Li-Ping Xu, Jia-Peng Qiu, Gang-Ming Xu, Ai-Ming Liu

2845 related Products with: [The cholestatic fibrosis induced by α-naphthylisothiocyanate in mice and the inflammation pathway].

116 Arrays/Slide

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#32743931   2020/08/02 To Up

Validation of the bag-mediated filtration system for environmental surveillance of poliovirus in Nairobi, Kenya.

This study compared the bag-mediated filtration system (BMFS) and standard WHO two-phase separation methods for poliovirus (PV) environmental surveillance, examined factors impacting PV detection, and monitored Sabin-like (SL) PV type 2 presence with withdrawal of oral polio vaccine type 2 (OPV2) in April 2016.
Christine S Fagnant-Sperati, Yuqi Ren, Nicolette A Zhou, Evans Komen, Benlick Mwangi, Joanne Hassan, Agnes Chepkurui, Rosemary Nzunza, James Nyangao, Walda B van Zyl, Marianne Wolfaardt, Peter N Matsapola, Fhatuwani B Ngwana, Stacey Jeffries-Miles, Angela Coulliette-Salmond, Silvia Peñaranda, Everardo Vega, Jeffry H Shirai, Alexandra L Kossik, Nicola K Beck, David S Boyle, Cara C Burns, Maureen B Taylor, Peter Borus, John Scott Meschke

2613 related Products with: Validation of the bag-mediated filtration system for environmental surveillance of poliovirus in Nairobi, Kenya.

5 G

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#32743910   2020/08/02 To Up

Phylogenomic approaches reveal how climate shapes patterns of genetic diversity in an African rain forest tree species.

The world's second largest expanse of tropical rain forest is in Central Africa and it harbours enormous species diversity. Population genetic studies have consistently revealed significant structure across central African rain forest plants, in particular a North-South genetic discontinuity around the equatorial line, in a continuous expanse of rain forest but where a climatic inversion is documented. Here, we took a phylogeographic approach by sequencing 351 nuclear markers in 112 individuals across the distribution of the African rain forest tree species Annickia affinis (Annonaceae). We showed for the first time that the North-South divide is the result of a single, major colonisation event across the climatic inversion from an ancestral population located in Gabon. We suggested that differences in ecological niche of populations located on either side of this inversion may have contributed to this phylogenetic discontinuity. We found evidence for inland dispersal, predominantly in northern areas, and variable demographic histories among genetic clusters, indicating that populations responded differently to past climate change. We show how newly-developed genomic tools can provide invaluable insights into our understanding of tropical rain forest evolutionary dynamics.
Andrew J Helmstetter, Biowa E N Amoussou, Kevin Bethune, Narcisse G Kandem, Romain Glèlè Kakaï, Bonaventure Sonké, Thomas L P Couvreur

2762 related Products with: Phylogenomic approaches reveal how climate shapes patterns of genetic diversity in an African rain forest tree species.

100ul 100ul50ul 100ul 100ul 100ul96T 100ul 100ul 100ul50 ug 100ul

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