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[Effects of Low Concentration Hydrogen Inhalation on Asthma and Sleep Function in Mice].

This study was designed to investigate the effects of low concentration hydrogen inhalation on asthma and sleep function in mice and the potential mechanism.

2958 related Products with: [Effects of Low Concentration Hydrogen Inhalation on Asthma and Sleep Function in Mice].



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Implementation of community and facility based HIV self-testing under routine conditions in southern Eswatini.

WHO recommends HIV self-testing (HIVST) as an additional approach to HIV testing services. The study describes the strategies used during phase-in of HIVST under routine conditions in Eswatini (formerly Swaziland).

1311 related Products with: Implementation of community and facility based HIV self-testing under routine conditions in southern Eswatini.

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Differences in Virus Detection and Cytokine Profiles between First Wheeze and Childhood Asthma.

To distinguish between first wheeze and asthma in early childhood, we investigated respiratory viruses and cytokine/chemokine profiles among patients with first wheeze and established asthma.

1785 related Products with: Differences in Virus Detection and Cytokine Profiles between First Wheeze and Childhood Asthma.

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Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma.

Growing evidence supports that isothiocyanates exert a wide range of bioactivities amongst of which is their capacity to interact with the epigenetic machinery in various cancers including melanoma. Our aim was to characterise the effect of sulforaphane and iberin on histone acetylation and methylation as a potential anti-melanoma strategy.

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Role of adiponectin in diabetes myocardial ischemia-reperfusion injury and ischemic postconditioning.

Patients with diabetes are vulnerable to myocardial I/R (ischaemia/reperfusion) injury, but are not responsive to IPO (ischaemic post-conditioning). We hypothesized that decreased cardiac Adiponectin (APN) is responsible for the loss of diabetic heart sensitivity to IPO cardioprotecton.

2575 related Products with: Role of adiponectin in diabetes myocardial ischemia-reperfusion injury and ischemic postconditioning.

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Catalpol Promotes the Proliferation and Differentiation of Osteoblasts Induced by High Glucose by Inhibiting KDM7A.

The protective effect of catalpol on diabetic osteoporosis (DOP) and its mechanism remain unclear. This study aimed to explore whether catalpol enhanced the proliferation and differentiation of MC3T3 cells induced by high glucose by inhibiting the expression of KDM7A.

1325 related Products with: Catalpol Promotes the Proliferation and Differentiation of Osteoblasts Induced by High Glucose by Inhibiting KDM7A.

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Investigation of Pre- and Post-Weaning Mortalities in Rabbits Bred in Egypt, with Reference to Parasitic and Bacterial Causes.

This study was conducted to investigate the causes of mortality in young rabbits. A total of 110 V-Line breed female rabbits aged 5 m were used in this study. Rabbit kits were examined daily in pre- and postweaning stages to detect clinical disorders that caused death. The postmortem examination was carried out on dead kits. Furthermore, rabbits were examined for the probable bacteriological and parasitological causes of death. Fecal samples were collected from each dead kit and examined by standard microbiological procedures for bacterial pathogens and macroscopically and microscopically for the presence of endo- and ectoparasites. Throughout two breeding seasons, 2238 newborns were obtained, of which 1736 died, accounting for a 77.57% mortality rate. During preweaning (1st month of age) and postweaning (up to 3 months of age), 1501 (67.10%) and 235 (31.90%) deaths were recorded, respectively. A postweaning fecal examination revealed that 198 out of 229 (86.50%) were diarrheic rabbits due to infection. spp. eggs were detected in 4.37% of fecal samples, and mites () were present in 6.55%. was detected in 100% of examined animals during pre- and postweaning periods; however, spp. were 97.22% and 43.67, respectively. Managemental risk factors were the main causes in preweaning mortality, including insufficient milk supply (37.37%), cannibalism (26.38%), mange infestation of a rabbit doe (22.20%), mastitis (4.30%), lack of doe care (5.00%), bronchopneumonia (2.13%), and enteritis (1.80%). However, risk factors in postweaning mortality included sudden death with general septicemia (13.80%), enteritis (9.63%), bronchopneumonia (5.43%), mange infestation (2.04%), and malnutrition (0.81%). In conclusion, the etiology of preweaning mortality in kits was related mainly to the doe, especially managemental risk factors. However, a combination of multiple pathogenic agents (parasites and bacteria) and managemental factors was reported in the postweaning stage. Careful attention must be paid to avoid these causes.

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Local health departments and the implementation of evidence-based policies to address opioid overdose mortality.

In the context of the opioid overdose crisis, local health departments are on the front lines, coordinating programs and services and translating state and federal policies into community action. While media reports describe growth of Overdose Education and Naloxone Distribution (OEND) programs among local health departments, little is known about program features, scope, and target populations. We surveyed health departments in 180 United States counties with high overdose mortality rates. Among health officials from 54 counties (30% response), many counties reported implementation of evidence-based practices, with a high degree of programmatic variation. The majority of responding health departments (94%) conducted overdose education and naloxone distribution (OEND) programs. Programs were heterogeneous in scale, with a reported median of 250 naloxone kits (range 1-25,000 kits) acquired for community distribution. In addition, four in five respondents were aware of their state's standing order policy for increasing naloxone access. While the majority of respondents reported county-level availability of at least one form of evidence-based medications to treat opioid use disorder (MOUD), many reported no availability of buprenorphine (33%) or methadone (43%). Local health departments are vital to reducing opioid overdose mortality, and many are implementing relevant evidence-based practices. To support further adoption of potentially life-saving strategies, health departments need adequate funding and staffing as well as policies and guidelines to support implementation.

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