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Search results for: Liver

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#32650341   2020/07/10 To Up

Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.

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Calvin Koh, Sundeep Lakhtakia, Mitsuhiro Kida, Cosmas Rinaldi Lesmana, Tiing Ang, Charles K F Vu, Than Aye Than, Sun Hwa Park, Majid Almadi, Charing Chong, Raymond Tang, Xi Wu, Hilmi Ida, Vinay Dhir, Nonthalee Pausawasdi, Basha Jahangeer, Zhendong Jin, Ai-Ming Yang, Anthony Teoh, Dong Wan Seo, Hsiu-Po Wang, Khek-Yu Ho

1357 related Products with: Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.

50 UG20 µl (10 mM)100 μg100 μg100ug100 μg

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#32650248   2020/07/02 To Up

A dual thiourea-appended perylenebisimide "turn-on" fluorescent chemosensor with high selectivity and sensitivity for Hg in living cells.

Sensing heavy metal ions particularly for the most toxic Hg is a long-term pursuit for chemists because of its obvious and extreme harmfulness to both the environment and human health. Herein, a novel 'turn-on' perylenebisimide-thiourea fluorescent probe PBI-BTB is achieved for rapid detection of Hg in a DMSO/HO (5/1, v/v) solution through a typical Hg-promoting desulfurization reaction, which has been investigated through Job's plot titration, FT-IR, H NMR and HRMS analysis. A remarkable fluorescence emission enhancement at 540 and 580 nm is observed in the presence of Hg, which is visible to the naked eye with high selectivity and sensitivity. Moreover, probe PBI-BTB combined strong anti-interference recognition with short response time (< 1 min). The rapid fluorescence response with low limit of detection (0.35 μM) in a wide pH range of 3.0-11.0 makes PBI-BTB a promising candidate for detection of Hg without any buffer system. Furthermore, the practicability of probe PBI-BTB upon the Hg recognition in human liver cancer cells (HepG-2) has been studied through fluorescent live cell imaging which reveals the probe's low toxicity to organism as well as the favorable cell permeability of PBI-BTB for detecting Hg in biological systems.
Yulong Liu, Liu Yang, Lu Li, Xiaomin Liang, Shijie Li, Ying Fu

1783 related Products with: A dual thiourea-appended perylenebisimide "turn-on" fluorescent chemosensor with high selectivity and sensitivity for Hg in living cells.

4 Arrays/Slide2 Pieces/Box2 ml4 Membranes/Box2 Pieces/Box4 Membranes/Box1.00 flask4 Arrays/Slide50 ul

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#32650222   2020/06/06 To Up

Distinct utilization of biotin in and between adipose and brain during aging is associated with a lipogenic shift in Wistar rat brain.

Tissue-specific metabolism determines their functions that collectively sense and respond to numerous stress cues to achieve systemic homeostasis. Chronic stress skews such metabolic profiles and leads to failure of organs as evidenced by a bias towards lipid synthesis and storage in the aging brain, muscle, and liver under Alzheimer's disease, sarcopenia, and non-alcoholic fatty liver disease, respectively. In contrast, the tissue destined for lipid synthesis and storage, such as adipose, limits its threshold and develops diabetes mellitus. However, the underlying factors that contribute to this lipogenic shift between organs are unknown. From this perspective, differential biotin utilization between lipid-rich tissues such as adipose and brain during aging was hypothesized owing to the established role of biotin in lipogenesis. The same was tested using young and aged Wistar rats. We found that adipose-specific biotin content was much higher than the brain irrespective of aging status, as well as its associated cues. However, within tissues, the adipose fails to maintain its biotinylation levels during aging whereas the brain seizes more biotin and exhibits lipid accumulation. Furthermore, mimicking the age-related stress cues in vitro such as high glucose and endoplasmic reticulum stress deprive the astroglial biotin content, but not that of adipocytes. Lipid accumulation in the aging brain was also correlated with increased S-adenosylmethionine levels and biotin utilization by astrocytes. In summary, differential biotin utilization between adipose and brain under aging and their respective cell types like adipocytes and astrocytes under age-associated stress cues connects well with the lipogenic shift in rat brain.
Ramaian Santhaseela Anand, Dhasarathan Ganesan, Senthilraja Selvam, Sudarshana Rajasekaran, Tamilselvan Jayavelu

2113 related Products with: Distinct utilization of biotin in and between adipose and brain during aging is associated with a lipogenic shift in Wistar rat brain.

50 UG96 tests100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#32650189   2020/06/27 To Up

Suspension of ulipristal acetate for uterine fibroids during ongoing EMA's review of liver injury risk: Unfortunate timing during the Covid-19 pandemic!

EMA decided that with ulipristal acetate (UPA) treatment for uterine fibroids, should be discontinued due to the associated risk of hepatic failure, We analyzed whether the risk of recurrent symptoms due to fibroids may lead to an increased risk of Covid -19 infection and death, that would exceed the former risk of hepatic failure and transplantation.
Serge Rozenberg, Perrine Revercez, Maxime Fastrez, Jean Vandromme, Dario Bucella

1630 related Products with: Suspension of ulipristal acetate for uterine fibroids during ongoing EMA's review of liver injury risk: Unfortunate timing during the Covid-19 pandemic!

500 ml 500 ml 96T0.1 ml100 mg100ug

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#32650183   2020/06/27 To Up

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.

A series of Pyrazolo[1,5-a]Pyrimidine analogs were designed and synthesized as novel tubulin inhibitors. Among them, compounds 1a and 1b showed the highest antiproliferative activity against a panel of cancer cell lines with average IC values of 24.8 nM and 28 nM, respectively. We determined the crystal structures of 1a and 1b in complex with tubulin and confirmed their direct binding to the colchicine site. Compounds 1a and 1b also effectively inhibited tubulin polymerization in vitro, induced cell cycle arrest in G2/M phase, and inhibited cancer cell migration. In addition, compound 1b exhibited high metabolic stability in human liver microsomes. Finally, 1b was highly effective in suppressing tumor growth in a B16-F10 mouse melanoma model without apparent toxicity. In summary, these results suggest that 1b represents a promising tubulin inhibitor worthy of further investigation.
Gang Li, Yuxi Wang, Ling Li, Yichang Ren, Xin Deng, Jin Liu, Wei Wang, Meihua Luo, Shuwen Liu, Jianjun Chen

1435 related Products with: Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.

10 mg1 kit25 Tests400Tests10 mg1 kit1 kit100 tests5 mg1 kit10 mg

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#32650164   2020/07/01 To Up

Evaluating toxicity impacts of environmental exposed chromium on small Indian mongoose (Urva auropunctatus) hematological, biochemical and histopathological functioning.

Sub-lethal toxic impacts of chromium on hematological, biochemical and histological parameters were analyzed in the female small Indian mongoose (Urva auropuctatus) residing contaminated environment of tannery industry. Chromium bioaccumulation in the blood, liver and kidney tissue of the exposed mongooses was found elevated compared to the control mongooses' tissues. Total body weight (75.7%), liver weight (83.6%) as well as HSI (68.1%), RSI (86.2%) and the platelets counts (59.7%) were found significantly elevated, with significantly reduced RBCs (59.6%), and WBCs (64%). LFT and RFT were also found abnormal, moreover, the histopathological injuries had been distinct inside the kidney (>75%) and hepatic (>75%) tissues of exposed animals. Shrinkage and vacuolization (>75%) inside the hepatocyte expanded sinusoidal spaces and nuclear pyknosis (>75%) was evident within the hepatic tissue. Hypertrophy of epithelial cells of renal tubules and inter-renal cells of the head kidney with a reduction in tubular lumens (>75%) and vacuolization of tubules were witnessed within the kidney section. Atrophy inside the kidney inter-renal cells, glomeruli compression within the Bowman's capsules (>75%) following the necrosis in hematopoietic tissues were found in exposed animals. The present findings indicate that chronic exposure to chromium induces severe anemia, decreased serum protein concentration, hepatic and renal tissue histopathology, impairing the vital capabilities of liver, metabolic regulation, excretion, and stress homeostasis maintenance of which within the long-run may posture a severe risk to animal well-being then distress their inhabitants.
Shaista Andleeb, Zulfiqar Ahmad, Tariq Mahmood, Shenxu Bao, Abdullah Arif Saeed, Sunil Kumar Jha

1779 related Products with: Evaluating toxicity impacts of environmental exposed chromium on small Indian mongoose (Urva auropunctatus) hematological, biochemical and histopathological functioning.

200ug 25 ml Ready-to-use 1 mg1 mg2 1.00 flask1,000 tests100ug 6 ml

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#32650090   2020/06/29 To Up

Computer-aided classification of hepatocellular ballooning in liver biopsies from patients with NASH using persistent homology.

Hepatocellular ballooning is an important histological parameter in the diagnosis of nonalcoholic steatohepatitis (NASH), and it is considered to be a morphological pattern that indicates the severity and the progression to cirrhosis and liver-related deaths. There remains uncertainty about the pathological criteria for evaluating the spectrum of non-alcoholic fatty liver disease (NAFLD) in liver biopsies. We introduce persistence images as novel mathematical descriptors for the classification of ballooning degeneration in the pathological diagnosis.
Takashi Teramoto, Toshiya Shinohara, Akihiro Takiyama

1353 related Products with: Computer-aided classification of hepatocellular ballooning in liver biopsies from patients with NASH using persistent homology.



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#32650064   2020/07/01 To Up

Anti-diabetic properties of genistein-chromium (III) complex in db/db diabetic mice and its sub-acute toxicity evaluation in normal mice.

In this study, chromium (III) complex was synthesized from genistein (GEN) which had good hypoglycemic activity and inorganic chromium (III) element, and its hypoglycemic activity and sub-acute toxicity were studied.
Pengshou Li, Yujia Cao, Ge Song, Baosheng Zhao, Qixiang Ma, Ziyong Li, Chaojun He

2999 related Products with: Anti-diabetic properties of genistein-chromium (III) complex in db/db diabetic mice and its sub-acute toxicity evaluation in normal mice.

50 ul

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#32650028   2020/07/07 To Up

The nootropic and anticholinesterase activities of Clitoria ternatea Linn. root extract: Potential treatment for cognitive decline.

Clitoria ternatea (CT) is an herbal plant that has been used as a memory booster in folk medicine. CT root extract has been proven to restore chronic cerebral hypoperfusion (CCH)-induced memory deficits in a rat model, but the underlying mechanisms and the toxicity profile following repeated exposure have yet to be explored.
Thenmoly Damodaran, Cheah Pike See, Vikneswaran Murugaiyah, Zurina Hassan

1046 related Products with: The nootropic and anticholinesterase activities of Clitoria ternatea Linn. root extract: Potential treatment for cognitive decline.

1200 mg2000 rxn1 mg10 mg500 Units25 g96 wells250 ml100 plates1000 tests

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#32649978   2020/07/07 To Up

Tβ4 suppresses lincRNA-p21-mediated hepatic apoptosis and fibrosis by inhibiting PI3K-AKT-NF-κB pathway.

Hepatic injury is one of the most challenging diseases in clinical medicine. Hepatic injury is accompanied by hepatocyte apoptosis and leads to hepatic fibrosis and cirrhosis, which may cause liver cancer and increased mortality. Therefore, it is essential to investigate the regulation mechanism and therapeutic strategies for hepatic injury. In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated. Results showed that lincRNA-p21 overexpression promoted hepatocytes apoptosis, which was blocked by Tβ4. Besides, Tβ4 reversed the levels of cleaved caspase-3 and caspase-9 induced by lincRNA-p21. LincRNA-p21 overexpression also caused the pathological injury and fibrosis in hepatic tissues and increased the levels of fibrosis-related proteins (Collagen I, α-SMA and TIMP-1), and induced hydroxyproline and ALT production. However, Tβ4 reversed the effects of overexpression of lincRNA-p21 on hepatic injury and fibrosis. In vitro experiments, after lincRNA-p21 was overexpressed in hepatic stellate cells (HSCs), the proliferation ability and the levels of HSCs markers α-SMA and Desmin were increased. However, Tβ4 reversed the effects of lincRNA-p21 on HSCs. Furthermore, the PI3K-AKT-NF-κB pathway was activated by lincRNA-p21, which was then reversed by the Tβ4 administration. After the mice treated by insulin-like growth factor-1 (IGF-1) (the activator of PI3K-AKT), the inhibitory effect of Tβ4 on activated the PI3K-AKT-NF-κB pathway was abrogated. Besides, IGF-1 abolished the protective effects of Tβ4 on hepatic apoptosis and fibrosis induced by lincRNA-p21. Therefore, Tβ4 reversed lincRNA-p21-mediated liver injury through inhibiting PI3K-AKT-NF-κB pathway. Tβ4 may be a promising drug for fibrosis therapy.
Li Yang, Wei-Li Fu, Ying Zhu, Xiao-Guang Wang

2285 related Products with: Tβ4 suppresses lincRNA-p21-mediated hepatic apoptosis and fibrosis by inhibiting PI3K-AKT-NF-κB pathway.

2 Pieces/Box2 Pieces/Box2 Pieces/Box1.5 x 10^6 cells100 ug100 ug 100 assays100ug Lyophilized5mg25 mg5100ul

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