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Search results for: Liver

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#33249748   2020/11/29 To Up

Beyond energy storage: roles of glycogen metabolism in health and disease.

Beyond storing and supplying energy in the liver and muscles, glycogen also plays critical roles in cell differentiation, signaling, redox regulation and stemness under various physiological and pathophysiological conditions. Such versatile functions have been revealed by various forms of glycogen storage diseases. Here, we outline the source of carbon flux in glycogen metabolism and discuss how glycogen metabolism guides CD8 T cell memory formation and maintenance. Likewise, we review how this affects macrophage polarization and inflammatory responses. Furthermore, we dissect how glycogen metabolism supports tumor development by promoting tumor-repopulating cell growth in hypoxic tumor microenvironments. This review highlights the essential role of the gluconeogenesis-glycogenesis-glycogenolysis-PPP metabolic chain in redox homeostasis, thus providing insights into potential therapeutic strategies against major chronic diseases including cancer.
Huafeng Zhang, Jingwei Ma, Ke Tang, Bo Huang

2940 related Products with: Beyond energy storage: roles of glycogen metabolism in health and disease.

96 tests96 tests1-99 mg/ml/ea price x 2

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#33249746   2020/11/29 To Up

Simulation of a detoxifying organ function: focus on hemodynamics modeling and convection-reaction numerical simulation in microcirculatory networks.

When modelling a detoxifying organ function, an important component is the impact of flow on the metabolism of a compound of interest carried by the blood. We here study the effects of red blood cells (such as the Fahraeus-Lindqvist effect and plasma skimming) on blood flow in typical microcirculatory components such as tubes, bifurcations and entire networks, with particular emphasis on the liver as important representative of detoxifying organs. In one of the plasma skimming models, under certain conditions, oscillations between states are found and analysed in a methodical study to identify their causes and influencing parameters. The flow solution obtained is then used to define the velocity at which a compound would be transported. A convection-reaction equation is studied to simulate the transport of a compound in blood and its uptake by the surrounding cells. Different types of signal sharpness have to be handled depending on the application to address different temporal compound concentration profiles. To permit executing the studied models numerically stable and accurate, we here extend existing transport schemes to handle converging bifurcations, and more generally multi-furcations. We study the accuracy of different numerical schemes as well as the effect of reactions and of the network itself on the bolus shape. Even though this study is guided by applications in liver micro-architecture, the proposed methodology is general and can readily be applied to other capillary network geometries, hence to other organs or to bioengineered network designs. This article is protected by copyright. All rights reserved.
Noemie Boissier, Dirk Drasdo, Irene E Vignon-Clementel

2188 related Products with: Simulation of a detoxifying organ function: focus on hemodynamics modeling and convection-reaction numerical simulation in microcirculatory networks.



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#33249742   2020/11/28 To Up

Catechin-Rich Green Tea Extract and the Loss-of-TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis.

Catechin-rich green tea extract (GTE) limits inflammation in nonalcoholic steatohepatitis (NASH) consistent with a Toll-like receptor 4 (TLR4)-dependent mechanism. Our hypothesis was that GTE supplementation during NASH would shift the hepatic metabolome similar to that attributed to the loss-of-TLR4 signaling.
Geoffrey Y Sasaki, Jinhui Li, Morgan J Cichon, Rachel E Kopec, Richard S Bruno

1416 related Products with: Catechin-Rich Green Tea Extract and the Loss-of-TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis.

110 100 G1

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#33249727   2020/11/29 To Up

Low skeletal muscle mass and significant fibrosis in non-alcoholic fatty liver disease: cause or effect?

We read with great interest the study by Hsieh et al. in which the authors have shown the significance of low skeletal muscle mass and myosteatosis in predicting significant fibrosis in patients with non-alcoholic fatty liver disease. We would like to highlight some points pertaining to this study.
Abhinav Anand, Sanchit Sharma, Anoop Saraya

1657 related Products with: Low skeletal muscle mass and significant fibrosis in non-alcoholic fatty liver disease: cause or effect?

96 wells100

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#33249718   2020/11/29 To Up

Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery.

Intraabdominal surgery is a known risk factor for splanchnic vein thrombosis (SVT). SVT incidence, management, and prognosis after hepatopancreatobiliary surgery are unknown.
Emmanuelle Duceppe, Jean-François Lauzon, Steven Galliger, Betty Zhang, Hannah Solomon, Pablo E Serrano

1549 related Products with: Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery.

100.00 ul200ug10 mg1000 tests100ug200ul25 mg100 mg200 10 mg100ug

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#33249637   2020/11/29 To Up

Notes on the gross anatomy of the heart of the broad-snouted caiman, Caiman latirostris (Daudin, 1802).

The broad-snouted caiman, Caiman latirostris (Daudin, 1802), is one of the six crocodilian species from Brazil. The topography, morphology and morphometry of the broad-snouted caiman heart were studied. Data were obtained from the necropsy of four adult animals, three females and one male. The hearts were removed from the coelomic cavity and fixed in 10% formalin for 48 hr for morphological and morphometric description. The heart is in the cranial mediastinum. It is caudally involved by the liver cranial margins, and ventrally by the ribs, intercostal muscles, and sternum and dorsally by the lungs. The four-chambered morphology is typical with two (right and left) atria and ventricles. Right and left aortic, pulmonary and subclavian arteries branch from the truncus arteriosus. Gubernaculum cordis is present as ligamentous folds uniting the heart apex to the pericardium. Main morphometric means are the apex-to-base length (49.86 mm), circumference (105.25 mm) and heart weight (45.03 g). The right atrium is craniocaudally longer with thicker walls, whereas the left ventricle is narrower. The topography, morphology and morphometry of the heart of C. latirostris are consistent with the anatomy of other crocodilian species.
Mariana de Oliveira Lima, Yhuri Cardoso Nóbrega, Marcelo Renan de Deus Santos, Louisiane de Carvalho Nunes, Rodrigo Giesta Figueiredo, Maria Aparecida da Silva

1524 related Products with: Notes on the gross anatomy of the heart of the broad-snouted caiman, Caiman latirostris (Daudin, 1802).

1200 units100 500IUmin 2 cartons100.00 ul 100 G1200 units

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#33249627   2020/11/28 To Up

Prognostic value of B-type natriuretic peptide in liver transplant patients: Implication in post-transplant mortality.

Despite frequent cirrhotic cardiomyopathy or subclinical heart failure (HF), the prognostic value of peri-liver transplant (LT) B-type natriuretic peptide (BNP) has been poorly studied in advanced liver disease. We examined the association between BNP and mortality in a large cohort of LT patients and identified risk factors for peri-LT BNP increase.
Hye-Mee Kwon, Young-Jin Moon, Kyoung-Sun Kim, Won-Jung Shin, In-Young Huh, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang

1993 related Products with: Prognostic value of B-type natriuretic peptide in liver transplant patients: Implication in post-transplant mortality.

96 assays96 wells (1 kit)200ul96 wells50

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#33249625   2020/11/29 To Up

Immunosuppressive Drug Resistant Armored TCR T cells for immune-therapy of HCC in liver transplant patients.

HBV-specific T cell receptor (HBV-TCR) engineered T cells have the potential for treating hepatocellular carcinoma (HCC) relapses after liver transplantation, but their efficacy can be hampered by the concomitant immunosuppressive treatment required to prevent graft rejection. Our aim is to molecularly engineer TCR-T cells that could retain their polyfunctionality in such patients while minimising the associated risk of organ rejection.
Morteza Hafezi, Meiyin Lin, Adeline Chia, Alicia Chua, Zi Zong Ho, Royce Fam, Damien Tan, Joey Aw, Andrea Pavesi, Thinesh Lee Krishnamoorthy, Wan Cheng Chow, Wenjie Chen, Qi Zhang, Lu-En Wai, Sarene Koh, Anthony T Tan, Antonio Bertoletti

1631 related Products with: Immunosuppressive Drug Resistant Armored TCR T cells for immune-therapy of HCC in liver transplant patients.

900 tests

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#33249617   2020/11/28 To Up

Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity.

The association between serum ferritin and nonalcoholic fatty liver disease (NAFLD) in children with obesity is not clear. This study was designed to investigate whether serum ferritin can be an independent predictor for NAFLD.
Junfeng Zhang, Jiajia Cao, Hui Xu, Guanping Dong, Ke Huang, Wei Wu, Jingjing Ye, Junfen Fu

2168 related Products with: Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity.

0.1ml (1mg/ml)430 tests900 tests1 kit(96 Wells)20 20 1 kit1 kit

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