Search results for: Fenofibrate CAS Number [49562 28 9]
#35169201 2022/02/15 To Up
Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.
Peroxisomes play an important role in the metabolism of a variety of biomolecules, including lipids and bile acids. Peroxisomal Membrane Protein 4 (PXMP4) is a ubiquitously expressed peroxisomal membrane protein that is transcriptionally regulated by peroxisome proliferator-activated receptor α (PPARα), but its function is still unknown. To investigate the physiological function of PXMP4, we generated a Pxmp4 knockout (Pxmp4) mouse model using CRISPR/Cas9-mediated gene editing. Peroxisome function was studied under standard chow-fed conditions and after stimulation of peroxisomal activity using the PPARα ligand fenofibrate or by using phytol, a metabolite of chlorophyll that undergoes peroxisomal oxidation. Pxmp4 mice were viable, fertile, and displayed no changes in peroxisome numbers or morphology under standard conditions. Also, no differences were observed in the plasma levels of products from major peroxisomal pathways, including very long-chain fatty acids (VLCFAs), bile acids (BAs), and BA intermediates di- and trihydroxycholestanoic acid. Although elevated levels of the phytol metabolites phytanic and pristanic acid in Pxmp4 mice pointed towards an impairment in peroxisomal α-oxidation capacity, treatment of Pxmp4 mice with a phytol-enriched diet did not further increase phytanic/pristanic acid levels. Finally, lipidomic analysis revealed that loss of Pxmp4 decreased hepatic levels of the alkyldiacylglycerol class of neutral ether lipids, particularly those containing polyunsaturated fatty acids. Together, our data show that while PXMP4 is not critical for overall peroxisome function under the conditions tested, it may have a role in the metabolism of (ether)lipids.Maaike Blankestijn, Vincent W Bloks, Dicky Struik, Nicolette Huijkman, Niels Kloosterhuis, Justina C Wolters, Ronald J A Wanders, Frédéric M Vaz, Markus Islinger, Folkert Kuipers, Bart van de Sluis, Albert K Groen, Henkjan J Verkade, Johan W Jonker
2517 related Products with: Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.
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#24844853 2014/05/17 To Up
Comparison of pharmacokinetics of two fenofibrate tablet formulations in healthy human subjects.
Fenofibrate is a serum lipid-lowering agent used as an adjunct to diet in patients with hypercholesterolemia and hypertriglyceridemia. The new fenofibrate tablet formulation was developed as a pharmaceutical equivalent to the marketed tablet formulation containing 145 mg.Siddharth S Chachad, Milind Gole, Geena Malhotra, Raghu Naidu
1674 related Products with: Comparison of pharmacokinetics of two fenofibrate tablet formulations in healthy human subjects.
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#7923327 // To Up
[Relation between hypertriacylglycerolemia and the action of insulin in type 2 diabetes mellitus].
Insulin resistance and hypertriacylglycerolaemia are part of the X syndrome and are supposed to be interrelated. The objective of the present trial was to evaluate the impact of hypolipidaemic treatment on the action of insulin evaluated by means of a so-called hyperinsulimaemic clamp and by examination of insulin receptors.J Skrha, G Sindelka, T Haas, J Hilgertová, V Justová
2814 related Products with: [Relation between hypertriacylglycerolemia and the action of insulin in type 2 diabetes mellitus].
96 wells (1 kit)96 wells (1 kit)96 wells (1 kit)5 20ug250ul250ul96 wells (1 kit)100ug200 100ug LyophilizedRelated Pathways
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