Gentaur Pub

#38635971   2024/04/18 To Up

RNA splicing modulates the postharvest physiological deterioration of cassava storage root.

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Jinbao Gu, Xiaowen Ma, Qiuxiang Ma, Zhiqiang Xia, Yan Lin, Jianbo Yuan, Yang Li, Cong Li, Yanhang Chen, Wenquan Wang, Peng Zhang, Zhen-Yu Wang

1653 related Products with: RNA splicing modulates the postharvest physiological deterioration of cassava storage root.

200ul15 x 20 Boxes/case 500 Units1000 units10 nmol100.1 mg

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#38634537   2024/04/18 To Up

Z-Type Ligand Enables Efficient and Stable Deep-Blue Perovskite Light-Emitting Diodes.

During the synthesis of deep-blue perovskite quantum dots (PQDs), they generally emerge as a two-dimensional byproduct with poor yield and low photoluminescence quantum yield (PLQY) due to amine ligand enrichment-induced abundant surface defects. Herein, we provide a colloidal synthesis method to prepare deep-blue CsPbBr PQDs in a green nontoxic solvent via strategic Z-type ligand engineering. Z-type ligands of zinc octanoate enable the formation of robust coordination bonds with surface bromide ions of PQDs, maintaining acid-base equilibrium and reducing excess amine enrichment on the PQDs surface. Consequently, homogeneous and monodispersed PQDs with improved PLQY of 73% are successfully synthesized, achieving efficient deep-blue LEDs with a peak EQE of 5.46%, a maximum luminance of 847.6 cd/m, and an operational half-lifetime of 14 min. The devices exhibit color coordinates of (0.137, 0.049), closely approximating the Rec. 2020 blue standard. Our work offers a potentially eco-friendly and viable route for realizing high-performance LEDs in the deep-blue region.
Yanfeng Chen, Meng Nan, Yanxing He, Shuang Lu, Wei Shen, Gang Cheng, Shufen Chen, Wei Huang

1306 related Products with: Z-Type Ligand Enables Efficient and Stable Deep-Blue Perovskite Light-Emitting Diodes.

96T50 200 100 ml100ug2ug10 ug

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#38634253   2024/04/17 To Up

The ARPKD Protein DZIP1L Regulates Ciliary Protein Entry by Modulating the Architecture and Function of Ciliary Transition Fibers.

Serving as the cell's sensory antennae, primary cilia are linked to numerous human genetic diseases when they malfunction. DZIP1L, identified as one of the genetic causes of human autosomal recessive polycystic kidney disease (ARPKD), is an evolutionarily conserved ciliary basal body protein. Although it has been reported that DZIP1L is involved in the ciliary entry of PKD proteins, the underlying mechanism remains elusive. Here, an uncharacterized role of DZIP1L is reported in modulating the architecture and function of transition fibers (TFs), striking ciliary base structures essential for selective cilia gating. Using C. elegans as a model, C01G5.7 (hereafter termed DZIP-1) is identified as the sole homolog of DZIP1L, which specifically localizes to TFs. While DZIP-1 or ANKR-26 (the ortholog of ANKRD26) deficiency shows subtle impact on TFs, co-depletion of DZIP-1 and ANKR-26 disrupts TF assembly and cilia gating for soluble and membrane proteins, including the ortholog of ADPKD protein polycystin-2. Notably, the synergistic role for DZIP1L and ANKRD26 in the formation and function of TFs is highly conserved in mammalian cilia. Hence, the findings illuminate an evolutionarily conserved role of DZIP1L in TFs architecture and function, highlighting TFs as a vital part of the ciliary gate implicated in ciliopathies ARPKD.
Huicheng Chen, Zhimao Wu, Ziwei Yan, Chuan Chen, Yingying Zhang, Qiaoling Wang, Yuqing Gao, Kun Ling, Jinghua Hu, Qing Wei

1733 related Products with: The ARPKD Protein DZIP1L Regulates Ciliary Protein Entry by Modulating the Architecture and Function of Ciliary Transition Fibers.

1mg102100 U100ul1000 TESTS/0.65ml100ug10050 100100ug Lyophilized5

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#38631466   2024/04/15 To Up

Could soil microplastic pollution exacerbate climate change? A meta-analysis of greenhouse gas emissions and global warming potential.

Microplastics pollution and climate change are primarily investigated in isolation, despite their joint threat to the environment. Greenhouse gases (GHGs) are emitted during: the production of plastic and rubber, the use and degradation of plastic, and after contamination of environment. This is the first meta-analysis to assess underlying causal relationships and the influence of likely mediators. We included 60 peer-reviewed empirical studies; estimating GHGs emissions effect size and global warming potential (GWP), according to key microplastics properties and soil conditions. We investigated interrelationships with microbe functional gene expression. Overall, microplastics contamination was associated with increased GHGs emissions, with the strongest effect (60%) on CH emissions. Polylactic-acid caused 32% higher CO emissions, but only 1% of total GWP. Phenol-formaldehyde had the greatest (175%) GWP via 182% increased NO emissions. Only polystyrene resulted in reduced GWP by 50%, due to NO mitigation. Polyethylene caused the maximum (60%) CH emissions. Shapes of microplastics differed in GWP: fibre had the greatest GWP (66%) whereas beads reduced GWP by 53%. Films substantially increased emissions of all GHGs: 14% CO, 10% NO and 60% CH. Larger-sized microplastics had higher GWP (125%) due to their 9% CO and 63% NO emissions. GWP rose sharply if soil microplastics content exceeded 0.5%. Higher CO emissions, ranging from 4% to 20%, arose from soil which was either fine, saturated or had high-carbon content. Higher NO emissions, ranging from 10% to 95%, arose from soils that had either medium texture, saturated water content or low-carbon content. Both CO and NO emissions were 43% to 56% higher from soils with neutral pH. We conclude that microplastics contamination can cause raised GHGs emissions, posing a risk of exacerbating climate-change. We show clear links between GHGs emissions, microplastics properties, soil characteristics and soil microbe functional gene expression. Further research is needed regarding underlying mechanisms and processes.
Shahid Iqbal, Jianchu Xu, Muhammad Saleem Arif, Awais Shakoor, Fiona R Worthy, Gui Heng, Sehroon Khan, Dengpan Bu, Sadia Nader, Sailesh Ranjitkar

2824 related Products with: Could soil microplastic pollution exacerbate climate change? A meta-analysis of greenhouse gas emissions and global warming potential.

1 module100ug1 module 15 ml 1 module50 mg100ug 100ul100ug Lyophilized1 module

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#38631242   2024/04/11 To Up

Fulvic acid-mediated efficient anaerobic digestion for kitchen wastewater: Electrochemical and biochemical mechanisms.

Fulvic acid, prevalent in humus derived from the anaerobic digestion of kitchen wastewater, is crucial in organic matter transformation. However, its effects and underlying mechanisms remain unclear. In this study, the fate of anaerobic digestion of artificial and kitchen wastewater with different fulvic acid contents was investigated. The results showed that 125 mg/L fulvic acid resulted in a 64.02 and 51.72 % increase in methane production in synthetic and kitchen wastewater, respectively. Fulvic acid acted as an electron mediator and increased substrate oxidation by boosting NAD and ATP levels, thereby increasing microbial metabolic rates and ensuring an adequate substrate for methane generation. Isotope analysis suggested that fulvic acid boosts the conversion of volatile fatty acids to methane via the interspecies electron transfer pathway. Gene expression analysis revealed that cytochrome c, FAD, and other electron transport coenzymes were upregulated by fulvic acid, thereby enhancing substrate utilisation and biogas quality. Fulvic acid presented a dual stimulatory and inhibitory effect on anaerobic digestion, with concentrations over 125 mg/L diminishing its positive impact. This dual effect may stem from the properties and concentrations of fulvic acid. This study revealed the effect mechanism of fulvic acid and provided insights into the humus performance in anaerobic digestion.
Xinyu Yan, Pin Peng, Xudong Zhou, Xiang Li, Lixiang Chen, Feng Zhao

1907 related Products with: Fulvic acid-mediated efficient anaerobic digestion for kitchen wastewater: Electrochemical and biochemical mechanisms.

10 mg 1 G 1 G 1 G10 mg 1 G 1 G5mg 1 G 500 G25 g5 g

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#38627378   2024/04/16 To Up

Ultrasensitive single-step CRISPR detection of monkeypox virus in minutes with a vest-pocket diagnostic device.

The emerging monkeypox virus (MPXV) has raised global health concern, thereby highlighting the need for rapid, sensitive, and easy-to-use diagnostics. Here, we develop a single-step CRISPR-based diagnostic platform, termed SCOPE (Streamlined CRISPR On Pod Evaluation platform), for field-deployable ultrasensitive detection of MPXV in resource-limited settings. The viral nucleic acids are rapidly released from the rash fluid swab, oral swab, saliva, and urine samples in 2 min via a streamlined viral lysis protocol, followed by a 10-min single-step recombinase polymerase amplification (RPA)-CRISPR/Cas13a reaction. A pod-shaped vest-pocket analysis device achieves the whole process for reaction execution, signal acquisition, and result interpretation. SCOPE can detect as low as 0.5 copies/µL (2.5 copies/reaction) of MPXV within 15 min from the sample input to the answer. We validate the developed assay on 102 clinical samples from male patients / volunteers, and the testing results are 100% concordant with the real-time PCR. SCOPE achieves a single-molecular level sensitivity in minutes with a simplified procedure performed on a miniaturized wireless device, which is expected to spur substantial progress to enable the practice application of CRISPR-based diagnostics techniques in a point-of-care setting.
Yunxiang Wang, Hong Chen, Kai Lin, Yongjun Han, Zhixia Gu, Hongjuan Wei, Kai Mu, Dongfeng Wang, Liyan Liu, Ronghua Jin, Rui Song, Zhen Rong, Shengqi Wang

2215 related Products with: Ultrasensitive single-step CRISPR detection of monkeypox virus in minutes with a vest-pocket diagnostic device.

500 25100 1 mg1 mL1001 mg1 mL1 mg

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#38625749   2024/04/16 To Up

Handedness-Inverted and Stimuli-Responsive Circularly Polarized Luminescent Nano/Micro-Materials through Pathway-Dependent Chiral Supramolecular Polymorphism.

The precise manipulation of supramolecular polymorphs has been widely applied to control the morphologies and functions of self-assemblies, but is rarely utilized for the fabrication of circularly polarized luminescence (CPL) materials with tailored properties. Here, we report that an amphiphilic naphthalene-histidine compound (NIHis) readily self-assembled into distinct chiral nanostructures through pathway-dependent supramolecular polymorphism, which showed opposite and multi-stimuli responsive CPL signals. Specifically, NIHis displayed assembly-induced CPL from the polymorphic keto tautomer, which became predominant during enol-keto tautomerization shifting controlled by a bulk solvent effect. Interestingly, chiral polymorphs of nanofiber and microbelt with inverted CPL signals could be prepared from the same NIHis monomer in exactly the same solvent compositions and concentrations by only changing the temperature. The tunable CPL performance of the solid microbelts is realized under multi external physical or chemical external stimuli including grinding, acid fuming and heating. In particular, an emission color and CPL on-off switch based on the microbelt polymorph by reversible heating-cooling protocol was developed. This work brings a new approach for developing smart CPL materials via supramolecular polymorphism engineering. This article is protected by copyright. All rights reserved.
Chenyang Zhao, Yuan Wang, Yuqian Jiang, Ningning Wu, Hanxiao Wang, Tiejun Li, Guanghui Ouyang, Minghua Liu

1979 related Products with: Handedness-Inverted and Stimuli-Responsive Circularly Polarized Luminescent Nano/Micro-Materials through Pathway-Dependent Chiral Supramolecular Polymorphism.

25 mg1100.00 ul250ul10 mg100ug100ug Lyophilized50 ug 500 MG2 Pieces/Box2 Pieces/Box

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#38623704   2024/04/16 To Up

Multiple physical crosslinked highly adhesive and conductive hydrogels for human motion and electrophysiological signal monitoring.

Hydrogel-based flexible electronic devices serve as a next-generation bridge for human-machine interaction and find extensive applications in clinical therapy, military equipment, and wearable devices. However, the mechanical mismatch between hydrogels and human tissues, coupled with the failure of conformal interfaces, hinders the transmission of information between living organisms and flexible devices, which resulted in the instability and low fidelity of signals, especially in the acquisition of electromyographic (EMG) and electrocardiographic (ECG) signals. In this study, we designed an ion-conductive hydrogel (ICHgel) utilizing multiple physical interactions, successfully applied for human motion monitoring and the collection of epidermal physiological signals. By incorporating fumed silica (F-SiO) nanoparticles and calcium chloride into an interpenetrating network (IPN) composed of polyvinyl alcohol (PVA) and polyacrylamide (AAm)/acrylic acid (AA) chains, the ICHgel exhibited exceptional tunable stretchability (>1450% strain) and conductivity (10.58 ± 0.85 S m). Additionally, the outstanding adhesion of the ICHgel proved to be a critical factor for effective communication between epidermal tissues and flexible devices. Demonstrating its capability to acquire stable electromechanical signals, the ICHgel was attached to different parts of the human body. More importantly, as a flexible electrode, the ICHgel outperformed commercial Ag/AgCl electrodes in the collection of ECG and EMG signals. In summary, the synthesized ICHgel with its outstanding conformal interface capabilities and mechanical adaptability paves the way for enhanced human-machine interaction, fostering the development of flexible electronic devices.
Qirui Wu, Anbang Chen, Yidan Xu, Songjiu Han, Jiayu Zhang, Yujia Chen, Jianren Hang, Xiaoxiang Yang, Lunhui Guan

2017 related Products with: Multiple physical crosslinked highly adhesive and conductive hydrogels for human motion and electrophysiological signal monitoring.

1 ml200 1000 0.1 mg100ul16 Arrays/Slide16 Arrays/Slide4 Arrays/Slide1 mg16 Arrays/Slide4 Membranes/Box

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#38623300   2024/04/15 To Up

Influences of Ru and ZrO interaction on the hydroesterification of styrene.

Interfacial Lewis acid-base pairs are commonly found in ZrO-supported metal catalysts due to the facile generation of oxygen vacancies of ZrO. These pairs have been reported to play a crucial role in olefin hydroesterification, especially in the absence of acid promoters and ligands. In this study, a series of ZrO-supported Ru catalysts with ruthenium(iii) chloride and ruthenium(iii) acetylacetonate as precursors were prepared for the styrene hydroesterification. The catalysts were thoroughly characterized by TPR, TEM, EPR, XPS, and FTIR. The Ru precursors significantly influenced the size and electronic properties of Ru clusters, albeit having minimal impact on oxygen vacancies. Mechanistic studies of styrene hydroesterification over ZrO-supported Ru catalysts revealed that the carbon monoxide insertion followed the hydrogen transfer step to activated styrene. Higher activity is exhibited over ZrO-supported Ru catalysts prepared with ruthenium(iii) chloride as a precursor, attributed to the lower adsorption strength of CO over Ru clusters, as evidenced by FTIR and DFT calculations.
Fei Xue, Fang Wang, Min Liao, Mengli Liu, Qunye Hong, Zhen Li, Chungu Xia, Jinbang Wang

1249 related Products with: Influences of Ru and ZrO interaction on the hydroesterification of styrene.

1 Set1 Set 5 G1 Set1 Set1 Set196T1 Set1 Set1 Set100ug

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#38622379   2024/04/15 To Up

DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity.

Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR-Cas, detect and cleave invader nucleic acids using complementary guides and the nuclease activities of pAgo or Cas proteins. However, not all pAgos are active nucleases. A large clade of short pAgos bind nucleic acid guides but lack nuclease activity, suggesting a different mechanism of action. Here we investigate short pAgos associated with a putative effector nuclease, NbaAgo from Novosphingopyxis baekryungensis and CmeAgo from Cupriavidus metallidurans. We show that these pAgos form a heterodimeric complex with co-encoded effector nucleases (short prokaryotic Argonaute, DNase and RNase associated (SPARDA)). RNA-guided target DNA recognition unleashes the nuclease activity of SPARDA leading to indiscriminate collateral cleavage of DNA and RNA. Activation of SPARDA by plasmids or phages results in degradation of cellular DNA and cell death or dormancy, conferring target-specific population protection and expanding the range of known prokaryotic immune systems.
Maria Prostova, Anna Kanevskaya, Vladimir Panteleev, Lidia Lisitskaya, Kristina V Perfilova Tugaeva, Nikolai N Sluchanko, Daria Esyunina, Andrey Kulbachinskiy

1447 related Products with: DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity.

1g1 ml100ul100mg20mg0.2 mg1mg1 mg100ug200

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