Search results for: MAGI2
#39323814 
2024/09/14
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Prognostic signature and immune landscape of 5-methylcytosine-related long non-coding RNAs in gastric cancer.
Long non-coding RNAs (lncRNAs) have been demonstrated to be useful in assessing the prognosis of cancer patients. However, few studies have focused on 5-methylcytosine-related lncRNAs (m5C-lncRNAs) in gastric cancer (GC). In this study, we aimed to establish a m5C-lncRNAs prognostic signature (m5C-LPS) and explore its potential impact on guiding clinical practice for GC.Qingyu Song, Jingyu Wu, Hao Wan, Desen Fan
2258 related Products with: Prognostic signature and immune landscape of 5-methylcytosine-related long non-coding RNAs in gastric cancer.
200ul
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#39169280 2024/08/21
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CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation.
Breast cancer (BC) ranks as the third most fatal malignant tumor worldwide, with a strong reliance on fatty acid metabolism. CLDN6, a candidate BC suppressor gene, was previously identified as a regulator of fatty acid biosynthesis; however, the underlying mechanism remains elusive. In this research, we aim to clarify the specific mechanism through which CLDN6 modulates fatty acid anabolism and its impact on BC growth and metastasis.Qiu Jin, Da Qi, Mingzi Zhang, Huinan Qu, Yuan Dong, Minghao Sun, Chengshi Quan
2270 related Products with: CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation.
100ulEach
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#39080678 2024/07/30
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Is cross-species horizontal gene transfer responsible for gallbladder carcinogenesis.
Cross-species horizontal gene transfer (HGT) involves the transfer of genetic material between different species of organisms. In recent years, mounting evidence has emerged that cross-species HGT does take place and may play a role in the development and progression of diseases.Monika Rajput, Manoj Pandey, Ruhi Dixit, Vijay K Shukla
2418 related Products with: Is cross-species horizontal gene transfer responsible for gallbladder carcinogenesis.
0.1 mg100 ml25 µg0.25 mg25 µg0.2 mg0.1 ml100 TESTS250 ml0.05 mg0.1 mg1 LITRE
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#38968594 2024/07/03
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Unveiling diabetic nephropathy: a novel diagnostic model through single-cell sequencing and co-expression analysis.
Diabetic nephropathy (DN) is a severe complication of diabetes that affects the kidneys. Disulfidptosis, a newly defined type of programmed cell death, has emerged as a potential area of interest, yet its significance in DN remains unexplored.Guoyi Wang, Jinwen Zhao, Min Zhou, Haiyuan Lu, Fei Mao
2520 related Products with: Unveiling diabetic nephropathy: a novel diagnostic model through single-cell sequencing and co-expression analysis.
24 reactions 25 100ug1 kit2 Pieces/Box0.1mg100ug5001 module
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#38943582 //
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[A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer].
Breast cancer is the most common type of cancer among women. The study of the mechanisms of metastasis, the main cause of death from breast cancer, as well as the search for new markers for early diagnosis and prognosis of breast cancer, is an extremely topical issue. New perspectives in the diagnosis and treatment of breast cancer are opened by the mechanisms of gene regulation involving non-coding RNAs, in particular, long non-coding RNAs (lncRNAs). In this work, we analyzed the methylation levels of seven lncRNA genes (MEG3, SEMA3B-AS1, HAND2-AS1, KCNK15-AS1, ZNF667-AS1, MAGI2-AS3, and PLUT) by quantitative methyl-specific PCR on a set of 79 paired (tumor/normal) samples of breast cancer. Hypermethylation of all seven lncRNA genes was revealed, and hypermethylation of HAND2-AS1, KCNK15-AS1, MAGI2-AS3, and PLUT was detected in breast cancer for the first time. It was found that the level of meth ylation of the studied lncRNA genes correlated statistically significantly with the stage of the tumor process, the size of the tumor, and the presence of metastases in the lymph nodes. Thus, methylation of the seven studied lncRNA genes is associated with the development and progression of breast cancer, and these genes can be useful as potential markers in the diagnosis and prognosis of breast cancer.E A Filippova, V I Loginov, S S Lukina, A M Burdennyy, I V Pronina, T P Kazubskaya, E A Braga
2992 related Products with: [A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer].
96T
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#38907263 2024/06/22
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LncRNA MAGI2-AS3 promotes fracture healing through downregulation of miR-223-3p.
Long non-coding RNAs (LncRNAs) are recognized as a pivotal element in the processes of fracture healing and the osteogenic differentiation of stem cells. This study investigated the molecular mechanism and regulatory significance of lncRNA MAGI2-AS3 (MAGI2-AS3) in fracture healing.Zhiqiang Dong, Bingbing Hu, Shantao Wang, Mingwei Wang, Shengliang Sun, Xinsheng Liu, Danzhi Li, Dengjiang Wu
1072 related Products with: LncRNA MAGI2-AS3 promotes fracture healing through downregulation of miR-223-3p.
25UG10, 10ml whole blood 5 G200ul200ul100 μgUp to 200 ml cultures100 μg10x96, 2.0ml cultures
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#38810140 2024/05/29
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Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development.
Wilms tumor-1(WT1) is a crucial transcription factor that regulates podocyte development. However, the epigenomic mechanism underlying the function of WT1 during podocyte development has yet to be fully elucidated. Here, single-cell chromatin accessibility and gene expression maps of foetal kidneys and kidney organoids are generated. Functional implications of WT1-targeted genes, which are crucial for the development of podocytes and the maintenance of their structure, including BMPER/PAX2/MAGI2 that regulates WNT signaling pathway, MYH9 that maintains actin filament organization and NPHS1 that modulates cell junction assembly are identified. To further illustrate the functional importance of WT1-mediated transcriptional regulation during podocyte development, cultured and implanted patient-derived kidney organoids derived from the Induced Pluripotent Stem Cell (iPSCs) of a patient with a heterozygous missense mutation in WT1 are generated. Results from single-cell RNA sequencing (scRNA-seq) and functional assays confirm that the WT1 mutation leads to delays in podocyte development and causes damage to cell structures, due to its failure to activate the targeting genes MAGI2, MYH9, and NPHS1. Notably, correcting the mutation in the patient iPSCs using CRISPR-Cas9 gene editing rescues the podocyte phenotype. Collectively, this work elucidates the WT1-related epigenomic landscape with respect to human podocyte development and identifies the disease-causing role of a WT1 mutation.Gang Wang, Hangdi Wu, Xiuwen Zhai, Li Zhang, Changming Zhang, Chen Cheng, Xiaodong Xu, Erzhi Gao, Xushen Xiong, Jin Zhang, Zhihong Liu
1834 related Products with: Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development.
Each300 units 5 G100μg
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#38806109 2024/05/26
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BMSC derived EVs inhibit colorectal Cancer progression by transporting MAGI2-AS3 or something similar.
In this study, we investigated the molecular mechanisms underlying the impact of extracellular vesicles (EVs) derived from bone marrow stromal cells (BMSCs) on colorectal cancer (CRC) development. The focus was on the role of MAGI2-AS3, delivered by BMSC-EVs, in regulating USP6NL DNA methylation-mediated MYC protein translation modification to promote CDK2 downregulation. Utilizing bioinformatics analysis, we identified significant enrichment of MAGI2-AS3 related to copper-induced cell death in CRC. In vitro experiments demonstrated the downregulation of MAGI2-AS3 in CRC cells, and BMSC-EVs were found to deliver MAGI2-AS3 to inhibit CRC cell proliferation, migration, and invasion. Further exploration revealed that MAGI2-AS3 suppressed MYC protein translation modification by regulating USP6NL DNA methylation, leading to CDK2 downregulation and prevention of colorectal cancer. Overexpression of MYC reversed the functional effects of BMSC-EVs-MAGI2-AS3. In vivo experiments validated the inhibitory impact of BMSC-EVs-MAGI2-AS3 on CRC tumorigenicity by promoting CDK2 downregulation through USP6NL DNA methylation-mediated MYC protein translation modification. Overall, BMSC-EVs-MAGI2-AS3 may serve as a potential intervention to prevent CRC occurrence by modulating key molecular pathways.Tianyi Ma, Meng Wang, Song Wang, Hanqing Hu, Xin Zhang, Hufei Wang, Guiyu Wang, Yinghu Jin