Search results for: MANBA
#39277179 
2024/09/13
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Recurrent ocular toxoplasmosis is associated with interferon-gamma deficiency possibly due to genetic origin.
Ocular toxoplasmosis (OT) can cause posterior uveitis; causes of recurrent OT are not well understood. We explored clinical, immunological and genetic properties associated with recurrent OT.Nina Maria Hautala, Maija Joensuu, Teija Paakkola, Virpi Glumoff, Kaisa Kettunen, Janna Saarela, Mira Siiskonen, Zhi Chen, Katri Pylkäs, Timo Hautala
2226 related Products with: Recurrent ocular toxoplasmosis is associated with interferon-gamma deficiency possibly due to genetic origin.
100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized
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#39218414 2024/08/30
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MRPL13 is a metastatic and prognostic marker of breast cancer: A silico analysis accompanied with experimental validation.
Although progress has been made in accurate diagnosis and targeted treatments, breast cancer (BC) patients with metastasis still present a grim prognosis. With the continuous emergence and development of new personalized and precision medicine targeting specific tumor biomarkers, there is an urgent need to find new metastatic and prognostic biomarkers for BC patients.Pei Dai, Yan'an Chen, Xiao Zhang, Long Liu, Zhenbo Cheng
2891 related Products with: MRPL13 is a metastatic and prognostic marker of breast cancer: A silico analysis accompanied with experimental validation.
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#39183036 2024/08/24
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Regional Collaboration for Heart Failure Patients Certified as Needing Support or Care in Long-Term Care Insurance System.
Heart failure (HF) patients with complex care needs often experience exacerbations during the transitional phase as care providers and settings change. Regional collaboration aims to ensure continuity of care; however, its impact on vulnerable patients certified as needing support or care under the Japanese long-term care insurance (LTCI) system remains unclear.Yoshiharu Kinugasa, Kensuke Nakamura, Masayuki Hirai, Midori Manba, Natsuko Ishiga, Takeshi Sota, Natsuko Nakayama, Tomoki Ota, Masahiko Kato, Toshiaki Adachi, Masaharu Fukuki, Yutaka Hirota, Einosuke Mizuta, Emiko Mura, Yoshihito Nozaka, Hiroki Omodani, Hiroaki Tanaka, Yasunori Tanaka, Izuru Watanabe, Masaaki Mikami, Kazuhiro Yamamoto
2600 related Products with: Regional Collaboration for Heart Failure Patients Certified as Needing Support or Care in Long-Term Care Insurance System.
1 kit100Tests100 μg100 μg5 mg 0.1 mg 100 plates
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#38929399 2024/06/13
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Genetic Foundation of Male Spur Length and Its Correlation with Female Egg Production in Chickens.
Spurs, which mainly appear in roosters, are protrusions near the tarsometatarsus on both sides of the calves of chickens, and are connected to the tarsometatarsus by a bony core. As a male-biased morphological characteristic, the diameter and length of spurs vary significantly between different individuals, mainly related to genetics and age. As a specific behavior of hens, egg-laying also varies greatly between individuals in terms of traits such as age at first egg (), egg weight (), and so on. At present, there are few studies on chicken spurs. In this study, we investigated the inheritance pattern of the spur trait in roosters with different phenotypes and the correlations between spur length, body weight at 18 weeks of age (), shank length at 18 weeks of age (), and the egg-laying trait in hens (both hens and roosters were from the same population and were grouped according to their family). These traits related to egg production included , body weight at first egg (), and first egg weight (). We estimated genetic parameters based on pedigree and phenotype data, and used variance analysis to calculate broad-sense heritability for correcting the parameter estimation results. The results showed that the heritability of male left and right spurs ranged from 0.6 to 0.7. There were significant positive correlations between left and right spur length, BW18, SL18, and BWA, as well as between left and right spur length and AFE. We selected 35 males with the longest spurs and 35 males with the shortest spurs in the population, and pooled them into two sets to obtain the pooled genome sequencing data. After genome-wide association and genome divergency analysis by F, allele frequency differences (), and XPEHH methods, we identified 7 overlapping genes (CENPE, FAT1, FAM149A, MANBA, NFKB1, SORBS2, UBE2D3) and 14 peak genes (SAMD12, TSPAN5, ENSGALG00000050071, ENSGALG00000053133, ENSGALG00000050348, CNTN5, TRPC6, ENSGALG00000047655,TMSB4X, LIX1, CKB, NEBL, PRTFDC1, MLLT10) related to left and right spur length through genome-wide selection signature analysis and a genome-wide association approach. Our results identified candidate genes associated with chicken spurs, which helps to understand the genetic mechanism of this trait and carry out subsequent research around it.Anqi Chen, Xiaoyu Zhao, Xiurong Zhao, Gang Wang, Xinye Zhang, Xufang Ren, Yalan Zhang, Xue Cheng, Xiaofan Yu, Huie Wang, Menghan Guo, Xiaoyu Jiang, Xiaohan Mei, Guozhen Wei, Xue Wang, Runshen Jiang, Xing Guo, Zhonghua Ning, Lujiang Qu
2287 related Products with: Genetic Foundation of Male Spur Length and Its Correlation with Female Egg Production in Chickens.
1 mg
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#38898596 //
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Identifying novel proteins for migraine by integrating proteomes from blood and CSF with genome-wide association data.
Proteome-wide Mendelian randomization studies have been increasingly utilized to identify potential drug targets for diseases. We aimed to identify potential therapeutic targets for migraine and its subtypes through the application of Mendelian randomization and co-localization analysis methods.Peng-Peng Niu, Rui Zhang, Chan Zhang, Shuo Li, Yu-Sheng Li
1123 related Products with: Identifying novel proteins for migraine by integrating proteomes from blood and CSF with genome-wide association data.
201mg250 1mg101051 mg101mg100
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#38736846 2024/04/20
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Association of a Transitional Heart Failure Management Program With Readmission and End-of-Life Care in Rural Japan.
Evidence on transitional care for heart failure (HF) in Japan is limited. We implemented a transitional HF management program in rural Japan in 2019. This involved collaboration with general practitioners or nursing care facilities and included symptom monitoring by medical/nursing staff using a handbook; standardized discharge care planning and information sharing on self-care and advance care planning using a collaborative sheet; and sharing expertise on HF management via manuals. We compared the outcomes within 1 year of discharge among patients hospitalized with HF in the 2 years before program implementation (2017-2018; historical control, n=198), in the first 2 years after program implementation (2019-2020; Intervention Phase 1, n=205), and in the second 2 years, following program revision and regional dissemination (2021-2022; Intervention Phase 2, n=195). HF readmission rates gradually decreased over Phases 1 and 2 (P<0.05). This association was consistent regardless of physician expertise, follow-up institution, or the use of nursing care services (P>0.1 for interaction). Mortality rates remained unchanged, but significantly more patients received end-of-life care at home in Phase 2 than before (P<0.05). The implementation of a transitional care program was associated with decreased HF readmissions and increased end-of-life care at home for HF patients in rural Japan.Yoshiharu Kinugasa, Kensuke Nakamura, Masayuki Hirai, Midori Manba, Natsuko Ishiga, Takeshi Sota, Natsuko Nakayama, Tomoki Ohta, Masahiko Kato, Toshiaki Adachi, Masaharu Fukuki, Yutaka Hirota, Einosuke Mizuta, Emiko Mura, Yoshihito Nozaka, Hiroki Omodani, Hiroaki Tanaka, Yasunori Tanaka, Izuru Watanabe, Masaaki Mikami, Kazuhiro Yamamoto
1576 related Products with: Association of a Transitional Heart Failure Management Program With Readmission and End-of-Life Care in Rural Japan.
100 UG1 Product tipe: Instrumen100.00 ug20 1 L.1.00 flask10 mg
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#38559486 2024/02/26
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Historical background and current situation of pharmacy education in Mongolia.
In Mongolia, the medical education system with a long history has developed with its characteristics since ancient times. Modern medical education, including pharmacy education, began to grow in 1921. Before modern pharmaceutical science developed in Mongolia, pharmacy and pharmacy education were part of Traditional Mongolian Medicine and education. Medical knowledge and experience were transferred from generation to generation through simple teaching. From the sixteenth century, Manba Datsan was established in religious temples to teach Mongolian medicine through discipleship. Modern pharmacy education in Mongolia began in 1926 with the course training of pharmacy technicians, and pharmacist training started in 1961. Pharmacy technician training with a 3-year and pharmacist training with 5-year programs oriented on patient-centered pharmaceutical care are implemented in Mongolia. Pharmacy technicians can also study towards a B. degree in Pharmacy with an additional 3 years of training. As of 2023, seven state-owned and private higher education institutions offer pharmacy education and the number of institutions and students of pharmacy is expected to increase. The pharmacy education policy and the license examination type may be reformable, and the curricula should be regularly updated in line with international trends.Purevsuren Sodnomtseren
2878 related Products with: Historical background and current situation of pharmacy education in Mongolia.
100 μg100 μg5 mg 25 G100ug Lyophilized12480/kit1 mg100ug Lyophilized
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#38420448 2024/02/14
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A novel lysosome-related prognostic signature associated with prognosis and immune infiltration landscape in oral squamous cell carcinoma.
Predicting the outcome of oral squamous cell carcinoma (OSCC) is challenging due to its diverse nature and intricate causes. This research explores how lysosome-associated genes (LRGs) might forecast overall survival (OS) and correlate with immune infiltration in OSCC patients.Jing-Jing Liu, Zhi-Ming Xu, Ying Liu, Xi-Yuan Guo, Wei-Bing Zhang
1754 related Products with: A novel lysosome-related prognostic signature associated with prognosis and immune infiltration landscape in oral squamous cell carcinoma.
96tests
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#38274828 2024/01/11
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Examining the function of macrophage oxidative stress response and immune system in glioblastoma multiforme through analysis of single-cell transcriptomics.
Glioblastoma (GBM), a prevalent malignant neoplasm within the neuro-oncological domain, has been a subject of considerable scrutiny. Macrophages, serving as the principal immunological constituents, profoundly infiltrate the microenvironment of GBM. However, investigations elucidating the intricate immunological mechanisms governing macrophage involvement in GBM at the single-cell level remain notably limited.Jin Xing, Huabao Cai, Zhiheng Lin, Liang Zhao, Hao Xu, Yanbing Song, Zhihan Wang, Chaobo Liu, Guangdong Hu, Jiajie Zheng, Li Ren, Zilong Wei
2714 related Products with: Examining the function of macrophage oxidative stress response and immune system in glioblastoma multiforme through analysis of single-cell transcriptomics.
10 ug1 mg 100 UG6case96 samples100ug Lyophilized
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#38149987 2023/12/26
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Mapping of the gene network that regulates glycan clock of ageing.
Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association studies (GWAS) identified 29 genomic regions involved in regulation of IgG glycosylation, but only a few were functionally validated. One of the key functional features of IgG glycosylation is the addition of galactose (galactosylation), a trait which was shown to be associated with ageing. We performed GWAS of IgG galactosylation (N=13,705) and identified 16 significantly associated loci, indicating that IgG galactosylation is regulated by a complex network of genes that extends beyond the galactosyltransferase enzyme that adds galactose to IgG glycans. Gene prioritization identified 37 candidate genes. Using a recently developed CRISPR/dCas9 system we manipulated gene expression of candidate genes in the IgG expression system. Upregulation of three genes, and , changed the IgG glycome composition, which confirmed that these three genes are involved in IgG galactosylation in this expression system.Azra Frkatović-Hodžić, Anika Mijakovac, Karlo Miškec, Arina Nostaeva, Sodbo Z Sharapov, Arianna Landini, Toomas Haller, Erik van den Akker, Sapna Sharma, Rafael R C Cuadrat, Massimo Mangino, Yong Li, Toma Keser, Najda Rudman, Tamara Štambuk, Maja Pučić-Baković, Irena Trbojević-Akmačić, Ivan Gudelj, Jerko Štambuk, Tea Pribić, Barbara Radovani, Petra Tominac, Krista Fischer, Marian Beekman, Manfred Wuhrer, Christian Gieger, Matthias B Schulze, Clemens Wittenbecher, Ozren Polasek, Caroline Hayward, James F Wilson, Tim D Spector, Anna Köttgen, Frano Vučković, Yurii S Aulchenko, Aleksandar Vojta, Jasminka Krištić, Lucija Klarić, Vlatka Zoldoš, Gordan Lauc