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Search results for: Mouse Anti-Human CD42a Antibodies

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#30223883   2018/09/17 To Up

Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction.

Platelet glycoprotein Ibα (GPIbα) extracellular domain, which is part of the receptor complex GPIb-IX-V, plays an important role in tumor metastasis. However, the mechanism through which GPIbα participates in the metastatic process remains unclear. In addition, potential bleeding complication remains an obstacle for the clinical use of anti-platelet agents in cancer therapy.
Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang, Renhao Li, Jianwen Liu, Xin Liang

2913 related Products with: Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction.

100 100.00 ug100.00 ug20 mg25mg100.00 ug100 1 ml0.1 ml100.00 ug50 mg250 TESTS

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#24601701   // To Up

Activated platelets in patients suffering from inflammatory bowel disease.

There is an increased risk of thromboembolic complications in inflammatory bowel disease. Activated platelets play a crucial role in the pathogenesis of this disease.
Y Tekelioglu, H Uzun, G Sisman

1612 related Products with: Activated platelets in patients suffering from inflammatory bowel disease.

96 tests1-99 mg/ml/ea price x 25ug5ug96 tests

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#12490794   // To Up

The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation.

Porcine von Willebrand factor (pvWF) has been shown to bind to human glycoprotein Ib (GPIb) and cause activation of human (or primate) platelets in the absence of shear stress. Pulmonary xenografts develop disseminated intravascular coagulation (DIC) and microvascular thrombosis within hours of reperfusion, and the aberrant interaction between pvWF and human platelets may be a possible cause of xenograft-associated DIC.
Jeffrey G Gaca, Aaron Lesher, Olcay Aksoy, Zaverio M Ruggeri, William Parker, R Duane Davis

1958 related Products with: The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation.

1110 100.00 ug

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#10971412   // To Up

Monoclonal antibody-mediated inhibition of the human HLA alloimmune response to platelet transfusion is antigen specific and independent of Fcgamma receptor-mediated immune suppression.

Presensitization of donor platelets with allo-specific immunoglobulin (Ig)G results in a diminished immune response against subsequent transfusions of platelets. To understand better the mechanism of how alloantibody presensitization results in a decreased alloimmune response, we have used murine monoclonal antibodies directed to polymorphic and non-polymorphic regions of human leucocyte antigen (HLA) as well as platelet-specific molecules. Here, we demonstrated that presensitization with anti-human HLA class I antibodies, as well as beta2-microglobulin-specific antibody, protected against alloantibody production to five subsequent untreated platelet challenges. Use of complement fixing, non-fixing or F(ab')2 fragments of HLA-specific antibody also resulted in complete inhibition of alloantibody production. This protection was not seen when the platelets were presensitized with monoclonal antibodies to CD42a (GPIX), CD32 (low-affinity IgG/Fcgamma receptor) or murine IgG and was thus independent of B-cell FcgammaRII-mediated immune suppression. The inhibition observed was independent of HLA alloantigenic specificity as antibodies directed at the beta2-microglobulin portion of HLA class I were as effective as antibodies against any of the HLA-alpha regions (either polymorphic or non-polymorphic) of class I. This work demonstrates that monoclonal antibody-mediated suppression of the human HLA alloimmune response to platelet transfusion is antigen specific and is independent of FcgammaRII-mediated immune regulation, complement fixing or HLA alloantigenic specificity.
A R Crow, J Freedman, B Hannach, A H Lazarus

2666 related Products with: Monoclonal antibody-mediated inhibition of the human HLA alloimmune response to platelet transfusion is antigen specific and independent of Fcgamma receptor-mediated immune suppression.

25 µg25 µg100 TESTS200 ug0.2 mg200 ug100ug Lyophilized100ug Lyophilized100ug Lyophilized100 ug1 mg

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